Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ADM Gene

Aliases for ADM Gene

  • Adrenomedullin 2 3 5
  • AM 3 4
  • Proadrenomedullin N-20 Terminal Peptide 3
  • Preproadrenomedullin 3
  • PAMP 3

External Ids for ADM Gene

Previous GeneCards Identifiers for ADM Gene

  • GC11P011338
  • GC11P010896
  • GC11P010365
  • GC11P010290
  • GC11P010283
  • GC11P009999

Summaries for ADM Gene

Entrez Gene Summary for ADM Gene

  • The protein encoded by this gene is a preprohormone which is cleaved to form two biologically active peptides, adrenomedullin and proadrenomedullin N-terminal 20 peptide. Adrenomedullin is a 52 aa peptide with several functions, including vasodilation, regulation of hormone secretion, promotion of angiogenesis, and antimicrobial activity. The antimicrobial activity is antibacterial, as the peptide has been shown to kill E. coli and S. aureus at low concentration. [provided by RefSeq, Aug 2014]

GeneCards Summary for ADM Gene

ADM (Adrenomedullin) is a Protein Coding gene. Diseases associated with ADM include pheochromocytoma and adrenomyeloneuropathy. Among its related pathways are Signaling by GPCR and HIF-1-alpha transcription factor network. GO annotations related to this gene include receptor binding and adrenomedullin receptor binding.

UniProtKB/Swiss-Prot for ADM Gene

  • AM and PAMP are potent hypotensive and vasodilatator agents. Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, am is diuretic and natriuretic, and both am and pamp inhibit aldosterone secretion by direct adrenal actions. In pituitary gland, both peptides at physiologically relevant doses inhibit basal ACTH secretion. Both peptides appear to act in brain and pituitary gland to facilitate the loss of plasma volume, actions which complement their hypotensive effects in blood vessels.

Gene Wiki entry for ADM Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADM Gene

Genomics for ADM Gene

Regulatory Elements for ADM Gene

Promoters for ADM Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ADM on UCSC Golden Path with GeneCards custom track

Genomic Location for ADM Gene

Chromosome:
11
Start:
10,304,680 bp from pter
End:
10,307,402 bp from pter
Size:
2,723 bases
Orientation:
Plus strand

Genomic View for ADM Gene

Genes around ADM on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADM Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADM Gene

Proteins for ADM Gene

  • Protein details for ADM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35318-ADML_HUMAN
    Recommended name:
    ADM
    Protein Accession:
    P35318
    Secondary Accessions:
    • B2R793
    • D3DQV3
    • Q6FGW2

    Protein attributes for ADM Gene

    Size:
    185 amino acids
    Molecular mass:
    20420 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ADM Gene

neXtProt entry for ADM Gene

Proteomics data for ADM Gene at MOPED

Post-translational modifications for ADM Gene

  • Glycosylation at Thr 54, Thr 66, Tyr 125, Ser 178, and Ser 180
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for ADM (Adrenomedullin/ADM)

No data available for DME Specific Peptides for ADM Gene

Domains & Families for ADM Gene

Gene Families for ADM Gene

Protein Domains for ADM Gene

Suggested Antigen Peptide Sequences for ADM Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P35318

UniProtKB/Swiss-Prot:

ADML_HUMAN :
  • Belongs to the adrenomedullin family.
Family:
  • Belongs to the adrenomedullin family.
genes like me logo Genes that share domains with ADM: view

Function for ADM Gene

Molecular function for ADM Gene

GENATLAS Biochemistry:
adrenomedullin downregulated by cMyc
UniProtKB/Swiss-Prot Function:
AM and PAMP are potent hypotensive and vasodilatator agents. Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, am is diuretic and natriuretic, and both am and pamp inhibit aldosterone secretion by direct adrenal actions. In pituitary gland, both peptides at physiologically relevant doses inhibit basal ACTH secretion. Both peptides appear to act in brain and pituitary gland to facilitate the loss of plasma volume, actions which complement their hypotensive effects in blood vessels.

Gene Ontology (GO) - Molecular Function for ADM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005179 hormone activity IEA --
genes like me logo Genes that share ontologies with ADM: view
genes like me logo Genes that share phenotypes with ADM: view

Animal Models for ADM Gene

MGI Knock Outs for ADM:

Animal Model Products

miRNA for ADM Gene

miRTarBase miRNAs that target ADM

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADM Gene

Localization for ADM Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADM Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADM Gene COMPARTMENTS Subcellular localization image for ADM gene
Compartment Confidence
extracellular 5
cytosol 3
nucleus 3
cytoskeleton 2
plasma membrane 2
endoplasmic reticulum 1
lysosome 1
mitochondrion 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for ADM Gene

Pathways & Interactions for ADM Gene

genes like me logo Genes that share pathways with ADM: view

Gene Ontology (GO) - Biological Process for ADM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001570 vasculogenesis IDA 16964401
GO:0001666 response to hypoxia IEA --
GO:0001843 neural tube closure IEA --
GO:0001878 NOT response to yeast IDA 10225288
GO:0002026 regulation of the force of heart contraction IEA --
genes like me logo Genes that share ontologies with ADM: view

No data available for SIGNOR curated interactions for ADM Gene

Drugs & Compounds for ADM Gene

(50) Drugs for ADM Gene - From: Novoseek, HMDB, and PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Paroxetine Approved, Investigational Pharma Inhibition, Inhibitor 221
Aldosterone Experimental Pharma Agonist 0

(62) Additional Compounds for ADM Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ADM: view

Transcripts for ADM Gene

Unigene Clusters for ADM Gene

Adrenomedullin:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADM Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d · 4e
SP1: - -
SP2: -
SP3: - -
SP4: - -
SP5:
SP6:

Relevant External Links for ADM Gene

GeneLoc Exon Structure for
ADM
ECgene alternative splicing isoforms for
ADM

Expression for ADM Gene

mRNA expression in normal human tissues for ADM Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADM Gene

This gene is overexpressed in Whole Blood (x4.8).

Protein differential expression in normal tissues from HIPED for ADM Gene

This gene is overexpressed in Adipocyte (51.0) and Peripheral blood mononuclear cells (18.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ADM Gene



SOURCE GeneReport for Unigene cluster for ADM Gene Hs.441047

mRNA Expression by UniProt/SwissProt for ADM Gene

P35318-ADML_HUMAN
Tissue specificity: Highest levels found in pheochromocytoma and adrenal medulla. Also found in lung, ventricle and kidney tissues.
genes like me logo Genes that share expression patterns with ADM: view

Protein tissue co-expression partners for ADM Gene

Primer Products

In Situ Assay Products

Orthologs for ADM Gene

This gene was present in the common ancestor of chordates.

Orthologs for ADM Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADM 36
  • 100 (a)
OneToOne
ADM 35
  • 100 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia ADM 35
  • 84.29 (n)
  • 87.93 (a)
bta-mir-6518 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ADM 36
  • 82 (a)
OneToOne
ADM 35
  • 86.74 (n)
  • 86.36 (a)
mouse
(Mus musculus)
Mammalia Adm 35
  • 75.29 (n)
  • 69.54 (a)
Adm 16
Adm 36
  • 66 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ADM 36
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ADM 36
  • 51 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Adm 35
  • 78.48 (n)
  • 73.71 (a)
chicken
(Gallus gallus)
Aves ADM 36
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia adm 35
  • 56.55 (n)
  • 46.21 (a)
Str.12882 35
zebrafish
(Danio rerio)
Actinopterygii adma 36
  • 28 (a)
OneToOne
Species with no ortholog for ADM:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ADM Gene

ENSEMBL:
Gene Tree for ADM (if available)
TreeFam:
Gene Tree for ADM (if available)

Paralogs for ADM Gene

No data available for Paralogs for ADM Gene

Variants for ADM Gene

Sequence variations from dbSNP and Humsavar for ADM Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
VAR_014861 -
VAR_048205 -

Structural Variations from Database of Genomic Variants (DGV) for ADM Gene

Variant ID Type Subtype PubMed ID
nsv483076 CNV Complex 15286789

Variation tolerance for ADM Gene

Residual Variation Intolerance Score: 54% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.38; 54.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADM Gene

HapMap Linkage Disequilibrium report
ADM
Human Gene Mutation Database (HGMD)
ADM

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADM Gene

Disorders for ADM Gene

MalaCards: The human disease database

(14) MalaCards diseases for ADM Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
pheochromocytoma
  • pheochromocytoma, modifier of
adrenomyeloneuropathy
  • amn
acute pyelonephritis
  • acute pyelonephritis nos
pulmonary hypertension
  • primary pulmonary hypertension
ectopic pregnancy
  • eccyesis
- elite association - COSMIC cancer census association via MalaCards
Search ADM in MalaCards View complete list of genes associated with diseases

Relevant External Links for ADM

Genetic Association Database (GAD)
ADM
Human Genome Epidemiology (HuGE) Navigator
ADM
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADM
genes like me logo Genes that share disorders with ADM: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ADM Gene

Publications for ADM Gene

  1. Cloning and characterization of cDNA encoding a precursor for human adrenomedullin. (PMID: 7688224) Kitamura K. … Eto T. (Biochem. Biophys. Res. Commun. 1993) 2 3 4 67
  2. Adrenomedullin is increased in alveolar macrophages and released from the lungs into the circulation in severe heart failure. (PMID: 19823891) A9ie E. … Attramadal H. (Basic Res. Cardiol. 2010) 3 23
  3. Adrenomedullin protects against hypoxia/reoxygenation-induced cell death by suppression of reactive oxygen species via thiol redox systems. (PMID: 19932100) Kim S.M. … Park J.H. (FEBS Lett. 2010) 3 23
  4. Adrenomedullin and endothelin-1 are related to inflammation in chronic heart failure. (PMID: 19212702) Gombos T. … ProhA!szka Z. (Inflamm. Res. 2009) 3 23
  5. Expression of adrenomedullin in human ovaries, ovarian sex cord-stromal tumors and cultured granulosa-luteal cells. (PMID: 19253104) Liu J. … Voutilainen R. (Gynecol. Endocrinol. 2009) 3 23

Products for ADM Gene

Sources for ADM Gene

Back to Top

Content