Aliases for CPE Gene
External Ids for CPE Gene
Previous GeneCards Identifiers for CPE Gene
This gene encodes a member of the M14 family of metallocarboxypeptidases. The encoded preproprotein is proteolytically processed to generate the mature peptidase. This peripheral membrane protein cleaves C-terminal amino acid residues and is involved in the biosynthesis of peptide hormones and neurotransmitters, including insulin. This protein may also function independently of its peptidase activity, as a neurotrophic factor that promotes neuronal survival, and as a sorting receptor that binds to regulated secretory pathway proteins, including prohormones. Mutations in this gene are implicated in type 2 diabetes. [provided by RefSeq, Nov 2015]
GeneCards Summary for CPE Gene
CPE (Carboxypeptidase E) is a Protein Coding gene. Diseases associated with CPE include hyperproinsulinemia and insulinoma. Among its related pathways are Transport to the Golgi and subsequent modification and Arf6 trafficking events. GO annotations related to this gene include cell adhesion molecule binding and carboxypeptidase activity. An important paralog of this gene is CPXM2.
UniProtKB/Swiss-Prot for CPE Gene
Removes residual C-terminal Arg or Lys remaining after initial endoprotease cleavage during prohormone processing. Processes proinsulin.