Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CREB1 Gene

Aliases for CREB1 Gene

  • CAMP Responsive Element Binding Protein 1 2 3 5
  • CREB-1 3 4
  • Cyclic Adenosine 3,5-Monophosphate Response Element-Binding Protein CREB 3
  • Cyclic AMP-Responsive Element-Binding Protein 1 3
  • CAMP-Responsive Element-Binding Protein 1 4
  • CAMP-Response Element-Binding Protein-1 3
  • Active Transcription Factor CREB 3
  • Transactivator Protein 3
  • CREB 3

External Ids for CREB1 Gene

Previous GeneCards Identifiers for CREB1 Gene

  • GC02P206611
  • GC02P207119
  • GC02P208358
  • GC02P208597
  • GC02P208220
  • GC02P208102
  • GC02P200237
  • GC02P208394

Summaries for CREB1 Gene

Entrez Gene Summary for CREB1 Gene

  • This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Alternate splicing of this gene results in several transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]

GeneCards Summary for CREB1 Gene

CREB1 (CAMP Responsive Element Binding Protein 1) is a Protein Coding gene. Diseases associated with CREB1 include Histiocytoma, Angiomatoid Fibrous, Somatic and Melanoma Of Soft Tissue. Among its related pathways are Trk receptor signaling mediated by the MAPK pathway and Constitutive Signaling by AKT1 E17K in Cancer. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and enzyme binding. An important paralog of this gene is CREM.

UniProtKB/Swiss-Prot for CREB1 Gene

  • Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells.

Gene Wiki entry for CREB1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CREB1 Gene

Genomics for CREB1 Gene

Regulatory Elements for CREB1 Gene

Enhancers for CREB1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G207501 1.8 FANTOM5 Ensembl ENCODE dbSUPER 15.9 -25.2 -25233 5.4 ATF1 FOXA2 PKNOX1 YY1 TCF12 GATA2 FOS TBX21 ZNF592 SMARCA4 METTL21A CREB1 ENSG00000223725 GC02M207504 GC02P207503
GH02G207526 1.8 FANTOM5 ENCODE dbSUPER 12.3 +1.4 1411 8.9 HDGF PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 METTL21A CREB1 KLF7-IT1 ENSG00000223725 RNU6-664P PPP1R14BP2 ENSG00000200764 PLEKHM3 GC02P207602
GH02G207498 1.1 FANTOM5 Ensembl 17.2 -30.5 -30537 1.2 CTCF PKNOX1 FOSL1 FOXM1 GATA3 ARID3A CTBP1 GATA2 ZNF547 FOSL2 CREB1 ENSG00000223725 METTL21A GC02M207494 GC02P207502
GH02G207549 1.2 Ensembl ENCODE dbSUPER 12.3 +20.5 20508 1.8 STAT1 TBL1XR1 TAL1 JUN BHLHE40 JUNB DPF2 MEF2D TCF12 PRDM6 ENSG00000223725 CREB1 METTL21A GC02P207602
GH02G207138 1.7 FANTOM5 Ensembl ENCODE dbSUPER 8.5 -387.7 -387670 6.5 CTCF PKNOX1 MAX ZNF384 ZIC2 RAD21 ZKSCAN1 POLR2A SCRT2 SMC3 KLF7 MIR2355 MIR1302-4 CREB1 METTL21A GC02P207126 MIR7845
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CREB1 on UCSC Golden Path with GeneCards custom track

Promoters for CREB1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for CREB1 Gene

207,529,737 bp from pter
207,605,560 bp from pter
75,824 bases
Plus strand

Genomic View for CREB1 Gene

Genes around CREB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CREB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CREB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CREB1 Gene

Proteins for CREB1 Gene

  • Protein details for CREB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cyclic AMP-responsive element-binding protein 1
    Protein Accession:
    Secondary Accessions:
    • P21934
    • Q6V963
    • Q9UMA7

    Protein attributes for CREB1 Gene

    341 amino acids
    Molecular mass:
    36688 Da
    Quaternary structure:
    • Interacts with PPRC1. Binds DNA as a dimer. This dimer is stabilized by magnesium ions. Interacts, through the bZIP domain, with the coactivators TORC1/CRTC1, TORC2/CRTC2 and TORC3/CRTC3. When phosphorylated on Ser-133, binds CREBBP (By similarity). Interacts with CREBL2; regulates CREB1 phosphorylation, stability and transcriptional activity (By similarity). Interacts (phosphorylated form) with TOX3. Interacts with ARRB1. Binds to HIPK2. Interacts with SGK1.

    Three dimensional structures from OCA and Proteopedia for CREB1 Gene

    Alternative splice isoforms for CREB1 Gene


neXtProt entry for CREB1 Gene

Post-translational modifications for CREB1 Gene

  • Stimulated by phosphorylation. Phosphorylation of both Ser-133 and Ser-142 in the SCN regulates the activity of CREB and participates in circadian rhythm generation. Phosphorylation of Ser-133 allows CREBBP binding. In liver, phosphorylation is induced by fasting or glucagon in a circadian fashion (By similarity). CREBL2 positively regulates phosphorylation at Ser-133 thereby stimulating CREB1 transcriptional activity (By similarity). Phosphorylated upon calcium influx by CaMK4 and CaMK2 on Ser-133. CaMK4 is much more potent than CaMK2 in activating CREB. Phosphorylated by CaMK2 on Ser-142. Phosphorylation of Ser-142 blocks CREB-mediated transcription even when Ser-133 is phosphorylated. Phosphorylated by CaMK1 (By similarity). Phosphorylation of Ser-271 by HIPK2 in response to genotoxic stress promotes CREB1 activity, facilitating the recruitment of the coactivator CBP. Phosphorylated at Ser-133 by RPS6KA3, RPS6KA4 and RPS6KA5 in response to mitogenic or stress stimuli.
  • Sumoylated with SUMO1. Sumoylation on Lys-304, but not on Lys-285, is required for nuclear localization of this protein. Sumoylation is enhanced under hypoxia, promoting nuclear localization and stabilization.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CREB1 Gene

Domains & Families for CREB1 Gene

Gene Families for CREB1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the bZIP family.
  • Belongs to the bZIP family.
genes like me logo Genes that share domains with CREB1: view

Function for CREB1 Gene

Molecular function for CREB1 Gene

GENATLAS Biochemistry:
cAMP response element binding protein 1 (transcription regulator)
UniProtKB/Swiss-Prot Function:
Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells.

Gene Ontology (GO) - Molecular Function for CREB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000975 regulatory region DNA binding IEA --
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 9065434
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding IDA 19861239
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IC --
GO:0001102 RNA polymerase II activating transcription factor binding IPI 19861239
genes like me logo Genes that share ontologies with CREB1: view
genes like me logo Genes that share phenotypes with CREB1: view

Human Phenotype Ontology for CREB1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for CREB1 Gene

MGI Knock Outs for CREB1:

Animal Model Products

CRISPR Products

miRNA for CREB1 Gene

miRTarBase miRNAs that target CREB1

Transcription Factor Targets for CREB1 Gene

Selected GeneGlobe predicted Target genes for CREB1
Targeted motifs for CREB1 Gene
HOMER Transcription Factor Regulatory Elements motif CREB1
  • Consensus sequence: CGGTGACGTCAC Submotif: canonical Cell Type: NA

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) for CREB1 Gene

Localization for CREB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CREB1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CREB1 gene
Compartment Confidence
nucleus 5
mitochondrion 4
plasma membrane 2
extracellular 2
cytoskeleton 2
peroxisome 2
endoplasmic reticulum 2
cytosol 2

Gene Ontology (GO) - Cellular Components for CREB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin IEA --
GO:0005634 nucleus IEA,IDA 8798441
GO:0005654 nucleoplasm TAS,IDA --
GO:0005667 transcription factor complex IEA --
GO:0005719 nuclear euchromatin IDA 19861239
genes like me logo Genes that share ontologies with CREB1: view

Pathways & Interactions for CREB1 Gene

SuperPathways for CREB1 Gene

SuperPathway Contained pathways
1 Activated TLR4 signalling
2 DAG and IP3 signaling
3 RET signaling
4 Post NMDA receptor activation events
5 GAB1 signalosome
genes like me logo Genes that share pathways with CREB1: view

Pathways by source for CREB1 Gene

SIGNOR curated interactions for CREB1 Gene

Gene Ontology (GO) - Biological Process for CREB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001666 response to hypoxia IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter IEA --
GO:0006468 protein phosphorylation IDA 8798441
genes like me logo Genes that share ontologies with CREB1: view

Drugs & Compounds for CREB1 Gene

(94) Drugs for CREB1 Gene - From: DrugBank, PharmGKB, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Naloxone Approved, Vet_approved Pharma Antagonist, Target, other/unknown 252
Adenosine monophosphate Approved Nutra Target, activator 0
Citalopram Approved Pharma 512
cyclic amp Experimental Pharma 0
antidepressants Pharma 0

(49) Additional Compounds for CREB1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CREB1: view

Transcripts for CREB1 Gene

Unigene Clusters for CREB1 Gene

CAMP responsive element binding protein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for CREB1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b · 12c · 12d · 12e
SP1: - - - - - - -
SP2: - - - - - - - -
SP3: - -
SP4: - - - - - - - - - -
SP5: - - - - - -
SP6: - - - - - -
SP7: - - -
SP8: -
SP9: - -

Relevant External Links for CREB1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CREB1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CREB1 Gene

Protein differential expression in normal tissues from HIPED for CREB1 Gene

This gene is overexpressed in Monocytes (14.1), CD4 Tcells (9.0), and Fetal Brain (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CREB1 Gene

Protein tissue co-expression partners for CREB1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CREB1 Gene:


SOURCE GeneReport for Unigene cluster for CREB1 Gene:


Evidence on tissue expression from TISSUES for CREB1 Gene

  • Eye(4.5)
  • Liver(4.5)
  • Nervous system(4.4)
  • Blood(3.4)
  • Adrenal gland(2.9)
  • Muscle(2.9)
  • Lung(2.8)
  • Pancreas(2.7)
  • Skin(2.7)
  • Heart(2.6)
  • Kidney(2.6)
  • Intestine(2.5)
  • Thyroid gland(2.5)
  • Bone marrow(2.4)
  • Spleen(2.3)
  • Lymph node(2.2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for CREB1 Gene

Germ Layers:
  • ectoderm
  • integumentary
  • skin
genes like me logo Genes that share expression patterns with CREB1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CREB1 Gene

Orthologs for CREB1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CREB1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CREB1 34 35
  • 99.9 (n)
(Canis familiaris)
Mammalia CREB1 34 35
  • 96.09 (n)
(Bos Taurus)
Mammalia CREB1 34 35
  • 95.38 (n)
(Mus musculus)
Mammalia Creb1 34 16 35
  • 95.31 (n)
(Rattus norvegicus)
Mammalia Creb1 34
  • 95.31 (n)
(Monodelphis domestica)
Mammalia CREB1 35
  • 95 (a)
(Ornithorhynchus anatinus)
Mammalia CREB1 35
  • 84 (a)
(Gallus gallus)
Aves CREB1 34 35
  • 85.73 (n)
(Anolis carolinensis)
Reptilia CREB1 35
  • 82 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia creb1 34
  • 82.47 (n)
Str.10048 34
African clawed frog
(Xenopus laevis)
Amphibia creb1-prov 34
(Danio rerio)
Actinopterygii creb1b 35
  • 91 (a)
creb1a 34 35
  • 76.52 (n)
zgc55598 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6298 34
fruit fly
(Drosophila melanogaster)
Insecta CrebB-17A 35
  • 29 (a)
(Caenorhabditis elegans)
Secernentea crh-1 35
  • 23 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.714 35
  • 45 (a)
Species where no ortholog for CREB1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CREB1 Gene

Gene Tree for CREB1 (if available)
Gene Tree for CREB1 (if available)

Paralogs for CREB1 Gene

Paralogs for CREB1 Gene Pseudogenes for CREB1 Gene

genes like me logo Genes that share paralogs with CREB1: view

Variants for CREB1 Gene

Sequence variations from dbSNP and Humsavar for CREB1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs387906617 Uncertain significance 207,567,506(+) AGTGG(A/G)TAGTG nc-transcript-variant, reference, missense, utr-variant-5-prime
rs1000021094 -- 207,568,920(+) TGCCT(C/T)CCCAT intron-variant
rs1000026484 -- 207,546,152(+) AGCCT(C/T)TGAGA intron-variant
rs1000083791 -- 207,552,444(+) ATACC(A/G)GATGA intron-variant
rs1000122076 -- 207,532,132(+) GGCGG(A/G)TCACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CREB1 Gene

Variant ID Type Subtype PubMed ID
nsv1013908 CNV loss 25217958
nsv3131 CNV deletion 18451855
nsv478302 CNV novel sequence insertion 20440878
nsv821888 CNV gain 20364138

Variation tolerance for CREB1 Gene

Residual Variation Intolerance Score: 32% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.36; 41.93% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CREB1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CREB1 Gene

Disorders for CREB1 Gene

MalaCards: The human disease database

(28) MalaCards diseases for CREB1 Gene - From: OMIM, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
histiocytoma, angiomatoid fibrous, somatic
  • angiomatoid fibrous histiocytoma
melanoma of soft tissue
  • clear cell sarcoma of the tendons and aponeuroses
diabetic encephalopathy
coffin-lowry syndrome
  • cls
rubinstein-taybi syndrome
  • rubinstein-taybi syndrome 1
- elite association - COSMIC cancer census association via MalaCards
Search CREB1 in MalaCards View complete list of genes associated with diseases


  • Angiomatoid fibrous histiocytoma (AFH) [MIM:612160]: A distinct variant of malignant fibrous histiocytoma that typically occurs in children and adolescents and is manifest by nodular subcutaneous growth. Characteristic microscopic features include lobulated sheets of histiocyte-like cells intimately associated with areas of hemorrhage and cystic pseudovascular spaces, as well as a striking cuffing of inflammatory cells, mimicking a lymph node metastasis. Note=The gene represented in this entry may be involved in disease pathogenesis. A chromosomal aberration involving CREB1 is found in a patient with angiomatoid fibrous histiocytoma. Translocation t(2;22)(q33;q12) with CREB1 generates a EWSR1/CREB1 fusion gene that is most common genetic abnormality in this tumor type.
  • Note=A CREB1 mutation has been found in a patient with multiple congenital anomalies consisting of agenesis of the corpus callosum, cerebellar hypoplasia, severe neonatal respiratory distress refractory to surfactant, thymus hypoplasia, and thyroid follicular hypoplasia. {ECO:0000269 PubMed:22267179}.

Relevant External Links for CREB1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CREB1: view

No data available for Genatlas for CREB1 Gene

Publications for CREB1 Gene

  1. Sequence variations of ABCB1, SLC6A2, SLC6A3, SLC6A4, CREB1, CRHR1 and NTRK2: association with major depression and antidepressant response in Mexican-Americans. (PMID: 19844206) Dong C. … Licinio J. (Mol. Psychiatry 2009) 3 22 46 64
  2. Lithium response and genetic variation in the CREB family of genes. (PMID: 18189280) Mamdani F. … Turecki G. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008) 3 22 46 64
  3. Serum/glucocorticoid-inducible kinase can phosphorylate the cyclic AMP response element binding protein, CREB. (PMID: 15733869) David S. … Kalb R.G. (FEBS Lett. 2005) 3 4 22 64
  4. The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector. (PMID: 15454081) Screaton R.A. … Montminy M. (Cell 2004) 3 4 22 64
  5. CREB is a regulatory target for the protein kinase Akt/PKB. (PMID: 9829964) Du K. … Montminy M. (J. Biol. Chem. 1998) 3 4 22 64

Products for CREB1 Gene

  • Addgene plasmids for CREB1

Sources for CREB1 Gene

Loading form....