Aliases for GATA5 Gene
External Ids for GATA5 Gene
Previous GeneCards Identifiers for GATA5 Gene
The protein encoded by this gene is a transcription factor that contains two GATA-type zinc fingers. The encoded protein is known to bind to hepatocyte nuclear factor-1alpha (HNF-1alpha), and this interaction is essential for cooperative activation of the intestinal lactase-phlorizin hydrolase promoter. In other organisms, similar proteins may be involved in the establishment of cardiac smooth muscle cell diversity. [provided by RefSeq, Jul 2008]
GeneCards Summary for GATA5 Gene
GATA5 (GATA Binding Protein 5) is a Protein Coding gene. Diseases associated with GATA5 include Familial Bicuspid Aortic Valve and Familial Atrial Fibrillation. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and G-AlphaQ Signaling. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription regulatory region DNA binding. An important paralog of this gene is GATA6.
UniProtKB/Swiss-Prot for GATA5 Gene
Transcription factor required during cardiovascular development (PubMed:23289003). Plays an important role in the transcriptional program(s) that underlies smooth muscle cell diversity (By similarity). Binds to the functionally important CEF-1 nuclear protein binding site in the cardiac-specific slow/cardiac troponin C transcriptional enhancer (PubMed:25543888).