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Aliases for CRY2 Gene

Aliases for CRY2 Gene

  • Cryptochrome Circadian Clock 2 2 3 5
  • Cryptochrome 2 (Photolyase-Like) 2 3
  • Growth-Inhibiting Protein 37 3
  • KIAA0658 4
  • HCRY2 3
  • PHLL2 3

External Ids for CRY2 Gene

Previous GeneCards Identifiers for CRY2 Gene

  • GC11P047653
  • GC11P046558
  • GC11P045866
  • GC11P045833
  • GC11P045825
  • GC11P045575

Summaries for CRY2 Gene

Entrez Gene Summary for CRY2 Gene

  • This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene have been associated with altered sleep patterns. The encoded protein is widely conserved across plants and animals. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]

GeneCards Summary for CRY2 Gene

CRY2 (Cryptochrome Circadian Clock 2) is a Protein Coding gene. Diseases associated with CRY2 include major depressive disorder and accelerated response to antidepressant drug treatment. Among its related pathways are Circadian rhythm and Metabolic States and Circadian Oscillators. GO annotations related to this gene include protein kinase binding and kinase binding. An important paralog of this gene is CRY1.

UniProtKB/Swiss-Prot for CRY2 Gene

  • Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots circa (about) and diem (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for timegivers). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, ARNTL/BMAL1, ARNTL2/BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and ARNTL/BMAL1 or ARNTL2/BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5-CACGTG-3) within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK NPAS2-ARNTL/BMAL1 ARNTL2/BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress ARNTL/BMAL1 transcription, respectively. CRY1 and CRY2 have redundant functions but also differential and selective contributions at least in defining the pace of the SCN circadian clock and its circadian transcriptional outputs. Less potent transcriptional repressor in cerebellum and liver than CRY1, though less effective in lengthening the period of the SCN oscillator. Seems to play a critical role in tuning SCN circadian period by opposing the action of CRY1. With CRY1, dispensable for circadian rhythm generation but necessary for the development of intercellular networks for rhythm synchrony. May mediate circadian regulation of cAMP signaling and gluconeogenesis by blocking glucagon-mediated increases in intracellular cAMP concentrations and in CREB1 phosphorylation. Besides its role in the maintenance of the circadian clock, is also involved in the regulation of other processes. Plays a key role in glucose and lipid metabolism modulation, in part, through the transcriptional regulation of genes involved in these pathways, such as LEP or ACSL4. Represses glucocorticoid receptor NR3C1/GR-induced transcriptional activity by binding to glucocorticoid response elements (GREs). Represses the CLOCK-ARNTL/BMAL1 induced transcription of BHLHE40/DEC1. Represses the CLOCK-ARNTL/BMAL1 induced transcription of NAMPT (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRY2 Gene

Genomics for CRY2 Gene

Regulatory Elements for CRY2 Gene

Enhancers for CRY2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CRY2 on UCSC Golden Path with GeneCards custom track

Promoters for CRY2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CRY2 on UCSC Golden Path with GeneCards custom track

Genomic Location for CRY2 Gene

Chromosome:
11
Start:
45,847,118 bp from pter
End:
45,883,248 bp from pter
Size:
36,131 bases
Orientation:
Plus strand

Genomic View for CRY2 Gene

Genes around CRY2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CRY2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CRY2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRY2 Gene

Proteins for CRY2 Gene

  • Protein details for CRY2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q49AN0-CRY2_HUMAN
    Recommended name:
    Cryptochrome-2
    Protein Accession:
    Q49AN0
    Secondary Accessions:
    • B4DH32
    • B4DZD6
    • O75148
    • Q8IV71

    Protein attributes for CRY2 Gene

    Size:
    593 amino acids
    Molecular mass:
    66947 Da
    Cofactor:
    Name=5,10-methylenetetrahydrofolate; Xref=ChEBI:CHEBI:12071;
    Cofactor:
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Quaternary structure:
    • Component of the circadian core oscillator, which includes the CRY proteins, CLOCK or NPAS2, ARNTL/BMAL1 or ARNTL2/BMAL2, CSNK1D and/or CSNK1E, TIMELESS, and the PER proteins. Interacts directly with PER1 and PER2 C-terminal domains. Interaction with PER2 inhibits its ubiquitination and vice versa. Interacts with NFIL3. Interacts with FBXL3 (PubMed:17463251). Interacts with FBXL21. FBXL3, PER2 and the cofactor FAD compete for overlapping binding sites. FBXL3 cannot bind CRY2 that interacts already with PER2 or that contains bound FAD. Interacts with PPP5C (via TPR repeats); the interaction downregulates the PPP5C phosphatase activity on CSNK1E (PubMed:16790549). AR, NR1D1, NR3C1/GR, RORA and RORC; the interaction, at least, with NR3C1/GR is ligand dependent. Interacts with PRKDC and CIART. Interacts with ISCA1 (in vitro) (PubMed:26569474).
    SequenceCaution:
    • Sequence=AAH35161.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact. Aberrant splice sites.; Evidence={ECO:0000305}; Sequence=BAG57993.1; Type=Erroneous termination; Positions=110; Note=Translated as Trp.; Evidence={ECO:0000305}; Sequence=BAG57993.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=BAG64048.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for CRY2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CRY2 Gene

Proteomics data for CRY2 Gene at MOPED

Post-translational modifications for CRY2 Gene

  • Phosphorylation on Ser-266 by MAPK is important for the inhibition of CLOCK-ARNTL-mediated transcriptional activity. Phosphorylation by CSKNE requires interaction with PER1 or PER2. Phosphorylated in a circadian manner at Ser-554 and Ser-558 in the suprachiasmatic nucleus (SCN) and liver. Phosphorylation at Ser-558 by DYRK1A promotes subsequent phosphorylation at Ser-554 by GSK3-beta: the two-step phosphorylation at the neighboring Ser residues leads to its proteasomal degradation.
  • Ubiquitinated by the SCF(FBXL3) and SCF(FBXL21) complexes, regulating the balance between degradation and stabilization. The SCF(FBXL3) complex is mainly nuclear and mediates ubiquitination and subsequent degradation of CRY2. In contrast, cytoplasmic SCF(FBXL21) complex-mediated ubiquitination leads to stabilize CRY2 and counteract the activity of the SCF(FBXL3) complex. The SCF(FBXL3) and SCF(FBXL21) complexes probably mediate ubiquitination at different Lys residues. The SCF(FBXL3) complex recognizes and binds CRY2 phosphorylated at Ser-554 and Ser-558. Ubiquitination may be inhibited by PER2.
  • Ubiquitination at Lys 126, Lys 242, Lys 348, Lys 475, and Lys 504
  • Modification sites at PhosphoSitePlus

Other Protein References for CRY2 Gene

Antibody Products

No data available for DME Specific Peptides for CRY2 Gene

Domains & Families for CRY2 Gene

Protein Domains for CRY2 Gene

Suggested Antigen Peptide Sequences for CRY2 Gene

Graphical View of Domain Structure for InterPro Entry

Q49AN0

UniProtKB/Swiss-Prot:

CRY2_HUMAN :
  • Contains 1 photolyase/cryptochrome alpha/beta domain.
  • Belongs to the DNA photolyase class-1 family.
Domain:
  • Contains 1 photolyase/cryptochrome alpha/beta domain.
Family:
  • Belongs to the DNA photolyase class-1 family.
genes like me logo Genes that share domains with CRY2: view

No data available for Gene Families for CRY2 Gene

Function for CRY2 Gene

Molecular function for CRY2 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots circa (about) and diem (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for timegivers). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, ARNTL/BMAL1, ARNTL2/BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and ARNTL/BMAL1 or ARNTL2/BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5-CACGTG-3) within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK NPAS2-ARNTL/BMAL1 ARNTL2/BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress ARNTL/BMAL1 transcription, respectively. CRY1 and CRY2 have redundant functions but also differential and selective contributions at least in defining the pace of the SCN circadian clock and its circadian transcriptional outputs. Less potent transcriptional repressor in cerebellum and liver than CRY1, though less effective in lengthening the period of the SCN oscillator. Seems to play a critical role in tuning SCN circadian period by opposing the action of CRY1. With CRY1, dispensable for circadian rhythm generation but necessary for the development of intercellular networks for rhythm synchrony. May mediate circadian regulation of cAMP signaling and gluconeogenesis by blocking glucagon-mediated increases in intracellular cAMP concentrations and in CREB1 phosphorylation. Besides its role in the maintenance of the circadian clock, is also involved in the regulation of other processes. Plays a key role in glucose and lipid metabolism modulation, in part, through the transcriptional regulation of genes involved in these pathways, such as LEP or ACSL4. Represses glucocorticoid receptor NR3C1/GR-induced transcriptional activity by binding to glucocorticoid response elements (GREs). Represses the CLOCK-ARNTL/BMAL1 induced transcription of BHLHE40/DEC1. Represses the CLOCK-ARNTL/BMAL1 induced transcription of NAMPT (By similarity).

Gene Ontology (GO) - Molecular Function for CRY2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000976 transcription regulatory region sequence-specific DNA binding IEA,ISS --
GO:0000989 transcription factor activity, transcription factor binding IDA 15147242
GO:0003684 damaged DNA binding IDA 12627958
GO:0003697 single-stranded DNA binding IDA 12627958
GO:0005515 protein binding IEA,IPI 9383998
genes like me logo Genes that share ontologies with CRY2: view
genes like me logo Genes that share phenotypes with CRY2: view

Animal Models for CRY2 Gene

MGI Knock Outs for CRY2:

Animal Model Products

miRNA for CRY2 Gene

miRTarBase miRNAs that target CRY2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CRY2 Gene

Localization for CRY2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CRY2 Gene

Cytoplasm. Nucleus. Note=Translocated to the nucleus through interaction with other Clock proteins such as PER2 or ARNTL.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CRY2 Gene COMPARTMENTS Subcellular localization image for CRY2 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 3
endoplasmic reticulum 1
lysosome 1
mitochondrion 1
peroxisome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for CRY2 Gene

Pathways & Interactions for CRY2 Gene

genes like me logo Genes that share pathways with CRY2: view

Pathways by source for CRY2 Gene

1 KEGG pathway for CRY2 Gene

Gene Ontology (GO) - Biological Process for CRY2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000719 NOT photoreactive repair IDA 12627958
GO:0007623 circadian rhythm IEA,ISS --
GO:0019915 lipid storage IEA --
GO:0032515 negative regulation of phosphoprotein phosphatase activity IDA 9383998
GO:0032868 response to insulin IEA --
genes like me logo Genes that share ontologies with CRY2: view

No data available for SIGNOR curated interactions for CRY2 Gene

Drugs & Compounds for CRY2 Gene

(1) Drugs for CRY2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
FAD Approved Pharma 0

(1) Additional Compounds for CRY2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CRY2: view

Transcripts for CRY2 Gene

Unigene Clusters for CRY2 Gene

Cryptochrome 2 (photolyase-like):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CRY2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b
SP1: -
SP2: -
SP3: - - -
SP4:
SP5:

Relevant External Links for CRY2 Gene

GeneLoc Exon Structure for
CRY2
ECgene alternative splicing isoforms for
CRY2

Expression for CRY2 Gene

mRNA expression in normal human tissues for CRY2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CRY2 Gene

This gene is overexpressed in Testis (36.2), Retina (20.7), and Pancreas (12.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CRY2 Gene



SOURCE GeneReport for Unigene cluster for CRY2 Gene Hs.532491

mRNA Expression by UniProt/SwissProt for CRY2 Gene

Q49AN0-CRY2_HUMAN
Tissue specificity: Expressed in all tissues examined including fetal brain, fibroblasts, heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and leukocytes. Highest levels in heart and skeletal muscle.
genes like me logo Genes that share expression patterns with CRY2: view

Protein tissue co-expression partners for CRY2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for CRY2 Gene

Orthologs for CRY2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CRY2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC509058 35
  • 91.25 (n)
  • 95.45 (a)
CRY2 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CRY2 35
  • 93.29 (n)
  • 97.57 (a)
CRY2 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cry2 35
  • 90.97 (n)
  • 96.01 (a)
Cry2 16
Cry2 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CRY2 35
  • 99.57 (n)
  • 99.67 (a)
CRY2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cry2 35
  • 89.93 (n)
  • 95.49 (a)
oppossum
(Monodelphis domestica)
Mammalia CRY2 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CRY2 36
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves CRY2 35
  • 79.26 (n)
  • 88.05 (a)
CRY2 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CRY2 36
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cry2 35
  • 73.68 (n)
  • 83.43 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.12080 35
zebrafish
(Danio rerio)
Actinopterygii cry3 35
  • 72.44 (n)
  • 78.99 (a)
cry3 36
  • 71 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta cry 37
  • 41 (a)
phr6-4 37
  • 53 (a)
cry 36
  • 39 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PHR1 36
  • 18 (a)
OneToMany
Species with no ortholog for CRY2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CRY2 Gene

ENSEMBL:
Gene Tree for CRY2 (if available)
TreeFam:
Gene Tree for CRY2 (if available)

Paralogs for CRY2 Gene

Paralogs for CRY2 Gene

(1) SIMAP similar genes for CRY2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CRY2: view

Variants for CRY2 Gene

Sequence variations from dbSNP and Humsavar for CRY2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs877412 -- 45,876,100(+) TCTGT(A/C)ATTTT intron-variant
rs939104 -- 45,862,581(-) TAAGG(G/T)GAGCA intron-variant
rs1043746 -- 45,883,193(+) CTCCC(A/C)CAATT utr-variant-3-prime
rs1401417 -- 45,858,559(-) GTTCA(C/G)AAAGT intron-variant
rs1401418 -- 45,858,488(-) GGTAG(G/T)CAGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CRY2 Gene

Variant ID Type Subtype PubMed ID
nsv897314 CNV Loss 21882294
nsv307 CNV Insertion 18451855
nsv516442 CNV Loss 19592680

Variation tolerance for CRY2 Gene

Residual Variation Intolerance Score: 16.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.92; 48.94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CRY2 Gene

HapMap Linkage Disequilibrium report
CRY2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CRY2 Gene

Disorders for CRY2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CRY2 Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards
Search CRY2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CRY2

Genetic Association Database (GAD)
CRY2
Human Genome Epidemiology (HuGE) Navigator
CRY2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CRY2
genes like me logo Genes that share disorders with CRY2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CRY2 Gene

Publications for CRY2 Gene

  1. Putative human blue-light photoreceptors hCRY1 and hCRY2 are flavoproteins. (PMID: 8909283) Hsu D.S. … Sancar A. (Biochemistry 1996) 2 3 4 23 67
  2. Differential association of circadian genes with mood disorders: CRY1 and NPAS2 are associated with unipolar major depression and CLOCK and VIP with bipolar disorder. (PMID: 20072116) Soria V. … Urretavizcaya M. (Neuropsychopharmacology 2010) 3 23
  3. CRY2 is associated with depression. (PMID: 20195522) Lavebratt C. … Schalling M. (PLoS ONE 2010) 3 23
  4. New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. (PMID: 20081858) Dupuis J. … Barroso I. (Nat. Genet. 2010) 3 23
  5. The core circadian gene Cryptochrome 2 influences breast cancer risk, possibly by mediating hormone signaling. (PMID: 20233903) Hoffman A.E. … Zhu Y. (Cancer Prev Res (Phila) 2010) 3 23

Products for CRY2 Gene

Sources for CRY2 Gene

Content