Aliases for CR1 Gene
External Ids for CR1 Gene
Previous GeneCards Identifiers for CR1 Gene
This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. Alternate allele-specific splice variants, encoding different isoforms, have been characterized. Additional allele specific isoforms, including a secreted form, have been described but have not been fully characterized. [provided by RefSeq, Jul 2008]
GeneCards Summary for CR1 Gene
CR1 (Complement Component (3b/4b) Receptor 1 (Knops Blood Group)) is a Protein Coding gene. Diseases associated with CR1 include plasmodium falciparum malaria and malaria. Among its related pathways are Immune System and Complement and coagulation cascades. GO annotations related to this gene include complement component C3b binding and complement component C4b receptor activity. An important paralog of this gene is CSMD3.
UniProtKB/Swiss-Prot for CR1 Gene
Mediates cellular binding of particles and immune complexes that have activated complement
(Microbial infection) Acts as a receptor for Epstein-Barr virus.