Aliases for MUC17 Gene
Aliases for MUC17 Gene
External Ids for MUC17 Gene
- HGNC: 16800
- Entrez Gene: 140453
- Ensembl: ENSG00000169876
- OMIM: 608424
- UniProtKB: Q685J3
Previous GeneCards Identifiers for MUC17 Gene
- GC07P099168
- GC07P100231
- GC07P100235
- GC07P100276
- GC07P100450
- GC07P100663
- GC07P100022
Summaries for MUC17 Gene
-
The protein encoded by this gene is a membrane-bound mucin that provides protection to gut epithelial cells. The encoded protein contains about 60 tandem repeats, with each repeat being around 60 aa. N-glycosylation enables the encoded protein to localize on the cell surface, while the C-terminus interacts with the scaffold protein PDZ domain containing 1 (PDZK1). Two transcript variants, one protein-coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Nov 2015]
GeneCards Summary for MUC17 Gene
MUC17 (Mucin 17, Cell Surface Associated) is a Protein Coding gene. Diseases associated with MUC17 include Biliary Papillomatosis and Tn Polyagglutination Syndrome. Among its related pathways are Metabolism of proteins and CLEC7A (Dectin-1) signaling. Gene Ontology (GO) annotations related to this gene include PDZ domain binding and extracellular matrix constituent, lubricant activity. An important paralog of this gene is MUC12.
UniProtKB/Swiss-Prot for MUC17 Gene
-
Probably plays a role in maintaining homeostasis on mucosal surfaces.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MUC17 Gene
Genomics for MUC17 Gene
GeneHancer (GH) Regulatory Elements for MUC17 Gene
- Top Transcription factor binding sites by QIAGEN in the MUC17 gene promoter:
Regulatory Element Products
Genomic Locations for MUC17 Gene
- chr7:101,020,072-101,058,859
- (GRCh38/hg38)
- Size:
- 38,788 bases
- Orientation:
- Plus strand
- chr7:100,663,353-100,702,140
- (GRCh37/hg19)
Genomic View for MUC17 Gene
- Cytogenetic band:
-
- 7q22.1 by Ensembl
- 7q22.1 by Entrez Gene
- 7q22.1 by HGNC


RefSeq DNA sequence for MUC17 Gene
Proteins for MUC17 Gene
-
Protein details for MUC17 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q685J3-MUC17_HUMAN
- Recommended name:
- Mucin-17
- Protein Accession:
- Q685J3
- O14761
- Q685J2
- Q8TDH7
Protein attributes for MUC17 Gene
- Size:
- 4493 amino acids
- Molecular mass:
- 451741 Da
- Quaternary structure:
-
- Interacts via its C-terminus with PDZK1 and this interaction appears important for proper localization.
Protein Expression for MUC17 Gene
Selected DME Specific Peptides for MUC17 Gene
- Q685J3:
-
- VVTSTAV
- EINSLST
Post-translational modifications for MUC17 Gene
- N-glycosylated. Contains high mannose and complex-type glycans. The forms containing the complex type glycans localize to the cell surface. Not O-glycosylated.
- Probably cleaved within the SEA domain.
- Glycosylation at Ser56, Asn471, Asn696, Asn898, Asn1345, isoforms=22077, isoforms=22194, isoforms=23344, isoforms=24116, isoforms=24205, Asn4236, Asn4267, Asn4297, and Asn4305
Other Protein References for MUC17 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for MUC17
-
Cloud-Clone Corp. Antibodies for MUC17
- Invitrogen Antibodies for MUC17
- Search GeneTex for Antibodies for MUC17
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MUC17
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- Novus Biologicals proteins for MUC17
-
Cloud-Clone Corp. Proteins for MUC17
- Search GeneTex for Proteins for MUC17
Assay Products
-
Cloud-Clone Corp. Assay Kits for MUC17
- antibodies-online: Search results for 14 available MUC17 Elisa Kits ranked by validation data
- Compare Top MUC17 Elisa Kits
-
Quality Products:
Domains & Families for MUC17 Gene
Gene Families for MUC17 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Predicted membrane proteins
Protein Domains for MUC17 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for MUC17 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for MUC17 Gene
Function for MUC17 Gene
Molecular function for MUC17 Gene
- UniProtKB/Swiss-Prot Function:
- Probably plays a role in maintaining homeostasis on mucosal surfaces.
Enzyme Numbers (IUBMB) for MUC17 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 17990980 |
GO:0030165 | PDZ domain binding | IPI | 17990980 |
GO:0030197 | extracellular matrix constituent, lubricant activity | NAS | 9299468 |
Phenotypes for MUC17 Gene
- GenomeRNAi human phenotypes for MUC17:
Animal Model Products
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-
-
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-
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CRISPR Products
-
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- Overview of 25 available MUC17 gene related products
- Applied Biological Materials CRISPR for MUC17
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for MUC17
- GenScript: Design CRISPR guide RNA sequences for MUC17
miRNA for MUC17 Gene
- miRTarBase miRNAs that target MUC17
-
- hsa-mir-17-5p (MIRT004710)
- hsa-mir-20a-5p (MIRT004711)
- hsa-mir-20b-5p (MIRT004712)
- hsa-mir-30c-5p (MIRT004714)
- hsa-mir-30e-5p (MIRT004715)
- hsa-mir-132-3p (MIRT021736)
- hsa-mir-6819-5p (MIRT459461)
- hsa-mir-6812-5p (MIRT459462)
- hsa-mir-6737-5p (MIRT459463)
- hsa-mir-6747-5p (MIRT459464)
- hsa-mir-608 (MIRT459465)
- hsa-mir-4651 (MIRT459466)
- hsa-mir-4664-5p (MIRT459467)
- hsa-mir-342-5p (MIRT459468)
- hsa-mir-8053 (MIRT459469)
- hsa-mir-8073 (MIRT459470)
- hsa-mir-6717-5p (MIRT459471)
- hsa-mir-221-5p (MIRT459472)
- hsa-mir-6890-5p (MIRT459473)
- hsa-mir-629-3p (MIRT723787)
- hsa-mir-6818-3p (MIRT723788)
- hsa-mir-4279 (MIRT723789)
- hsa-mir-6881-3p (MIRT723790)
- hsa-mir-593-3p (MIRT723791)
- hsa-mir-6895-3p (MIRT723792)
- hsa-mir-6876-3p (MIRT723793)
- hsa-mir-626 (MIRT723794)
- hsa-mir-130b-5p (MIRT723795)
- hsa-mir-6845-3p (MIRT723796)
- hsa-mir-877-3p (MIRT723797)
miRNA Products
- Search ViGene Biosciences for MUC17
Inhibitory RNA Products
- Origene RNAi, shrna, and sirna products in human, mouse, rat for MUC17
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Clone Products
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-
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- Mammalian expression: PiggyBac
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- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for MUC17
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for MUC17
-
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-
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-
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No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MUC17 Gene
Localization for MUC17 Gene
Subcellular locations from UniProtKB/Swiss-Prot for MUC17 Gene
- Isoform 1: Cell membrane; Single-pass membrane protein.
- Isoform 2: Secreted. Cell membrane.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | IEA | -- |
GO:0005796 | Golgi lumen | TAS | -- |
GO:0005886 | plasma membrane | TAS | -- |
GO:0009897 | external side of plasma membrane | IDA | 12888891 |
GO:0016020 | membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for MUC17 Gene
Pathways & Interactions for MUC17 Gene
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) |
.62
|
|
2 | Diseases of glycosylation | ||
3 | Innate Immune System |
.61
|
|
4 | Metabolism of proteins | ||
5 | O-linked glycosylation |
Pathways by source for MUC17 Gene
Interacting Proteins for MUC17 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0002223 | stimulatory C-type lectin receptor signaling pathway | TAS | -- |
GO:0016266 | O-glycan processing | TAS | -- |
GO:0019725 | cellular homeostasis | TAS | 17990980 |
No data available for SIGNOR curated interactions for MUC17 Gene
Transcripts for MUC17 Gene
mRNA/cDNA for MUC17 Gene
- (2) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (50) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for MUC17 Gene
- Mucin 17, cell surface associated:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for MUC17
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- Overview of 25 available MUC17 gene related products
- Applied Biological Materials CRISPR for MUC17
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for MUC17
- GenScript: Design CRISPR guide RNA sequences for MUC17
miRNA Products
- Search ViGene Biosciences for MUC17
Inhibitory RNA Products
- Origene RNAi, shrna, and sirna products in human, mouse, rat for MUC17
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- genomics-online: shRNA clones - Search results for 25 available MUC17 gene related products
- Overview of 25 available MUC17 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for MUC17 gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for MUC17
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MUC17
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for MUC17
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | |||||||||||||||||||||
SP2: | - |
Expression for MUC17 Gene
mRNA differential expression in normal tissues according to GTEx for MUC17 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MUC17 Gene
NURSA nuclear receptor signaling pathways regulating expression of MUC17 Gene:
MUC17SOURCE GeneReport for Unigene cluster for MUC17 Gene:
Hs.271819mRNA Expression by UniProt/SwissProt for MUC17 Gene:
Q685J3-MUC17_HUMANEvidence on tissue expression from TISSUES for MUC17 Gene
- Intestine(4.5)
- Stomach(3.1)
Primer Products
-
OriGene qPCR primer pairs for MUC17
- genomics-online: primer clones - Search results for 25 available MUC17 gene related products
- Overview of 25 available MUC17 gene related products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for MUC17 Gene
Orthologs for MUC17 Gene
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | MUC17 33 |
|
||
mouse (Mus musculus) |
Mammalia | Muc3 34 |
|
OneToOne | |
platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
oppossum (Monodelphis domestica) |
Mammalia | MUC17 34 |
|
OneToOne | |
dog (Canis familiaris) |
Mammalia | MUC17 34 |
|
OneToOne | |
cow (Bos Taurus) |
Mammalia | -- 34 |
|
ManyToMany | |
lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
ManyToMany |
- Species where no ortholog for MUC17 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for MUC17 Gene
(2) SIMAP similar genes for MUC17 Gene using alignment to 3 proteins:
Variants for MUC17 Gene
SNP ID | Clin | Chr 07 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs193920784 | uncertain-significance, Malignant tumor of prostate | 101,040,366(+) | G/A | coding_sequence_variant, missense_variant, non_coding_transcript_variant | |
rs1000004435 | -- | 101,039,451(+) | G/A/T | coding_sequence_variant, missense_variant, non_coding_transcript_variant | |
rs1000056282 | -- | 101,018,864(+) | GCACCCCTG/GCACCCCTGCACCCCTG | upstream_transcript_variant | |
rs1000107887 | -- | 101,050,287(+) | G/A | intron_variant | |
rs1000140890 | -- | 101,041,536(+) | T/G | coding_sequence_variant, missense_variant, non_coding_transcript_variant |
Additional Variant Information for MUC17 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MUC17 Gene
Disorders for MUC17 Gene
Disorder | Aliases | PubMed IDs |
---|---|---|
biliary papillomatosis |
|
|
tn polyagglutination syndrome |
|
|
colorectal cancer 1 |
|
|
Additional Disease Information for MUC17
No data available for UniProtKB/Swiss-Prot and Genatlas for MUC17 Gene
Publications for MUC17 Gene
- MUC17, a novel membrane-tethered mucin. (PMID: 11855812) Gum JR … Kim YS (Biochemical and biophysical research communications 2002) 2 3 4 22 58
- Human intestinal MUC17 mucin augments intestinal cell restitution and enhances healing of experimental colitis. (PMID: 20211273) Luu Y … Ho SB (The international journal of biochemistry & cell biology 2010) 3 22 58
- The C-terminus of the transmembrane mucin MUC17 binds to the scaffold protein PDZK1 that stably localizes it to the enterocyte apical membrane in the small intestine. (PMID: 17990980) Malmberg EK … Hansson GC (The Biochemical journal 2008) 3 4 58
- Characterization of human mucin MUC17. Complete coding sequence and organization. (PMID: 16737958) Moniaux N … Batra SK (The Journal of biological chemistry 2006) 3 4 58
- N-glycosylation is required for the surface localization of MUC17 mucin. (PMID: 12888891) Ho JJ … Kim YS (International journal of oncology 2003) 3 4 58
Products for MUC17 Gene
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- Invitrogen Antibodies for MUC17
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- VectorBuilder custom plasmid, inducible vectors for MUC17
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MUC17
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for available MUC17 related products ranked by validation data
- antibodies-online: Search results for 14 available MUC17 Elisa Kits ranked by validation data
- Compare Top MUC17 Elisa Kits
- Quality Products:
- antibodies-online: Search results for available MUC17 related products ranked by validation data
- Search GeneTex for Antibodies for MUC17
- Search GeneTex for Proteins for MUC17
- ViGene Biosciences adenoviral particle packaged cDNA for MUC17 gene
- ViGene Biosciences lentiviral particle packaged cDNA for MUC17 gene
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- Browse Santa Cruz Biotechnology (SCBT) Antibodies
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- genomics-online: cdna clones - Search results for 25 available MUC17 gene related products
- Overview of 25 available MUC17 gene related products
- orf clones - Search results for 25 available MUC17 gene related products
- Overview of 25 available MUC17 gene related products
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- Overview of 25 available MUC17 gene related products
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- Overview of 25 available MUC17 gene related products
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- Overview of 25 available MUC17 gene related products
Sources for MUC17 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
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