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Aliases for CREB1 Gene

Aliases for CREB1 Gene

  • CAMP Responsive Element Binding Protein 1 2 3 5
  • CREB-1 3 4
  • CAMP-Responsive Element-Binding Protein 1 4
  • CAMP-Response Element-Binding Protein-1 3
  • Active Transcription Factor CREB 3
  • Transactivator Protein 3
  • CREB 3

External Ids for CREB1 Gene

Previous GeneCards Identifiers for CREB1 Gene

  • GC02P206611
  • GC02P207119
  • GC02P208358
  • GC02P208597
  • GC02P208220
  • GC02P208102
  • GC02P200237
  • GC02P208394

Summaries for CREB1 Gene

Entrez Gene Summary for CREB1 Gene

  • This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Alternate splicing of this gene results in several transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]

GeneCards Summary for CREB1 Gene

CREB1 (CAMP Responsive Element Binding Protein 1) is a Protein Coding gene. Diseases associated with CREB1 include histiocytoma, angiomatoid fibrous, somatic and melanoma of soft parts. Among its related pathways are Signaling by GPCR and Immune System. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and enzyme binding. An important paralog of this gene is ATF1.

UniProtKB/Swiss-Prot for CREB1 Gene

  • Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells.

Gene Wiki entry for CREB1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CREB1 Gene

Genomics for CREB1 Gene

Regulatory Elements for CREB1 Gene

Promoters for CREB1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CREB1 on UCSC Golden Path with GeneCards custom track

Genomic Location for CREB1 Gene

Chromosome:
2
Start:
207,529,737 bp from pter
End:
207,605,560 bp from pter
Size:
75,824 bases
Orientation:
Plus strand

Genomic View for CREB1 Gene

Genes around CREB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CREB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CREB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CREB1 Gene

Proteins for CREB1 Gene

  • Protein details for CREB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P16220-CREB1_HUMAN
    Recommended name:
    Cyclic AMP-responsive element-binding protein 1
    Protein Accession:
    P16220
    Secondary Accessions:
    • P21934
    • Q6V963
    • Q9UMA7

    Protein attributes for CREB1 Gene

    Size:
    341 amino acids
    Molecular mass:
    36688 Da
    Quaternary structure:
    • Interacts with PPRC1. Binds DNA as a dimer. This dimer is stabilized by magnesium ions. Interacts, through the bZIP domain, with the coactivators TORC1/CRTC1, TORC2/CRTC2 and TORC3/CRTC3. When phosphorylated on Ser-133, binds CREBBP (By similarity). Interacts with CREBL2; regulates CREB1 phosphorylation, stability and transcriptional activity (By similarity). Interacts (phosphorylated form) with TOX3. Interacts with ARRB1. Binds to HIPK2. Interacts with SGK1.

    Three dimensional structures from OCA and Proteopedia for CREB1 Gene

    Alternative splice isoforms for CREB1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CREB1 Gene

Proteomics data for CREB1 Gene at MOPED

Post-translational modifications for CREB1 Gene

  • Stimulated by phosphorylation. Phosphorylation of both Ser-133 and Ser-142 in the SCN regulates the activity of CREB and participates in circadian rhythm generation. Phosphorylation of Ser-133 allows CREBBP binding. In liver, phosphorylation is induced by fasting or glucagon in a circadian fashion (By similarity). CREBL2 positively regulates phosphorylation at Ser-133 thereby stimulating CREB1 transcriptional activity (By similarity). Phosphorylated upon calcium influx by CaMK4 and CaMK2 on Ser-133. CaMK4 is much more potent than CaMK2 in activating CREB. Phosphorylated by CaMK2 on Ser-142. Phosphorylation of Ser-142 blocks CREB-mediated transcription even when Ser-133 is phosphorylated. Phosphorylated by CaMK1 (By similarity). Phosphorylation of Ser-271 by HIPK2 in response to genotoxic stress promotes CREB1 activity, facilitating the recruitment of the coactivator CBP. Phosphorylated at Ser-133 by RPS6KA3, RPS6KA4 and RPS6KA5 in response to mitogenic or stress stimuli.
  • Sumoylated with SUMO1. Sumoylation on Lys-304, but not on Lys-285, is required for nuclear localization of this protein. Sumoylation is enhanced under hypoxia, promoting nuclear localization and stabilization.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CREB1 Gene

Domains & Families for CREB1 Gene

Gene Families for CREB1 Gene

Graphical View of Domain Structure for InterPro Entry

P16220

UniProtKB/Swiss-Prot:

CREB1_HUMAN :
  • Contains 1 bZIP (basic-leucine zipper) domain.
  • Belongs to the bZIP family.
Domain:
  • Contains 1 bZIP (basic-leucine zipper) domain.
  • Contains 1 KID (kinase-inducible) domain.
Family:
  • Belongs to the bZIP family.
genes like me logo Genes that share domains with CREB1: view

Function for CREB1 Gene

Molecular function for CREB1 Gene

GENATLAS Biochemistry:
cAMP response element binding protein 1 (transcription regulator)
UniProtKB/Swiss-Prot Function:
Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells.

Gene Ontology (GO) - Molecular Function for CREB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding IDA 19861239
GO:0035035 histone acetyltransferase binding IEA --
GO:0035497 cAMP response element binding IDA 19861239
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with CREB1: view
genes like me logo Genes that share phenotypes with CREB1: view

Human Phenotype Ontology for CREB1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for CREB1 Gene

MGI Knock Outs for CREB1:

Animal Model Products

miRNA for CREB1 Gene

miRTarBase miRNAs that target CREB1

Transcription Factor Targets for CREB1 Gene

Selected GeneGlobe predicted Target genes for CREB1
Targeted motifs for CREB1 Gene
HOMER Transcription Factor Regulatory Elements motif CREB1
  • Consensus sequence: CGGTGACGTCAC Submotif: canonical Cell Type: NA

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) for CREB1 Gene

Localization for CREB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CREB1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CREB1 Gene COMPARTMENTS Subcellular localization image for CREB1 gene
Compartment Confidence
nucleus 5
mitochondrion 4
cytoskeleton 2
cytosol 2
endoplasmic reticulum 2
extracellular 2
plasma membrane 2
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for CREB1 Gene

Pathways & Interactions for CREB1 Gene

SuperPathways for CREB1 Gene

Superpath Contained pathways
1 Interleukin-3, 5 and GM-CSF signaling
2 DAG and IP3 signaling
3 MyD88 cascade initiated on plasma membrane
4 PI3K events in ERBB4 signaling
5 Post NMDA receptor activation events
genes like me logo Genes that share pathways with CREB1: view

SIGNOR curated interactions for CREB1 Gene

Gene Ontology (GO) - Biological Process for CREB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001666 response to hypoxia IEA --
GO:0002224 toll-like receptor signaling pathway TAS --
GO:0002756 MyD88-independent toll-like receptor signaling pathway TAS --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with CREB1: view

Drugs & Compounds for CREB1 Gene

(89) Drugs for CREB1 Gene - From: HMDB, Novoseek, PharmGKB, and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Naloxone Approved Pharma Antagonist, Target, other/unknown 221
Adenosine monophosphate Approved Nutra Target, activator 0
cyclic amp Experimental Pharma 0
antidepressants Pharma 0
Magnesium Nutra 0

(54) Additional Compounds for CREB1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CREB1: view

Transcripts for CREB1 Gene

Unigene Clusters for CREB1 Gene

CAMP responsive element binding protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CREB1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b · 12c · 12d · 12e
SP1: - - - - - - -
SP2: - - - - - - - -
SP3: - -
SP4: - - - - - - - - - -
SP5: - - - - - -
SP6: - - - - - -
SP7: - - -
SP8: -
SP9: - -
SP10:

Relevant External Links for CREB1 Gene

GeneLoc Exon Structure for
CREB1
ECgene alternative splicing isoforms for
CREB1

Expression for CREB1 Gene

mRNA expression in normal human tissues for CREB1 Gene

Protein differential expression in normal tissues from HIPED for CREB1 Gene

This gene is overexpressed in Monocytes (14.1), CD4 Tcells (9.0), and Fetal Brain (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CREB1 Gene



SOURCE GeneReport for Unigene cluster for CREB1 Gene Hs.516646

genes like me logo Genes that share expression patterns with CREB1: view

Protein tissue co-expression partners for CREB1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CREB1 Gene

Orthologs for CREB1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CREB1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CREB1 36
  • 100 (a)
OneToOne
CREB1 35
  • 99.9 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia CREB1 36
  • 100 (a)
OneToOne
CREB1 35
  • 95.38 (n)
  • 99.08 (a)
dog
(Canis familiaris)
Mammalia CREB1 35
  • 96.09 (n)
  • 100 (a)
CREB1 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Creb1 36
  • 100 (a)
OneToOne
Creb1 16
Creb1 35
  • 95.31 (n)
  • 99.71 (a)
oppossum
(Monodelphis domestica)
Mammalia CREB1 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CREB1 36
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Creb1 35
  • 95.31 (n)
  • 99.12 (a)
chicken
(Gallus gallus)
Aves CREB1 35
  • 85.73 (n)
  • 98.78 (a)
CREB1 36
  • 99 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CREB1 36
  • 82 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia creb1-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia creb1 35
  • 82.47 (n)
  • 96.94 (a)
Str.10048 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6298 35
zebrafish
(Danio rerio)
Actinopterygii creb1a 36
  • 91 (a)
OneToMany
creb1b 36
  • 91 (a)
OneToMany
creb1a 35
  • 76.52 (n)
  • 91.19 (a)
zgc55598 35
fruit fly
(Drosophila melanogaster)
Insecta CrebB-17A 36
  • 29 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea crh-1 36
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.714 36
  • 45 (a)
OneToMany
Species with no ortholog for CREB1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CREB1 Gene

ENSEMBL:
Gene Tree for CREB1 (if available)
TreeFam:
Gene Tree for CREB1 (if available)

Paralogs for CREB1 Gene

Paralogs for CREB1 Gene

Pseudogenes.org Pseudogenes for CREB1 Gene

genes like me logo Genes that share paralogs with CREB1: view

Variants for CREB1 Gene

Sequence variations from dbSNP and Humsavar for CREB1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
VAR_068077 -
rs889895 -- 207,534,205(-) GCACT(C/T)GACAC intron-variant
rs1064176 -- 207,578,034(+) atttt(A/T)tctat intron-variant
rs2042485 -- 207,552,876(-) cactt(G/T)gggag intron-variant
rs2194430 -- 207,579,691(-) CAATG(A/G)GAAGT intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CREB1 Gene

Variant ID Type Subtype PubMed ID
nsv821888 CNV Gain 20364138
nsv3131 CNV Loss 18451855

Variation tolerance for CREB1 Gene

Residual Variation Intolerance Score: 32% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.36; 41.93% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CREB1 Gene

HapMap Linkage Disequilibrium report
CREB1
Human Gene Mutation Database (HGMD)
CREB1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CREB1 Gene

Disorders for CREB1 Gene

MalaCards: The human disease database

(35) MalaCards diseases for CREB1 Gene - From: OMIM, GeneTests, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
histiocytoma, angiomatoid fibrous, somatic
  • angiomatoid fibrous histiocytoma
melanoma of soft parts
  • clear cell sarcoma of soft tissue
opiate dependence
  • opioid type dependence
drug addiction
  • drug addiction, susceptibility to
diabetic encephalopathy
- elite association - COSMIC cancer census association via MalaCards
Search CREB1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

CREB1_HUMAN
  • Angiomatoid fibrous histiocytoma (AFH) [MIM:612160]: A distinct variant of malignant fibrous histiocytoma that typically occurs in children and adolescents and is manifest by nodular subcutaneous growth. Characteristic microscopic features include lobulated sheets of histiocyte-like cells intimately associated with areas of hemorrhage and cystic pseudovascular spaces, as well as a striking cuffing of inflammatory cells, mimicking a lymph node metastasis. Note=The gene represented in this entry may be involved in disease pathogenesis. A chromosomal aberration involving CREB1 is found in a patient with angiomatoid fibrous histiocytoma. Translocation t(2;22)(q33;q12) with CREB1 generates a EWSR1/CREB1 fusion gene that is most common genetic abnormality in this tumor type.
  • Note=A CREB1 mutation has been found in a patient with multiple congenital anomalies consisting of agenesis of the corpus callosum, cerebellar hypoplasia, severe neonatal respiratory distress refractory to surfactant, thymus hypoplasia, and thyroid follicular hypoplasia. {ECO:0000269 PubMed:22267179}.

Relevant External Links for CREB1

Genetic Association Database (GAD)
CREB1
Human Genome Epidemiology (HuGE) Navigator
CREB1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CREB1
genes like me logo Genes that share disorders with CREB1: view

No data available for Genatlas for CREB1 Gene

Publications for CREB1 Gene

  1. Serum/glucocorticoid-inducible kinase can phosphorylate the cyclic AMP response element binding protein, CREB. (PMID: 15733869) David S. … Kalb R.G. (FEBS Lett. 2005) 3 4 23 67
  2. Galanin attenuates cyclic AMP regulatory element-binding protein (CREB) phosphorylation induced by chronic morphine and naloxone challenge in Cath.a cells and primary striatal cultures. (PMID: 16417577) Hawes J.J. … Picciotto M.R. (J. Neurochem. 2006) 23 25 26
  3. Cooperation of NFkappaB and CREB to induce synergistic IL-6 expression in astrocytes. (PMID: 20100571) Spooren A. … Gerlo S. (Cell. Signal. 2010) 3 23
  4. Podophyllotoxin induces CREB phosphorylation and CRE-driven gene expression via PKA but not MAPKs. (PMID: 20033853) Chen Y.Q. … Xie X. (Mol. Cells 2010) 3 23
  5. PPARgamma agonists inhibit angiogenesis by suppressing PKCalpha- and CREB-mediated COX-2 expression in the human endothelium. (PMID: 20032081) Scoditti E. … De Caterina R. (Cardiovasc. Res. 2010) 3 23

Products for CREB1 Gene

Sources for CREB1 Gene

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