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Aliases for CPE Gene

Aliases for CPE Gene

  • Carboxypeptidase E 2 3
  • Enkephalin Convertase 2 3 4
  • Carboxypeptidase H 2 3 4
  • Cobalt-Stimulated Chromaffin Granule Carboxypeptidase 2 3
  • Insulin Granule-Associated Carboxypeptidase 2 3
  • Prohormone-Processing Carboxypeptidase 3 4
  • EC 3.4.17.10 4 63
  • CPH 3 4
  • EC 3.4.17 63

External Ids for CPE Gene

Previous GeneCards Identifiers for CPE Gene

  • GC04P167151
  • GC04P166728
  • GC04P166877
  • GC04P166657
  • GC04P166519
  • GC04P166300
  • GC04P162051

Summaries for CPE Gene

Entrez Gene Summary for CPE Gene

  • This gene encodes a member of the M14 family of metallocarboxypeptidases. The encoded preproprotein is proteolytically processed to generate the mature peptidase. This peripheral membrane protein cleaves C-terminal amino acid residues and is involved in the biosynthesis of peptide hormones and neurotransmitters, including insulin. This protein may also function independently of its peptidase activity, as a neurotrophic factor that promotes neuronal survival, and as a sorting receptor that binds to regulated secretory pathway proteins, including prohormones. Mutations in this gene are implicated in type 2 diabetes. [provided by RefSeq, Nov 2015]

GeneCards Summary for CPE Gene

CPE (Carboxypeptidase E) is a Protein Coding gene. Diseases associated with CPE include hyperproinsulinemia and diabetes mellitus, insulin-dependent. Among its related pathways are Transport to the Golgi and subsequent modification and Arf6 trafficking events. GO annotations related to this gene include cell adhesion molecule binding and carboxypeptidase activity. An important paralog of this gene is CPN1.

UniProtKB/Swiss-Prot for CPE Gene

  • Removes residual C-terminal Arg or Lys remaining after initial endoprotease cleavage during prohormone processing. Processes proinsulin

Gene Wiki entry for CPE Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPE Gene

Genomics for CPE Gene

Regulatory Elements for CPE Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CPE Gene

Chromosome:
4
Start:
165,361,194 bp from pter
End:
165,498,330 bp from pter
Size:
137,137 bases
Orientation:
Plus strand

Genomic View for CPE Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CPE Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPE Gene

Proteins for CPE Gene

  • Protein details for CPE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P16870-CBPE_HUMAN
    Recommended name:
    Carboxypeptidase E
    Protein Accession:
    P16870
    Secondary Accessions:
    • A8K4N1
    • B3KR42
    • B4DFN4
    • D3DP33
    • Q9UIU9

    Protein attributes for CPE Gene

    Size:
    476 amino acids
    Molecular mass:
    53151 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
    Quaternary structure:
    • Isoform 2 interacts with HDAC1 and HDAC2.
    SequenceCaution:
    • Sequence=BAG52254.1; Type=Frameshift; Positions=415; Evidence={ECO:0000305};

    Alternative splice isoforms for CPE Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CPE Gene

Proteomics data for CPE Gene at MOPED

Post-translational modifications for CPE Gene

  • Glycosylation at Asn 139 and Asn 390
  • Modification sites at PhosphoSitePlus

Other Protein References for CPE Gene

Antibody Products

  • R&D Systems Antibodies for CPE (Carboxypeptidase E/CPE)

Domains & Families for CPE Gene

Gene Families for CPE Gene

Suggested Antigen Peptide Sequences for CPE Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P16870

UniProtKB/Swiss-Prot:

CBPE_HUMAN :
  • Belongs to the peptidase M14 family.
Family:
  • Belongs to the peptidase M14 family.
genes like me logo Genes that share domains with CPE: view

Function for CPE Gene

Molecular function for CPE Gene

GENATLAS Biochemistry:
carboxypeptidase E,metallo carboxypeptidase family,regulated secretory pathway sorting receptor,involved in the trimming of paired basic residues at the C terminus of prohormone-derived peptides,mutated in the obese fat mouse
UniProtKB/Swiss-Prot CatalyticActivity:
Release of C-terminal arginine or lysine residues from polypeptides
UniProtKB/Swiss-Prot Function:
Removes residual C-terminal Arg or Lys remaining after initial endoprotease cleavage during prohormone processing. Processes proinsulin

Enzyme Numbers (IUBMB) for CPE Gene

Gene Ontology (GO) - Molecular Function for CPE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004180 carboxypeptidase activity TAS 9019408
GO:0004181 metallocarboxypeptidase activity IEA --
GO:0008270 zinc ion binding IEA --
GO:0042043 neurexin family protein binding IPI 19166515
GO:0050839 cell adhesion molecule binding IPI 19166515
genes like me logo Genes that share ontologies with CPE: view
genes like me logo Genes that share phenotypes with CPE: view

Animal Models for CPE Gene

MGI Knock Outs for CPE:

Animal Model Products

miRNA for CPE Gene

miRTarBase miRNAs that target CPE

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CPE

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for CPE Gene

Localization for CPE Gene

Subcellular locations from UniProtKB/Swiss-Prot for CPE Gene

Isoform 1: Cytoplasmic vesicle, secretory vesicle membrane; Peripheral membrane protein. Secreted. Note=Associated with the secretory granule membrane through direct binding to lipid rafts in intragranular conditions. {ECO:0000250}.
Isoform 2: Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CPE Gene COMPARTMENTS Subcellular localization image for CPE gene
Compartment Confidence
extracellular 5
nucleus 5
golgi apparatus 4
plasma membrane 4
cytoskeleton 2
endoplasmic reticulum 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for CPE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005794 Golgi apparatus IDA 19166515
GO:0005886 plasma membrane TAS 9019408
GO:0030658 transport vesicle membrane IEA --
GO:0030667 secretory granule membrane TAS --
genes like me logo Genes that share ontologies with CPE: view

Pathways & Interactions for CPE Gene

genes like me logo Genes that share pathways with CPE: view

Pathways by source for CPE Gene

1 BioSystems pathway for CPE Gene
1 KEGG pathway for CPE Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for CPE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003214 cardiac left ventricle morphogenesis IMP 19593212
GO:0006464 cellular protein modification process NAS 2334405
GO:0006508 proteolysis --
GO:0007218 neuropeptide signaling pathway NAS 2334405
GO:0008152 metabolic process TAS 7663508
genes like me logo Genes that share ontologies with CPE: view

No data available for SIGNOR curated interactions for CPE Gene

Drugs & Compounds for CPE Gene

(10) Drugs for CPE Gene - From: NovoSeek, DrugBank, and ClinicalTrials

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Insulin Regular Approved, Experimental, Investigational Pharma Target 0
Insulin, porcine Approved Pharma Target 0
Colistin Approved Pharma 54
Meropenem Approved, Investigational Pharma 78
Tigecycline Approved Pharma Glycylcycline antibiotic 53

(9) Additional Compounds for CPE Gene - From: NovoSeek

genes like me logo Genes that share compounds with CPE: view

Transcripts for CPE Gene

Unigene Clusters for CPE Gene

Carboxypeptidase E:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CPE

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CPE Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14
SP1: - - - -
SP2: - - - - -
SP3: -
SP4: - -
SP5: - - - -
SP6: - -
SP7: -

Relevant External Links for CPE Gene

GeneLoc Exon Structure for
CPE
ECgene alternative splicing isoforms for
CPE

Expression for CPE Gene

mRNA expression in normal human tissues for CPE Gene

mRNA differential expression in normal tissues according to GTEx for CPE Gene

This gene is overexpressed in Brain - Amygdala (x4.5), Brain - Caudate (basal ganglia) (x4.4), and Brain - Nucleus accumbens (basal ganglia) (x4.2).

Protein differential expression in normal tissues from HIPED for CPE Gene

This gene is overexpressed in Islet of Langerhans (17.8), Vitreous humor (14.6), Pancreas (6.7), Cerebrospinal fluid (6.6), and Amniocyte (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CPE Gene



SOURCE GeneReport for Unigene cluster for CPE Gene Hs.75360

mRNA Expression by UniProt/SwissProt for CPE Gene

P16870-CBPE_HUMAN
Tissue specificity: Isoform 2, but not isoform 1, is overexpressed in hepatocellular carcinoma (at protein level), as well as in other tumors, including pheochromocytomas and paragangliomas.
genes like me logo Genes that share expression patterns with CPE: view

Protein tissue co-expression partners for CPE Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for CPE Gene

Orthologs for CPE Gene

This gene was present in the common ancestor of animals.

Orthologs for CPE Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CPE 35
  • 90.18 (n)
  • 93.05 (a)
CPE 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CPE 35
  • 90.2 (n)
  • 96.15 (a)
CPE 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cpe 35
  • 88.66 (n)
  • 96.64 (a)
Cpe 16
Cpe 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CPE 35
  • 99.3 (n)
  • 99.37 (a)
CPE 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cpe 35
  • 88.87 (n)
  • 96.01 (a)
oppossum
(Monodelphis domestica)
Mammalia CPE 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CPE 36
  • 92 (a)
OneToOne
chicken
(Gallus gallus)
Aves CPE 35
  • 83.74 (n)
  • 91.61 (a)
CPE 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CPE 36
  • 93 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cpe 35
  • 76.45 (n)
  • 82.84 (a)
Str.15474 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.8836 35
zebrafish
(Danio rerio)
Actinopterygii cpe 35
  • 74.08 (n)
  • 82.8 (a)
cpe 36
  • 80 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG4678 37
  • 41 (a)
worm
(Caenorhabditis elegans)
Secernentea F01D4.4 37
  • 44 (a)
F59A3.1 37
  • 40 (a)
T27A8.1 37
  • 39 (a)
egl-21 35
  • 53.81 (n)
  • 47.51 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.504 35
Species with no ortholog for CPE:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CPE Gene

ENSEMBL:
Gene Tree for CPE (if available)
TreeFam:
Gene Tree for CPE (if available)

Paralogs for CPE Gene

Paralogs for CPE Gene

(8) SIMAP similar genes for CPE Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with CPE: view

Variants for CPE Gene

Sequence variations from dbSNP and Humsavar for CPE Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
VAR_036011 A colorectal cancer sample
VAR_048599 -

Structural Variations from Database of Genomic Variants (DGV) for CPE Gene

Variant ID Type Subtype PubMed ID
nsv822819 CNV Loss 20364138
nsv819783 CNV Loss 19587683
nsv822820 CNV Loss 20364138

Variation tolerance for CPE Gene

Residual Variation Intolerance Score: 79.75% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.29; 25.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CPE Gene

HapMap Linkage Disequilibrium report
CPE
Human Gene Mutation Database (HGMD)
CPE

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CPE Gene

Disorders for CPE Gene

MalaCards: The human disease database

(3) MalaCards diseases for CPE Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
hyperproinsulinemia
  • hpri
diabetes mellitus, insulin-dependent
  • diabetes, type 1
obesity
  • obesity, association with
- elite association
Search CPE in MalaCards View complete list of genes associated with diseases

Relevant External Links for CPE

Genetic Association Database (GAD)
CPE
Human Genome Epidemiology (HuGE) Navigator
CPE
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CPE
genes like me logo Genes that share disorders with CPE: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CPE Gene

Publications for CPE Gene

  1. Effects of carboxypeptidase E overexpression on insulin mRNA levels, regulated insulin secretion, and proinsulin processing of pituitary GH3 cells transfected with a furin-cleavable human proinsulin cDNA. (PMID: 12588113) Polastri L. … Davalli A.M. (Cell Transplant 2002) 23 25 67
  2. Human carboxypeptidase E. Isolation and characterization of the cDNA, sequence conservation, expression and processing in vitro. (PMID: 2334405) Manser E. … Lim L. (Biochem. J. 1990) 2 23 67
  3. Enkephalin, its precursor, processing enzymes, and receptor as part of a local opioid network throughout the respiratory system of lung cancer patients. (PMID: 20040394) Krajnik M. … Mousa S.A. (Hum. Pathol. 2010) 23 67
  4. Local pulmonary opioid network in patients with lung cancer: a putative modulator of respiratory function. (PMID: 20360624) Krajnik M. … Mousa S.A. (Pharmacol Rep 2010) 23 67
  5. Dynorphin expression, processing and receptors in the alveolar macrophages, cancer cells and bronchial epithelium of lung cancer patients. (PMID: 20376782) Mousa S.A. … SchAofer M. (Histol. Histopathol. 2010) 23 67

Products for CPE Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • Pathway & Disease-focused RT² Profiler PCR Arrays
  • QIAGEN qRT-PCR Assays for microRNAs that regulate CPE
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat
  • Predesigned siRNA for gene silencing in human,mouse,rat for CPE
  • Block miRNA regulation of CPE using miScript Target Protectors

Sources for CPE Gene

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