Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CRABP2 Gene

Aliases for CRABP2 Gene

  • Cellular Retinoic Acid Binding Protein 2 2 3 5
  • Cellular Retinoic Acid-Binding Protein II 3 4
  • CRABP-II 3 4
  • Cellular Retinoic Acid-Binding Protein 2 2
  • RBP6 3

External Ids for CRABP2 Gene

Previous GeneCards Identifiers for CRABP2 Gene

  • GC01M154538
  • GC01M152434
  • GC01M153447
  • GC01M153886
  • GC01M153482
  • GC01M154936
  • GC01M156669
  • GC01M128026

Summaries for CRABP2 Gene

Entrez Gene Summary for CRABP2 Gene

  • This gene encodes a member of the retinoic acid (RA, a form of vitamin A) binding protein family and lipocalin/cytosolic fatty-acid binding protein family. The protein is a cytosol-to-nuclear shuttling protein, which facilitates RA binding to its cognate receptor complex and transfer to the nucleus. It is involved in the retinoid signaling pathway, and is associated with increased circulating low-density lipoprotein cholesterol. Alternatively spliced transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Dec 2010]

GeneCards Summary for CRABP2 Gene

CRABP2 (Cellular Retinoic Acid Binding Protein 2) is a Protein Coding gene. Diseases associated with CRABP2 include embryonal carcinoma and leukemia, acute promyelocytic, somatic. Among its related pathways are Signaling by GPCR and Vitamin A and carotenoid metabolism. GO annotations related to this gene include transporter activity and retinol binding. An important paralog of this gene is FABP3.

UniProtKB/Swiss-Prot for CRABP2 Gene

  • Transports retinoic acid to the nucleus. Regulates the access of retinoic acid to the nuclear retinoic acid receptors.

Gene Wiki entry for CRABP2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRABP2 Gene

Genomics for CRABP2 Gene

Regulatory Elements for CRABP2 Gene

Promoters for CRABP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CRABP2 on UCSC Golden Path with GeneCards custom track

Genomic Location for CRABP2 Gene

Chromosome:
1
Start:
156,699,606 bp from pter
End:
156,705,816 bp from pter
Size:
6,211 bases
Orientation:
Minus strand

Genomic View for CRABP2 Gene

Genes around CRABP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CRABP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CRABP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRABP2 Gene

Proteins for CRABP2 Gene

  • Protein details for CRABP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P29373-RABP2_HUMAN
    Recommended name:
    Cellular retinoic acid-binding protein 2
    Protein Accession:
    P29373
    Secondary Accessions:
    • B2R4Z8
    • D3DVC5
    • F1T098
    • Q6ICN6

    Protein attributes for CRABP2 Gene

    Size:
    138 amino acids
    Molecular mass:
    15693 Da
    Quaternary structure:
    • Interacts with RXR and RARA (By similarity). Interacts with importin alpha.

    Three dimensional structures from OCA and Proteopedia for CRABP2 Gene

neXtProt entry for CRABP2 Gene

Proteomics data for CRABP2 Gene at MOPED

Post-translational modifications for CRABP2 Gene

  • Sumoylated in response to retinoic acid binding, sumoylation is critical for dissociation from ER and subsequent nuclear translocation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CRABP2 Gene

Antibody Products

No data available for DME Specific Peptides for CRABP2 Gene

Domains & Families for CRABP2 Gene

Gene Families for CRABP2 Gene

Suggested Antigen Peptide Sequences for CRABP2 Gene

Graphical View of Domain Structure for InterPro Entry

P29373

UniProtKB/Swiss-Prot:

RABP2_HUMAN :
  • Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.
  • Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
Domain:
  • Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.
Family:
  • Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
genes like me logo Genes that share domains with CRABP2: view

Function for CRABP2 Gene

Molecular function for CRABP2 Gene

GENATLAS Biochemistry:
retinoic acid binding protein,cellular II,highly expressed in skin,(lipocalin family,kernel group)
UniProtKB/Swiss-Prot Function:
Transports retinoic acid to the nucleus. Regulates the access of retinoic acid to the nuclear retinoic acid receptors.
UniProtKB/Swiss-Prot Induction:
By retinoic acid.

Gene Ontology (GO) - Molecular Function for CRABP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001972 retinoic acid binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0008289 lipid binding IEA --
GO:0019841 retinol binding IEA --
genes like me logo Genes that share ontologies with CRABP2: view
genes like me logo Genes that share phenotypes with CRABP2: view

Animal Models for CRABP2 Gene

MGI Knock Outs for CRABP2:

Animal Model Products

miRNA for CRABP2 Gene

miRTarBase miRNAs that target CRABP2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CRABP2 Gene

Localization for CRABP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CRABP2 Gene

Cytoplasm. Endoplasmic reticulum. Nucleus. Note=Upon ligand binding, a conformation change exposes a nuclear localization motif and the protein is transported into the nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CRABP2 Gene COMPARTMENTS Subcellular localization image for CRABP2 gene
Compartment Confidence
cytosol 5
endoplasmic reticulum 5
extracellular 5
nucleus 5
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CRABP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IDA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with CRABP2: view

Pathways & Interactions for CRABP2 Gene

genes like me logo Genes that share pathways with CRABP2: view

SIGNOR curated interactions for CRABP2 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for CRABP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0035115 embryonic forelimb morphogenesis IEA --
GO:0048385 regulation of retinoic acid receptor signaling pathway IEA --
GO:0048672 positive regulation of collateral sprouting IEA --
genes like me logo Genes that share ontologies with CRABP2: view

Drugs & Compounds for CRABP2 Gene

(14) Drugs for CRABP2 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Tretinoin Approved, Investigational Nutra Full agonist, Agonist, Transporter, substrate 210
Alitretinoin Approved, Investigational Pharma Carrier 15
1,3,3-trimethyl-2-[(1E,3E)-3-methylpenta-1,3-dien-1-yl]cyclohexene Experimental Pharma Carrier 0
6-(2,3,4,5,6,7-HEXAHYDRO-2,4,4-TRIMETHYL-1-METYLENEINDEN-2-YL)-3-METHYLHEXA-2,4-DIENOIC ACID Experimental Pharma Carrier 0
9-(4-HYDROXY-2,6-DIMETHYL-PHENYL)-3,7-DIMETHYL-NONA-4,6,8-TRIENOIC ACID Experimental Pharma Carrier 0

(12) Additional Compounds for CRABP2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CRABP2: view

Transcripts for CRABP2 Gene

Unigene Clusters for CRABP2 Gene

Cellular retinoic acid binding protein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CRABP2 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b
SP1: -
SP2: - -
SP3:

Relevant External Links for CRABP2 Gene

GeneLoc Exon Structure for
CRABP2
ECgene alternative splicing isoforms for
CRABP2

Expression for CRABP2 Gene

mRNA expression in normal human tissues for CRABP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CRABP2 Gene

This gene is overexpressed in Esophagus - Mucosa (x19.1), Vagina (x9.2), and Cervix - Ectocervix (x5.2).

Protein differential expression in normal tissues from HIPED for CRABP2 Gene

This gene is overexpressed in Breast (24.0), Urine (7.6), Oral epithelium (7.0), and Esophagus (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CRABP2 Gene



SOURCE GeneReport for Unigene cluster for CRABP2 Gene Hs.405662

genes like me logo Genes that share expression patterns with CRABP2: view

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for CRABP2 Gene

Orthologs for CRABP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CRABP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CRABP2 36
  • 100 (a)
OneToOne
CRABP2 35
  • 99.76 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia CRABP2 35
  • 93.96 (n)
  • 97.1 (a)
CRABP2 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CRABP2 36
  • 96 (a)
OneToOne
CRABP2 35
  • 89.86 (n)
  • 95.65 (a)
mouse
(Mus musculus)
Mammalia Crabp2 16
Crabp2 35
  • 89.37 (n)
  • 93.48 (a)
Crabp2 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CRABP2 36
  • 93 (a)
OneToOne
chicken
(Gallus gallus)
Aves CRABP2 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CRABP2 36
  • 86 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia crabp2-A 35
tropical clawed frog
(Silurana tropicalis)
Amphibia crabp2 35
  • 80.19 (n)
  • 83.33 (a)
Str.1681 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9548 35
zebrafish
(Danio rerio)
Actinopterygii crabp2a 36
  • 73 (a)
OneToMany
crabp2a 36
  • 73 (a)
OneToMany
crabp2b 36
  • 66 (a)
OneToMany
crabp2 35
LOC100332539 35
  • 70.77 (n)
  • 74.64 (a)
fruit fly
(Drosophila melanogaster)
Insecta fabp 36
  • 33 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea lbp-5 36
  • 38 (a)
ManyToMany
lbp-6 36
  • 44 (a)
ManyToMany
lbp-7 36
  • 36 (a)
ManyToMany
lbp-8 36
  • 35 (a)
ManyToMany
lbp-9 36
  • 30 (a)
ManyToMany
Species with no ortholog for CRABP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CRABP2 Gene

ENSEMBL:
Gene Tree for CRABP2 (if available)
TreeFam:
Gene Tree for CRABP2 (if available)

Paralogs for CRABP2 Gene

Paralogs for CRABP2 Gene

(16) SIMAP similar genes for CRABP2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CRABP2: view

Variants for CRABP2 Gene

Sequence variations from dbSNP and Humsavar for CRABP2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs4468158 -- 156,702,452(+) actcc(A/G)tctca intron-variant
rs4387174 -- 156,703,392(+) AAGAC(A/G)TGCAG intron-variant
rs4661213 -- 156,700,753(+) ACCAC(C/T)ACCTA intron-variant
rs6701908 -- 156,702,649(+) tgcct(C/G)tactc intron-variant
rs11549891 -- 156,700,987(-) TCAAA(C/T)AGGAG reference, stop-gained

Structural Variations from Database of Genomic Variants (DGV) for CRABP2 Gene

Variant ID Type Subtype PubMed ID
nsv523181 CNV Loss 19592680
nsv831648 CNV Loss 17160897
esv2675449 CNV Deletion 23128226

Variation tolerance for CRABP2 Gene

Residual Variation Intolerance Score: 36.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.19; 4.33% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CRABP2 Gene

HapMap Linkage Disequilibrium report
CRABP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CRABP2 Gene

Disorders for CRABP2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CRABP2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
embryonal carcinoma
  • primary extragonadal embryonal carcinoma
leukemia, acute promyelocytic, somatic
  • leukemia, acute promyelocytic
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CRABP2

Genetic Association Database (GAD)
CRABP2
Human Genome Epidemiology (HuGE) Navigator
CRABP2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CRABP2
genes like me logo Genes that share disorders with CRABP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CRABP2 Gene

Publications for CRABP2 Gene

  1. Molecular cloning of two human cellular retinoic acid-binding proteins (CRABP). Retinoic acid-induced expression of CRABP-II but not CRABP-I in adult human skin in vivo and in skin fibroblasts in vitro. (PMID: 1654334) Astroem A. … Voorhees J.J. (J. Biol. Chem. 1991) 2 3 4 23 67
  2. Regulation of CRABP-II expression by MycN in Wilms tumor. (PMID: 18955045) Gupta A. … Williams B.R. (Exp. Cell Res. 2008) 3 23
  3. AP2 transcription factors regulate expression of CRABPII in hormone responsive breast carcinoma. (PMID: 17187826) McPherson L.A. … Weigel R.J. (J. Surg. Res. 2007) 3 23
  4. Association of a polymorphism in the promoter of the cellular retinoic acid-binding protein II gene (CRABP2) with increased circulating low-density lipoprotein cholesterol. (PMID: 17484622) Salazar J. … Ribalta J. (Clin. Chem. Lab. Med. 2007) 3 23
  5. Cellular retinoic acid-binding protein II is a direct transcriptional target of MycN in neuroblastoma. (PMID: 16912187) Gupta A. … Rawwas J. (Cancer Res. 2006) 3 23

Products for CRABP2 Gene

Sources for CRABP2 Gene

Back to Top

Content