External Ids for ADORA2B Gene
Previous GeneCards Identifiers for ADORA2B Gene
This gene encodes an adenosine receptor that is a member of the G protein-coupled receptor superfamily. This integral membrane protein stimulates adenylate cyclase activity in the presence of adenosine. This protein also interacts with netrin-1, which is involved in axon elongation. The gene is located near the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]
GeneCards Summary for ADORA2B Gene
ADORA2B (Adenosine A2b Receptor) is a Protein Coding gene. Diseases associated with ADORA2B include priapism. Among its related pathways are Ras signaling pathway and Signaling by GPCR. GO annotations related to this gene include G-protein coupled adenosine receptor activity. An important paralog of this gene is GPR119.
UniProtKB/Swiss-Prot for ADORA2B Gene
Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase
Adenosine A2B receptors are members of the adenosine receptor group of G-protein-coupled receptors that also includes A1, A2A and A3. A2B receptors display high expression levels in the cecum, colon and bladder, with lower levels found in the lung, blood vessels, eye, median eminence and mast cells. A2B receptors play a role in the relaxation of smooth muscle in the vasculature and intestines, inhibit monocyte and macrophage function and stimulate mast cell mediator release. The human A2B receptor gene is localized on chromosome 17 (17p12-p11.2).