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Aliases for ADORA2A Gene

Aliases for ADORA2A Gene

  • Adenosine A2a Receptor 2 3 5
  • ADORA2 3 4
  • Adenosine Receptor Subtype A2a 3
  • A2aR 3
  • RDC8 3

External Ids for ADORA2A Gene

Previous HGNC Symbols for ADORA2A Gene

  • ADORA2

Previous GeneCards Identifiers for ADORA2A Gene

  • GC22P021519
  • GC22P023148
  • GC22P023153
  • GC22P022997
  • GC22P024813
  • GC22P007773

Summaries for ADORA2A Gene

Entrez Gene Summary for ADORA2A Gene

  • This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily, which is subdivided into classes and subtypes. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein, an adenosine receptor of A2A subtype, uses adenosine as the preferred endogenous agonist and preferentially interacts with the G(s) and G(olf) family of G proteins to increase intracellular cAMP levels. It plays an important role in many biological functions, such as cardiac rhythm and circulation, cerebral and renal blood flow, immune function, pain regulation, and sleep. It has been implicated in pathophysiological conditions such as inflammatory diseases and neurodegenerative disorders. Alternative splicing results in multiple transcript variants. A read-through transcript composed of the upstream SPECC1L (sperm antigen with calponin homology and coiled-coil domains 1-like) and ADORA2A (adenosine A2a receptor) gene sequence has been identified, but it is thought to be non-coding. [provided by RefSeq, Jun 2013]

GeneCards Summary for ADORA2A Gene

ADORA2A (Adenosine A2a Receptor) is a Protein Coding gene. Diseases associated with ADORA2A include acute encephalopathy with biphasic seizures and late reduced diffusion and bruxism. Among its related pathways are Signaling by GPCR and Transport to the Golgi and subsequent modification. GO annotations related to this gene include G-protein coupled receptor activity and protein heterodimerization activity. An important paralog of this gene is ADORA1.

UniProtKB/Swiss-Prot for ADORA2A Gene

  • Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

Tocris Summary for ADORA2A Gene

  • Adenosine A2A receptors are members of the adenosine receptor group of G-protein-coupled receptors that also includes A1, A2B and A3. A2A receptors display high expression levels in the spleen, thymus, leukocytes, blood platelets and the olfactory bulb.

Gene Wiki entry for ADORA2A Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADORA2A Gene

Genomics for ADORA2A Gene

Regulatory Elements for ADORA2A Gene

Genomic Location for ADORA2A Gene

Chromosome:
22
Start:
24,417,879 bp from pter
End:
24,442,360 bp from pter
Size:
24,482 bases
Orientation:
Plus strand

Genomic View for ADORA2A Gene

Genes around ADORA2A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADORA2A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADORA2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADORA2A Gene

Proteins for ADORA2A Gene

  • Protein details for ADORA2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P29274-AA2AR_HUMAN
    Recommended name:
    Adenosine receptor A2a
    Protein Accession:
    P29274
    Secondary Accessions:
    • B2R7E0

    Protein attributes for ADORA2A Gene

    Size:
    412 amino acids
    Molecular mass:
    44707 Da
    Quaternary structure:
    • Interacts (via cytoplasmic C-terminal domain) with USP4; the interaction is direct. May interact with DRD4.
    • Interacts (via cytoplasmic C-terminal domain) with USP4; the interaction is direct. May interact with DRD4.
    SequenceCaution:
    • Sequence=AAA58356.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ADORA2A Gene

neXtProt entry for ADORA2A Gene

Proteomics data for ADORA2A Gene at MOPED

Post-translational modifications for ADORA2A Gene

  • Ubiquitinated. Deubiquitinated by USP4; leading to stabilization and expression at the cell surface.
  • Glycosylation at Asn 154
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for ADORA2A Gene

Domains & Families for ADORA2A Gene

Gene Families for ADORA2A Gene

Suggested Antigen Peptide Sequences for ADORA2A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P29274

UniProtKB/Swiss-Prot:

AA2AR_HUMAN :
  • The cytoplasmic C-terminal domain is necessary for targeting the non-ubiquitinated form of this protein to the cell surface.
  • Belongs to the G-protein coupled receptor 1 family.
Domain:
  • The cytoplasmic C-terminal domain is necessary for targeting the non-ubiquitinated form of this protein to the cell surface.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with ADORA2A: view

Function for ADORA2A Gene

Molecular function for ADORA2A Gene

GENATLAS Biochemistry:
adenosine receptor A2A,mainly expressed in the basal ganglia and immune tissues,G protein coupled receptor superfamily,activating adenylate cyclase
UniProtKB/Swiss-Prot Function:
Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
genes like me logo Genes that share phenotypes with ADORA2A: view

Animal Models for ADORA2A Gene

MGI Knock Outs for ADORA2A:

Animal Model Products

miRNA for ADORA2A Gene

miRTarBase miRNAs that target ADORA2A

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADORA2A Gene

Localization for ADORA2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADORA2A Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADORA2A Gene COMPARTMENTS Subcellular localization image for ADORA2A gene
Compartment Confidence
plasma membrane 5
extracellular 2
mitochondrion 2
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for ADORA2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane TAS 10051547
genes like me logo Genes that share ontologies with ADORA2A: view

Pathways & Interactions for ADORA2A Gene

genes like me logo Genes that share pathways with ADORA2A: view

Gene Ontology (GO) - Biological Process for ADORA2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001973 adenosine receptor signaling pathway IEA --
GO:0006915 apoptotic process TAS 7818494
GO:0006954 inflammatory response TAS 8360491
GO:0006968 cellular defense response TAS 10051547
GO:0007186 G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with ADORA2A: view

No data available for SIGNOR curated interactions for ADORA2A Gene

Drugs & Compounds for ADORA2A Gene

(142) Drugs for ADORA2A Gene - From: IUPHAR, DGIdb, Novoseek, DrugBank, HMDB, PharmGKB, and ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Caffeine Approved Nutra Antagonist, antagonist, Target, multitarget 339
Theophylline Approved Pharma Antagonist, antagonist, Target 56
Adenosine Approved, Investigational Pharma Agonist, agonist, Target 363
Regadenoson Approved Pharma Agonist, Target, agonist 62
Pentoxifylline Approved, Investigational Pharma Target, antagonist 90

(52) Additional Compounds for ADORA2A Gene - From: Novoseek, IUPHAR, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
SCH4421416
Antagonist
XAC
Antagonist
CGS 21680 hydrochloride
124431-80-7
CV 1808
53296-10-9
LUF 5834
333962-91-7
genes like me logo Genes that share compounds with ADORA2A: view

Drug Products

Transcripts for ADORA2A Gene

Unigene Clusters for ADORA2A Gene

Adenosine A2a receptor:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADORA2A Gene

No ASD Table

Relevant External Links for ADORA2A Gene

GeneLoc Exon Structure for
ADORA2A
ECgene alternative splicing isoforms for
ADORA2A

Expression for ADORA2A Gene

mRNA expression in normal human tissues for ADORA2A Gene

mRNA differential expression in normal tissues according to GTEx for ADORA2A Gene

This gene is overexpressed in Liver (x6.2), Whole Blood (x4.7), Brain - Putamen (basal ganglia) (x4.7), and Brain - Nucleus accumbens (basal ganglia) (x4.5).

SOURCE GeneReport for Unigene cluster for ADORA2A Gene Hs.197029

genes like me logo Genes that share expression patterns with ADORA2A: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ADORA2A Gene

Orthologs for ADORA2A Gene

This gene was present in the common ancestor of animals.

Orthologs for ADORA2A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADORA2A 36
  • 100 (a)
OneToOne
ADORA2A 35
  • 99.51 (n)
  • 99.76 (a)
cow
(Bos Taurus)
Mammalia ADORA2A 36
  • 82 (a)
OneToOne
ADORA2A 35
  • 84.44 (n)
  • 83.67 (a)
dog
(Canis familiaris)
Mammalia ADORA2A 35
  • 91.02 (n)
  • 93.2 (a)
ADORA2A 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Adora2a 16
Adora2a 35
  • 84.46 (n)
  • 84.79 (a)
Adora2a 36
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ADORA2A 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 87 (a)
OneToMany
-- 36
  • 71 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Adora2a 35
  • 83.62 (n)
  • 84.29 (a)
chicken
(Gallus gallus)
Aves ADORA2A 35
  • 71.94 (n)
  • 73.99 (a)
ADORA2A 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ADORA2A 36
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia adora2a 35
  • 66.76 (n)
  • 69.44 (a)
zebrafish
(Danio rerio)
Actinopterygii adora2aa 36
  • 56 (a)
OneToOne
adora2ab 35
  • 67.81 (n)
  • 70.19 (a)
fruit fly
(Drosophila melanogaster)
Insecta AdoR 36
  • 18 (a)
OneToMany
CG9753 37
  • 36 (a)
worm
(Caenorhabditis elegans)
Secernentea ador-1 36
  • 24 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11260 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 42 (a)
OneToMany
Species with no ortholog for ADORA2A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADORA2A Gene

ENSEMBL:
Gene Tree for ADORA2A (if available)
TreeFam:
Gene Tree for ADORA2A (if available)

Paralogs for ADORA2A Gene

Paralogs for ADORA2A Gene

genes like me logo Genes that share paralogs with ADORA2A: view

Variants for ADORA2A Gene

Sequence variations from dbSNP and Humsavar for ADORA2A Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
VAR_003451 -
VAR_011835 -
VAR_011836 -

Structural Variations from Database of Genomic Variants (DGV) for ADORA2A Gene

Variant ID Type Subtype PubMed ID
nsv7350 OTHER Inversion 18451855
esv2724041 CNV Deletion 23290073
nsv526567 CNV Gain 19592680
nsv914599 CNV Gain 21882294
nsv914629 CNV Gain 21882294
esv2724068 CNV Deletion 23290073
nsv834160 CNV Gain 17160897
nsv914633 CNV Loss 21882294
nsv9884 CNV Gain+Loss 18304495
nsv914634 CNV Loss 21882294

Variation tolerance for ADORA2A Gene

Residual Variation Intolerance Score: 24.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.66; 45.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADORA2A Gene

HapMap Linkage Disequilibrium report
ADORA2A
Human Gene Mutation Database (HGMD)
ADORA2A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADORA2A Gene

Disorders for ADORA2A Gene

MalaCards: The human disease database

(6) MalaCards diseases for ADORA2A Gene - From: Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
acute encephalopathy with biphasic seizures and late reduced diffusion
  • aesd
bruxism
  • bruxism - teeth grinding
conduct disorder
parkinson disease, late-onset
  • parkinson disease
huntington disease
  • congenital anomalies of kidney and urinary tract 2
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ADORA2A

Genetic Association Database (GAD)
ADORA2A
Human Genome Epidemiology (HuGE) Navigator
ADORA2A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADORA2A
genes like me logo Genes that share disorders with ADORA2A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ADORA2A Gene

Publications for ADORA2A Gene

  1. Association between ADORA2A and DRD2 polymorphisms and caffeine-induced anxiety. (PMID: 18305461) Childs E. … de Wit H. (Neuropsychopharmacology 2008) 3 23 48 67
  2. The 1976C>T polymorphism in the adenosine A2A receptor gene does not affect the vasodilator response to adenosine in humans in vivo. (PMID: 17558310) Riksen N.P. … Rongen G.A. (Pharmacogenet. Genomics 2007) 3 23 25 26
  3. Genetic polymorphism of the adenosine A2A receptor is associated with habitual caffeine consumption. (PMID: 17616786) Cornelis M.C. … Campos H. (Am. J. Clin. Nutr. 2007) 3 23 25 26
  4. A2A adenosine receptor stimulation decreases foam cell formation by enhancing ABCA1-dependent cholesterol efflux. (PMID: 20089670) Bingham T.C. … Cronstein B.N. (J. Leukoc. Biol. 2010) 3 23
  5. Immunomodulatory properties of pentoxifylline are mediated via adenosine-dependent pathways. (PMID: 19997047) Kreth S. … Thiel M. (Shock 2010) 25 26

Products for ADORA2A Gene

Sources for ADORA2A Gene

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