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Aliases for PPARGC1B Gene

Aliases for PPARGC1B Gene

  • Peroxisome Proliferator-Activated Receptor Gamma, Coactivator 1 Beta 2 3
  • PGC1B 3 4 6
  • PERC 3 4 6
  • PGC-1-Related Estrogen Receptor Alpha Coactivator 3 4
  • PPAR-Gamma Coactivator 1-Beta 3 4
  • PPARGC-1-Beta 3 4
  • Peroxisome Proliferative Activated Receptor, Gamma, Coactivator 1, Beta 2
  • Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-Beta 3
  • PGC-1(Beta) 3
  • PGC-1-Beta 4
  • PPARGC1 4
  • ERRL1 3
  • PGC1 4

External Ids for PPARGC1B Gene

Previous GeneCards Identifiers for PPARGC1B Gene

  • GC05P149138
  • GC05P149090
  • GC05P149109
  • GC05P144256

Summaries for PPARGC1B Gene

Entrez Gene Summary for PPARGC1B Gene

  • The protein encoded by this gene stimulates the activity of several transcription factors and nuclear receptors, including estrogen receptor alpha, nuclear respiratory factor 1, and glucocorticoid receptor. The encoded protein may be involved in fat oxidation, non-oxidative glucose metabolism, and the regulation of energy expenditure. This protein is downregulated in prediabetic and type 2 diabetes mellitus patients. Certain allelic variations in this gene increase the risk of the development of obesity. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]

GeneCards Summary for PPARGC1B Gene

PPARGC1B (Peroxisome Proliferator-Activated Receptor Gamma, Coactivator 1 Beta) is a Protein Coding gene. Diseases associated with PPARGC1B include obesity. Among its related pathways are Regulation of Cholesterol Biosynthesis by SREBP (SREBF) and Metabolism. GO annotations related to this gene include RNA binding and ligand-dependent nuclear receptor transcription coactivator activity. An important paralog of this gene is PPARGC1A.

UniProtKB/Swiss-Prot for PPARGC1B Gene

  • Plays a role of stimulator of transcription factors and nuclear receptors activities. Activates transcritional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids. May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as suggested by increased basal oxygen consumption and mitochondrial number when overexpressed. May be involved in fat oxidation and non-oxidative glucose metabolism and in the regulation of energy expenditure. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner.

Gene Wiki entry for PPARGC1B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPARGC1B Gene

Genomics for PPARGC1B Gene

Regulatory Elements for PPARGC1B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PPARGC1B Gene

Start:
149,730,252 bp from pter
End:
149,855,022 bp from pter
Size:
124,771 bases
Orientation:
Plus strand

Genomic View for PPARGC1B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PPARGC1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPARGC1B Gene

Proteins for PPARGC1B Gene

  • Protein details for PPARGC1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86YN6-PRGC2_HUMAN
    Recommended name:
    Peroxisome proliferator-activated receptor gamma coactivator 1-beta
    Protein Accession:
    Q86YN6
    Secondary Accessions:
    • A2RUM8
    • A2RUN0
    • B3KVW0
    • Q86YN3
    • Q86YN4
    • Q86YN5
    • Q8N1N9
    • Q8TDE4
    • Q8TDE5

    Protein attributes for PPARGC1B Gene

    Size:
    1023 amino acids
    Molecular mass:
    113222 Da
    Quaternary structure:
    • Interacts with hepatocyte nuclear factor 4-alpha/HNF4A, Sterol regulatory binding transcription factor 1/SREBF1, PPAR-alpha/PPARA, thyroid hormone receptor beta/THRB and host cell factor/HCFC1. Interacts with estrogen-related receptor gamma/ESRRG and alpha/ESRRA. Interacts with PRDM16 (By similarity). Interacts with estrogen receptor alpha/ESR1.

    Three dimensional structures from OCA and Proteopedia for PPARGC1B Gene

    Alternative splice isoforms for PPARGC1B Gene

neXtProt entry for PPARGC1B Gene

Proteomics data for PPARGC1B Gene at MOPED

Post-translational modifications for PPARGC1B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PPARGC1B Gene

Antibody Products

No data available for DME Specific Peptides for PPARGC1B Gene

Domains for PPARGC1B Gene

Gene Families for PPARGC1B Gene

HGNC:
  • RBM :RNA binding motif (RRM) containing

Protein Domains for PPARGC1B Gene

Graphical View of Domain Structure for InterPro Entry

Q86YN6

UniProtKB/Swiss-Prot:

PRGC2_HUMAN :
  • Q86YN6
Domain:
  • Contains 2 Leu-Xaa-Xaa-Leu-Leu (LXXLL) motif, which are usually required for the association with nuclear receptors.
  • Contains 1 RRM (RNA recognition motif) domain.
genes like me logo Genes that share domains with PPARGC1B: view

Function for PPARGC1B Gene

Molecular function for PPARGC1B Gene

UniProtKB/Swiss-Prot Function:
Plays a role of stimulator of transcription factors and nuclear receptors activities. Activates transcritional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids. May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as suggested by increased basal oxygen consumption and mitochondrial number when overexpressed. May be involved in fat oxidation and non-oxidative glucose metabolism and in the regulation of energy expenditure. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner.
UniProtKB/Swiss-Prot Induction:
Repressed by saturated fatty acids such as palmitate and stearate in skeletal muscle cells. Induced by insulin and reduced by aging in skeletal muscle biopsies. Down-regulated in type 2 diabetes mellitus subjects as well as in pre-diabetics.

Gene Ontology (GO) - Molecular Function for PPARGC1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0001104 RNA polymerase II transcription cofactor activity IDA 11854298
GO:0003676 nucleic acid binding --
GO:0003723 RNA binding NAS 11854298
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with PPARGC1B: view
genes like me logo Genes that share phenotypes with PPARGC1B: view

Animal Models for PPARGC1B Gene

MGI Knock Outs for PPARGC1B:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PPARGC1B

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for PPARGC1B Gene

Localization for PPARGC1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPARGC1B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPARGC1B Gene COMPARTMENTS Subcellular localization image for PPARGC1B gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 2

Gene Ontology (GO) - Cellular Components for PPARGC1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 11854298
GO:0005654 nucleoplasm TAS --
GO:0005739 mitochondrion IEA --
GO:0016592 mediator complex IDA 11854298
genes like me logo Genes that share ontologies with PPARGC1B: view

Pathways for PPARGC1B Gene

genes like me logo Genes that share pathways with PPARGC1B: view

PCR Array Products

Gene Ontology (GO) - Biological Process for PPARGC1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001503 ossification IEA --
GO:0006355 regulation of transcription, DNA-templated IDA 23836911
GO:0006366 transcription from RNA polymerase II promoter IDA 11854298
GO:0006390 transcription from mitochondrial promoter IEA --
GO:0006996 organelle organization TAS --
genes like me logo Genes that share ontologies with PPARGC1B: view

Compounds for PPARGC1B Gene

(2) Novoseek inferred chemical compound relationships for PPARGC1B Gene

Compound -log(P) Hits PubMed IDs
fructose 47.3 1
fatty acid 33.6 1
genes like me logo Genes that share compounds with PPARGC1B: view

Transcripts for PPARGC1B Gene

Unigene Clusters for PPARGC1B Gene

Peroxisome proliferator-activated receptor gamma, coactivator 1 beta:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PPARGC1B

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPARGC1B Gene

No ASD Table

Relevant External Links for PPARGC1B Gene

GeneLoc Exon Structure for
PPARGC1B
ECgene alternative splicing isoforms for
PPARGC1B

Expression for PPARGC1B Gene

mRNA expression in normal human tissues for PPARGC1B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for PPARGC1B Gene Hs.483816

mRNA Expression by UniProt/SwissProt for PPARGC1B Gene

Q86YN6-PRGC2_HUMAN
Tissue specificity: Ubiquitous with higher expression in heart, brain and skeletal muscle.
genes like me logo Genes that share expressions with PPARGC1B: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Expression partners for PPARGC1B Gene

Orthologs for PPARGC1B Gene

This gene was present in the common ancestor of animals.

Orthologs for PPARGC1B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PPARGC1B 35
  • 86.24 (n)
  • 84.36 (a)
PPARGC1B 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PPARGC1B 35
  • 88.33 (n)
  • 86.43 (a)
PPARGC1B 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ppargc1b 35
  • 82.74 (n)
  • 79.5 (a)
Ppargc1b 16
Ppargc1b 36
  • 73 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PPARGC1B 35
  • 99.48 (n)
  • 99.32 (a)
PPARGC1B 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ppargc1b 35
  • 81.91 (n)
  • 78.4 (a)
oppossum
(Monodelphis domestica)
Mammalia PPARGC1B 36
  • 55 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PPARGC1B 36
  • 57 (a)
OneToOne
chicken
(Gallus gallus)
Aves PPARGC1B 35
  • 64.07 (n)
  • 55.3 (a)
PPARGC1B 36
  • 45 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PPARGC1B 36
  • 46 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ppargc1b 35
  • 55.31 (n)
  • 50.29 (a)
Str.17645 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.20150 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
ppargc1b 35
  • 52.88 (n)
  • 43.08 (a)
ppargc1b 36
  • 31 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Spargel 36
  • 11 (a)
OneToMany
Species with no ortholog for PPARGC1B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PPARGC1B Gene

ENSEMBL:
Gene Tree for PPARGC1B (if available)
TreeFam:
Gene Tree for PPARGC1B (if available)

Paralogs for PPARGC1B Gene

Paralogs for PPARGC1B Gene

genes like me logo Genes that share paralogs with PPARGC1B: view

Variants for PPARGC1B Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for PPARGC1B Gene

Q86YN6-PRGC2_HUMAN
Variation of PPARGC1B may contribute to the pathogenesis of obesity, with a widespread Ala-203 allele being a risk factor for the development of this common disorders

Sequence variations from dbSNP and Humsavar for PPARGC1B Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs25846 -- 149,851,167(+) TGACG(C/T)GGGAG utr-variant-3-prime
rs25847 -- 149,848,366(-) CCTCC(A/C)CTGGA utr-variant-3-prime
rs26119 -- 149,852,744(+) TTAGG(A/C)GCTTT utr-variant-3-prime
rs26120 -- 149,852,650(-) CATTC(A/G)GATTA utr-variant-3-prime
rs26121 -- 149,852,267(-) TCACA(C/T)AGCAA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for PPARGC1B Gene

Variant ID Type Subtype PubMed ID
nsv5060 CNV Loss 18451855
esv32926 CNV Gain 17666407
nsv5061 CNV Insertion 18451855
esv2730909 CNV Deletion 23290073
esv1706104 CNV Deletion 17803354
esv2730910 CNV Deletion 23290073
nsv462482 CNV Loss 19166990
nsv462484 CNV Loss 19166990
nsv883024 CNV Gain 21882294
dgv727n27 CNV Gain 19166990
esv24664 CNV Gain+Loss 19812545

Relevant External Links for PPARGC1B Gene

HapMap Linkage Disequilibrium report
PPARGC1B
Human Gene Mutation Database (HGMD)
PPARGC1B

Disorders for PPARGC1B Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for PPARGC1B Gene in MalaCards »

(1) Diseases for PPARGC1B Gene including...

(1) OMIM Diseases for PPARGC1B Gene (608886)

(1) Novoseek inferred disease relationships for PPARGC1B Gene

Disease -log(P) Hits PubMed IDs
obesity 12.8 3

Relevant External Links for PPARGC1B

Genetic Association Database (GAD)
PPARGC1B
Human Genome Epidemiology (HuGE) Navigator
PPARGC1B
genes like me logo Genes that share disorders with PPARGC1B: view

No data available for UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for PPARGC1B Gene

Publications for PPARGC1B Gene

  1. The PGC-1-related protein PERC is a selective coactivator of estrogen receptor alpha. (PMID: 11854298) Kressler D. … Kralli A. (J. Biol. Chem. 2002) 2 3 4 23
  2. Evidence of an association between genetic variation of the coactivator PGC-1beta and obesity. (PMID: 15863669) Andersen G. … Pedersen O. (J. Med. Genet. 2005) 3 4 23 48
  3. Impact of the peroxisome proliferator activated receptor-gamma coactivator-1beta (PGC-1beta) Ala203Pro polymorphism on in vivo metabolism, PGC-1beta expression and fibre type composition in human skeletal muscle. (PMID: 17579828) Ling C. … Poulsen P. (Diabetologia 2007) 3 23 48
  4. Mutation analysis of peroxisome proliferator-activated receptor-gamma coactivator-1 (PGC-1) and relationships of identified amino acid polymorphisms to Type II diabetes mellitus. (PMID: 11793024) Ek J. … Pedersen O. (Diabetologia 2001) 2 3
  5. Associations of genetic variants in the estrogen receptor coactivators PPARGC1A, PPARGC1B and EP300 with familial breast cancer. (PMID: 16704985) Wirtenberger M. … Burwinkel B. (Carcinogenesis 2006) 3 48

Products for PPARGC1B Gene

Sources for PPARGC1B Gene

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