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Aliases for CPE Gene

Aliases for CPE Gene

  • Carboxypeptidase E 2 3
  • Enkephalin Convertase 2 3 4
  • Carboxypeptidase H 2 3 4
  • Cobalt-Stimulated Chromaffin Granule Carboxypeptidase 2 3
  • Insulin Granule-Associated Carboxypeptidase 2 3
  • Prohormone-Processing Carboxypeptidase 3 4
  • EC 4 63
  • CPH 3 4
  • EC 3.4.17 63

External Ids for CPE Gene

Summaries for CPE Gene

Entrez Gene Summary for CPE Gene

  • This gene encodes a carboxypeptidase that cleaves C-terminal amino acid residues and is involved in the biosynthesis of peptide hormones and neurotransmitters, including insulin. It is a peripheral membrane protein. The protein specifically binds regulated secretory pathway proteins, including prohormones, but not constitutively secreted proteins. Mutations in this gene are implicated in type II diabetes. [provided by RefSeq, Jul 2008]

GeneCards Summary for CPE Gene

CPE (Carboxypeptidase E) is a Protein Coding gene. Diseases associated with CPE include hyperproinsulinemia and pulmonary neuroendocrine tumor. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Arf6 trafficking events. GO annotations related to this gene include cell adhesion molecule binding and carboxypeptidase activity. An important paralog of this gene is CPN1.

UniProtKB/Swiss-Prot for CPE Gene

  • Removes residual C-terminal Arg or Lys remaining after initial endoprotease cleavage during prohormone processing. Processes proinsulin

Gene Wiki entry for CPE Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPE Gene

Genomics for CPE Gene

Genomic Location for CPE Gene

165,361,194 bp from pter
165,498,330 bp from pter
137,137 bases
Plus strand

Genomic View for CPE Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CPE Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPE Gene

Regulatory Elements for CPE Gene

Proteins for CPE Gene

  • Protein details for CPE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Carboxypeptidase E
    Protein Accession:
    Secondary Accessions:
    • A8K4N1
    • B3KR42
    • B4DFN4
    • D3DP33
    • Q9UIU9

    Protein attributes for CPE Gene

    476 amino acids
    Molecular mass:
    53151 Da
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
    Quaternary structure:
    • Isoform 2 interacts with HDAC1 and HDAC2.
    • Sequence=BAG52254.1; Type=Frameshift; Positions=415; Evidence={ECO:0000305};

    Alternative splice isoforms for CPE Gene


neXtProt entry for CPE Gene

Proteomics data for CPE Gene at MOPED

Post-translational modifications for CPE Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn139 and Asn390

Other Protein References for CPE Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for CPE Gene

Gene Families for CPE Gene

Suggested Antigen Peptide Sequences for CPE Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase M14 family.:
    • P16870
genes like me logo Genes that share domains with CPE: view

Function for CPE Gene

Molecular function for CPE Gene

GENATLAS Biochemistry: carboxypeptidase E,metallo carboxypeptidase family,regulated secretory pathway sorting receptor,involved in the trimming of paired basic residues at the C terminus of prohormone-derived peptides,mutated in the obese fat mouse
UniProtKB/Swiss-Prot CatalyticActivity: Release of C-terminal arginine or lysine residues from polypeptides
UniProtKB/Swiss-Prot Function: Removes residual C-terminal Arg or Lys remaining after initial endoprotease cleavage during prohormone processing. Processes proinsulin

Enzyme Numbers (IUBMB) for CPE Gene

Gene Ontology (GO) - Molecular Function for CPE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004180 carboxypeptidase activity TAS 9019408
GO:0004181 metallocarboxypeptidase activity IEA --
GO:0008270 zinc ion binding IEA --
GO:0042043 neurexin family protein binding IPI 19166515
GO:0050839 cell adhesion molecule binding IPI 19166515
genes like me logo Genes that share ontologies with CPE: view
genes like me logo Genes that share phenotypes with CPE: view

Animal Models for CPE Gene

MGI Knock Outs for CPE:

miRNA for CPE Gene

miRTarBase miRNAs that target CPE

No data available for Transcription Factor Targeting and HOMER Transcription for CPE Gene

Localization for CPE Gene

Subcellular locations from UniProtKB/Swiss-Prot for CPE Gene

Isoform 1: Cytoplasmic vesicle, secretory vesicle membrane; Peripheral membrane protein. Secreted. Note=Associated with the secretory granule membrane through direct binding to lipid rafts in intragranular conditions. {ECO:0000250}.
Isoform 2: Nucleus.

Subcellular locations from

Jensen Localization Image for CPE Gene COMPARTMENTS Subcellular localization image for CPE gene
Compartment Confidence
nucleus 5
golgi apparatus 4
plasma membrane 4
extracellular 3
endoplasmic reticulum 2
lysosome 1

Gene Ontology (GO) - Cellular Components for CPE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005794 Golgi apparatus IDA 19166515
GO:0005886 plasma membrane TAS 9019408
GO:0030658 transport vesicle membrane IEA --
GO:0030667 secretory granule membrane TAS --
genes like me logo Genes that share ontologies with CPE: view

Pathways for CPE Gene

genes like me logo Genes that share pathways with CPE: view

Pathways by source for CPE Gene

1 BioSystems pathway for CPE Gene
1 KEGG pathway for CPE Gene

Gene Ontology (GO) - Biological Process for CPE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003214 cardiac left ventricle morphogenesis IMP 19593212
GO:0006464 cellular protein modification process NAS 2334405
GO:0006508 proteolysis --
GO:0007218 neuropeptide signaling pathway NAS 2334405
GO:0008152 metabolic process TAS 7663508
genes like me logo Genes that share ontologies with CPE: view

Compounds for CPE Gene

(2) HMDB Compounds for CPE Gene

Compound Synonyms Cas Number PubMed IDs
  • Co
  • Zinc

(2) Drugbank Compounds for CPE Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Insulin Regular
11061-68-0 target
Insulin, porcine
9004-14-2 target

(14) Novoseek inferred chemical compound relationships for CPE Gene

Compound -log(P) Hits PubMed IDs
peptidylglycine 86.3 7
gemsa 82.1 2
prepro npy 67.2 3
proglucagon 54.1 1
c-peptide 46.7 1
genes like me logo Genes that share compounds with CPE: view

Transcripts for CPE Gene

Unigene Clusters for CPE Gene

Carboxypeptidase E:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CPE Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14
SP1: - - - -
SP2: - - - - -
SP3: -
SP4: - -
SP5: - - - -
SP6: - -
SP7: -

Relevant External Links for CPE Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CPE Gene

mRNA expression in normal human tissues for CPE Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CPE Gene

This gene is overexpressed in Brain - Amygdala (4.5), Brain - Caudate (basal ganglia) (4.4), and Brain - Nucleus accumbens (basal ganglia) (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CPE Gene

SOURCE GeneReport for Unigene cluster for CPE Gene Hs.75360

mRNA Expression by UniProt/SwissProt for CPE Gene

Tissue specificity: Isoform 2, but not isoform 1, is overexpressed in hepatocellular carcinoma (at protein level), as well as in other tumors, including pheochromocytomas and paragangliomas.
genes like me logo Genes that share expressions with CPE: view

Orthologs for CPE Gene

This gene was present in the common ancestor of animals.

Orthologs for CPE Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CPE 35
  • 99.3 (n)
  • 99.37 (a)
CPE 36
  • 100 (a)
(Bos Taurus)
Mammalia CPE 35
  • 90.18 (n)
  • 93.05 (a)
CPE 36
  • 93 (a)
(Canis familiaris)
Mammalia CPE 35
  • 90.2 (n)
  • 96.15 (a)
CPE 36
  • 96 (a)
(Mus musculus)
Mammalia Cpe 35
  • 88.66 (n)
  • 96.64 (a)
Cpe 16
Cpe 36
  • 97 (a)
(Monodelphis domestica)
Mammalia CPE 36
  • 92 (a)
(Ornithorhynchus anatinus)
Mammalia CPE 36
  • 92 (a)
(Rattus norvegicus)
Mammalia Cpe 35
  • 88.87 (n)
  • 96.01 (a)
(Gallus gallus)
Aves CPE 35
  • 83.74 (n)
  • 91.61 (a)
CPE 36
  • 84 (a)
(Anolis carolinensis)
Reptilia CPE 36
  • 93 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.8836 35
tropical clawed frog
(Silurana tropicalis)
Amphibia cpe 35
  • 76.45 (n)
  • 82.84 (a)
Str.15474 35
(Danio rerio)
Actinopterygii cpe 35
  • 74.08 (n)
  • 82.8 (a)
cpe 36
  • 80 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4678 37
  • 41 (a)
(Caenorhabditis elegans)
Secernentea egl-21 35
  • 53.81 (n)
  • 47.51 (a)
F01D4.4 37
  • 44 (a)
T27A8.1 37
  • 39 (a)
F59A3.1 37
  • 40 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.504 35
Species with no ortholog for CPE:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CPE Gene

Gene Tree for CPE (if available)
Gene Tree for CPE (if available)

Paralogs for CPE Gene

Paralogs for CPE Gene

Selected SIMAP similar genes for CPE Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with CPE: view

Variants for CPE Gene

Sequence variations from dbSNP and Humsavar for CPE Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs12200 -- 165,498,286(+) AATTG(C/T)ATTCT utr-variant-3-prime
rs729699 -- 165,414,029(+) TAGCA(A/C/T)ACTGG intron-variant
rs934813 -- 165,390,401(+) AAATA(C/T)GGAGA intron-variant
rs934819 -- 165,405,858(-) TTCGG(C/T)GCTCC intron-variant
rs1001045 -- 165,460,427(+) ATCTT(C/G)TTGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CPE Gene

Variant ID Type Subtype PubMed ID
nsv822819 CNV Loss 20364138
nsv819783 CNV Loss 19587683
nsv822820 CNV Loss 20364138

Relevant External Links for CPE Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CPE Gene

Disorders for CPE Gene

(2) University of Copenhagen DISEASES for CPE Gene

(11) Novoseek inferred disease relationships for CPE Gene

Disease -log(P) Hits PubMed IDs
diabetes autoimmune 54.2 7
insulinoma 42.3 3
diabetes mellitus insulin-dependent 28.1 1
obesity 27.6 5
neuroendocrine tumors 22.5 2

Relevant External Links for CPE

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with CPE: view

No data available for UniProtKB/Swiss-Prot for CPE Gene

Publications for CPE Gene

  1. Human carboxypeptidase E. Isolation and characterization of the cDNA, sequence conservation, expression and processing in vitro. (PMID: 2334405) Manser E. … Lim L. (Biochem. J. 1990) 2 3 4 23
  2. Organization of the human carboxypeptidase E gene and molecular scanning for mutations in Japanese subjects with NIDDM or obesity. (PMID: 9662053) Utsunomiya N. … Nanjo K. (Diabetologia 1998) 3 4 23
  3. Molecular scanning of the human carboxypeptidase E gene for mutations in Chinese subjects with coronary atherosclerosis. (PMID: 17957445) Jia E.Z. … Ma W.Z. (Mol. Cell. Biochem. 2008) 3 23 48
  4. Association of the mutation for the human carboxypeptidase E gene exon 4 with the severity of coronary artery atherosclerosis. (PMID: 18080843) Jia E.Z. … Ma W.Z. (Mol. Biol. Rep. 2009) 3 23 48
  5. Association of human carboxypeptidase E exon5 gene polymorphisms with angiographical characteristics of coronary atherosclerosis in a Chinese population. (PMID: 18501121) Wang J. … Jia E.Z. (Acta Pharmacol. Sin. 2008) 3 23 48

Products for CPE Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • Pathway & Disease-focused RT² Profiler PCR Arrays
  • QIAGEN qRT-PCR Assays for microRNAs that regulate CPE
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat
  • Predesigned siRNA for gene silencing in human,mouse,rat for CPE
  • Block miRNA regulation of CPE using miScript Target Protectors

Sources for CPE Gene

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