Free for academic non-profit institutions. Other users need a Commercial license

Aliases for NUDCD2 Gene

Aliases for NUDCD2 Gene

  • NudC Domain Containing 2 2 3 5
  • NudC Domain-Containing Protein 2 3
  • NudC-Like Protein 2 3
  • NudCL2 3

External Ids for NUDCD2 Gene

Previous GeneCards Identifiers for NUDCD2 Gene

  • GC05M162800
  • GC05M157980
  • GC05M162880

Summaries for NUDCD2 Gene

GeneCards Summary for NUDCD2 Gene

NUDCD2 (NudC Domain Containing 2) is a Protein Coding gene. Diseases associated with NUDCD2 include Endometrial Disease.

UniProtKB/Swiss-Prot for NUDCD2 Gene

  • May regulate the LIS1/dynein pathway by stabilizing LIS1 with Hsp90 chaperone.

Gene Wiki entry for NUDCD2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUDCD2 Gene

Genomics for NUDCD2 Gene

Regulatory Elements for NUDCD2 Gene

Enhancers for NUDCD2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05G163436 1.1 ENCODE 17.8 +22.1 22113 3.8 PKNOX1 FOXA2 ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 NUDCD2 HMMR HMMR-AS1 LOC105377700 GC05M163448
GH05G163434 1.1 Ensembl ENCODE 11.7 +25.5 25540 0.4 HDAC1 ATF1 YY1 TCF12 GATA2 ELF4 ZEB2 NR2F2 ZNF592 NFIC NUDCD2 HMMR HMMR-AS1 CCNG1 ENSG00000250114
GH05G163457 1.4 ENCODE dbSUPER 8.6 -0.5 -513 6.0 HDGF PKNOX1 CREB3L1 ARNT WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 CCNG1 MAT2B HMMR-AS1 LOC105377700 NUDCD2 HMMR
GH05G163502 1.4 ENCODE dbSUPER 4.7 -46.4 -46355 8.7 HDGF HNRNPUL1 PKNOX1 FOXA2 CREB3L1 ARNT WRNIP1 ARID4B SIN3A DMAP1 MAT2B HMMR CCNG1 NUDCD2 GC05P163619
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NUDCD2 on UCSC Golden Path with GeneCards custom track

Promoters for NUDCD2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000190054 -260 3601 HDGF PKNOX1 CREB3L1 ARNT WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1

Genomic Location for NUDCD2 Gene

Chromosome:
5
Start:
163,446,526 bp from pter
End:
163,460,140 bp from pter
Size:
13,615 bases
Orientation:
Minus strand

Genomic View for NUDCD2 Gene

Genes around NUDCD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUDCD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUDCD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUDCD2 Gene

Proteins for NUDCD2 Gene

  • Protein details for NUDCD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WVJ2-NUDC2_HUMAN
    Recommended name:
    NudC domain-containing protein 2
    Protein Accession:
    Q8WVJ2
    Secondary Accessions:
    • B2R4V0

    Protein attributes for NUDCD2 Gene

    Size:
    157 amino acids
    Molecular mass:
    17676 Da
    Quaternary structure:
    • Interacts with LIS1.

neXtProt entry for NUDCD2 Gene

Post-translational modifications for NUDCD2 Gene

  • Ubiquitination at posLast=6565, posLast=129129, and Lys147
  • Modification sites at PhosphoSitePlus

Other Protein References for NUDCD2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NUDCD2 Gene

Domains & Families for NUDCD2 Gene

Gene Families for NUDCD2 Gene

Protein Domains for NUDCD2 Gene

Suggested Antigen Peptide Sequences for NUDCD2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with NUDCD2: view

No data available for UniProtKB/Swiss-Prot for NUDCD2 Gene

Function for NUDCD2 Gene

Molecular function for NUDCD2 Gene

UniProtKB/Swiss-Prot Function:
May regulate the LIS1/dynein pathway by stabilizing LIS1 with Hsp90 chaperone.

Gene Ontology (GO) - Molecular Function for NUDCD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 23455924
GO:0051082 unfolded protein binding IBA --
genes like me logo Genes that share ontologies with NUDCD2: view

Phenotypes for NUDCD2 Gene

GenomeRNAi human phenotypes for NUDCD2:
genes like me logo Genes that share phenotypes with NUDCD2: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NUDCD2 Gene

Localization for NUDCD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUDCD2 Gene

Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Note=Associates with centrosomes in interphase and to spindle poles and kinetochores during mitosis.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NUDCD2 gene
Compartment Confidence
extracellular 5
cytoskeleton 5
cytosol 5
nucleus 2

Gene Ontology (GO) - Cellular Components for NUDCD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000776 kinetochore IEA --
GO:0000777 condensed chromosome kinetochore IEA --
GO:0000922 spindle pole IEA --
GO:0005622 intracellular IDA --
GO:0005694 chromosome IEA --
genes like me logo Genes that share ontologies with NUDCD2: view

Pathways & Interactions for NUDCD2 Gene

SuperPathways for NUDCD2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NUDCD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding IBA --
GO:0032502 developmental process IBA --
genes like me logo Genes that share ontologies with NUDCD2: view

No data available for Pathways by source and SIGNOR curated interactions for NUDCD2 Gene

Transcripts for NUDCD2 Gene

Unigene Clusters for NUDCD2 Gene

NudC domain containing 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NUDCD2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5
SP1: - -
SP2: -
SP3:

Relevant External Links for NUDCD2 Gene

GeneLoc Exon Structure for
NUDCD2
ECgene alternative splicing isoforms for
NUDCD2

Expression for NUDCD2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NUDCD2 Gene

Protein differential expression in normal tissues from HIPED for NUDCD2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NUDCD2 Gene



Protein tissue co-expression partners for NUDCD2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NUDCD2 Gene:

NUDCD2

SOURCE GeneReport for Unigene cluster for NUDCD2 Gene:

Hs.140443

Evidence on tissue expression from TISSUES for NUDCD2 Gene

  • Liver(4.3)
  • Kidney(4.2)
  • Nervous system(2.5)
genes like me logo Genes that share expression patterns with NUDCD2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NUDCD2 Gene

Orthologs for NUDCD2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NUDCD2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NUDCD2 34 35
  • 99.15 (n)
dog
(Canis familiaris)
Mammalia NUDCD2 34 35
  • 95.12 (n)
cow
(Bos Taurus)
Mammalia NUDCD2 34 35
  • 94.69 (n)
mouse
(Mus musculus)
Mammalia Nudcd2 34 16 35
  • 90.23 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia NUDCD2 35
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nudcd2 34
  • 87.9 (n)
oppossum
(Monodelphis domestica)
Mammalia NUDCD2 35
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves NUDCD2 34 35
  • 81.1 (n)
lizard
(Anolis carolinensis)
Reptilia NUDCD2 35
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nudcd2 34
  • 70.28 (n)
Str.7314 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.33196 34
zebrafish
(Danio rerio)
Actinopterygii nudcd2 34 35
  • 69 (n)
Species where no ortholog for NUDCD2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NUDCD2 Gene

ENSEMBL:
Gene Tree for NUDCD2 (if available)
TreeFam:
Gene Tree for NUDCD2 (if available)

Paralogs for NUDCD2 Gene

No data available for Paralogs for NUDCD2 Gene

Variants for NUDCD2 Gene

Sequence variations from dbSNP and Humsavar for NUDCD2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000057593 -- 163,449,622(+) GAAAA(A/G)GATTT nc-transcript-variant, utr-variant-3-prime
rs1000128828 -- 163,450,799(+) AAATT(C/T)TACTC nc-transcript-variant, utr-variant-3-prime
rs1000146521 -- 163,450,789(+) TATAA(A/C)CTAAA nc-transcript-variant, utr-variant-3-prime
rs1000162278 -- 163,457,244(+) CTCCT(A/G)CCTCA intron-variant
rs1000278532 -- 163,456,773(+) ATCCA(C/T)ACAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NUDCD2 Gene

Variant ID Type Subtype PubMed ID
esv3607453 CNV gain 21293372
nsv1017056 CNV gain 25217958
nsv1018494 CNV gain 25217958
nsv1029437 CNV gain 25217958
nsv830538 CNV gain+loss 17160897

Variation tolerance for NUDCD2 Gene

Residual Variation Intolerance Score: 43.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.08; 1.93% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NUDCD2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NUDCD2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUDCD2 Gene

Disorders for NUDCD2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NUDCD2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
endometrial disease
  • endometrial disorder
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for NUDCD2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NUDCD2
genes like me logo Genes that share disorders with NUDCD2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NUDCD2 Gene

Publications for NUDCD2 Gene

  1. NudC-like protein 2 regulates the LIS1/dynein pathway by stabilizing LIS1 with Hsp90. (PMID: 20133715) Yang Y. … Zhou T. (Proc. Natl. Acad. Sci. U.S.A. 2010) 2 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Proteomic analysis and identification of cellular interactors of the giant ubiquitin ligase HERC2. (PMID: 25476789) Galligan J.T. … Howley P.M. (J. Proteome Res. 2015) 3 64
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3 64
  5. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3 64

Products for NUDCD2 Gene

Sources for NUDCD2 Gene

Content
Loading form....