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Aliases for OR2Y1 Gene

Aliases for OR2Y1 Gene

  • Olfactory Receptor, Family 2, Subfamily Y, Member 1 2 3
  • Olfactory Receptor OR5-2 3 4
  • Olfactory Receptor 2Y1 3
  • OR5-2 3

External Ids for OR2Y1 Gene

Previous GeneCards Identifiers for OR2Y1 Gene

  • GC05U990148
  • GC05M180277
  • GC05M180098
  • GC05M180166

Summaries for OR2Y1 Gene

Entrez Gene Summary for OR2Y1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2Y1 Gene

OR2Y1 (Olfactory Receptor, Family 2, Subfamily Y, Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2C1.

UniProtKB/Swiss-Prot for OR2Y1 Gene

  • Odorant receptor.

Gene Wiki entry for OR2Y1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR2Y1 Gene

Genomics for OR2Y1 Gene

Regulatory Elements for OR2Y1 Gene

Genomic Location for OR2Y1 Gene

Start:
180,739,042 bp from pter
End:
180,740,099 bp from pter
Size:
1,058 bases
Orientation:
Minus strand

Genomic View for OR2Y1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR2Y1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2Y1 Gene

Proteins for OR2Y1 Gene

  • Protein details for OR2Y1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGV0-OR2Y1_HUMAN
    Recommended name:
    Olfactory receptor 2Y1
    Protein Accession:
    Q8NGV0
    Secondary Accessions:
    • B9EIP1
    • Q6IFB1
    • Q96R16

    Protein attributes for OR2Y1 Gene

    Size:
    311 amino acids
    Molecular mass:
    34731 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR2Y1 Gene

Proteomics data for OR2Y1 Gene at MOPED

Post-translational modifications for OR2Y1 Gene

  • Glycosylation at Asn5 and Asn264
  • Modification sites at PhosphoSitePlus

Other Protein References for OR2Y1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR2Y1 Gene

Domains for OR2Y1 Gene

Gene Families for OR2Y1 Gene

HGNC:
  • OR2 :GPCR / Class A : Olfactory receptors

Protein Domains for OR2Y1 Gene

Suggested Antigen Peptide Sequences for OR2Y1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NGV0

UniProtKB/Swiss-Prot:

OR2Y1_HUMAN :
  • Q8NGV0
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2Y1: view

Function for OR2Y1 Gene

Molecular function for OR2Y1 Gene

UniProtKB/Swiss-Prot Function: Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR2Y1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR2Y1: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR2Y1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OR2Y1 Gene

Localization for OR2Y1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2Y1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR2Y1 Gene COMPARTMENTS Subcellular localization image for OR2Y1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2Y1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR2Y1: view

Pathways for OR2Y1 Gene

genes like me logo Genes that share pathways with OR2Y1: view

Pathways by source for OR2Y1 Gene

Interacting Proteins for OR2Y1 Gene

Gene Ontology (GO) - Biological Process for OR2Y1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR2Y1: view

Transcripts for OR2Y1 Gene

mRNA/cDNA for OR2Y1 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR2Y1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for OR2Y1
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR2Y1 Gene

No ASD Table

Relevant External Links for OR2Y1 Gene

GeneLoc Exon Structure for
OR2Y1
ECgene alternative splicing isoforms for
OR2Y1

Expression for OR2Y1 Gene

mRNA expression in normal human tissues for OR2Y1 Gene

SOURCE GeneReport for Unigene cluster for OR2Y1 Gene Hs.554719

genes like me logo Genes that share expressions with OR2Y1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for OR2Y1 Gene

Orthologs for OR2Y1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR2Y1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC471778 35
  • 99.25 (n)
  • 98.71 (a)
OR2Y1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OR2Y1 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 59 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Olfr1385 16
Olfr1386 35
  • 82.74 (n)
  • 83.17 (a)
Olfr1387 36
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 72 (a)
OneToMany
-- 36
  • 71 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia OR2Y1 36
  • 54 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Olr1394 35
  • 81.88 (n)
  • 82.52 (a)
Species with no ortholog for OR2Y1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR2Y1 Gene

ENSEMBL:
Gene Tree for OR2Y1 (if available)
TreeFam:
Gene Tree for OR2Y1 (if available)

Paralogs for OR2Y1 Gene

Paralogs for OR2Y1 Gene

Selected SIMAP similar genes for OR2Y1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR2Y1: view

Variants for OR2Y1 Gene

Sequence variations from dbSNP and Humsavar for OR2Y1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs1463602 -- 180,740,388(-) TATTG(C/T)ATTTG upstream-variant-2KB
rs2054696 -- 180,738,983(-) ggtgg(C/G)ggggg downstream-variant-500B
rs5873710 -- 180,741,238(+) TAGTG(-/TCTT)TCTTT upstream-variant-2KB
rs6879842 -- 180,740,197(+) TGTGT(C/T)TGGTG upstream-variant-2KB
rs6885920 -- 180,741,466(+) CAAAA(A/C)GTCTA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR2Y1 Gene

Variant ID Type Subtype PubMed ID
nsv830565 CNV Loss 17160897
dgv1882e1 CNV Complex 17122850
nsv517459 CNV Gain 19592680

Relevant External Links for OR2Y1 Gene

HapMap Linkage Disequilibrium report
OR2Y1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR2Y1 Gene

Disorders for OR2Y1 Gene

Relevant External Links for OR2Y1

Genetic Association Database (GAD)
OR2Y1
genes like me logo Genes that share disorders with OR2Y1: view

No data available for UniProtKB/Swiss-Prot for OR2Y1 Gene

Publications for OR2Y1 Gene

  1. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 3 4
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4
  3. Linkage and genome-wide association analysis of obesity-related phenotypes: association of weight with the MGAT1 gene. (PMID: 19851299) Johansson A. … Gyllensten U. (Obesity (Silver Spring) 2010) 48
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for OR2Y1 Gene

Sources for OR2Y1 Gene

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