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Aliases for SLC32A1 Gene

Aliases for SLC32A1 Gene

  • Solute Carrier Family 32 (GABA Vesicular Transporter), Member 1 2 3
  • Vesicular Inhibitory Amino Acid Transporter 2 3
  • Solute Carrier Family 32 Member 1 3 4
  • GABA And Glycine Transporter 3 4
  • Vesicular GABA Transporter 3 4
  • HVIAAT 3 4
  • VIAAT 3 4
  • VGAT 3 4

External Ids for SLC32A1 Gene

Previous HGNC Symbols for SLC32A1 Gene


Previous GeneCards Identifiers for SLC32A1 Gene

  • GC00U990497
  • GC20P036787
  • GC20P037353
  • GC20P034090

Summaries for SLC32A1 Gene

Entrez Gene Summary for SLC32A1 Gene

  • The protein encoded by this gene is an integral membrane protein involved in gamma-aminobutyric acid (GABA) and glycine uptake into synaptic vesicles. The encoded protein is a member of amino acid/polyamine transporter family II. [provided by RefSeq, Jul 2008]

GeneCards Summary for SLC32A1 Gene

SLC32A1 (Solute Carrier Family 32 (GABA Vesicular Transporter), Member 1) is a Protein Coding gene. Among its related pathways are Circadian entrainment and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include glycine transmembrane transporter activity and gamma-aminobutyric acid:proton symporter activity.

UniProtKB/Swiss-Prot for SLC32A1 Gene

  • Involved in the uptake of GABA and glycine into the synaptic vesicles

Gene Wiki entry for SLC32A1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC32A1 Gene

Genomics for SLC32A1 Gene

Regulatory Elements for SLC32A1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SLC32A1 Gene

38,724,462 bp from pter
38,729,372 bp from pter
4,911 bases
Plus strand

Genomic View for SLC32A1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC32A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC32A1 Gene

Proteins for SLC32A1 Gene

  • Protein details for SLC32A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Vesicular inhibitory amino acid transporter
    Protein Accession:
    Secondary Accessions:
    • Q8N489

    Protein attributes for SLC32A1 Gene

    525 amino acids
    Molecular mass:
    57415 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH36458.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for SLC32A1 Gene

Proteomics data for SLC32A1 Gene at MOPED

Post-translational modifications for SLC32A1 Gene

  • Glycosylation at Asn341
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC32A1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC32A1 Gene

Domains for SLC32A1 Gene

Gene Families for SLC32A1 Gene

Protein Domains for SLC32A1 Gene


Suggested Antigen Peptide Sequences for SLC32A1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9H598
  • Belongs to the amino acid/polyamine transporter 2 family.
genes like me logo Genes that share domains with SLC32A1: view

Function for SLC32A1 Gene

Molecular function for SLC32A1 Gene

UniProtKB/Swiss-Prot Function: Involved in the uptake of GABA and glycine into the synaptic vesicles

Gene Ontology (GO) - Molecular Function for SLC32A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015171 amino acid transmembrane transporter activity IBA --
GO:0015187 glycine transmembrane transporter activity IEA --
GO:0015495 gamma-aminobutyric acid:proton symporter activity IEA --
genes like me logo Genes that share ontologies with SLC32A1: view
genes like me logo Genes that share phenotypes with SLC32A1: view

Animal Models for SLC32A1 Gene

MGI Knock Outs for SLC32A1:

Animal Model Products

CRISPR Products

miRNA for SLC32A1 Gene

miRTarBase miRNAs that target SLC32A1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SLC32A1 Gene

Localization for SLC32A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC32A1 Gene

Cytoplasmic vesicle membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for SLC32A1 Gene COMPARTMENTS Subcellular localization image for SLC32A1 gene
Compartment Confidence
plasma membrane 4
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for SLC32A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0008021 synaptic vesicle --
GO:0016021 integral component of membrane IEA --
GO:0030425 dendrite IDA 12115694
GO:0030672 synaptic vesicle membrane TAS --
genes like me logo Genes that share ontologies with SLC32A1: view

Pathways for SLC32A1 Gene

genes like me logo Genes that share pathways with SLC32A1: view

PCR Array Products

Interacting Proteins for SLC32A1 Gene

Gene Ontology (GO) - Biological Process for SLC32A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003333 amino acid transmembrane transport IBA --
GO:0006811 ion transport TAS --
GO:0007268 synaptic transmission TAS --
GO:0007269 neurotransmitter secretion TAS --
GO:0007568 aging IEA --
genes like me logo Genes that share ontologies with SLC32A1: view

Compounds for SLC32A1 Gene

(1) Drugbank Compounds for SLC32A1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
  • 2-Aminoacetic acid
56-40-6 target

(1) IUPHAR Ligand for SLC32A1 Gene

Ligand Type Action Affinity Pubmed IDs
vigabatrin Inhibitor Inhibition 2.1

(8) Novoseek inferred chemical compound relationships for SLC32A1 Gene

Compound -log(P) Hits PubMed IDs
gaba 81.8 60
glutamate 66.7 17
baclofen 44 2
acetylcholine 28.5 5
dopamine 2.46 2
genes like me logo Genes that share compounds with SLC32A1: view

Transcripts for SLC32A1 Gene

mRNA/cDNA for SLC32A1 Gene

(25) Selected AceView cDNA sequences:
(6) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SLC32A1 Gene

Solute carrier family 32 (GABA vesicular transporter), member 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC32A1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC32A1 Gene

No ASD Table

Relevant External Links for SLC32A1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC32A1 Gene

mRNA expression in normal human tissues for SLC32A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC32A1 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (12.3), Brain - Putamen (basal ganglia) (8.8), Brain - Caudate (basal ganglia) (6.9), and Brain - Hypothalamus (4.3).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SLC32A1 Gene

SOURCE GeneReport for Unigene cluster for SLC32A1 Gene Hs.179080

mRNA Expression by UniProt/SwissProt for SLC32A1 Gene

Tissue specificity: Retina. Expressed throughout the horizontal cells or more specifically at the terminals.
genes like me logo Genes that share expressions with SLC32A1: view

In Situ Assay Products

Orthologs for SLC32A1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC32A1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLC32A1 35
  • 99.43 (n)
  • 99.43 (a)
SLC32A1 36
  • 99 (a)
(Bos Taurus)
Mammalia SLC32A1 35
  • 93.46 (n)
  • 98.67 (a)
SLC32A1 36
  • 98 (a)
(Canis familiaris)
Mammalia SLC32A1 35
  • 93.59 (n)
  • 98.48 (a)
SLC32A1 36
  • 98 (a)
(Mus musculus)
Mammalia Slc32a1 35
  • 91.92 (n)
  • 98.85 (a)
Slc32a1 16
Slc32a1 36
  • 98 (a)
(Monodelphis domestica)
Mammalia SLC32A1 36
  • 93 (a)
(Ornithorhynchus anatinus)
Mammalia SLC32A1 36
  • 83 (a)
(Rattus norvegicus)
Mammalia Slc32a1 35
  • 92.18 (n)
  • 98.85 (a)
(Gallus gallus)
Aves SLC32A1 35
  • 80.23 (n)
  • 92.71 (a)
SLC32A1 36
  • 92 (a)
(Anolis carolinensis)
Reptilia SLC32A1 36
  • 91 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC68938 35
tropical clawed frog
(Silurana tropicalis)
Amphibia slc32a1 35
  • 75.87 (n)
  • 90.54 (a)
(Danio rerio)
Actinopterygii slc32a1 35
  • 81.26 (n)
  • 87.38 (a)
slc32a1 36
  • 86 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011116 35
  • 61.44 (n)
  • 50.75 (a)
fruit fly
(Drosophila melanogaster)
Insecta VGAT 35
  • 58.06 (n)
  • 49.88 (a)
  • 39 (a)
(Caenorhabditis elegans)
Secernentea unc-47 35
  • 48.65 (n)
  • 43.15 (a)
unc-47 36
  • 38 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AVT1 36
  • 17 (a)
AVT1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G41190 35
  • 37.62 (n)
  • 25.74 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 39 (a)
Species with no ortholog for SLC32A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC32A1 Gene

Gene Tree for SLC32A1 (if available)
Gene Tree for SLC32A1 (if available)

Paralogs for SLC32A1 Gene

No data available for Paralogs for SLC32A1 Gene

Variants for SLC32A1 Gene

Sequence variations from dbSNP and Humsavar for SLC32A1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs2865 -- 38,729,291(-) ACATT(C/T)CATCT utr-variant-3-prime
rs1322183 -- 38,729,631(-) GCCCC(A/C)AGGGG downstream-variant-500B
rs2867326 -- 38,723,063(+) CACTT(A/C)CAGTC upstream-variant-2KB
rs4328688 -- 38,723,915(+) GACTT(A/C)TAGAC upstream-variant-2KB
rs6027609 -- 38,726,031(+) CTCTA(A/G)GCCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC32A1 Gene

Variant ID Type Subtype PubMed ID
dgv4568n71 CNV Loss 21882294

Relevant External Links for SLC32A1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC32A1 Gene

Disorders for SLC32A1 Gene

Relevant External Links for SLC32A1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with SLC32A1: view

No data available for UniProtKB/Swiss-Prot for SLC32A1 Gene

Publications for SLC32A1 Gene

  1. Vesicular inhibitory amino acid transporter is a Cl-/gamma-aminobutyrate Co-transporter. (PMID: 19843525) Juge N. … Moriyama Y. (J. Biol. Chem. 2009) 2 3 23
  2. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4
  3. Cellular localization of the vesicular inhibitory amino acid transporter in the mouse and human retina. (PMID: 12115694) Jellali A. … Picaud S. (J. Comp. Neurol. 2002) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for SLC32A1 Gene

  • antibodies-online peptides for SLC32A1
  • antibodies-online antibodies for SLC32A1
  • antibodies-online kits for SLC32A1

Sources for SLC32A1 Gene

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