Aliases for MUC17 Gene
Aliases for MUC17 Gene
External Ids for MUC17 Gene
- HGNC: 16800
- Entrez Gene: 140453
- Ensembl: ENSG00000169876
- OMIM: 608424
- UniProtKB: Q685J3
Previous GeneCards Identifiers for MUC17 Gene
- GC07P099168
- GC07P100231
- GC07P100235
- GC07P100276
- GC07P100450
- GC07P100663
- GC07P100022
Summaries for MUC17 Gene
-
The protein encoded by this gene is a membrane-bound mucin that provides protection to gut epithelial cells. The encoded protein contains about 60 tandem repeats, with each repeat being around 60 aa. N-glycosylation enables the encoded protein to localize on the cell surface, while the C-terminus interacts with the scaffold protein PDZ domain containing 1 (PDZK1). Two transcript variants, one protein-coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Nov 2015]
GeneCards Summary for MUC17 Gene
MUC17 (Mucin 17, Cell Surface Associated) is a Protein Coding gene. Diseases associated with MUC17 include Biliary Papillomatosis and Tn Polyagglutination Syndrome. Among its related pathways are Metabolism of proteins and CLEC7A (Dectin-1) signaling. Gene Ontology (GO) annotations related to this gene include PDZ domain binding and extracellular matrix constituent, lubricant activity. An important paralog of this gene is MUC12.
UniProtKB/Swiss-Prot for MUC17 Gene
-
Probably plays a role in maintaining homeostasis on mucosal surfaces.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MUC17 Gene
Genomics for MUC17 Gene
GeneHancer (GH) Regulatory Elements for MUC17 Gene
Promoters and enhancers for MUC17 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around MUC17 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the MUC17 gene promoter:
Regulatory Element Products
Genomic Locations for MUC17 Gene
Genomic Locations for MUC17 Gene
- chr7:101,020,072-101,058,859
- (GRCh38/hg38)
- Size:
- 38,788 bases
- Orientation:
- Plus strand
- chr7:100,663,353-100,702,140
- (GRCh37/hg19)
Genomic View for MUC17 Gene
Genes around MUC17 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 7q22.1 by Ensembl
- 7q22.1 by Entrez Gene
- 7q22.1 by HGNC
MUC17 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MUC17 Gene
Proteins for MUC17 Gene
-
Protein details for MUC17 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q685J3-MUC17_HUMAN
- Recommended name:
- Mucin-17
- Protein Accession:
- Q685J3
- O14761
- Q685J2
- Q8TDH7
Protein attributes for MUC17 Gene
- Size:
- 4493 amino acids
- Molecular mass:
- 451741 Da
- Quaternary structure:
-
- Interacts via its C-terminus with PDZK1 and this interaction appears important for proper localization.
Protein Expression for MUC17 Gene
Selected DME Specific Peptides for MUC17 Gene
- Q685J3:
-
- VVTSTAV
- EINSLST
Post-translational modifications for MUC17 Gene
- N-glycosylated. Contains high mannose and complex-type glycans. The forms containing the complex type glycans localize to the cell surface. Not O-glycosylated.
- Probably cleaved within the SEA domain.
- Glycosylation at Ser56, Asn471, Asn696, Asn898, Asn1345, isoforms=22077, isoforms=22194, isoforms=23344, isoforms=24116, isoforms=24205, Asn4236, Asn4267, Asn4297, and Asn4305
Other Protein References for MUC17 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for MUC17
-
Cloud-Clone Corp. Antibodies for MUC17
- Invitrogen Antibodies for MUC17
- Search GeneTex for Antibodies for MUC17
Protein Products
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-
Cloud-Clone Corp. Proteins for MUC17
- Search GeneTex for Proteins for MUC17
Assay Products
-
Cloud-Clone Corp. Assay Kits for MUC17
- antibodies-online: Search results for 14 available MUC17 Elisa Kits ranked by validation data
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-
Quality Products:
Domains & Families for MUC17 Gene
Gene Families for MUC17 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Predicted membrane proteins
Protein Domains for MUC17 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for MUC17 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for MUC17 Gene
Function for MUC17 Gene
Molecular function for MUC17 Gene
- UniProtKB/Swiss-Prot Function:
- Probably plays a role in maintaining homeostasis on mucosal surfaces.
Enzyme Numbers (IUBMB) for MUC17 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 17990980 |
| GO:0030165 | PDZ domain binding | IPI | 17990980 |
| GO:0030197 | extracellular matrix constituent, lubricant activity | NAS | 9299468 |
Phenotypes for MUC17 Gene
- GenomeRNAi human phenotypes for MUC17:
Animal Model Products
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for MUC17 gene
-
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- Search ViGene Biosciences for MUC17
CRISPR Products
-
OriGene CRISPR knockouts for MUC17
- genomics-online: gRNA clones - Search results for 25 available MUC17 gene related products
- Overview of 25 available MUC17 gene related products
- Applied Biological Materials CRISPR for MUC17
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for MUC17
- GenScript: Design CRISPR guide RNA sequences for MUC17
miRNA for MUC17 Gene
- miRTarBase miRNAs that target MUC17
-
- hsa-mir-17-5p (MIRT004710)
- hsa-mir-20a-5p (MIRT004711)
- hsa-mir-20b-5p (MIRT004712)
- hsa-mir-30c-5p (MIRT004714)
- hsa-mir-30e-5p (MIRT004715)
- hsa-mir-132-3p (MIRT021736)
- hsa-mir-6819-5p (MIRT459461)
- hsa-mir-6812-5p (MIRT459462)
- hsa-mir-6737-5p (MIRT459463)
- hsa-mir-6747-5p (MIRT459464)
- hsa-mir-608 (MIRT459465)
- hsa-mir-4651 (MIRT459466)
- hsa-mir-4664-5p (MIRT459467)
- hsa-mir-342-5p (MIRT459468)
- hsa-mir-8053 (MIRT459469)
- hsa-mir-8073 (MIRT459470)
- hsa-mir-6717-5p (MIRT459471)
- hsa-mir-221-5p (MIRT459472)
- hsa-mir-6890-5p (MIRT459473)
- hsa-mir-629-3p (MIRT723787)
- hsa-mir-6818-3p (MIRT723788)
- hsa-mir-4279 (MIRT723789)
- hsa-mir-6881-3p (MIRT723790)
- hsa-mir-593-3p (MIRT723791)
- hsa-mir-6895-3p (MIRT723792)
- hsa-mir-6876-3p (MIRT723793)
- hsa-mir-626 (MIRT723794)
- hsa-mir-130b-5p (MIRT723795)
- hsa-mir-6845-3p (MIRT723796)
- hsa-mir-877-3p (MIRT723797)
miRNA Products
- Search ViGene Biosciences for MUC17
Inhibitory RNA Products
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- Overview of 25 available MUC17 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for MUC17 gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for MUC17
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-
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for MUC17
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
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Horizon Cell Lines for MUC17
-
ViGene Biosciences adenoviral particle packaged cDNA for MUC17 gene
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ViGene Biosciences lentiviral particle packaged cDNA for MUC17 gene
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No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MUC17 Gene
Localization for MUC17 Gene
Subcellular locations from UniProtKB/Swiss-Prot for MUC17 Gene
- Isoform 1: Cell membrane; Single-pass membrane protein.
- Isoform 2: Secreted. Cell membrane.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| golgi apparatus | 5 |
| extracellular | 4 |
| endoplasmic reticulum | 1 |
| lysosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA | -- |
| GO:0005796 | Golgi lumen | TAS | -- |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0009897 | external side of plasma membrane | IDA | 12888891 |
| GO:0016020 | membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for MUC17 Gene
Pathways & Interactions for MUC17 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) |
.62
|
|
| 2 | Diseases of glycosylation | ||
| 3 | Innate Immune System |
.61
|
|
| 4 | Metabolism of proteins | ||
| 5 | O-linked glycosylation | ||
Pathways by source for MUC17 Gene
Interacting Proteins for MUC17 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002223 | stimulatory C-type lectin receptor signaling pathway | TAS | -- |
| GO:0016266 | O-glycan processing | TAS | -- |
| GO:0019725 | cellular homeostasis | TAS | 17990980 |
No data available for SIGNOR curated interactions for MUC17 Gene
Transcripts for MUC17 Gene
mRNA/cDNA for MUC17 Gene
- (2) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (50) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for MUC17 Gene
- Mucin 17, cell surface associated:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for MUC17
- genomics-online: gRNA clones - Search results for 25 available MUC17 gene related products
- Overview of 25 available MUC17 gene related products
- Applied Biological Materials CRISPR for MUC17
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for MUC17
- GenScript: Design CRISPR guide RNA sequences for MUC17
miRNA Products
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Inhibitory RNA Products
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- genomics-online: shRNA clones - Search results for 25 available MUC17 gene related products
- Overview of 25 available MUC17 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for MUC17 gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for MUC17
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MUC17
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for MUC17
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||
| SP2: | - |
Expression for MUC17 Gene
mRNA differential expression in normal tissues according to GTEx for MUC17 Gene
This gene is overexpressed in Small Intestine - Terminal Ileum (x48.2).
This gene is overexpressed in Kidney (58.8) and Fetal gut (8.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MUC17 Gene
NURSA nuclear receptor signaling pathways regulating expression of MUC17 Gene:
MUC17SOURCE GeneReport for Unigene cluster for MUC17 Gene:
Hs.271819mRNA Expression by UniProt/SwissProt for MUC17 Gene:
Q685J3-MUC17_HUMAN
Tissue specificity:
Expressed almost exclusively in the intestine. Expression is especially high in both the duodenum and transverse colon. Expressed in mature absorptive cells of the small intestinal villi. No expression is detected in goblet cells. Highly expressed in pancreatic adenocarcinoma tissue (at protein level). Expression is not detectable in normal pancreas, in pancreatitis or in cell lines derived from other cancers.
Evidence on tissue expression from TISSUES for MUC17 Gene
- Intestine(4.5)
- Stomach(3.1)
Primer Products
-
OriGene qPCR primer pairs for MUC17
- genomics-online: primer clones - Search results for 25 available MUC17 gene related products
- Overview of 25 available MUC17 gene related products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for MUC17 Gene
Orthologs for MUC17 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | MUC17 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Muc3 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
| oppossum (Monodelphis domestica) |
Mammalia | MUC17 34 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | MUC17 34 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | -- 34 |
|
ManyToMany | |
| lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
ManyToMany |
- Species where no ortholog for MUC17 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for MUC17 Gene
(2) SIMAP similar genes for MUC17 Gene using alignment to 3 proteins:
Variants for MUC17 Gene
| SNP ID | Clin | Chr 07 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs193920784 | uncertain-significance, Malignant tumor of prostate | 101,040,366(+) | G/A | coding_sequence_variant, missense_variant, non_coding_transcript_variant | |
| rs1000004435 | -- | 101,039,451(+) | G/A/T | coding_sequence_variant, missense_variant, non_coding_transcript_variant | |
| rs1000056282 | -- | 101,018,864(+) | GCACCCCTG/GCACCCCTGCACCCCTG | upstream_transcript_variant | |
| rs1000107887 | -- | 101,050,287(+) | G/A | intron_variant | |
| rs1000140890 | -- | 101,041,536(+) | T/G | coding_sequence_variant, missense_variant, non_coding_transcript_variant |
Residual Variation Intolerance Score:
100% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
13.19;
95.20% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for MUC17 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MUC17 Gene
Disorders for MUC17 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| biliary papillomatosis |
|
|
| tn polyagglutination syndrome |
|
|
| colorectal cancer 1 |
|
|
Search MUC17 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for MUC17
No data available for UniProtKB/Swiss-Prot and Genatlas for MUC17 Gene
Publications for MUC17 Gene
- MUC17, a novel membrane-tethered mucin. (PMID: 11855812) Gum JR … Kim YS (Biochemical and biophysical research communications 2002) 2 3 4 22 58
- Human intestinal MUC17 mucin augments intestinal cell restitution and enhances healing of experimental colitis. (PMID: 20211273) Luu Y … Ho SB (The international journal of biochemistry & cell biology 2010) 3 22 58
- The C-terminus of the transmembrane mucin MUC17 binds to the scaffold protein PDZK1 that stably localizes it to the enterocyte apical membrane in the small intestine. (PMID: 17990980) Malmberg EK … Hansson GC (The Biochemical journal 2008) 3 4 58
- Characterization of human mucin MUC17. Complete coding sequence and organization. (PMID: 16737958) Moniaux N … Batra SK (The Journal of biological chemistry 2006) 3 4 58
- N-glycosylation is required for the surface localization of MUC17 mucin. (PMID: 12888891) Ho JJ … Kim YS (International journal of oncology 2003) 3 4 58
Products for MUC17 Gene
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- VectorBuilder custom plasmid, inducible vectors for MUC17
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for available MUC17 related products ranked by validation data
- antibodies-online: Search results for 14 available MUC17 Elisa Kits ranked by validation data
- Compare Top MUC17 Elisa Kits
- Quality Products:
- antibodies-online: Search results for available MUC17 related products ranked by validation data
- Search GeneTex for Antibodies for MUC17
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- ViGene Biosciences adenoviral particle packaged cDNA for MUC17 gene
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- Overview of 25 available MUC17 gene related products
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- Overview of 25 available MUC17 gene related products
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- Overview of 25 available MUC17 gene related products
Sources for MUC17 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
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