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Aliases for CRP Gene

Aliases for CRP Gene

  • C-Reactive Protein, Pentraxin-Related 2 3 5
  • Pentraxin 1 2 3
  • PTX1 3 4

External Ids for CRP Gene

Previous GeneCards Identifiers for CRP Gene

  • GC01M157474
  • GC01M155414
  • GC01M156459
  • GC01M156899
  • GC01M156495
  • GC01M157948
  • GC01M131038

Summaries for CRP Gene

Entrez Gene Summary for CRP Gene

  • The protein encoded by this gene belongs to the pentaxin family. It is involved in several host defense related functions based on its ability to recognize foreign pathogens and damaged cells of the host and to initiate their elimination by interacting with humoral and cellular effector systems in the blood. Consequently, the level of this protein in plasma increases greatly during acute phase response to tissue injury, infection, or other inflammatory stimuli. [provided by RefSeq, Sep 2009]

GeneCards Summary for CRP Gene

CRP (C-Reactive Protein, Pentraxin-Related) is a Protein Coding gene. Diseases associated with CRP include appendicitis and polymyalgia rheumatica. Among its related pathways are IL6-mediated signaling events and Immune System. GO annotations related to this gene include calcium ion binding and cholesterol binding. An important paralog of this gene is PTX3.

UniProtKB/Swiss-Prot for CRP Gene

  • Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells.

Gene Wiki entry for CRP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRP Gene

Genomics for CRP Gene

Regulatory Elements for CRP Gene

Genomic Location for CRP Gene

Chromosome:
1
Start:
159,712,289 bp from pter
End:
159,714,609 bp from pter
Size:
2,321 bases
Orientation:
Minus strand

Genomic View for CRP Gene

Genes around CRP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CRP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CRP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRP Gene

Proteins for CRP Gene

  • Protein details for CRP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P02741-CRP_HUMAN
    Recommended name:
    C-reactive protein
    Protein Accession:
    P02741
    Secondary Accessions:
    • A8K078
    • D3DVD9
    • D3DVE0
    • Q08AK3
    • Q8WW75

    Protein attributes for CRP Gene

    Size:
    224 amino acids
    Molecular mass:
    25039 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    • Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits. Interacts with FCN1; may regulate monocyte activation by FCN1.
    Miscellaneous:
    • This protein owes its name to its ability precipitate pneumococcal C-polysaccharide in the presence of calcium.

    Three dimensional structures from OCA and Proteopedia for CRP Gene

    Alternative splice isoforms for CRP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CRP Gene

Proteomics data for CRP Gene at MOPED

Post-translational modifications for CRP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CRP Gene

Antibody Products

  • R&D Systems Antibodies for CRP (C-Reactive Protein/CRP)
  • Cell Signaling Technology (CST) Antibodies for CRP (CRP)

Protein Products

No data available for DME Specific Peptides for CRP Gene

Domains & Families for CRP Gene

Gene Families for CRP Gene

Protein Domains for CRP Gene

Suggested Antigen Peptide Sequences for CRP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P02741

UniProtKB/Swiss-Prot:

CRP_HUMAN :
  • Contains 1 pentaxin domain.
  • Belongs to the pentaxin family.
Domain:
  • Contains 1 pentaxin domain.
Family:
  • Belongs to the pentaxin family.
genes like me logo Genes that share domains with CRP: view

Function for CRP Gene

Molecular function for CRP Gene

GENATLAS Biochemistry:
C-reactive protein,acute phase reactant,pentaxin (pentraxin) family,bacterial catabolite activator protein
UniProtKB/Swiss-Prot Function:
Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells.
UniProtKB/Swiss-Prot Induction:
The concentration of CRP in plasma increases greatly during acute phase response to tissue injury, infection or other inflammatory stimuli. It is induced by IL1/interleukin-1 and IL6/interleukin-6.

Gene Ontology (GO) - Molecular Function for CRP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030169 low-density lipoprotein particle binding IDA 18322245
GO:0050750 low-density lipoprotein particle receptor binding IPI 24141169
genes like me logo Genes that share ontologies with CRP: view
genes like me logo Genes that share phenotypes with CRP: view

Animal Models for CRP Gene

MGI Knock Outs for CRP:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CRP Gene

Localization for CRP Gene

Subcellular locations from UniProtKB/Swiss-Prot for CRP Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CRP Gene COMPARTMENTS Subcellular localization image for CRP gene
Compartment Confidence
extracellular 5
cytosol 3
cytoskeleton 2
nucleus 2
plasma membrane 2
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1
mitochondrion 1
peroxisome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for CRP Gene

Pathways & Interactions for CRP Gene

genes like me logo Genes that share pathways with CRP: view

Gene Ontology (GO) - Biological Process for CRP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006954 inflammatory response TAS 10408362
GO:0008228 opsonization TAS 2477488
GO:0010628 positive regulation of gene expression IDA 24141169
GO:0050830 defense response to Gram-positive bacterium TAS 2477488
GO:2000482 regulation of interleukin-8 secretion IDA 21037097
genes like me logo Genes that share ontologies with CRP: view

No data available for SIGNOR curated interactions for CRP Gene

Drugs & Compounds for CRP Gene

(180) Drugs for CRP Gene - From: ClinicalTrials, Novoseek, PharmGKB, DrugBank, HMDB, and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pyridoxine Approved Nutra 165,165
Vitamin C Approved Nutra 424,424
Cholecalciferol Approved Nutra Fat-soluble secosteroids 799,792
Etanercept Approved, Investigational Pharma 383
Fenofibrate Approved Pharma PPARalpha agonist 160

(56) Additional Compounds for CRP Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CRP: view

Transcripts for CRP Gene

Unigene Clusters for CRP Gene

C-reactive protein, pentraxin-related:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CRP Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f
SP1: - -
SP2: - - -
SP3: - - -
SP4: - - - - -
SP5: - -
SP6:
SP7: - - - -
SP8: -

Relevant External Links for CRP Gene

GeneLoc Exon Structure for
CRP
ECgene alternative splicing isoforms for
CRP

Expression for CRP Gene

mRNA expression in normal human tissues for CRP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CRP Gene

This gene is overexpressed in Liver (x52.1).

Protein differential expression in normal tissues from HIPED for CRP Gene

This gene is overexpressed in Synovial fluid (11.2), Serum (7.9), and Stomach (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CRP Gene



SOURCE GeneReport for Unigene cluster for CRP Gene Hs.76452

mRNA Expression by UniProt/SwissProt for CRP Gene

P02741-CRP_HUMAN
Tissue specificity: Found in plasma.
genes like me logo Genes that share expression patterns with CRP: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for CRP Gene

Orthologs for CRP Gene

This gene was present in the common ancestor of chordates.

Orthologs for CRP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CRP 36
  • 99 (a)
OneToOne
CRP 35
  • 99.55 (n)
  • 99.11 (a)
cow
(Bos Taurus)
Mammalia CRP 36
  • 70 (a)
OneToOne
CRP 35
  • 79.07 (n)
  • 70.4 (a)
dog
(Canis familiaris)
Mammalia CRP 35
  • 69.23 (n)
  • 61.09 (a)
CRP 36
  • 54 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Crp 16
Crp 35
  • 76.08 (n)
  • 70.4 (a)
Crp 36
  • 70 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CRP 36
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 49 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Crp 35
  • 74.17 (n)
  • 67.12 (a)
chicken
(Gallus gallus)
Aves CRP 35
  • 55.71 (n)
  • 48.15 (a)
CRP 36
  • 46 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 19 (a)
ManyToMany
-- 36
  • 39 (a)
ManyToMany
-- 36
  • 45 (a)
ManyToMany
-- 36
  • 43 (a)
ManyToMany
-- 36
  • 43 (a)
ManyToMany
-- 36
  • 46 (a)
ManyToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.16219 35
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486739 35
  • 52.82 (n)
  • 45.21 (a)
zebrafish
(Danio rerio)
Actinopterygii CRP 36
  • 21 (a)
OneToMany
Species with no ortholog for CRP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CRP Gene

ENSEMBL:
Gene Tree for CRP (if available)
TreeFam:
Gene Tree for CRP (if available)

Paralogs for CRP Gene

Paralogs for CRP Gene

(3) SIMAP similar genes for CRP Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for CRP Gene

genes like me logo Genes that share paralogs with CRP: view

Variants for CRP Gene

Sequence variations from dbSNP and Humsavar for CRP Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1800947 -- 159,713,648(-) GTGCT(A/C/G/T)TCACC reference, synonymous-codon
rs3116637 -- 159,712,717(-) TCTTT(C/T)TTCAT utr-variant-3-prime
rs3116638 -- 159,712,632(-) CCYAT(C/T)TCCCC utr-variant-3-prime
rs3116639 -- 159,712,616(-) CCTAT(C/T)TGGAG utr-variant-3-prime
rs3091244 -- 159,714,875(-) CCACT(A/C/T)GTTTA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CRP Gene

Variant ID Type Subtype PubMed ID
nsv825076 CNV Loss 20364138

Variation tolerance for CRP Gene

Residual Variation Intolerance Score: 54.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.10; 22.35% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CRP Gene

HapMap Linkage Disequilibrium report
CRP
Human Gene Mutation Database (HGMD)
CRP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CRP Gene

Disorders for CRP Gene

MalaCards: The human disease database

(281) MalaCards diseases for CRP Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
appendicitis
  • acute appendicitis
polymyalgia rheumatica
  • polymyalgia rheumatica [dup]
peripheral artery disease
  • peripheral arterial diseases
acute pyelonephritis
  • acute pyelonephritis nos
septic arthritis
  • infectious arthritis
- elite association - COSMIC cancer census association via MalaCards
Search CRP in MalaCards View complete list of genes associated with diseases

Relevant External Links for CRP

Genetic Association Database (GAD)
CRP
Human Genome Epidemiology (HuGE) Navigator
CRP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CRP
genes like me logo Genes that share disorders with CRP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CRP Gene

Publications for CRP Gene

  1. Characterization of genomic and complementary DNA sequence of human C-reactive protein, and comparison with the complementary DNA sequence of serum amyloid P component. (PMID: 3840479) Woo P. … Whitehead A.S. (J. Biol. Chem. 1985) 2 3 4 67
  2. Polymorphisms in the CRP gene moderate an association between depressive symptoms and circulating levels of C-reactive protein. (PMID: 19796676) Halder I. … Manuck S.B. (Brain Behav. Immun. 2010) 3 23
  3. Atorvastatin decreases C-reactive protein-induced inflammatory response in pulmonary artery smooth muscle cells by inhibiting nuclear factor-kappaB pathway. (PMID: 20074254) Li J. … Xiong C.M. (Cardiovasc Ther 2010) 3 23
  4. C-reactive protein and homocysteine levels are associated with abnormal heart rate recovery in women with polycystic ovary syndrome. (PMID: 19362308) Kaya C. … Pabuccu R. (Fertil. Steril. 2010) 3 23
  5. C-reactive protein, gamma-glutamyltransferase and type 2 diabetes in a Chinese population. (PMID: 19900432) Wen J. … Wang N. (Clin. Chim. Acta 2010) 3 23

Products for CRP Gene

Sources for CRP Gene

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