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Aliases for CRY1 Gene

Aliases for CRY1 Gene

  • Cryptochrome Circadian Clock 1 2 3
  • PHLL1 3 4 6
  • Cryptochrome 1 (Photolyase-Like) 2 3
  • Cryptochrome-1 3

External Ids for CRY1 Gene

Previous Symbols for CRY1 Gene

  • PHLL1

Summaries for CRY1 Gene

Entrez Gene Summary for CRY1 Gene

  • This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene have been associated with altered sleep patterns. The encoded protein is widely conserved across plants and animals. Loss of the related gene in mouse results in a shortened circadian cycle in complete darkness. [provided by RefSeq, Jan 2014]

GeneCards Summary for CRY1 Gene

CRY1 (Cryptochrome Circadian Clock 1) is a Protein Coding gene. Among its related pathways are Circadian Clock and Circadian Clock. GO annotations related to this gene include nucleotide binding and double-stranded DNA binding. An important paralog of this gene is CRY2.

UniProtKB/Swiss-Prot for CRY1 Gene

  • Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots circa (about) and diem (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for timegivers). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, ARNTL/BMAL1, ARNTL2/BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and ARNTL/BMAL1 or ARNTL2/BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5-CACGTG-3) within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK NPAS2-ARNTL/BMAL1 ARNTL2/BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress ARNTL/BMAL1 transcription, respectively. CRY1 and CRY2 have redundant functions but also differential and selective contributions at least in defining the pace of the SCN circadian clock and its circadian transcriptional outputs. More potent transcriptional repressor in cerebellum and liver than CRY2, though more effective in lengthening the period of the SCN oscillator. On its side, CRY2 seems to play a critical role in tuning SCN circadian period by opposing the action of CRY1. With CRY2, is dispensable for circadian rhythm generation but necessary for the development of intercellular networks for rhythm synchrony. Capable of translocating circadian clock core proteins such as PER proteins to the nucleus. Interacts with CLOCK-ARNTL/BMAL1 independently of PER proteins and is found at CLOCK-ARNTL/BMAL1-bound sites, suggesting that CRY may act as a molecular gatekeeper to maintain CLOCK-ARNTL/BMAL1 in a poised and repressed state until the proper time for transcriptional activation. Represses the CLOCK-ARNTL/BMAL1 induced transcription of BHLHE40/DEC1. Represses the CLOCK-ARNTL/BMAL1 induced transcription of ATF4, MTA1, KLF10 and NAMPT (By similarity). May repress circadian target genes expression in collaboration with HDAC1 and HDAC2 through histone deacetylation. Mediates the clock-control activation of ATR and modulates ATR-mediated DNA damage checkpoint. In liver, mediates circadian regulation of cAMP signaling and gluconeogenesis by binding to membrane-coupled G proteins and blocking glucagon-mediated increases in intracellular cAMP concentrations and CREB1 phosphorylation. Besides its role in the maintenance of the circadian clock, is also involved in the regulation of other processes. Represses glucocorticoid receptor NR3C1/GR-induced transcriptional activity by binding to glucocorticoid response elements (GREs). Plays a key role in glucose and lipid metabolism modulation, in part, through the transcriptional regulation of genes involved in these pathways, such as LEP or ACSL4.

Gene Wiki entry for CRY1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRY1 Gene

Genomics for CRY1 Gene

Genomic Location for CRY1 Gene

Start:
106,991,364 bp from pter
End:
107,093,857 bp from pter
Size:
102,494 bases
Orientation:
Minus strand

Genomic View for CRY1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CRY1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRY1 Gene

Regulatory Elements for CRY1 Gene

Proteins for CRY1 Gene

  • Protein details for CRY1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16526-CRY1_HUMAN
    Recommended name:
    Cryptochrome-1
    Protein Accession:
    Q16526
    Secondary Accessions:

    Protein attributes for CRY1 Gene

    Size:
    586 amino acids
    Molecular mass:
    66395 Da
    Cofactor:
    Name=5,10-methylenetetrahydrofolate; Xref=ChEBI:CHEBI:12071; Note=Binds 1 5,10-methenyltetrahydrofolate non-covalently per subunit.;
    Cofactor:
    Name=FAD; Xref=ChEBI:CHEBI:57692; Note=Binds 1 FAD per subunit. Only a minority of the protein molecules contain bound FAD. Contrary to the situation in photolyases, the FAD is bound in a shallow, surface-exposed pocket.;
    Quaternary structure:
    • Component of the circadian core oscillator, which includes the CRY proteins, CLOCK or NPAS2, ARNTL/BMAL1 or ARNTL2/BMAL2, CSNK1D and/or CSNK1E, TIMELESS, and the PER proteins. Interacts directly with TIMELESS. Interacts directly with PER1 and PER2 C-terminal domains. Interaction with PER2 inhibits its ubiquitination and vice versa. Interacts with FBXL21. Interacts with FBXL3. Interacts with PPP5C (via TPR repeats). Interacts with CLOCK-ARNTL/BMAL1 independently of PER2 and DNA. Interacts with HDAC1, HDAC2 and SIN3B. Interacts with nuclear receptors AR, NR1D1, NR3C1/GR, RORA and RORC; the interaction with at least NR3C1/GR is ligand dependent. Interacts with PRKDC. Interacts with the G protein subunit alpha GNAS; the interaction may block GPCR-mediated regulation of cAMP concentrations. Interacts with PRMT5. Interacts with EZH2 (By similarity). Interacts with MYBBP1A, DOCK7, HNRNPU, RPL7A, RPL8 and RPS3 (By similarity).

neXtProt entry for CRY1 Gene

Proteomics data for CRY1 Gene at MOPED

Post-translational modifications for CRY1 Gene

  • Phosphorylation on Ser-247 by MAPK is important for the inhibition of CLOCK-ARNTL/BMAL1-mediated transcriptional activity. Phosphorylation by CSNK1E requires interaction with PER1 or PER2. Phosphorylation at Ser-71 and Ser-280 by AMPK decreases protein stability. Phosphorylation at Ser-568 exhibits a robust circadian rhythm with a peak at CT8, increases protein stability, prevents SCF(FBXL3)-mediated degradation and is antagonized by interaction with PRKDC.
  • Ubiquitinated by the SCF(FBXL3) and SCF(FBXL21) complexes, regulating the balance between degradation and stabilization. The SCF(FBXL3) complex is mainly nuclear and mediates ubiquitination and subsequent degradation of CRY1. In contrast, cytoplasmic SCF(FBXL21) complex-mediated ubiquitination leads to stabilize CRY1 and counteract the activity of the SCF(FBXL3) complex. The SCF(FBXL3) and SCF(FBXL21) complexes probably mediate ubiquitination at different Lys residues. Ubiquitination at Lys-11 and Lys-107 are specifically ubiquitinated by the SCF(FBXL21) complex but not by the SCF(FBXL3) complex. Ubiquitination may be inhibited by PER2.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys11, Lys107, Lys159, Lys329, Lys442, and Lys485

Other Protein References for CRY1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CRY1 Gene

Domains for CRY1 Gene

Protein Domains for CRY1 Gene

Suggested Antigen Peptide Sequences for CRY1 Gene

Graphical View of Domain Structure for InterPro Entry

Q16526

UniProtKB/Swiss-Prot:

CRY1_HUMAN
Domain:
  • Contains 1 photolyase/cryptochrome alpha/beta domain.:
    • Q16526
Family:
  • Belongs to the DNA photolyase class-1 family.:
    • Q16526
genes like me logo Genes that share domains with CRY1: view

No data available for Gene Families for CRY1 Gene

Function for CRY1 Gene

Molecular function for CRY1 Gene

GENATLAS Biochemistry: cryptochrome 1,photolyase-like,66kDa,putatively involved in photoreactivation,i.e DNA repair by excision of UV induced DNA damage
UniProtKB/Swiss-Prot Function: Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots circa (about) and diem (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for timegivers). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, ARNTL/BMAL1, ARNTL2/BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and ARNTL/BMAL1 or ARNTL2/BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5-CACGTG-3) within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK NPAS2-ARNTL/BMAL1 ARNTL2/BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress ARNTL/BMAL1 transcription, respectively. CRY1 and CRY2 have redundant functions but also differential and selective contributions at least in defining the pace of the SCN circadian clock and its circadian transcriptional outputs. More potent transcriptional repressor in cerebellum and liver than CRY2, though more effective in lengthening the period of the SCN oscillator. On its side, CRY2 seems to play a critical role in tuning SCN circadian period by opposing the action of CRY1. With CRY2, is dispensable for circadian rhythm generation but necessary for the development of intercellular networks for rhythm synchrony. Capable of translocating circadian clock core proteins such as PER proteins to the nucleus. Interacts with CLOCK-ARNTL/BMAL1 independently of PER proteins and is found at CLOCK-ARNTL/BMAL1-bound sites, suggesting that CRY may act as a molecular gatekeeper to maintain CLOCK-ARNTL/BMAL1 in a poised and repressed state until the proper time for transcriptional activation. Represses the CLOCK-ARNTL/BMAL1 induced transcription of BHLHE40/DEC1. Represses the CLOCK-ARNTL/BMAL1 induced transcription of ATF4, MTA1, KLF10 and NAMPT (By similarity). May repress circadian target genes expression in collaboration with HDAC1 and HDAC2 through histone deacetylation. Mediates the clock-control activation of ATR and modulates ATR-mediated DNA damage checkpoint. In liver, mediates circadian regulation of cAMP signaling and gluconeogenesis by binding to membrane-coupled G proteins and blocking glucagon-mediated increases in intracellular cAMP concentrations and CREB1 phosphorylation. Besides its role in the maintenance of the circadian clock, is also involved in the regulation of other processes. Represses glucocorticoid receptor NR3C1/GR-induced transcriptional activity by binding to glucocorticoid response elements (GREs). Plays a key role in glucose and lipid metabolism modulation, in part, through the transcriptional regulation of genes involved in these pathways, such as LEP or ACSL4.
UniProtKB/Swiss-Prot Induction: Expression is regulated by light and circadian rhythms and osicllates diurnally. Peak expression in the suprachiasma nucleus (SCN) and eye at the day/night transition (CT12). Levels decrease with ARNTL/BMAL1-CLOCK inhibition as part of the autoregulatory feedback loop

Gene Ontology (GO) - Molecular Function for CRY1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0000989 transcription factor binding transcription factor activity IDA 15147242
GO:0001046 core promoter sequence-specific DNA binding IEA --
GO:0001047 core promoter binding ISS --
GO:0003677 DNA binding TAS 9801304
genes like me logo Genes that share ontologies with CRY1: view
genes like me logo Genes that share phenotypes with CRY1: view

Animal Models for CRY1 Gene

MGI Knock Outs for CRY1:

miRNA for CRY1 Gene

miRTarBase miRNAs that target CRY1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CRY1 Gene

Localization for CRY1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CRY1 Gene

Cytoplasm. Nucleus. Note=Translocated to the nucleus through interaction with other clock proteins such as PER2 or ARNTL/BMAL1. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CRY1 Gene COMPARTMENTS Subcellular localization image for CRY1 gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 2
plasma membrane 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for CRY1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005730 nucleolus --
GO:0005737 cytoplasm --
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with CRY1: view

Pathways for CRY1 Gene

genes like me logo Genes that share pathways with CRY1: view

Pathways by source for CRY1 Gene

1 KEGG pathway for CRY1 Gene

Gene Ontology (GO) - Biological Process for CRY1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 12397359
GO:0006094 gluconeogenesis ISS --
GO:0006281 DNA repair IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006975 DNA damage induced protein phosphorylation ISS --
genes like me logo Genes that share ontologies with CRY1: view

Compounds for CRY1 Gene

(1) HMDB Compounds for CRY1 Gene

Compound Synonyms Cas Number PubMed IDs
FAD
  • 1H-Purin-6-amine flavin dinucleotide
146-14-5

(1) Novoseek inferred chemical compound relationships for CRY1 Gene

Compound -log(P) Hits PubMed IDs
flavin 64 1

(1) PharmGKB related drug/compound annotations for CRY1 Gene

Drug/compound Annotation
lithium CA
genes like me logo Genes that share compounds with CRY1: view

Transcripts for CRY1 Gene

Unigene Clusters for CRY1 Gene

Cryptochrome 1 (photolyase-like):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CRY1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b
SP1: - -
SP2: -
SP3:
SP4:

Relevant External Links for CRY1 Gene

GeneLoc Exon Structure for
CRY1
ECgene alternative splicing isoforms for
CRY1

Expression for CRY1 Gene

mRNA expression in normal human tissues for CRY1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CRY1 Gene

SOURCE GeneReport for Unigene cluster for CRY1 Gene Hs.151573

genes like me logo Genes that share expressions with CRY1: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CRY1 Gene

Orthologs for CRY1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CRY1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CRY1 35
  • 99.77 (n)
  • 99.83 (a)
CRY1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CRY1 35
  • 94.71 (n)
  • 98.29 (a)
CRY1 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CRY1 35
  • 95.79 (n)
  • 98.63 (a)
CRY1 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cry1 35
  • 89.08 (n)
  • 96.42 (a)
Cry1 16
Cry1 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CRY1 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CRY1 36
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cry1 35
  • 88.4 (n)
  • 96.25 (a)
chicken
(Gallus gallus)
Aves CRY1 35
  • 83.11 (n)
  • 92.32 (a)
CRY1 36
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CRY1 36
  • 87 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia cry1-A 35
tropical clawed frog
(Silurana tropicalis)
Amphibia cry1 35
  • 77.15 (n)
  • 91.45 (a)
Str.16341 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
cry1a 36
  • 78 (a)
OneToMany
cry1b 35
  • 74.71 (n)
  • 88.63 (a)
cry1b 36
  • 77 (a)
OneToMany
cry2a 36
  • 71 (a)
OneToMany
cry2b 36
  • 66 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004261 35
  • 64.36 (n)
  • 74.34 (a)
fruit fly
(Drosophila melanogaster)
Insecta phr6-4 36
  • 49 (a)
ManyToMany
cry 37
  • 40 (a)
phr6-4 37
  • 52 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PHR1 36
  • 18 (a)
OneToMany
barley
(Hordeum vulgare)
Liliopsida Hv.2572 35
Species with no ortholog for CRY1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CRY1 Gene

ENSEMBL:
Gene Tree for CRY1 (if available)
TreeFam:
Gene Tree for CRY1 (if available)

Paralogs for CRY1 Gene

Paralogs for CRY1 Gene

Selected SIMAP similar genes for CRY1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CRY1: view

Variants for CRY1 Gene

Sequence variations from dbSNP and Humsavar for CRY1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs763594 -- 107,041,802(-) CTCTT(C/T)CCCAC intron-variant
rs1017168 -- 107,041,627(-) AAGTA(G/T)ATTTT intron-variant
rs1056554 -- 107,005,189(-) GAACG(A/G)GACGC reference, synonymous-codon
rs1056555 -- 106,999,704(-) TTAGC(A/C)AAATG synonymous-codon, reference
rs1056556 -- 106,999,653(-) ATGAC(A/G)CAGCT reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for CRY1 Gene

Variant ID Type Subtype PubMed ID
esv1001965 CNV Insertion 20482838
esv1520737 CNV Insertion 17803354
esv2485513 CNV Deletion 19546169

Relevant External Links for CRY1 Gene

HapMap Linkage Disequilibrium report
CRY1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CRY1 Gene

Disorders for CRY1 Gene

Relevant External Links for CRY1

Genetic Association Database (GAD)
CRY1
Human Genome Epidemiology (HuGE) Navigator
CRY1
genes like me logo Genes that share disorders with CRY1: view

No data available for UniProtKB/Swiss-Prot for CRY1 Gene

Publications for CRY1 Gene

  1. Putative human blue-light photoreceptors hCRY1 and hCRY2 are flavoproteins. (PMID: 8909283) Hsu D.S. … Sancar A. (Biochemistry 1996) 3 4 23
  2. Clock genes may influence bipolar disorder susceptibility and dysfunctional circadian rhythm. (PMID: 18228528) Shi J. … Liu C. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008) 3 23 48
  3. Testing the circadian gene hypothesis in prostate cancer: a population-based case-control study. (PMID: 19934327) Zhu Y. … Stanford J.L. (Cancer Res. 2009) 3 23 48
  4. Cloning, tissue expression, and mapping of a human photolyase homolog with similarity to plant blue-light receptors. (PMID: 8921389) van der Spek P.J. … Yasui A. (Genomics 1996) 2 3 4
  5. Differential association of circadian genes with mood disorders: CRY1 and NPAS2 are associated with unipolar major depression and CLOCK and VIP with bipolar disorder. (PMID: 20072116) Soria V. … Urretavizcaya M. (Neuropsychopharmacology 2010) 3 23 48

Products for CRY1 Gene

  • Addgene plasmids for CRY1

Sources for CRY1 Gene

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