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Aliases for GPR119 Gene

Aliases for GPR119 Gene

  • G Protein-Coupled Receptor 119 2 3
  • GPCR2 3 6
  • Glucose-Dependent Insulinotropic Receptor 3
  • G-Protein Coupled Receptor 119 4
  • G-Protein Coupled Receptor 2 3

External Ids for GPR119 Gene

Previous GeneCards Identifiers for GPR119 Gene

  • GC0XM128224
  • GC0XM129243
  • GC0XM129346
  • GC0XM129518
  • GC0XM118912

Summaries for GPR119 Gene

Entrez Gene Summary for GPR119 Gene

  • This gene encodes a member of the rhodopsin subfamily of G-protein-coupled receptors that is expressed in the pancreas and gastrointestinal tract. The encoded protein is activated by lipid amides including lysophosphatidylcholine and oleoylethanolamide and may be involved in glucose homeostasis. This protein is a potential drug target in the treatment of type 2 diabetes.[provided by RefSeq, Jan 2010]

GeneCards Summary for GPR119 Gene

GPR119 (G Protein-Coupled Receptor 119) is a Protein Coding gene. Among its related pathways are Akt Signaling and GPCR Pathway. GO annotations related to this gene include G-protein coupled receptor activity and phosphatidylcholine binding. An important paralog of this gene is ADORA1.

UniProtKB/Swiss-Prot for GPR119 Gene

  • Receptor for the endogenous fatty-acid ethanolamide oleoylethanolamide (OEA) and lysophosphatidylcholine (LPC). Functions as a glucose-dependent insulinotropic receptor. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Seems to act through a G(s) mediated pathway.

Tocris Summary for GPR119 Gene

  • GPR119 receptors, also referred to as SNORF25, RUP3, GPCR2 and OSGPR116, are Galphas-protein-coupled receptors with a degree of homology to cannabinoid receptors. They are predominantly expressed in the pancreas and gastrointestinal tract in humans and rodents. High expression levels are also seen in many areas of the rat brain, including the cerebellum, cerebral cortex, chorid plexus, dorsal root ganglion, hippocampus and hypothalamus. Ethanolamides are proposed to be the endogenous ligands for GPR119. Oleoylethanolamide (OEA) is the most potent endogenous GPR119 agonist identified to date, and the compound's effects on feeding are mediated through this receptor. GPR119 receptors are proposed to play a role in glucose homeostasis through modulation of insulin secretion. Activation of GPR119 receptors potentiates glucose-stimulated insulin secretion in a manner analogous to that of the incretin hormones glucagon-like peptide 1 (GLP-1) and gastric inhibitory poylpeptide (GIP). In addition, GPR119 agonists have been shown to directly stimulate GLP-1 and GIP secretion, which are both powerful antihyperglycemic agents. GPR119 receptors are attracting attention from antidiabetes and antiobesity researchers, as receptor modulation may provide favorable effects on glucose homeostasis, food intake, weight gain and possibly beta-islet cell preservation.

Gene Wiki entry for GPR119 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR119 Gene

Genomics for GPR119 Gene

Regulatory Elements for GPR119 Gene

Genomic Location for GPR119 Gene

Start:
130,384,345 bp from pter
End:
130,385,537 bp from pter
Size:
1,193 bases
Orientation:
Minus strand

Genomic View for GPR119 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GPR119 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR119 Gene

Proteins for GPR119 Gene

  • Protein details for GPR119 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TDV5-GP119_HUMAN
    Recommended name:
    Glucose-dependent insulinotropic receptor
    Protein Accession:
    Q8TDV5
    Secondary Accessions:
    • Q495H7
    • Q4VBN3

    Protein attributes for GPR119 Gene

    Size:
    335 amino acids
    Molecular mass:
    36889 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR119 Gene

Proteomics data for GPR119 Gene at MOPED

Post-translational modifications for GPR119 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GPR119 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for GPR119 Gene

Domains for GPR119 Gene

Gene Families for GPR119 Gene

HGNC:
  • GPCRAO :GPCR / Class A : Orphans
IUPHAR :

Protein Domains for GPR119 Gene

Suggested Antigen Peptide Sequences for GPR119 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TDV5

UniProtKB/Swiss-Prot:

GP119_HUMAN :
  • Q8TDV5
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR119: view

Function for GPR119 Gene

Molecular function for GPR119 Gene

UniProtKB/Swiss-Prot Function: Receptor for the endogenous fatty-acid ethanolamide oleoylethanolamide (OEA) and lysophosphatidylcholine (LPC). Functions as a glucose-dependent insulinotropic receptor. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Seems to act through a G(s) mediated pathway.

Gene Ontology (GO) - Molecular Function for GPR119 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0031210 phosphatidylcholine binding IEA --
genes like me logo Genes that share ontologies with GPR119: view

Phenotypes for GPR119 Gene

genes like me logo Genes that share phenotypes with GPR119: view

Animal Models for GPR119 Gene

MGI Knock Outs for GPR119:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GPR119

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for GPR119 Gene

Localization for GPR119 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR119 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GPR119 Gene COMPARTMENTS Subcellular localization image for GPR119 gene
Compartment Confidence
plasma membrane 5
nucleus 1

Gene Ontology (GO) - Cellular Components for GPR119 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0043235 receptor complex IDA 23382219
genes like me logo Genes that share ontologies with GPR119: view

Pathways for GPR119 Gene

genes like me logo Genes that share pathways with GPR119: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for GPR119 Gene

Gene Ontology (GO) - Biological Process for GPR119 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0030073 insulin secretion IEA --
genes like me logo Genes that share ontologies with GPR119: view

Compounds for GPR119 Gene

(2) Tocris Compounds for GPR119 Gene

Compound Action Cas Number
AS 1269574 GPR119 receptor agonist [330981-72-1]
PSN 375963 hydrochloride GPR119 receptor agonist [388575-52-8]

(35) IUPHAR Ligand for GPR119 Gene

Ligand Type Action Affinity Pubmed IDs
compound 8g [PMID:21444206] Agonist Agonist 9.3
compound 23 [PMID:21444206] Agonist Agonist 9.22
compound 29a [PMID:21444206] Agonist Agonist 9.15
compound 3j [PMID:21444206] Agonist Agonist 9.05
compound 3a [PMID:21444206] Agonist Agonist 8.96
5-(4-cyano-3-methylphenyl)-2-(4-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-1-yl)nicotinitrile Agonist Agonist 8.77
compound 36j [PMID:21536438] Agonist Agonist 8.52
compound 58 [PMID:21273063] Agonist Agonist 8.4
AR231453 Agonist Agonist 8.2
compound 42 [PMID:22545772] Agonist Agonist 8.1
compound 20f [PMID:21536438] Agonist Agonist 7.74
compound 36 [PMID:21273063] Agonist Agonist 7.72
lysophosphatidylinositol Agonist Agonist 7.31
JNJ-38431055 Agonist Agonist 7.3
compound 3 [PMID:21310611] Agonist Agonist 7.1
oleoylethanolamide Agonist Agonist 6.5
(R)-N-oleoyltyrosinol Agonist Agonist 6.3
(S)-N-oleoyltyrosinol Agonist Agonist 6.2
isopropyl-4-(3-cyano-5-(quinoxalin-6-yl)pyridine-2-yl)piperazine-1-carboxylate Agonist Agonist 6.1
AS1907417 Agonist Agonist 6
AS1535907 Agonist Agonist 5.9
oleoyl-lysophosphatidylcholine Agonist Agonist 5.8
1-palmitoyl-lysophosphatidylcholine Agonist Agonist 5.8
2-oleoyl glycerol Agonist Agonist 5.6
AS1269574 Agonist Agonist 5.6
1-oleoyl glycerol Agonist Agonist 5.6
N-oleoyldopamine Agonist Agonist 5.5
1-stearoyl-lysophosphatidylcholine Agonist Agonist 5.5
2-methyl-2-propanyl 1-(3-pyridinyl)-4,4-bipiperidine-1-carboxylate Agonist Agonist 5.44
PSN632408 Agonist Agonist 5.3
lysophosphatidylethanolamine Agonist Agonist 5.2
PSN375963 Agonist Agonist 5.1
olvanil Activator None
SEA Agonist Full agonist
N-palmitoylethanolamine Agonist Full agonist
genes like me logo Genes that share compounds with GPR119: view

Transcripts for GPR119 Gene

mRNA/cDNA for GPR119 Gene

(11) Selected AceView cDNA sequences:
(7) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPR119 Gene

G protein-coupled receptor 119:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GPR119

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPR119 Gene

No ASD Table

Relevant External Links for GPR119 Gene

GeneLoc Exon Structure for
GPR119
ECgene alternative splicing isoforms for
GPR119

Expression for GPR119 Gene

mRNA expression in normal human tissues for GPR119 Gene

mRNA differential expression in normal tissues according to GTEx for GPR119 Gene

This gene is overexpressed in Pancreas (39.8) and Testis (7.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for GPR119 Gene

SOURCE GeneReport for Unigene cluster for GPR119 Gene Hs.496762

mRNA Expression by UniProt/SwissProt for GPR119 Gene

Q8TDV5-GP119_HUMAN
Tissue specificity: Predominantly expressed in the pancreas, especially in the islets.
genes like me logo Genes that share expressions with GPR119: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for GPR119 Gene

Orthologs for GPR119 Gene

This gene was present in the common ancestor of animals.

Orthologs for GPR119 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPR119 35
  • 99.8 (n)
  • 99.7 (a)
GPR119 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GPR119 35
  • 84.78 (n)
  • 79.1 (a)
GPR119 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GPR119 35
  • 88.26 (n)
  • 84.18 (a)
GPR119 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gpr119 35
  • 84.48 (n)
  • 82.09 (a)
Gpr119 16
Gpr119 36
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GPR119 36
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gpr119 35
  • 84.29 (n)
  • 81.82 (a)
chicken
(Gallus gallus)
Aves GPR119 35
  • 62.99 (n)
  • 55.52 (a)
GPR119 36
  • 53 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GPR119 36
  • 50 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii GPR119 36
  • 41 (a)
OneToOne
LOC100001479 35
  • 51.5 (n)
  • 44.79 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12796 36
  • 19 (a)
OneToOne
Species with no ortholog for GPR119:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR119 Gene

ENSEMBL:
Gene Tree for GPR119 (if available)
TreeFam:
Gene Tree for GPR119 (if available)

Paralogs for GPR119 Gene

Paralogs for GPR119 Gene

genes like me logo Genes that share paralogs with GPR119: view

Variants for GPR119 Gene

Sequence variations from dbSNP and Humsavar for GPR119 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs5975187 - 130,384,522(+) TGGCC(A/G)AGAGA reference, missense
rs12843361 -- 130,387,222(+) AGTTT(C/T)GCTCT upstream-variant-2KB
rs12850013 -- 130,387,200(+) TTTTT(A/T)TTTTT upstream-variant-2KB
rs16999669 -- 130,386,890(+) TATTC(C/T)AGTTG upstream-variant-2KB
rs34483672 -- 130,384,668(+) GTTCC(-/C)AGCAC reference, frameshift-variant

Structural Variations from Database of Genomic Variants (DGV) for GPR119 Gene

Variant ID Type Subtype PubMed ID
nsv528290 CNV Gain 19592680

Relevant External Links for GPR119 Gene

HapMap Linkage Disequilibrium report
GPR119
Locus Specific Mutation Databases (LSDB)
GPR119

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR119 Gene

Disorders for GPR119 Gene

(1) University of Copenhagen DISEASES for GPR119 Gene

genes like me logo Genes that share disorders with GPR119: view

No data available for UniProtKB/Swiss-Prot for GPR119 Gene

Publications for GPR119 Gene

  1. Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives. (PMID: 14623098) Fredriksson R. … Schioeth H.B. (FEBS Lett. 2003) 2 3 4
  2. Identification of G protein-coupled receptor genes from the human genome sequence. (PMID: 12044878) Takeda S. … Mitaku S. (FEBS Lett. 2002) 2 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4
  5. Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents. (PMID: 16517404) Overton H.A. … Reynet C. (Cell Metab. 2006) 3 4

Products for GPR119 Gene

Sources for GPR119 Gene

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