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Aliases for NUDCD2 Gene

Aliases for NUDCD2 Gene

  • NudC Domain Containing 2 2 3 5

External Ids for NUDCD2 Gene

Previous GeneCards Identifiers for NUDCD2 Gene

  • GC05M162800
  • GC05M157980
  • GC05M162880

Summaries for NUDCD2 Gene

GeneCards Summary for NUDCD2 Gene

NUDCD2 (NudC Domain Containing 2) is a Protein Coding gene. Diseases associated with NUDCD2 include Endometrial Disease.

UniProtKB/Swiss-Prot for NUDCD2 Gene

  • May regulate the LIS1/dynein pathway by stabilizing LIS1 with Hsp90 chaperone.

Gene Wiki entry for NUDCD2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUDCD2 Gene

Genomics for NUDCD2 Gene

Regulatory Elements for NUDCD2 Gene

Enhancers for NUDCD2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NUDCD2 on UCSC Golden Path with GeneCards custom track

Promoters for NUDCD2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NUDCD2 on UCSC Golden Path with GeneCards custom track

Genomic Location for NUDCD2 Gene

163,446,526 bp from pter
163,460,140 bp from pter
13,615 bases
Minus strand

Genomic View for NUDCD2 Gene

Genes around NUDCD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUDCD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUDCD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUDCD2 Gene

Proteins for NUDCD2 Gene

  • Protein details for NUDCD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    NudC domain-containing protein 2
    Protein Accession:
    Secondary Accessions:
    • B2R4V0

    Protein attributes for NUDCD2 Gene

    157 amino acids
    Molecular mass:
    17676 Da
    Quaternary structure:
    • Interacts with LIS1.

neXtProt entry for NUDCD2 Gene

Proteomics data for NUDCD2 Gene at MOPED

Post-translational modifications for NUDCD2 Gene

  • Ubiquitination at Lys 65, Lys 129, and Lys 147
  • Modification sites at PhosphoSitePlus

Other Protein References for NUDCD2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NUDCD2 Gene

Domains & Families for NUDCD2 Gene

Protein Domains for NUDCD2 Gene


Suggested Antigen Peptide Sequences for NUDCD2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 CS domain.
  • Contains 1 CS domain.
genes like me logo Genes that share domains with NUDCD2: view

No data available for Gene Families for NUDCD2 Gene

Function for NUDCD2 Gene

Molecular function for NUDCD2 Gene

UniProtKB/Swiss-Prot Function:
May regulate the LIS1/dynein pathway by stabilizing LIS1 with Hsp90 chaperone.

Phenotypes for NUDCD2 Gene

GenomeRNAi human phenotypes for NUDCD2:
genes like me logo Genes that share phenotypes with NUDCD2: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NUDCD2 Gene

Localization for NUDCD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUDCD2 Gene

Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Note=Associates with centrosomes in interphase and to spindle poles and kinetochores during mitosis.

Subcellular locations from

Jensen Localization Image for NUDCD2 Gene COMPARTMENTS Subcellular localization image for NUDCD2 gene
Compartment Confidence
cytoskeleton 5
extracellular 5
cytosol 4
nucleus 2

Gene Ontology (GO) - Cellular Components for NUDCD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000777 condensed chromosome kinetochore IEA --
GO:0005622 intracellular IDA --
GO:0005737 cytoplasm IDA --
GO:0005815 microtubule organizing center IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with NUDCD2: view

Pathways & Interactions for NUDCD2 Gene

SuperPathways for NUDCD2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NUDCD2 Gene


No data available for Pathways by source and SIGNOR curated interactions for NUDCD2 Gene

Drugs & Compounds for NUDCD2 Gene

No Compound Related Data Available

Transcripts for NUDCD2 Gene

Unigene Clusters for NUDCD2 Gene

NudC domain containing 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NUDCD2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5
SP1: - -
SP2: -

Relevant External Links for NUDCD2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NUDCD2 Gene

mRNA expression in normal human tissues for NUDCD2 Gene

Protein differential expression in normal tissues from HIPED for NUDCD2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NUDCD2 Gene

SOURCE GeneReport for Unigene cluster for NUDCD2 Gene Hs.140443

genes like me logo Genes that share expression patterns with NUDCD2: view

Protein tissue co-expression partners for NUDCD2 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NUDCD2 Gene

Orthologs for NUDCD2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NUDCD2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NUDCD2 35
  • 94.69 (n)
  • 98.73 (a)
  • 99 (a)
(Canis familiaris)
Mammalia NUDCD2 35
  • 95.12 (n)
  • 99.36 (a)
  • 81 (a)
(Mus musculus)
Mammalia Nudcd2 35
  • 90.23 (n)
  • 99.36 (a)
Nudcd2 16
Nudcd2 36
  • 99 (a)
(Pan troglodytes)
Mammalia NUDCD2 35
  • 99.15 (n)
  • 100 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Nudcd2 35
  • 87.9 (n)
  • 98.73 (a)
(Monodelphis domestica)
Mammalia NUDCD2 36
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia NUDCD2 36
  • 89 (a)
(Gallus gallus)
Aves NUDCD2 35
  • 81.1 (n)
  • 87.9 (a)
  • 87 (a)
(Anolis carolinensis)
Reptilia NUDCD2 36
  • 80 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nudcd2 35
  • 70.28 (n)
  • 77.07 (a)
Str.7314 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.33196 35
(Danio rerio)
Actinopterygii nudcd2 35
  • 69 (n)
  • 70.06 (a)
nudcd2 36
  • 70 (a)
Species with no ortholog for NUDCD2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NUDCD2 Gene

Gene Tree for NUDCD2 (if available)
Gene Tree for NUDCD2 (if available)

Paralogs for NUDCD2 Gene

No data available for Paralogs for NUDCD2 Gene

Variants for NUDCD2 Gene

Sequence variations from dbSNP and Humsavar for NUDCD2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1053108 -- 163,453,618(+) CAAAA(A/G)AAAAA utr-variant-3-prime
rs1345742 -- 163,457,239(+) tgatt(C/T)tcctg intron-variant
rs299301 -- 163,454,502(+) atgcc(C/T)ggcta intron-variant
rs7721010 -- 163,456,565(+) acata(C/T)gagat intron-variant
rs411112 -- 163,457,127(-) ATGAA(A/G)AACTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NUDCD2 Gene

Variant ID Type Subtype PubMed ID
nsv830538 CNV Gain+Loss 17160897

Variation tolerance for NUDCD2 Gene

Residual Variation Intolerance Score: 43.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.08; 1.93% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for NUDCD2 Gene

Disorders for NUDCD2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NUDCD2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
endometrial disease
  • endometrial disorder
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for NUDCD2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with NUDCD2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NUDCD2 Gene

Publications for NUDCD2 Gene

  1. NudC-like protein 2 regulates the LIS1/dynein pathway by stabilizing LIS1 with Hsp90. (PMID: 20133715) Yang Y. … Zhou T. (Proc. Natl. Acad. Sci. U.S.A. 2010) 3 4 67
  2. Proteomic analysis and identification of cellular interactors of the giant ubiquitin ligase HERC2. (PMID: 25476789) Galligan J.T. … Howley P.M. (J. Proteome Res. 2015) 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3
  5. A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways. (PMID: 25036637) Taipale M. … Lindquist S. (Cell 2014) 3

Products for NUDCD2 Gene

Sources for NUDCD2 Gene