Aliases for CRMP1 Gene
External Ids for CRMP1 Gene
Previous GeneCards Identifiers for CRMP1 Gene
This gene encodes a member of a family of cytosolic phosphoproteins expressed exclusively in the nervous system. The encoded protein is thought to be a part of the semaphorin signal transduction pathway implicated in semaphorin-induced growth cone collapse during neural development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]
GeneCards Summary for CRMP1 Gene
CRMP1 (Collapsin Response Mediator Protein 1) is a Protein Coding gene. Among its related pathways are Developmental Biology and Semaphorin interactions. GO annotations related to this gene include hydrolase activity and hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides. An important paralog of this gene is DPYSL5.
UniProtKB/Swiss-Prot for CRMP1 Gene
Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. May participate in cytokinesis.