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Aliases for CRK Gene

Aliases for CRK Gene

  • V-Crk Avian Sarcoma Virus CT10 Oncogene Homolog 2 3 5
  • Proto-Oncogene C-Crk 3 4
  • P38 3 4
  • V-Crk Sarcoma Virus CT10 Oncogene-Like Protein 3
  • CRKII 3

External Ids for CRK Gene

Previous GeneCards Identifiers for CRK Gene

  • GC17M001318
  • GC17M001659
  • GC17M001533
  • GC17M001534
  • GC17M001272
  • GC17M001323

Summaries for CRK Gene

Entrez Gene Summary for CRK Gene

  • This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for CRK Gene

CRK (V-Crk Avian Sarcoma Virus CT10 Oncogene Homolog) is a Protein Coding gene. Diseases associated with CRK include Sarcoma and Chromosome 17P13.3 Duplication Syndrome. Among its related pathways are Bacterial invasion of epithelial cells and Regulation of actin dynamics for phagocytic cup formation. GO annotations related to this gene include protein domain specific binding and SH3/SH2 adaptor activity. An important paralog of this gene is CRKL.

UniProtKB/Swiss-Prot for CRK Gene

  • The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less transforming activity than Crk-I. Crk-II mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling.

Gene Wiki entry for CRK Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRK Gene

Genomics for CRK Gene

Regulatory Elements for CRK Gene

Enhancers for CRK Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CRK on UCSC Golden Path with GeneCards custom track

Genomic Location for CRK Gene

Chromosome:
17
Start:
1,420,689 bp from pter
End:
1,463,162 bp from pter
Size:
42,474 bases
Orientation:
Minus strand

Genomic View for CRK Gene

Genes around CRK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CRK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CRK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRK Gene

Proteins for CRK Gene

  • Protein details for CRK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P46108-CRK_HUMAN
    Recommended name:
    Adapter molecule crk
    Protein Accession:
    P46108
    Secondary Accessions:
    • A8MWE8
    • B0LPE8
    • D3DTH6
    • Q96GA9
    • Q96HJ0

    Protein attributes for CRK Gene

    Size:
    304 amino acids
    Molecular mass:
    33831 Da
    Quaternary structure:
    • Interacts with ABL1, C3G, DOCK3, MAP4K1, MAPK8 and SOS via its first SH3 domain. Interacts (via SH2 domain) with BCAR1, CBL, CBLB, PXN, IRS4 and GAB1 upon stimulus-induced tyrosine phosphorylation. Interacts (via SH2 domain) with several tyrosine-phosphorylated growth factor receptors such as EGFR and INSR. Interacts with FLT1 (tyrosine-phosphorylated). Interacts with DOCK1 and DOCK4. Interacts with SHB. Interacts with PEAK1. Interacts with FASLG. Isoform Crk-II interacts with KIT. Interacts with EPHA3; upon activation of EPHA3 by the ligand EFNA5 and EPHA3 tyrosine kinase activity-dependent. Interacts with EPHA3 (phosphorylated); mediates EFNA5-EPHA3 signaling through RHOA GTPase activation. Interacts with FLT4 (tyrosine-phosphorylated). Isoform Crk-II (via SH2 domain) interacts with PDGFRA (tyrosine phosphorylated) and PDGFRB (tyrosine phosphorylated). Part of a collagen stimulated complex involved in cell migration composed of CDC42, CRK, TNK2 and p130cas/BCAR1. Interacts (via SH2 domain) with the Tyr-9 phosphorylated form of PDPK1. Interacts with CBLC. Found in a complex with ABL1, ABL2, CRK and UNC119; leading to the inhibition of CRK phosphorylation by ABL kinases.

    Three dimensional structures from OCA and Proteopedia for CRK Gene

    Alternative splice isoforms for CRK Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CRK Gene

Proteomics data for CRK Gene at MOPED

Post-translational modifications for CRK Gene

  • Phosphorylated on Tyr-221 upon cell adhesion. Results in the negative regulation of the association with SH2- and SH3-binding partners, possibly by the formation of an intramolecular interaction of phosphorylated Tyr-221 with the SH2 domain. This leads finally to the down-regulation of the Crk signaling pathway.
  • Phosphorylation of Crk-II (40 kDa) gives rise to a 42 kDa form. Isoform Crk-II is phosphorylated by KIT.
  • Proline isomerization at Pro-237 by PPIA acts as a switch between two conformations: an autoinhibitory conformation in the cis form, where the tandem SH3 domains interact intramolecularly, and an activated conformation in the trans form.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CRK Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CRK (CRK)

No data available for DME Specific Peptides for CRK Gene

Domains & Families for CRK Gene

Gene Families for CRK Gene

Protein Domains for CRK Gene

Suggested Antigen Peptide Sequences for CRK Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P46108

UniProtKB/Swiss-Prot:

CRK_HUMAN :
  • The C-terminal SH3 domain function as a negative modulator for transformation and the N-terminal SH3 domain appears to function as a positive regulator for transformation.
  • Belongs to the CRK family.
Domain:
  • The C-terminal SH3 domain function as a negative modulator for transformation and the N-terminal SH3 domain appears to function as a positive regulator for transformation.
  • The SH2 domain mediates interaction with tyrosine phosphorylated proteins. Mediates interaction with SHB.
  • Contains 1 SH2 domain.
  • Contains 2 SH3 domains.
Family:
  • Belongs to the CRK family.
genes like me logo Genes that share domains with CRK: view

Function for CRK Gene

Molecular function for CRK Gene

GENATLAS Biochemistry:
avian sarcoma virus CT10 (v-crk) homolog
UniProtKB/Swiss-Prot Function:
The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less transforming activity than Crk-I. Crk-II mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling.

Gene Ontology (GO) - Molecular Function for CRK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005070 SH3/SH2 adaptor activity IEA --
genes like me logo Genes that share ontologies with CRK: view
genes like me logo Genes that share phenotypes with CRK: view

Animal Models for CRK Gene

MGI Knock Outs for CRK:

Animal Model Products

miRNA for CRK Gene

miRTarBase miRNAs that target CRK

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CRK Gene

Localization for CRK Gene

Subcellular locations from UniProtKB/Swiss-Prot for CRK Gene

Cytoplasm. Cell membrane. Note=Translocated to the plasma membrane upon cell adhesion. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CRK Gene COMPARTMENTS Subcellular localization image for CRK gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5
plasma membrane 4
cytoskeleton 3
endoplasmic reticulum 2

Gene Ontology (GO) - Cellular Components for CRK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IC 11870224
GO:0015629 actin cytoskeleton IEA --
genes like me logo Genes that share ontologies with CRK: view

Pathways & Interactions for CRK Gene

genes like me logo Genes that share pathways with CRK: view

SIGNOR curated interactions for CRK Gene

Activates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for CRK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032956 regulation of actin cytoskeleton organization IEA,IDA 11870224
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS --
GO:0045087 innate immune response TAS --
GO:0048010 vascular endothelial growth factor receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with CRK: view

Drugs & Compounds for CRK Gene

(9) Drugs for CRK Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(11) Additional Compounds for CRK Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CRK: view

Transcripts for CRK Gene

Unigene Clusters for CRK Gene

V-crk sarcoma virus CT10 oncogene homolog (avian):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CRK Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b
SP1: -
SP2:

Relevant External Links for CRK Gene

GeneLoc Exon Structure for
CRK
ECgene alternative splicing isoforms for
CRK

Expression for CRK Gene

mRNA expression in normal human tissues for CRK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CRK Gene

This gene is overexpressed in Uterus (6.2) and Oral epithelium (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CRK Gene



SOURCE GeneReport for Unigene cluster for CRK Gene Hs.461896

genes like me logo Genes that share expression patterns with CRK: view

Protein tissue co-expression partners for CRK Gene

- Elite partner

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CRK Gene

Orthologs for CRK Gene

This gene was present in the common ancestor of animals.

Orthologs for CRK Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CRK 35
  • 98.14 (n)
  • 100 (a)
CRK 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CRK 35
  • 97.7 (n)
  • 99.67 (a)
CRK 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Crk 35
  • 96.16 (n)
  • 99.67 (a)
Crk 16
Crk 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CRK 35
  • 99.55 (n)
  • 99.31 (a)
CRK 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Crk 35
  • 96.05 (n)
  • 99.67 (a)
oppossum
(Monodelphis domestica)
Mammalia CRK 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CRK 36
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves CRK 35
  • 83.99 (n)
  • 84.87 (a)
CRK 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CRK 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia crk 35
  • 79.62 (n)
  • 86.82 (a)
Str.6504 35
African clawed frog
(Xenopus laevis)
Amphibia MGC68492 35
zebrafish
(Danio rerio)
Actinopterygii crk 35
  • 69.4 (n)
  • 76.45 (a)
crk 36
  • 70 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4632 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009499 35
  • 49.33 (n)
  • 43.15 (a)
fruit fly
(Drosophila melanogaster)
Insecta Crk 35
  • 51.25 (n)
  • 52.57 (a)
Crk 36
  • 48 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ced-2 35
  • 45.51 (n)
  • 35.38 (a)
ced-2 36
  • 32 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6350 36
  • 48 (a)
OneToMany
Species with no ortholog for CRK:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CRK Gene

ENSEMBL:
Gene Tree for CRK (if available)
TreeFam:
Gene Tree for CRK (if available)

Paralogs for CRK Gene

Paralogs for CRK Gene

(6) SIMAP similar genes for CRK Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for CRK Gene

genes like me logo Genes that share paralogs with CRK: view

Variants for CRK Gene

Sequence variations from dbSNP and Humsavar for CRK Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1083 -- 1,422,003(-) AAGTA(C/T)GGAAT utr-variant-3-prime
rs15948 -- 1,421,123(-) CCTCA(A/G)GAAAT downstream-variant-500B
rs1041967 -- 1,437,071(-) CTATT(G/T)GGACA reference, missense
rs1041975 -- 1,423,028(-) GGAGC(A/G)TGACC utr-variant-3-prime
rs1041976 -- 1,423,017(-) AGCGT(A/G)TGACT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CRK Gene

Variant ID Type Subtype PubMed ID
nsv470567 CNV Gain 18288195
nsv833334 CNV Loss 17160897
esv1931977 CNV Deletion 18987734
dgv3028n71 CNV Loss 21882294
esv2715463 CNV Deletion 23290073

Variation tolerance for CRK Gene

Residual Variation Intolerance Score: 18.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.19; 4.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CRK Gene

Human Gene Mutation Database (HGMD)
CRK

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CRK Gene

Disorders for CRK Gene

MalaCards: The human disease database

(5) MalaCards diseases for CRK Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
sarcoma
  • connective and soft tissue neoplasm
chromosome 17p13.3 duplication syndrome
  • 17p13.3 duplication syndrome
shigellosis
  • bacillary dysentery
avian influenza
  • avian flu
miller-dieker lissencephaly syndrome
  • mds
- elite association - COSMIC cancer census association via MalaCards
Search CRK in MalaCards View complete list of genes associated with diseases

Relevant External Links for CRK

Genetic Association Database (GAD)
CRK
Human Genome Epidemiology (HuGE) Navigator
CRK
Tumor Gene Database (TGDB):
CRK
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CRK
genes like me logo Genes that share disorders with CRK: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CRK Gene

Publications for CRK Gene

  1. Interplay of the proto-oncogene proteins CrkL and CrkII in insulin- like growth factor-I receptor-mediated signal transduction. (PMID: 9614078) Koval A.P. … LeRoith D. (J. Biol. Chem. 1998) 3 4 23 67
  2. DOCK5 and DOCK1 regulate Caco-2 intestinal epithelial cell spreading and migration on collagen IV. (PMID: 19004829) Sanders M.A. … Basson M.D. (J. Biol. Chem. 2009) 3 23
  3. Adaptor protein Crk induces Src-dependent activation of p38 MAPK in regulation of synovial sarcoma cell proliferation. (PMID: 19737974) Watanabe T. … Minami A. (Mol. Cancer Res. 2009) 3 23
  4. MicroRNA-126 inhibits invasion in non-small cell lung carcinoma cell lines. (PMID: 18602365) Crawford M. … Nana-Sinkam S.P. (Biochem. Biophys. Res. Commun. 2008) 3 23
  5. Inhibitory receptor signaling via tyrosine phosphorylation of the adaptor Crk. (PMID: 18835194) Peterson M.E. … Long E.O. (Immunity 2008) 3 23

Products for CRK Gene

Sources for CRK Gene

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