Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CR1 Gene

Aliases for CR1 Gene

  • Complement Component (3b/4b) Receptor 1 (Knops Blood Group) 2 3
  • C3BR 3 4 6
  • C3b/C4b Receptor 3 4
  • CD35 Antigen 3 4
  • Complement Component (3b/4b) Receptor 1, Including Knops Blood Group System 2
  • Complement Receptor Type 1 3
  • Knops Blood Group Antigen 3
  • C3-Binding Protein 3
  • C4BR 3
  • CD35 3
  • KN 3

External Ids for CR1 Gene

Previous GeneCards Identifiers for CR1 Gene

  • GC01P206329
  • GC01P203379
  • GC01P204312
  • GC01P204753
  • GC01P204057
  • GC01P205736
  • GC01P207669
  • GC01P178362

Summaries for CR1 Gene

Entrez Gene Summary for CR1 Gene

  • This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. Alternate allele-specific splice variants, encoding different isoforms, have been characterized. Additional allele specific isoforms, including a secreted form, have been described but have not been fully characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for CR1 Gene

CR1 (Complement Component (3b/4b) Receptor 1 (Knops Blood Group)) is a Protein Coding gene. Diseases associated with CR1 include malaria and diffuse glomerulonephritis. Among its related pathways are Complement and coagulation cascades and Complement and coagulation cascades. GO annotations related to this gene include complement component C3b binding and complement component C4b receptor activity. An important paralog of this gene is CSMD3.

UniProtKB/Swiss-Prot for CR1 Gene

  • Mediates cellular binding of particles and immune complexes that have activated complement

Gene Wiki entry for CR1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CR1 Gene

Genomics for CR1 Gene

Regulatory Elements for CR1 Gene

Genomic Location for CR1 Gene

207,496,128 bp from pter
207,641,765 bp from pter
145,638 bases
Plus strand

Genomic View for CR1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CR1 Gene

Proteins for CR1 Gene

  • Protein details for CR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Complement receptor type 1
    Protein Accession:
    Secondary Accessions:
    • Q16744
    • Q16745
    • Q5SR43
    • Q5SR45
    • Q9UQV2

    Protein attributes for CR1 Gene

    2039 amino acids
    Molecular mass:
    223663 Da
    Quaternary structure:
    • Monomer

    Three dimensional structures from OCA and Proteopedia for CR1 Gene

neXtProt entry for CR1 Gene

Proteomics data for CR1 Gene at MOPED

Post-translational modifications for CR1 Gene

  • Glycosylation at Asn56, Asn252, Asn410, Asn447, Asn509, Asn578, Asn702, Asn860, Asn897, Asn959, Asn1028, Asn1152, Asn1310, Asn1481, Asn1504, Asn1534, Asn1540, Asn1605, Asn1763, and Asn1908
  • Modification sites at PhosphoSitePlus

Other Protein References for CR1 Gene

No data available for DME Specific Peptides for CR1 Gene

Domains for CR1 Gene

Gene Families for CR1 Gene

Protein Domains for CR1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 30 Sushi (CCP/SCR) domains.
  • Belongs to the receptors of complement activation (RCA) family.
  • Contains 30 Sushi (CCP/SCR) domains.
  • Belongs to the receptors of complement activation (RCA) family.
genes like me logo Genes that share domains with CR1: view

Function for CR1 Gene

Molecular function for CR1 Gene

GENATLAS Biochemistry:
complement component (3b/4b) receptor 1 (see RCA@)
UniProtKB/Swiss-Prot Function:
Mediates cellular binding of particles and immune complexes that have activated complement

Gene Ontology (GO) - Molecular Function for CR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001851 complement component C3b binding IDA 2972794
GO:0001855 complement component C4b binding IDA 2972794
GO:0001861 complement component C4b receptor activity IDA 2972794
GO:0004877 complement component C3b receptor activity IDA 2972794
genes like me logo Genes that share ontologies with CR1: view

Animal Model Products

miRNA for CR1 Gene

miRTarBase miRNAs that target CR1

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for CR1 Gene

Localization for CR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CR1 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for CR1 Gene COMPARTMENTS Subcellular localization image for CR1 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 2
extracellular 2
nucleus 2
chloroplast 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for CR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IDA 6910481
GO:0009986 cell surface IDA 2972794
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with CR1: view

Pathways for CR1 Gene

genes like me logo Genes that share pathways with CR1: view

Pathways by source for CR1 Gene

Gene Ontology (GO) - Biological Process for CR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002430 complement receptor mediated signaling pathway IDA 2972794
GO:0006958 complement activation, classical pathway IEA --
GO:0030449 regulation of complement activation TAS --
GO:0045087 innate immune response TAS --
GO:0045957 negative regulation of complement activation, alternative pathway IDA 10531307
genes like me logo Genes that share ontologies with CR1: view

Drugs for CR1 Gene

(41) Novoseek inferred chemical compound relationships for CR1 Gene

Compound -log(P) Hits PubMed IDs
tp 10 88.7 13
fmlp 65.7 31
hind iii 54 15
cr2+ 53 1
n-formylmethionyl-leucylphenylalanine 48.9 4

(1) PharmGKB related drug/compound annotations for CR1 Gene

Drug/compound Annotation
eculizumab Clinical Annotation
genes like me logo Genes that share compounds with CR1: view

Transcripts for CR1 Gene

Unigene Clusters for CR1 Gene

Complement component (3b/4b) receptor 1 (Knops blood group):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CR1 Gene

No ASD Table

Relevant External Links for CR1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CR1 Gene

mRNA expression in normal human tissues for CR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CR1 Gene

This gene is overexpressed in Whole Blood (31.7) and Spleen (7.4).

Protein differential expression in normal tissues for CR1 Gene

This gene is overexpressed in Urine (50.9) and Neutrophil (8.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CR1 Gene

SOURCE GeneReport for Unigene cluster for CR1 Gene Hs.334019

mRNA Expression by UniProt/SwissProt for CR1 Gene

Tissue specificity: Present on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells
genes like me logo Genes that share expressions with CR1: view

Expression partners for CR1 Gene

* - Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

Orthologs for CR1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CR1 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia LOC102157092 35
  • 69.17 (n)
  • 57.18 (a)
-- 36
  • 52 (a)
(Pan troglodytes)
Mammalia CR1 35
  • 97.13 (n)
  • 96.25 (a)
CR1 36
  • 99 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 45 (a)
(Mus musculus)
Mammalia Cr1l 36
  • 57 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 44 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 32 (a)
(Danio rerio)
Actinopterygii ntd5 36
  • 21 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10186 37
  • 26 (a)
fw 36
  • 17 (a)
(Caenorhabditis elegans)
Secernentea T07H6.5 37
  • 25 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 9 (a)
Species with no ortholog for CR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CR1 Gene

Gene Tree for CR1 (if available)
Gene Tree for CR1 (if available)

Paralogs for CR1 Gene

Paralogs for CR1 Gene Pseudogenes for CR1 Gene

genes like me logo Genes that share paralogs with CR1: view

Variants for CR1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for CR1 Gene

CR1 contains a system of antigens called the Knops blood group system. Polymorphisms within this system are involved in malarial rosetting, a process associated with cerebral malaria, the major cause of mortality in Plasmodium falciparum malaria. Common Knops system antigens include McCoy (McC) and Sl(a)/Vil (Kn4, or Swain-Langley; Vil or Villien). Sl(a-) phenotype is more common in persons of African descent and may protect against fatal malaria

Sequence variations from dbSNP and Humsavar for CR1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs12075343 -- 207,634,794(+) CTGAA(A/G)CTGAC intron-variant
rs12075933 -- 207,502,508(+) TAAAA(G/T)TGCGT intron-variant
rs12076910 -- 207,573,396(+) TTTTT(A/T)AAGCA intron-variant
rs12078225 -- 207,515,291(+) tgtat(A/G)catat intron-variant
rs12075041 -- 207,637,761(+) ggatt(A/T)tccat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CR1 Gene

Variant ID Type Subtype PubMed ID
dgv174e1 CNV Complex 17122850
dgv175e1 CNV Complex 17122850
esv2722106 CNV Deletion 23290073
nsv508690 CNV Loss 20534489
nsv4232 CNV Loss 18451855
nsv821188 CNV Deletion 20802225
nsv826476 CNV Loss 20364138
esv26263 CNV Gain+Loss 19812545
nsv124 CNV Loss 15895083
nsv8724 CNV Gain+Loss 18304495
nsv471426 CNV Duplication 19718026
nsv514918 CNV Complex 21397061
dgv94e199 CNV Deletion 23128226
dgv5n47 CNV Loss 21111241
esv2675458 CNV Deletion 23128226
dgv6n47 CNV Loss 21111241
nsv436034 CNV Insertion 17901297
esv33009 CNV Gain+Loss 17666407
nsv514919 CNV Complex 21397061
esv2722117 CNV Deletion 23290073
nsv826487 CNV Gain 20364138

Relevant External Links for CR1 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)
Locus Specific Mutation Databases (LSDB)
Blood Group Antigen Gene Mutation Database (BGMUT)
Blood Group

Disorders for CR1 Gene

(2) OMIM Diseases for CR1 Gene (120620)

(97) Novoseek inferred disease relationships for CR1 Gene

Disease -log(P) Hits PubMed IDs
lupus erythematosus systemic 59.9 39
proliferative diffuse glomerulonephritis 49.4 2
malaria falciparum 49.1 9
afibrinogenemia 48.5 1
lupus nephritis 46.5 7

Genatlas disease for CR1 Gene

lupus systemic syndrome

Relevant External Links for CR1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with CR1: view

No data available for UniProtKB/Swiss-Prot for CR1 Gene

Publications for CR1 Gene

  1. A human complement receptor 1 polymorphism that reduces Plasmodium falciparum rosetting confers protection against severe malaria. (PMID: 14694201) Cockburn I.A. … Rowe J.A. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 23 48
  2. Quantitative polymorphism of complement receptor type 1 (CR1) in patients undergoing haemodialysis. (PMID: 15069174) Tamano M. … Tomino Y. (Nephrol. Dial. Transplant. 2004) 3 23 48
  3. Association of complement receptor 1 (CR1, CD35, C3b/C4b receptor) density polymorphism with glomerulonephritis in Indian subjects. (PMID: 15072851) Katyal M. … Das N. (Mol. Immunol. 2004) 3 23 48
  4. Genetic and structural polymorphism of complement receptor 1 in normal Indian subjects. (PMID: 14556965) Katyal M. … Das N. (Immunol. Lett. 2003) 3 23 48
  5. Structure of the C3b binding site of CR1 (CD35), the immune adherence receptor. (PMID: 11955431) Smith B.O. … Barlow P.N. (Cell 2002) 3 4 23

Products for CR1 Gene

Sources for CR1 Gene

Back to Top