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Aliases for PASD1 Gene

Aliases for PASD1 Gene

  • PAS Domain Containing 1 2 3 5
  • Cancer/Testis Antigen 63 2 3 4
  • CT63 3 4
  • PAS Domain-Containing Protein 1 4
  • OX-TES-1 4
  • OXTES1 3

External Ids for PASD1 Gene

Previous GeneCards Identifiers for PASD1 Gene

  • GC0XP150402
  • GC0XP150482
  • GC0XP150732
  • GC0XP139588

Summaries for PASD1 Gene

Entrez Gene Summary for PASD1 Gene

  • This gene encodes a protein that is thought to function as a transcription factor. The protein is a cancer-associated antigen that can stimulate autologous T-cell responses, and it is therefore considered to be a potential immunotherapeutic target for the treatment of various hematopoietic malignancies, including diffuse large B-cell lymphoma. [provided by RefSeq, May 2010]

GeneCards Summary for PASD1 Gene

PASD1 (PAS Domain Containing 1) is a Protein Coding gene. Diseases associated with PASD1 include diffuse large b-cell lymphoma. GO annotations related to this gene include signal transducer activity.

UniProtKB/Swiss-Prot for PASD1 Gene

  • Functions as a suppressor of the biological clock that drives the daily circadian rhythms of cells throughout the body (PubMed:25936801). Acts as a nuclear repressor of the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock components (PubMed:25936801). Inhibits circadian clock function in cancer cells, when overexpressed (PubMed:25936801).

Gene Wiki entry for PASD1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PASD1 Gene

Genomics for PASD1 Gene

Genomic Location for PASD1 Gene

Chromosome:
X
Start:
151,563,535 bp from pter
End:
151,676,739 bp from pter
Size:
113,205 bases
Orientation:
Plus strand

Genomic View for PASD1 Gene

Genes around PASD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PASD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PASD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PASD1 Gene

No data available for Regulatory Elements for PASD1 Gene

Proteins for PASD1 Gene

  • Protein details for PASD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IV76-PASD1_HUMAN
    Recommended name:
    Circadian clock protein PASD1
    Protein Accession:
    Q8IV76
    Secondary Accessions:
    • Q3MNE0
    • Q69HD7
    • Q8N7X9

    Protein attributes for PASD1 Gene

    Size:
    773 amino acids
    Molecular mass:
    87428 Da
    Quaternary structure:
    • Interacts with the CLOCK-ARNTL/BMAL1 heterodimer; this interaction inhibits CLOCK-ARNTL/BMAL1 transcriptional activation and suppress circadian timekeeping (PubMed:25936801). Interacts with ARNTL/BMAL1 (PubMed:25936801).

    Alternative splice isoforms for PASD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PASD1 Gene

Proteomics data for PASD1 Gene at MOPED

Post-translational modifications for PASD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PASD1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PASD1 Gene

Domains & Families for PASD1 Gene

Protein Domains for PASD1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PASD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IV76

UniProtKB/Swiss-Prot:

PASD1_HUMAN :
  • C-terminus of isoform 1 and isoform 2 are sufficient to interact with and to repress the activity of CLOCK-ARNTL/BMAL1 (PubMed:25936801).
Domain:
  • C-terminus of isoform 1 and isoform 2 are sufficient to interact with and to repress the activity of CLOCK-ARNTL/BMAL1 (PubMed:25936801).
  • Contains 1 PAS (PER-ARNT-SIM) domain.
genes like me logo Genes that share domains with PASD1: view

No data available for Gene Families for PASD1 Gene

Function for PASD1 Gene

Molecular function for PASD1 Gene

UniProtKB/Swiss-Prot Function:
Functions as a suppressor of the biological clock that drives the daily circadian rhythms of cells throughout the body (PubMed:25936801). Acts as a nuclear repressor of the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock components (PubMed:25936801). Inhibits circadian clock function in cancer cells, when overexpressed (PubMed:25936801).
genes like me logo Genes that share phenotypes with PASD1: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PASD1 Gene

Localization for PASD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PASD1 Gene

Isoform 1: Nucleus. Note=Associates preferentially at the periphery of the nucleus with heterochromatin (PubMed:25936801). {ECO:0000269 PubMed:25936801}.
Isoform 2: Nucleus. Note=Associates preferentially at the periphery of the nucleus with heterochromatin (PubMed:25936801). {ECO:0000269 PubMed:25936801}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PASD1 Gene COMPARTMENTS Subcellular localization image for PASD1 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for PASD1 Gene

Pathways & Interactions for PASD1 Gene

SuperPathways for PASD1 Gene

No Data Available

Interacting Proteins for PASD1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000359382%0d%0a9606.ENSP00000405965%0d%0a
Selected Interacting proteins: ENSP00000359382 for PASD1 Gene via STRING

Symbol External ID(s) Details
SUMO2

Gene Ontology (GO) - Biological Process for PASD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042754 negative regulation of circadian rhythm IDA 25936801
genes like me logo Genes that share ontologies with PASD1: view

No data available for Pathways by source and SIGNOR curated interactions for PASD1 Gene

Drugs & Compounds for PASD1 Gene

No Compound Related Data Available

Transcripts for PASD1 Gene

mRNA/cDNA for PASD1 Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PASD1 Gene

PAS domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PASD1 Gene

No ASD Table

Relevant External Links for PASD1 Gene

GeneLoc Exon Structure for
PASD1
ECgene alternative splicing isoforms for
PASD1

Expression for PASD1 Gene

mRNA expression in normal human tissues for PASD1 Gene

mRNA differential expression in normal tissues according to GTEx for PASD1 Gene

This gene is overexpressed in Testis (x51.6).

Protein differential expression in normal tissues from HIPED for PASD1 Gene

This gene is overexpressed in Testis (49.6) and Ovary (19.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PASD1 Gene



SOURCE GeneReport for Unigene cluster for PASD1 Gene Hs.160594

mRNA Expression by UniProt/SwissProt for PASD1 Gene

Q8IV76-PASD1_HUMAN
Tissue specificity: Testis-specific (PubMed:25936801). Expressed in a broad range of cancer cells, including melanoma, lung cancer, and breast cancer (at protein level). Testis-specific (PubMed:15162151). Found in histologically normal tissues from patients with uterus, lung and small intestine cancers. Widespread expression seen in solid tumors and diffuse large B-cell lymphoma (DLBCL)-derived cell lines. Isoform 2 is expressed in all DLBCL-derived cell lines, while isoform 1 is preferentially expressed in cell lines derived from non-germinal center DLBCL (PubMed:15162151).
genes like me logo Genes that share expression patterns with PASD1: view

Protein tissue co-expression partners for PASD1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for PASD1 Gene

Orthologs for PASD1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for PASD1 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia PASD1 35
  • 66.18 (n)
  • 44.31 (a)
PASD1 36
  • 38 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PASD1 35
  • 93.67 (n)
  • 89.63 (a)
PASD1 36
  • 92 (a)
OneToOne
Species with no ortholog for PASD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PASD1 Gene

ENSEMBL:
Gene Tree for PASD1 (if available)
TreeFam:
Gene Tree for PASD1 (if available)

Paralogs for PASD1 Gene

No data available for Paralogs for PASD1 Gene

Variants for PASD1 Gene

Sequence variations from dbSNP and Humsavar for PASD1 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs5924658 - 151,648,622(+) GCTCT(C/G/T)AAGGT reference, missense
rs867634 -- 151,650,501(+) ATGAA(A/C)AATAT intron-variant
rs881307 -- 151,571,750(-) GTTTT(C/T)TCTTA intron-variant
rs881893 -- 151,668,873(+) ATCAT(C/G)CTGAT intron-variant
rs881962 -- 151,620,499(+) CGGGG(G/T)TCGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PASD1 Gene

Variant ID Type Subtype PubMed ID
nsv517909 CNV Gain 19592680
nsv436635 CNV Deletion 17901297
nsv7156 CNV Insertion 18451855

Variation tolerance for PASD1 Gene

Residual Variation Intolerance Score: 63.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.68; 57.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PASD1 Gene

HapMap Linkage Disequilibrium report
PASD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PASD1 Gene

Disorders for PASD1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PASD1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
diffuse large b-cell lymphoma
  • large b cell diffuse lymphoma
- elite association - COSMIC cancer census association via MalaCards
Search PASD1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PASD1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PASD1
genes like me logo Genes that share disorders with PASD1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PASD1 Gene

Publications for PASD1 Gene

  1. A novel diffuse large B-cell lymphoma-associated cancer testis antigen encoding a PAS domain protein. (PMID: 15162151) Liggins A.P. … Banham A.H. (Br. J. Cancer 2004) 2 3 4 67
  2. Serologic detection of diffuse large B-cell lymphoma-associated antigens. (PMID: 15122589) Liggins A.P. … Banham A.H. (Int. J. Cancer 2004) 2 3
  3. Cancer/testis antigen PASD1 silences the circadian clock. (PMID: 25936801) Michael A.K. … Partch C.L. (Mol. Cell 2015) 3
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  5. Elevated expression levels of testis-specific genes TEX101 and SPATA19 in basal cell carcinoma and their correlation with clinical and pathological features. (PMID: 19886887) Ghafouri-Fard S. … Modarressi M.H. (Br. J. Dermatol. 2010) 3

Products for PASD1 Gene

Sources for PASD1 Gene

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