Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SPATA18 Gene

Aliases for SPATA18 Gene

  • Spermatogenesis Associated 18 2 3
  • Spermatogenesis-Associated Protein 18 3 4
  • SPETEX1 3 6
  • Mieap 3 4
  • Spermatogenesis Associated 18 Homolog (Rat) 2
  • Spermatogenesis Associated 18 Homolog 3
  • Mitochondria-Eating Protein 3

External Ids for SPATA18 Gene

Summaries for SPATA18 Gene

GeneCards Summary for SPATA18 Gene

SPATA18 (Spermatogenesis Associated 18) is a Protein Coding gene.

UniProtKB/Swiss-Prot for SPATA18 Gene

  • Key regulator of mitochondrial quality that mediates the repairing or degradation of unhealthy mitochondria in response to mitochondrial damage. Mediator of mitochondrial protein catabolic process (also named MALM) by mediating the degradation of damaged proteins inside mitochondria by promoting the accumulation in the mitochondrial matrix of hydrolases that are characteristic of the lysosomal lumen. Also involved in mitochondrion degradation of damaged mitochondria by promoting the formation of vacuole-like structures (named MIV), which engulf and degrade unhealthy mitochondria by accumulating lysosomes. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPATA18 Gene

Genomics for SPATA18 Gene

Genomic Location for SPATA18 Gene

Start:
52,051,331 bp from pter
End:
52,097,295 bp from pter
Size:
45,965 bases
Orientation:
Plus strand

Genomic View for SPATA18 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SPATA18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPATA18 Gene

Regulatory Elements for SPATA18 Gene

Proteins for SPATA18 Gene

  • Protein details for SPATA18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TC71-MIEAP_HUMAN
    Recommended name:
    Mitochondria-eating protein
    Protein Accession:
    Q8TC71
    Secondary Accessions:
    • B4E2R0
    • E5RLK1
    • Q8IY48
    • Q8N7D7

    Protein attributes for SPATA18 Gene

    Size:
    538 amino acids
    Molecular mass:
    61109 Da
    Quaternary structure:
    • Interacts (via coiled-coil domains) with BNIP3L (via BH3 domain). Interacts (via coiled-coil domains) with BNIP3 (via BH3 domain).
    SequenceCaution:
    • Sequence=BAC05356.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for SPATA18 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SPATA18 Gene

Proteomics data for SPATA18 Gene at MOPED

Post-translational modifications for SPATA18 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SPATA18 Gene

No data available for DME Specific Peptides for SPATA18 Gene

Domains for SPATA18 Gene

Protein Domains for SPATA18 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

MIEAP_HUMAN
Family:
  • Belongs to the MIEAP family.:
    • Q8TC71
genes like me logo Genes that share domains with SPATA18: view

No data available for Gene Families for SPATA18 Gene

Function for SPATA18 Gene

Molecular function for SPATA18 Gene

UniProtKB/Swiss-Prot Function: Key regulator of mitochondrial quality that mediates the repairing or degradation of unhealthy mitochondria in response to mitochondrial damage. Mediator of mitochondrial protein catabolic process (also named MALM) by mediating the degradation of damaged proteins inside mitochondria by promoting the accumulation in the mitochondrial matrix of hydrolases that are characteristic of the lysosomal lumen. Also involved in mitochondrion degradation of damaged mitochondria by promoting the formation of vacuole-like structures (named MIV), which engulf and degrade unhealthy mitochondria by accumulating lysosomes. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix.
UniProtKB/Swiss-Prot Induction: By p53/TP53 and p63/TP63. Directly activated by p53/TP53.

Gene Ontology (GO) - Molecular Function for SPATA18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21264221
genes like me logo Genes that share ontologies with SPATA18: view

miRNA for SPATA18 Gene

miRTarBase miRNAs that target SPATA18

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SPATA18 Gene

Localization for SPATA18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPATA18 Gene

Cytoplasm. Mitochondrion outer membrane. Note=Localizes to the cytoplasm under normal conditions. Relocalizes to mitochondrion outer membrane following cellular stress. Colocalizes with BNIP3 and BNIP3L at the mitochondrion outer membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SPATA18 Gene COMPARTMENTS Subcellular localization image for SPATA18 gene
Compartment Confidence
mitochondrion 5
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for SPATA18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 21264221
GO:0005741 mitochondrial outer membrane IDA 21264221
GO:0036126 sperm flagellum IEA --
GO:0043231 intracellular membrane-bounded organelle IDA 21264228
genes like me logo Genes that share ontologies with SPATA18: view

Pathways for SPATA18 Gene

SuperPathways for SPATA18 Gene

No Data Available

Interacting Proteins for SPATA18 Gene

Selected Interacting proteins: Q8TC71-MIEAP_HUMAN for SPATA18 Gene via I2D

Symbol External ID(s) Details
PRKCI
TRAF2

Gene Ontology (GO) - Biological Process for SPATA18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006974 cellular response to DNA damage stimulus IDA 21264221
GO:0033554 cellular response to stress --
GO:0035694 mitochondrial protein catabolic process IMP 21264221
GO:0035695 mitochondrion degradation by induced vacuole formation IMP 21264228
genes like me logo Genes that share ontologies with SPATA18: view

No data available for Pathways by source for SPATA18 Gene

Transcripts for SPATA18 Gene

Unigene Clusters for SPATA18 Gene

Spermatogenesis associated 18:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SPATA18 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13
SP1: - - -
SP2: - -
SP3:
SP4: - - - -
SP5: - - - - -
SP6: -
SP7: - - - - - - - - - -
SP8: - - - - - -
SP9:

Relevant External Links for SPATA18 Gene

GeneLoc Exon Structure for
SPATA18
ECgene alternative splicing isoforms for
SPATA18

Expression for SPATA18 Gene

mRNA expression in normal human tissues for SPATA18 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SPATA18 Gene

This gene is overexpressed in Testis (11.8).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SPATA18 Gene

SOURCE GeneReport for Unigene cluster for SPATA18 Gene Hs.527090

genes like me logo Genes that share expressions with SPATA18: view

Orthologs for SPATA18 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SPATA18 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SPATA18 36
  • 99.07 (n)
  • 98.14 (a)
SPATA18 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SPATA18 36
  • 86.01 (n)
  • 80.97 (a)
SPATA18 37
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SPATA18 36
  • 85.23 (n)
  • 82.5 (a)
SPATA18 37
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Spata18 36
  • 77.65 (n)
  • 73.14 (a)
Spata18 16
Spata18 37
  • 71 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SPATA18 37
  • 52 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SPATA18 37
  • 36 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Spata18 36
  • 75.87 (n)
  • 70.67 (a)
chicken
(Gallus gallus)
Aves SPATA18 36
  • 59.27 (n)
  • 50.51 (a)
SPATA18 37
  • 40 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SPATA18 37
  • 51 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia spata18 36
  • 60.27 (n)
  • 55.88 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4160 36
zebrafish
(Danio rerio)
Actinopterygii Dr.13864 36
spata18 36
  • 57.68 (n)
  • 51.85 (a)
spata18 37
  • 52 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1722 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3999 37
  • 45 (a)
OneToOne
Species with no ortholog for SPATA18:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SPATA18 Gene

ENSEMBL:
Gene Tree for SPATA18 (if available)
TreeFam:
Gene Tree for SPATA18 (if available)

Paralogs for SPATA18 Gene

No data available for Paralogs for SPATA18 Gene

Variants for SPATA18 Gene

Sequence variations from dbSNP and Humsavar for SPATA18 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs711347 -- 52,060,050(+) tcttg(A/T)ggctc intron-variant
rs784942 -- 52,055,288(+) GGAAA(C/G)TTCTT intron-variant
rs784943 -- 52,057,039(+) CCTCA(C/T)CAGAG intron-variant
rs784944 -- 52,061,063(+) CAGGT(A/G)GAGAT intron-variant
rs999634 -- 52,060,947(+) TAAAA(A/C)GAATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SPATA18 Gene

Variant ID Type Subtype PubMed ID
nsv829932 CNV Gain 17160897
nsv879011 CNV Gain 21882294
nsv829933 CNV Gain 17160897
esv259487 OTHER Complex 20981092
esv260070 OTHER Complex 20981092
esv7897 CNV Gain 19470904
esv1364839 CNV Insertion 17803354

Relevant External Links for SPATA18 Gene

HapMap Linkage Disequilibrium report
SPATA18

Disorders for SPATA18 Gene

Relevant External Links for SPATA18

Genetic Association Database (GAD)
SPATA18
Human Genome Epidemiology (HuGE) Navigator
SPATA18
genes like me logo Genes that share disorders with SPATA18: view

No data available for UniProtKB/Swiss-Prot for SPATA18 Gene

Publications for SPATA18 Gene

  1. SPATA18, a spermatogenesis-associated gene, is a novel transcriptional target of p53 and p63. (PMID: 21300779) Bornstein C. … Rotter V. (Mol. Cell. Biol. 2011) 2 3 4
  2. BNIP3 and NIX mediate Mieap-induced accumulation of lysosomal proteins within mitochondria. (PMID: 22292033) Nakamura Y. … Arakawa H. (PLoS ONE 2012) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Possible existence of lysosome-like organella within mitochondria and its role in mitochondrial quality control. (PMID: 21264221) Miyamoto Y. … Arakawa H. (PLoS ONE 2011) 3 4

Products for SPATA18 Gene

Sources for SPATA18 Gene

Back to Top

Content