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Aliases for COL26A1 Gene

Aliases for COL26A1 Gene

  • Collagen, Type XXVI, Alpha 1 2 3
  • Emilin And Multimerin Domain-Containing Protein 2 3 4
  • EMI Domain Containing 2 2 3
  • EMID2 3 4
  • SH2B 3 6
  • EMU2 3 4
  • EMI Domain-Containing Protein 2 4
  • Collagen Alpha-1(XXVI) Chain 3
  • Alpha-1 Type XXVI Collagen 4
  • Emu2 Gene 2
  • KIAA1299 6
  • SH2B1 6
  • EMI6 3

External Ids for COL26A1 Gene

Previous HGNC Symbols for COL26A1 Gene

  • EMID2

Previous GeneCards Identifiers for COL26A1 Gene

  • GC07P099489
  • GC07P100552
  • GC07P100566
  • GC07P101007

Summaries for COL26A1 Gene

Entrez Gene Summary for COL26A1 Gene

  • This gene encodes a protein containing an emilin domain and two collagen stretches. This gene may be associated with aspirin-intolerant asthma. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2013]

GeneCards Summary for COL26A1 Gene

COL26A1 (Collagen, Type XXVI, Alpha 1) is a Protein Coding gene. Diseases associated with COL26A1 include asthma. Among its related pathways are PI-3K cascade and Signaling by GPCR. An important paralog of this gene is EMID1.

Gene Wiki entry for COL26A1 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COL26A1 Gene

Genomics for COL26A1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for COL26A1 Gene

Start:
101,362,820 bp from pter
End:
101,559,024 bp from pter
Size:
196,205 bases
Orientation:
Plus strand

Genomic View for COL26A1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for COL26A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COL26A1 Gene

No data available for Regulatory Elements for COL26A1 Gene

Proteins for COL26A1 Gene

  • Protein details for COL26A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96A83-COQA1_HUMAN
    Recommended name:
    Collagen alpha-1(XXVI) chain
    Protein Accession:
    Q96A83
    Secondary Accessions:
    • Q32M90

    Protein attributes for COL26A1 Gene

    Size:
    441 amino acids
    Molecular mass:
    45381 Da
    Quaternary structure:
    • Homotrimer or heterotrimer.

    Three dimensional structures from OCA and Proteopedia for COL26A1 Gene

    Alternative splice isoforms for COL26A1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for COL26A1 Gene

Proteomics data for COL26A1 Gene at MOPED

Post-translational modifications for COL26A1 Gene

  • Hydroxylated on proline residues.
  • Glycosylation at Asn70, Asn132, Thr339, Ser343, and Thr358
  • Modification sites at PhosphoSitePlus

Other Protein References for COL26A1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for COL26A1 Gene

Domains for COL26A1 Gene

Gene Families for COL26A1 Gene

HGNC:

Protein Domains for COL26A1 Gene

Graphical View of Domain Structure for InterPro Entry

Q96A83

UniProtKB/Swiss-Prot:

COQA1_HUMAN :
  • Q96A83
Domain:
  • Contains 2 collagen-like domains.
  • Contains 1 EMI domain.
genes like me logo Genes that share domains with COL26A1: view

No data available for Suggested Antigen Peptide Sequences for COL26A1 Gene

Function for COL26A1 Gene

Gene Ontology (GO) - Molecular Function for COL26A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with COL26A1: view

Animal Model Products

CRISPR Products

miRNA for COL26A1 Gene

miRTarBase miRNAs that target COL26A1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for COL26A1

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for COL26A1 Gene

Localization for COL26A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for COL26A1 Gene

Secreted, extracellular space, extracellular matrix.

Gene Ontology (GO) - Cellular Components for COL26A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005581 collagen trimer IEA --
GO:0005783 endoplasmic reticulum --
GO:0005788 endoplasmic reticulum lumen TAS --
genes like me logo Genes that share ontologies with COL26A1: view

No data available for Subcellular locations from COMPARTMENTS for COL26A1 Gene

Pathways for COL26A1 Gene

genes like me logo Genes that share pathways with COL26A1: view

Pathways by source for COL26A1 Gene

1 KEGG pathway for COL26A1 Gene
1 GeneGo (Thomson Reuters) pathway for COL26A1 Gene

Interacting Proteins for COL26A1 Gene

Selected Interacting proteins: Q96A83-COQA1_HUMAN for COL26A1 Gene via MINT I2D

Gene Ontology (GO) - Biological Process for COL26A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010811 positive regulation of cell-substrate adhesion IEA --
GO:0022617 extracellular matrix disassembly TAS --
GO:0030198 extracellular matrix organization TAS --
GO:0030574 collagen catabolic process TAS --
genes like me logo Genes that share ontologies with COL26A1: view

Compounds for COL26A1 Gene

(1) PharmGKB related drug/compound annotations for COL26A1 Gene

Drug/compound Annotation
citalopram CA
genes like me logo Genes that share compounds with COL26A1: view

Transcripts for COL26A1 Gene

mRNA/cDNA for COL26A1 Gene

Unigene Clusters for COL26A1 Gene

Collagen, type XXVI, alpha 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for COL26A1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for COL26A1
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for COL26A1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b
SP1: -
SP2:
SP3:
SP4:

Relevant External Links for COL26A1 Gene

GeneLoc Exon Structure for
COL26A1
ECgene alternative splicing isoforms for
COL26A1

Expression for COL26A1 Gene

mRNA expression in normal human tissues for COL26A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for COL26A1 Gene

This gene is overexpressed in Brain - Cortex (11.0), Brain - Frontal Cortex (BA9) (8.3), and Brain - Anterior cingulate cortex (BA24) (6.3).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for COL26A1 Gene

SOURCE GeneReport for Unigene cluster for COL26A1 Gene Hs.654854

genes like me logo Genes that share expressions with COL26A1: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for COL26A1 Gene

Orthologs for COL26A1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for COL26A1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia COL26A1 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia COL26A1 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Col26a1 35
  • 81.89 (n)
  • 88.18 (a)
Col26a1 16
Col26a1 36
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia COL26A1 36
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia COL26A1 36
  • 62 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Col26a1 35
  • 81.89 (n)
  • 87.67 (a)
chicken
(Gallus gallus)
Aves EMID2 35
  • 70.21 (n)
  • 72.1 (a)
lizard
(Anolis carolinensis)
Reptilia COL26A1 36
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia col26a1 35
  • 59.59 (n)
  • 59.51 (a)
zebrafish
(Danio rerio)
Actinopterygii COL26A1 36
  • 56 (a)
OneToOne
Species with no ortholog for COL26A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for COL26A1 Gene

ENSEMBL:
Gene Tree for COL26A1 (if available)
TreeFam:
Gene Tree for COL26A1 (if available)

Paralogs for COL26A1 Gene

Paralogs for COL26A1 Gene

genes like me logo Genes that share paralogs with COL26A1: view

Variants for COL26A1 Gene

Sequence variations from dbSNP and Humsavar for COL26A1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs221 -- 101,381,867(-) TCTCC(A/G)TTTGt intron-variant
rs821 -- 101,381,873(-) TTTTC(A/G)TCTCC intron-variant
rs4045 -- 101,423,808(-) ACTCC(A/G)AGGAG intron-variant
rs868845 -- 101,447,213(+) AGCAA(A/T)TTGGG intron-variant
rs869127 -- 101,448,189(-) AAATA(C/T)GTGGC intron-variant

Relevant External Links for COL26A1 Gene

HapMap Linkage Disequilibrium report
COL26A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for COL26A1 Gene

Disorders for COL26A1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for COL26A1 Gene including...

Search for COL26A1 Gene in MalaCards »
genes like me logo Genes that share disorders with COL26A1: view

No data available for UniProtKB/Swiss-Prot for COL26A1 Gene

Publications for COL26A1 Gene

  1. Developmental expression and biochemical characterization of Emu family members. (PMID: 12221002) Leimeister C. … Gessler M. (Dev. Biol. 2002) 2 3 4
  2. Type XXVI collagen, a new member of the collagen family, is specifically expressed in the testis and ovary. (PMID: 12145293) Sato K. … Nagata K. (J. Biol. Chem. 2002) 2 3
  3. Toward a complete human genome sequence. (PMID: 9847074) Sulston J.E. … Waterston R. (Genome Res. 1998) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PMID: 16713569) Lim J. … Zoghbi H.Y. (Cell 2006) 3

Products for COL26A1 Gene

Sources for COL26A1 Gene

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