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Aliases for CRK Gene

Aliases for CRK Gene

  • V-Crk Avian Sarcoma Virus CT10 Oncogene Homolog 2 3
  • Proto-Oncogene C-Crk 3 4
  • P38 3 4
  • Adapter Molecule Crk 3
  • CRKII 3

External Ids for CRK Gene

Summaries for CRK Gene

Entrez Gene Summary for CRK Gene

  • This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for CRK Gene

CRK (V-Crk Avian Sarcoma Virus CT10 Oncogene Homolog) is a Protein Coding gene. Diseases associated with CRK include miller-dieker syndrome. Among its related pathways are Signaling by FGFR and Signaling by FGFR. GO annotations related to this gene include SH3/SH2 adaptor activity and ephrin receptor binding. An important paralog of this gene is CRKL.

UniProtKB/Swiss-Prot for CRK Gene

  • The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less transforming activity than Crk-I. Crk-II mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling.

Gene Wiki entry for CRK Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRK Gene

Genomics for CRK Gene

Genomic Location for CRK Gene

Start:
1,420,689 bp from pter
End:
1,463,162 bp from pter
Size:
42,474 bases
Orientation:
Minus strand

Genomic View for CRK Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CRK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRK Gene

Regulatory Elements for CRK Gene

Proteins for CRK Gene

  • Protein details for CRK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P46108-CRK_HUMAN
    Recommended name:
    Adapter molecule crk
    Protein Accession:
    P46108
    Secondary Accessions:
    • A8MWE8
    • B0LPE8
    • D3DTH6
    • Q96GA9
    • Q96HJ0

    Protein attributes for CRK Gene

    Size:
    304 amino acids
    Molecular mass:
    33831 Da
    Quaternary structure:
    • Interacts with ABL1, C3G, DOCK3, MAP4K1, MAPK8 and SOS via its first SH3 domain. Interacts (via SH2 domain) with BCAR1, CBL, CBLB, PXN, IRS4 and GAB1 upon stimulus-induced tyrosine phosphorylation. Interacts (via SH2 domain) with several tyrosine-phosphorylated growth factor receptors such as EGFR and INSR. Interacts with FLT1 (tyrosine-phosphorylated). Interacts with DOCK1 and DOCK4. Interacts with SHB. Interacts with PEAK1. Interacts with FASLG. Isoform Crk-II interacts with KIT. Interacts with EPHA3; upon activation of EPHA3 by the ligand EFNA5 and EPHA3 tyrosine kinase activity-dependent. Interacts with EPHA3 (phosphorylated); mediates EFNA5-EPHA3 signaling through RHOA GTPase activation. Interacts with FLT4 (tyrosine-phosphorylated). Isoform Crk-II (via SH2 domain) interacts with PDGFRA (tyrosine phosphorylated) and PDGFRB (tyrosine phosphorylated). Part of a collagen stimulated complex involved in cell migration composed of CDC42, CRK, TNK2 and p130cas/BCAR1. Interacts (via SH2 domain) with the Tyr-9 phosphorylated form of PDPK1. Interacts with CBLC. Found in a complex with ABL1, ABL2, CRK and UNC119; leading to the inhibition of CRK phosphorylation by ABL kinases.

    Three dimensional structures from OCA and Proteopedia for CRK Gene

    Alternative splice isoforms for CRK Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CRK Gene

Proteomics data for CRK Gene at MOPED

Post-translational modifications for CRK Gene

  • Phosphorylated on Tyr-221 upon cell adhesion. Results in the negative regulation of the association with SH2- and SH3-binding partners, possibly by the formation of an intramolecular interaction of phosphorylated Tyr-221 with the SH2 domain. This leads finally to the down-regulation of the Crk signaling pathway.
  • Phosphorylation of Crk-II (40 kDa) gives rise to a 42 kDa form. Isoform Crk-II is phosphorylated by KIT
  • Proline isomerization at Pro-237 by PPIA acts as a switch between two conformations: an autoinhibitory conformation in the cis form, where the tandem SH3 domains interact intramolecularly, and an activated conformation in the trans form.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CRK Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CRK Gene

Domains for CRK Gene

Gene Families for CRK Gene

HGNC:
  • SH2D :SH2 domain containing

Protein Domains for CRK Gene

UniProtKB/Swiss-Prot:

CRK_HUMAN
Domain:
  • The C-terminal SH3 domain function as a negative modulator for transformation and the N-terminal SH3 domain appears to function as a positive regulator for transformation.:
    • P46108
  • The SH2 domain mediates interaction with tyrosine phosphorylated proteins. Mediates interaction with SHB:
    • P46108
  • Contains 1 SH2 domain.:
    • P46108
  • Contains 2 SH3 domains.:
    • P46108
Family:
  • Belongs to the CRK family.:
    • P46108
genes like me logo Genes that share domains with CRK: view

Function for CRK Gene

Molecular function for CRK Gene

GENATLAS Biochemistry: avian sarcoma virus CT10 (v-crk) homolog
UniProtKB/Swiss-Prot Function: The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less transforming activity than Crk-I. Crk-II mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling.

Gene Ontology (GO) - Molecular Function for CRK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005070 SH3/SH2 adaptor activity IEA --
GO:0005515 protein binding IPI 10464310
GO:0019904 protein domain specific binding --
GO:0030674 protein binding, bridging --
GO:0042169 SH2 domain binding IPI 9472046
genes like me logo Genes that share ontologies with CRK: view
genes like me logo Genes that share phenotypes with CRK: view

Animal Models for CRK Gene

MGI Knock Outs for CRK:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CRK Gene

Localization for CRK Gene

Subcellular locations from UniProtKB/Swiss-Prot for CRK Gene

Cytoplasm. Cell membrane. Note=Translocated to the plasma membrane upon cell adhesion. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CRK Gene COMPARTMENTS Subcellular localization image for CRK gene
Compartment Confidence
cytosol 4
nucleus 4
cytoskeleton 2
plasma membrane 2
extracellular 1

Gene Ontology (GO) - Cellular Components for CRK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 10748058
GO:0005737 cytoplasm IC 11870224
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IEA --
GO:0015629 actin cytoskeleton IEA --
genes like me logo Genes that share ontologies with CRK: view

Pathways for CRK Gene

genes like me logo Genes that share pathways with CRK: view

Gene Ontology (GO) - Biological Process for CRK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000186 activation of MAPKK activity TAS --
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS 10748058
GO:0007596 blood coagulation TAS --
GO:0008286 insulin receptor signaling pathway TAS --
GO:0009967 positive regulation of signal transduction --
genes like me logo Genes that share ontologies with CRK: view

Compounds for CRK Gene

(20) Novoseek inferred chemical compound relationships for CRK Gene

Compound -log(P) Hits PubMed IDs
tyrosine 78.3 118
phosphotyrosine 62.8 2
phosphatidylinositol 58.9 15
thiosemicarbazide 48.1 2
thiazolidinedione 38.8 2
genes like me logo Genes that share compounds with CRK: view

Transcripts for CRK Gene

Unigene Clusters for CRK Gene

V-crk sarcoma virus CT10 oncogene homolog (avian):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CRK Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b
SP1: -
SP2:

Relevant External Links for CRK Gene

GeneLoc Exon Structure for
CRK
ECgene alternative splicing isoforms for
CRK

Expression for CRK Gene

mRNA expression in normal human tissues for CRK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CRK Gene

SOURCE GeneReport for Unigene cluster for CRK Gene Hs.461896

genes like me logo Genes that share expressions with CRK: view

Orthologs for CRK Gene

This gene was present in the common ancestor of animals.

Orthologs for CRK Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CRK 36
  • 99.55 (n)
  • 99.31 (a)
CRK 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CRK 36
  • 98.14 (n)
  • 100 (a)
CRK 37
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CRK 36
  • 97.7 (n)
  • 99.67 (a)
CRK 37
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Crk 36
  • 96.16 (n)
  • 99.67 (a)
Crk 16
Crk 37
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CRK 37
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CRK 37
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Crk 36
  • 96.05 (n)
  • 99.67 (a)
chicken
(Gallus gallus)
Aves CRK 36
  • 83.99 (n)
  • 84.87 (a)
CRK 37
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CRK 37
  • 79 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC68492 36
tropical clawed frog
(Silurana tropicalis)
Amphibia crk 36
  • 79.62 (n)
  • 86.82 (a)
Str.6504 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4632 36
zebrafish
(Danio rerio)
Actinopterygii crk 36
  • 69.4 (n)
  • 76.45 (a)
crk 37
  • 70 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009499 36
  • 49.33 (n)
  • 43.15 (a)
fruit fly
(Drosophila melanogaster)
Insecta Crk 36
  • 51.25 (n)
  • 52.57 (a)
Crk 37
  • 48 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ced-2 36
  • 45.51 (n)
  • 35.38 (a)
ced-2 37
  • 32 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6350 37
  • 48 (a)
OneToMany
Species with no ortholog for CRK:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CRK Gene

ENSEMBL:
Gene Tree for CRK (if available)
TreeFam:
Gene Tree for CRK (if available)

Paralogs for CRK Gene

Paralogs for CRK Gene

Selected SIMAP similar genes for CRK Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for CRK Gene

genes like me logo Genes that share paralogs with CRK: view

Variants for CRK Gene

Sequence variations from dbSNP and Humsavar for CRK Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs1083 -- 1,422,003(-) AAGTA(C/T)GGAAT utr-variant-3-prime
rs15948 -- 1,421,123(-) CCTCA(A/G)GAAAT downstream-variant-500B
rs881054 -- 1,428,353(+) acttc(A/G)tgatc intron-variant
rs1041967 -- 1,437,071(-) CTATT(G/T)GGACA missense, reference
rs1041975 -- 1,423,028(-) GGAGC(A/G)TGACC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CRK Gene

Variant ID Type Subtype PubMed ID
nsv470567 CNV Gain 18288195
nsv833334 CNV Loss 17160897
esv1931977 CNV Deletion 18987734
dgv3028n71 CNV Loss 21882294
esv2715463 CNV Deletion 23290073

Relevant External Links for CRK Gene

HapMap Linkage Disequilibrium report
CRK
Human Gene Mutation Database (HGMD)
CRK

Disorders for CRK Gene

(1) MalaCards Diseases for CRK Gene

Search for CRK Gene in MalaCards »

(1) University of Copenhagen DISEASES for CRK Gene

(9) Novoseek inferred disease relationships for CRK Gene

Disease -log(P) Hits PubMed IDs
myeloid leukemia chronic 14.9 1
carcinoma squamous cell 0 2
inflammation 0 2
breast cancer 0 2
pheochromocytoma 0 1

Relevant External Links for CRK

Genetic Association Database (GAD)
CRK
Human Genome Epidemiology (HuGE) Navigator
CRK
Tumor Gene Database (TGDB):
CRK
genes like me logo Genes that share disorders with CRK: view

No data available for UniProtKB/Swiss-Prot for CRK Gene

Publications for CRK Gene

  1. Two species of human CRK cDNA encode proteins with distinct biological activities. (PMID: 1630456) Matsuda M. … Shibuya M. (Mol. Cell. Biol. 1992) 3 4 23
  2. Interaction between the amino-terminal SH3 domain of CRK and its natural target proteins. (PMID: 8662907) Matsuda M. … Kurata T. (J. Biol. Chem. 1996) 3 4 23
  3. Interplay of the proto-oncogene proteins CrkL and CrkII in insulin- like growth factor-I receptor-mediated signal transduction. (PMID: 9614078) Koval A.P. … LeRoith D. (J. Biol. Chem. 1998) 3 4 23
  4. Differential interaction of CrkII adaptor protein with platelet- derived growth factor alpha- and beta-receptors is determined by its internal tyrosine phosphorylation. (PMID: 10733900) Matsumoto T. … Mori S. (Biochem. Biophys. Res. Commun. 2000) 3 4 23
  5. CrkII participation in the cellular effects of growth hormone and insulin-like growth factor-1. Phosphatidylinositol-3 kinase dependent and independent effects. (PMID: 10748058) Goh E.L. … Lobie P.E. (J. Biol. Chem. 2000) 3 23

Products for CRK Gene

  • Addgene plasmids for CRK

Sources for CRK Gene

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