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Aliases for CR2 Gene

Aliases for CR2 Gene

  • Complement Component (3d/Epstein Barr Virus) Receptor 2 2 3
  • C3DR 3 4 6
  • Complement C3d Receptor 3 4
  • EBV Receptor 3 4
  • CVID7 3 6
  • SLEB9 3 6
  • Epstein-Barr Virus Receptor 4
  • Complement Receptor Type 2 3
  • CD21 Antigen 4
  • CD21 3
  • Cr2 4
  • CR 3

External Ids for CR2 Gene

Previous GeneCards Identifiers for CR2 Gene

  • GC01P206287
  • GC01P203337
  • GC01P204270
  • GC01P204578
  • GC01P204016
  • GC01P205694
  • GC01P207627
  • GC01P178320

Summaries for CR2 Gene

Entrez Gene Summary for CR2 Gene

  • This gene encodes a membrane protein, which functions as a receptor for Epstein-Barr virus (EBV) binding on B and T lymphocytes. Genetic variations in this gene are associated with susceptibility to systemic lupus erythematosus type 9 (SLEB9). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]

GeneCards Summary for CR2 Gene

CR2 (Complement Component (3d/Epstein Barr Virus) Receptor 2) is a Protein Coding gene. Diseases associated with CR2 include systemic lupus erythematosus 9 and immunodeficiency, common variable, 7. Among its related pathways are Epstein-Barr virus infection and Complement and coagulation cascades. GO annotations related to this gene include protein homodimerization activity and complement receptor activity. An important paralog of this gene is CSMD3.

UniProtKB/Swiss-Prot for CR2 Gene

  • Receptor for complement C3Dd, for the Epstein-Barr virus on human B-cells and T-cells and for HNRPU. Participates in B lymphocytes activation.

Gene Wiki entry for CR2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CR2 Gene

Genomics for CR2 Gene

Regulatory Elements for CR2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CR2 Gene

Start:
207,454,230 bp from pter
End:
207,489,895 bp from pter
Size:
35,666 bases
Orientation:
Plus strand

Genomic View for CR2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CR2 Gene

Proteins for CR2 Gene

  • Protein details for CR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P20023-CR2_HUMAN
    Recommended name:
    Complement receptor type 2
    Protein Accession:
    P20023
    Secondary Accessions:
    • C9JHD2
    • Q13866
    • Q14212
    • Q53EL2
    • Q5BKT9
    • Q5SR46
    • Q5SR48

    Protein attributes for CR2 Gene

    Size:
    1033 amino acids
    Molecular mass:
    112916 Da
    Quaternary structure:
    • Interacts (via Sushi domain 1 and 2) with C3dg.
    SequenceCaution:
    • Sequence=AAA35784.1; Type=Frameshift; Positions=758, 769, 776; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CR2 Gene

    Alternative splice isoforms for CR2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CR2 Gene

Proteomics data for CR2 Gene at MOPED

Post-translational modifications for CR2 Gene

  • Glycosylation at Asn121, Asn127, Asn294, Asn372, Asn492, Asn623, Asn682, Asn800, Asn823, Asn861, and Asn911
  • Modification sites at PhosphoSitePlus

Other Protein References for CR2 Gene

No data available for DME Specific Peptides for CR2 Gene

Domains for CR2 Gene

Gene Families for CR2 Gene

HGNC:

Protein Domains for CR2 Gene

Suggested Antigen Peptide Sequences for CR2 Gene

Graphical View of Domain Structure for InterPro Entry

P20023

UniProtKB/Swiss-Prot:

CR2_HUMAN :
  • P20023
Domain:
  • Contains 15 Sushi (CCP/SCR) domains.
Family:
  • Belongs to the receptors of complement activation (RCA) family.
genes like me logo Genes that share domains with CR2: view

Function for CR2 Gene

Molecular function for CR2 Gene

GENATLAS Biochemistry: complement component (C3d/Epstein Barr virus) receptor 2 (see RCA@)
UniProtKB/Swiss-Prot Function: Receptor for complement C3Dd, for the Epstein-Barr virus on human B-cells and T-cells and for HNRPU. Participates in B lymphocytes activation.

Gene Ontology (GO) - Molecular Function for CR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001848 complement binding IDA 11034390
GO:0003677 DNA binding IDA 22885687
GO:0004872 receptor activity --
GO:0004875 complement receptor activity NAS 2827171
GO:0004888 transmembrane signaling receptor activity NAS 2827171
genes like me logo Genes that share ontologies with CR2: view
genes like me logo Genes that share phenotypes with CR2: view

Animal Models for CR2 Gene

MGI Knock Outs for CR2:

Animal Model Products

CRISPR Products

miRNA for CR2 Gene

miRTarBase miRNAs that target CR2

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CR2 Gene

Localization for CR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CR2 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CR2 Gene COMPARTMENTS Subcellular localization image for CR2 gene
Compartment Confidence
plasma membrane 4
endoplasmic reticulum 2
extracellular 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane NAS 2563370
GO:0009897 external side of plasma membrane IEA --
GO:0016021 integral component of membrane NAS 2827171
GO:0043235 receptor complex IDA 23382219
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with CR2: view

Pathways for CR2 Gene

genes like me logo Genes that share pathways with CR2: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for CR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002430 complement receptor mediated signaling pathway IEA --
GO:0006955 immune response NAS 2827171
GO:0006958 complement activation, classical pathway IEA --
GO:0030183 B cell differentiation IDA 2995485
GO:0042100 B cell proliferation IDA 2995485
genes like me logo Genes that share ontologies with CR2: view

Compounds for CR2 Gene

(14) Novoseek inferred chemical compound relationships for CR2 Gene

Compound -log(P) Hits PubMed IDs
cr2+ 70.8 4
paraffin 17.7 4
tyrosine 15.7 21
okt3 14.5 1
streptavidin 5.83 2
genes like me logo Genes that share compounds with CR2: view

Transcripts for CR2 Gene

Unigene Clusters for CR2 Gene

Complement component (3d/Epstein Barr virus) receptor 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CR2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for CR2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CR2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c ^ 14 ^ 15 ^ 16a · 16b · 16c ^ 17 ^ 18 ^
SP1:
SP2:
SP3: - -
SP4: -
SP5:
SP6: - - -
SP7:
SP8:
SP9: -
SP10:

ExUns: 19 ^ 20
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for CR2 Gene

GeneLoc Exon Structure for
CR2
ECgene alternative splicing isoforms for
CR2

Expression for CR2 Gene

mRNA expression in normal human tissues for CR2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CR2 Gene

This gene is overexpressed in Spleen (22.1) and Small Intestine - Terminal Ileum (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CR2 Gene

SOURCE GeneReport for Unigene cluster for CR2 Gene Hs.445757

mRNA Expression by UniProt/SwissProt for CR2 Gene

P20023-CR2_HUMAN
Tissue specificity: Mature B-lymphocytes, T-lymphocytes, pharyngeal epithelial cells, astrocytes and follicular dendritic cells of the spleen
genes like me logo Genes that share expressions with CR2: view

In Situ Assay Products

Orthologs for CR2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CR2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CR2 35
  • 99.54 (n)
  • 99.27 (a)
CR2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CR2 35
  • 82.26 (n)
  • 71.09 (a)
CR2 36
  • 53 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CR2 35
  • 83.86 (n)
  • 75.37 (a)
mouse
(Mus musculus)
Mammalia Cr2 35
  • 76.64 (n)
  • 66.28 (a)
Cr2 16
Cr2 36
  • 66 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CR2 36
  • 42 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 30 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Cr2 35
  • 75.73 (n)
  • 65.5 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 31 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii selp 36
  • 10 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG10186 36
  • 13 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 8 (a)
OneToMany
Species with no ortholog for CR2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CR2 Gene

ENSEMBL:
Gene Tree for CR2 (if available)
TreeFam:
Gene Tree for CR2 (if available)

Paralogs for CR2 Gene

Paralogs for CR2 Gene

Selected SIMAP similar genes for CR2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CR2: view

Variants for CR2 Gene

Sequence variations from dbSNP and Humsavar for CR2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs17615 - 207,473,117(+) GGGCA(A/G)TAGTC missense, reference
rs17616 -- 207,473,578(+) TGGTC(A/G)TCATA missense, reference, intron-variant
rs17617 -- 207,480,050(+) CAGAG(A/C)ACGGT missense, reference
rs17618 -- 207,480,019(+) TTGTC(A/G)TTACC reference, missense
rs311302 -- 207,456,071(+) AAATA(C/T)ATATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CR2 Gene

Variant ID Type Subtype PubMed ID
dgv174e1 CNV Complex 17122850
dgv175e1 CNV Complex 17122850

Relevant External Links for CR2 Gene

HapMap Linkage Disequilibrium report
CR2
Human Gene Mutation Database (HGMD)
CR2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CR2 Gene

Disorders for CR2 Gene

(2) OMIM Diseases for CR2 Gene (120650)

UniProtKB/Swiss-Prot

CR2_HUMAN
  • Systemic lupus erythematosus 9 (SLEB9) [MIM:610927]: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. {ECO:0000269 PubMed:17360460}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
  • Immunodeficiency, common variable, 7 (CVID7) [MIM:614699]: A primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low. {ECO:0000269 PubMed:22035880}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(35) Novoseek inferred disease relationships for CR2 Gene

Disease -log(P) Hits PubMed IDs
ebv infections 80.5 12
lymphoma 52.2 8
burkitt lymphoma 49.9 2
infectious mononucleosis 46 2
smooth muscle tumor 43 1

Genatlas disease for CR2 Gene

infections,recurrent,pyogenic

Relevant External Links for CR2

Genetic Association Database (GAD)
CR2
Human Genome Epidemiology (HuGE) Navigator
CR2
genes like me logo Genes that share disorders with CR2: view

Publications for CR2 Gene

  1. Evidence for a new transcript of the Epstein-Barr virus/C3d receptor (CR2, CD21) which is due to alternative exon usage. (PMID: 10068037) Barel M. … Frade R. (Mol. Immunol. 1998) 3 4 23
  2. The crystal structure of human CD21: Implications for Epstein-Barr virus and C3d binding. (PMID: 12122212) Prota A.E. … Fingeroth J.D. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 4 23
  3. Association of a common complement receptor 2 haplotype with increased risk of systemic lupus erythematosus. (PMID: 17360460) Wu H. … Tsao B.P. (Proc. Natl. Acad. Sci. U.S.A. 2007) 3 4 48
  4. Complement receptor 2 polymorphisms associated with systemic lupus erythematosus modulate alternative splicing. (PMID: 19387458) Douglas K.B. … Boackle S.A. (Genes Immun. 2009) 3 23 48
  5. Transferability of type 2 diabetes implicated loci in multi-ethnic cohorts from Southeast Asia. (PMID: 21490949) Sim X. … Tai E.S. (PLoS Genet. 2011) 3 48

Products for CR2 Gene

Sources for CR2 Gene

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