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Aliases for CRP Gene

Aliases for CRP Gene

  • C-Reactive Protein 2 3 5
  • C-Reactive Protein, Pentraxin-Related 2 3
  • Pentraxin 1 2 3
  • PTX1 3 4

External Ids for CRP Gene

Previous GeneCards Identifiers for CRP Gene

  • GC01M157474
  • GC01M155414
  • GC01M156459
  • GC01M156899
  • GC01M156495
  • GC01M157948
  • GC01M131038

Summaries for CRP Gene

Entrez Gene Summary for CRP Gene

  • The protein encoded by this gene belongs to the pentaxin family. It is involved in several host defense related functions based on its ability to recognize foreign pathogens and damaged cells of the host and to initiate their elimination by interacting with humoral and cellular effector systems in the blood. Consequently, the level of this protein in plasma increases greatly during acute phase response to tissue injury, infection, or other inflammatory stimuli. [provided by RefSeq, Sep 2009]

GeneCards Summary for CRP Gene

CRP (C-Reactive Protein) is a Protein Coding gene. Diseases associated with CRP include Acute Pancreatitis and Appendicitis. Among its related pathways are Development_Leptin signaling via JAK/STAT and MAPK cascades and Innate Immune System. GO annotations related to this gene include calcium ion binding and cholesterol binding. An important paralog of this gene is APCS.

UniProtKB/Swiss-Prot for CRP Gene

  • Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells.

Gene Wiki entry for CRP Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRP Gene

Genomics for CRP Gene

Regulatory Elements for CRP Gene

Enhancers for CRP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G159751 1.1 Ensembl ENCODE 10.9 -38.0 -38005 3.2 TBP RAD21 YY1 CBX5 SCRT2 RCOR1 SMARCC1 USF2 CEBPB NR2F2 CRP FCRL6 DUSP23 ENSG00000212161 AIM2 RPL27P2
GH01G159746 0.4 ENCODE 11.3 -32.2 -32207 0.1 GATA2 CRP ENSG00000212161 RPL27P2
GH01G159682 0.3 FANTOM5 11.1 +31.7 31670 0.2 FCER1A CRP OR10J5 OR10J1 CRPP1 ENSG00000276632
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CRP on UCSC Golden Path with GeneCards custom track

Genomic Location for CRP Gene

Chromosome:
1
Start:
159,712,289 bp from pter
End:
159,714,609 bp from pter
Size:
2,321 bases
Orientation:
Minus strand

Genomic View for CRP Gene

Genes around CRP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CRP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CRP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRP Gene

Proteins for CRP Gene

  • Protein details for CRP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P02741-CRP_HUMAN
    Recommended name:
    C-reactive protein
    Protein Accession:
    P02741
    Secondary Accessions:
    • A8K078
    • D3DVD9
    • D3DVE0
    • Q08AK3
    • Q8WW75

    Protein attributes for CRP Gene

    Size:
    224 amino acids
    Molecular mass:
    25039 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    • Homopentamer. Pentraxin (or pentaxin) have a discoid arrangement of 5 non-covalently bound subunits. Interacts with FCN1; may regulate monocyte activation by FCN1.
    Miscellaneous:
    • This protein owes its name to its ability precipitate pneumococcal C-polysaccharide in the presence of calcium.

    Three dimensional structures from OCA and Proteopedia for CRP Gene

    Alternative splice isoforms for CRP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CRP Gene

Post-translational modifications for CRP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CRP Gene

Domains & Families for CRP Gene

Gene Families for CRP Gene

Protein Domains for CRP Gene

Suggested Antigen Peptide Sequences for CRP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P02741

UniProtKB/Swiss-Prot:

CRP_HUMAN :
  • Belongs to the pentraxin family.
Family:
  • Belongs to the pentraxin family.
genes like me logo Genes that share domains with CRP: view

Function for CRP Gene

Molecular function for CRP Gene

GENATLAS Biochemistry:
C-reactive protein,acute phase reactant,pentaxin (pentraxin) family,bacterial catabolite activator protein
UniProtKB/Swiss-Prot Function:
Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells.
UniProtKB/Swiss-Prot Induction:
The concentration of CRP in plasma increases greatly during acute phase response to tissue injury, infection or other inflammatory stimuli. It is induced by IL1/interleukin-1 and IL6/interleukin-6.

Gene Ontology (GO) - Molecular Function for CRP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001849 complement component C1q binding IDA 23544079
GO:0005509 calcium ion binding IDA 23544079
GO:0005515 protein binding IPI 17785206
GO:0030169 low-density lipoprotein particle binding IDA 18322245
GO:0033265 choline binding TAS 2477488
genes like me logo Genes that share ontologies with CRP: view
genes like me logo Genes that share phenotypes with CRP: view

Animal Models for CRP Gene

MGI Knock Outs for CRP:

Animal Model Products

  • Taconic Biosciences Mouse Models for CRP

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CRP Gene

Localization for CRP Gene

Subcellular locations from UniProtKB/Swiss-Prot for CRP Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CRP gene
Compartment Confidence
extracellular 5
cytoskeleton 3
cytosol 3
plasma membrane 2
peroxisome 2
nucleus 2
mitochondrion 1
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CRP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region NAS 14718574
GO:0005615 extracellular space IDA 21323571
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with CRP: view

Pathways & Interactions for CRP Gene

genes like me logo Genes that share pathways with CRP: view

Gene Ontology (GO) - Biological Process for CRP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006953 acute-phase response TAS 2477488
GO:0006954 inflammatory response TAS 10408362
GO:0008228 opsonization TAS 2477488
GO:0010628 positive regulation of gene expression IDA 24141169
GO:0010745 negative regulation of macrophage derived foam cell differentiation IDA 18322245
genes like me logo Genes that share ontologies with CRP: view

No data available for SIGNOR curated interactions for CRP Gene

Drugs & Compounds for CRP Gene

(183) Drugs for CRP Gene - From: DrugBank, PharmGKB, ClinicalTrials, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pyridoxine Approved, Vet_approved Nutra 188,188
Vitamin C Approved Nutra 531,531
Cholecalciferol Approved Nutra Fat-soluble secosteroids 875,869
Adalimumab Approved Pharma 494
Etanercept Approved, Investigational Pharma 403

(55) Additional Compounds for CRP Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
phosphorylcholine
  • Choline phosphate
  • N-Trimethyl-2-aminoethylphosphonate
  • O-Phosphocholine
  • Phosphocholine
  • Phosphoryl-choline
3616-04-4
genes like me logo Genes that share compounds with CRP: view

Transcripts for CRP Gene

Unigene Clusters for CRP Gene

C-reactive protein, pentraxin-related:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CRP Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f
SP1: - -
SP2: - - -
SP3: - - -
SP4: - - - - -
SP5: - -
SP6:
SP7: - - - -
SP8: -

Relevant External Links for CRP Gene

GeneLoc Exon Structure for
CRP
ECgene alternative splicing isoforms for
CRP

Expression for CRP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CRP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CRP Gene

This gene is overexpressed in Liver (x52.1).

Protein differential expression in normal tissues from HIPED for CRP Gene

This gene is overexpressed in Synovial fluid (11.2), Serum (7.9), and Stomach (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CRP Gene



NURSA nuclear receptor signaling pathways regulating expression of CRP Gene:

CRP

SOURCE GeneReport for Unigene cluster for CRP Gene:

Hs.76452

mRNA Expression by UniProt/SwissProt for CRP Gene:

P02741-CRP_HUMAN
Tissue specificity: Found in plasma.

Evidence on tissue expression from TISSUES for CRP Gene

  • Liver(5)
  • Blood(4)
  • Heart(3.7)
  • Muscle(3.4)
  • Intestine(3.3)
  • Lung(3.1)
  • Kidney(3)
  • Gall bladder(2.9)
  • Nervous system(2.9)
  • Urine(2.8)
  • Spleen(2.7)
  • Bone(2.6)
  • Skin(2.5)
  • Pancreas(2.3)
  • Bone marrow(2.1)
  • Thyroid gland(2.1)
  • Adrenal gland(2)
genes like me logo Genes that share expression patterns with CRP: view

Primer Products

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CRP Gene

Orthologs for CRP Gene

This gene was present in the common ancestor of chordates.

Orthologs for CRP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CRP 34 35
  • 99.55 (n)
cow
(Bos Taurus)
Mammalia CRP 34 35
  • 79.07 (n)
mouse
(Mus musculus)
Mammalia Crp 34 16 35
  • 76.08 (n)
rat
(Rattus norvegicus)
Mammalia Crp 34
  • 74.17 (n)
dog
(Canis familiaris)
Mammalia CRP 34 35
  • 69.23 (n)
oppossum
(Monodelphis domestica)
Mammalia CRP 35
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 49 (a)
OneToMany
chicken
(Gallus gallus)
Aves CRP 34 35
  • 55.71 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 46 (a)
ManyToMany
-- 35
  • 45 (a)
ManyToMany
-- 35
  • 43 (a)
ManyToMany
-- 35
  • 43 (a)
ManyToMany
-- 35
  • 39 (a)
ManyToMany
-- 35
  • 19 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486739 34
  • 52.82 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.16219 34
zebrafish
(Danio rerio)
Actinopterygii CRP 35
  • 21 (a)
OneToMany
Species where no ortholog for CRP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CRP Gene

ENSEMBL:
Gene Tree for CRP (if available)
TreeFam:
Gene Tree for CRP (if available)

Paralogs for CRP Gene

Paralogs for CRP Gene

(3) SIMAP similar genes for CRP Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for CRP Gene

genes like me logo Genes that share paralogs with CRP: view

Variants for CRP Gene

Sequence variations from dbSNP and Humsavar for CRP Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000114735 -- 159,714,247(+) TTCTC(C/T)AGTTA intron-variant
rs1000146741 -- 159,712,416(+) CTCCT(C/G)CACTT utr-variant-3-prime
rs1000501536 -- 159,712,712(+) CGGGG(A/C)TGAAG intron-variant, utr-variant-3-prime
rs1000518476 -- 159,712,652(+) CCTCT(A/G)ACAGG intron-variant, utr-variant-3-prime
rs1000957947 -- 159,712,626(+) GGAGC(C/T)GGGGA intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CRP Gene

Variant ID Type Subtype PubMed ID
esv3578217 CNV loss 25503493
nsv1005195 CNV gain 25217958
nsv825076 CNV loss 20364138

Variation tolerance for CRP Gene

Residual Variation Intolerance Score: 54.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.10; 22.35% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CRP Gene

Human Gene Mutation Database (HGMD)
CRP
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CRP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CRP Gene

Disorders for CRP Gene

MalaCards: The human disease database

(267) MalaCards diseases for CRP Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
acute pancreatitis
  • acute necrotizing pancreatitis
appendicitis
  • acute appendicitis
temporal arteritis
  • giant cell arteritis
pneumonia
  • acute pneumonia
acute pyelonephritis
  • acute pyelonephritis nos
- elite association - COSMIC cancer census association via MalaCards
Search CRP in MalaCards View complete list of genes associated with diseases

Relevant External Links for CRP

Genetic Association Database (GAD)
CRP
Human Genome Epidemiology (HuGE) Navigator
CRP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CRP
genes like me logo Genes that share disorders with CRP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CRP Gene

Publications for CRP Gene

  1. Polymorphisms in the CRP gene moderate an association between depressive symptoms and circulating levels of C-reactive protein. (PMID: 19796676) Halder I. … Manuck S.B. (Brain Behav. Immun. 2010) 3 22 46 64
  2. CRP gene variation and risk of community-acquired pneumonia. (PMID: 19947988) Mukamal K.J. … Rimm E.B. (Respirology 2010) 3 22 46 64
  3. Association of C-reactive protein (CRP) gene allelic variants with serum CRP levels and hypertension in Turkish adults. (PMID: 19410251) Komurcu-Bayrak E. … LehtimAoki T. (Atherosclerosis 2009) 3 22 46 64
  4. Polymorphisms of the CRP gene inhibit inflammatory response and increase susceptibility to depression: the Health in Men Study. (PMID: 19433520) Almeida O.P. … Flicker L. (Int J Epidemiol 2009) 3 22 46 64
  5. C-reactive protein gene polymorphisms affect plasma CRP and homocysteine concentrations in subjects with and without angiographically confirmed coronary artery disease. (PMID: 18401567) PasaliA8 D. … StavljeniA8-Rukavina A. (Mol. Biol. Rep. 2009) 3 22 46 64

Products for CRP Gene

Sources for CRP Gene

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