Aliases for SPATA18 Gene
Aliases for SPATA18 Gene
External Ids for SPATA18 Gene
- HGNC: 29579
- Entrez Gene: 132671
- Ensembl: ENSG00000163071
- OMIM: 612814
- UniProtKB: Q8TC71
Previous GeneCards Identifiers for SPATA18 Gene
- GC04P052759
- GC04P052612
- GC04P052917
- GC04P048859
Summaries for SPATA18 Gene
GeneCards Summary for SPATA18 Gene
SPATA18 (Spermatogenesis Associated 18) is a Protein Coding gene.
UniProtKB/Swiss-Prot for SPATA18 Gene
-
Key regulator of mitochondrial quality that mediates the repairing or degradation of unhealthy mitochondria in response to mitochondrial damage. Mediator of mitochondrial protein catabolic process (also named MALM) by mediating the degradation of damaged proteins inside mitochondria by promoting the accumulation in the mitochondrial matrix of hydrolases that are characteristic of the lysosomal lumen. Also involved in mitochondrion degradation of damaged mitochondria by promoting the formation of vacuole-like structures (named MIV), which engulf and degrade unhealthy mitochondria by accumulating lysosomes. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix.
No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPATA18 Gene
Genomics for SPATA18 Gene
Regulatory Elements for SPATA18 Gene
Enhancers for SPATA18 Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around SPATA18 on UCSC Golden Path with GeneCards custom track
Promoters for SPATA18 Gene
| Ensembl Regulatory Elements (ENSRs) | TSS Distance (bp) | Size (bp) | Binding Sites for Transcription Factors within promoters |
|---|
ENSRs around SPATA18 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the SPATA18 gene promoter:
Regulatory Element Products
Genomic Location for SPATA18 Gene
- Chromosome:
- 4
- Start:
- 52,051,331 bp from pter
- End:
- 52,097,305 bp from pter
- Size:
- 45,975 bases
- Orientation:
- Plus strand
Genomic View for SPATA18 Gene
Genes around SPATA18 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 4q12 by Ensembl
- 4q12 by Entrez Gene
- 4q11 by HGNC
SPATA18 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SPATA18 Gene
Proteins for SPATA18 Gene
-
Protein details for SPATA18 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8TC71-MIEAP_HUMAN
- Recommended name:
- Mitochondria-eating protein
- Protein Accession:
- Q8TC71
- B4E2R0
- E5RLK1
- Q8IY48
- Q8N7D7
Protein attributes for SPATA18 Gene
- Size:
- 538 amino acids
- Molecular mass:
- 61109 Da
- Quaternary structure:
-
- Interacts (via coiled-coil domains) with BNIP3L (via BH3 domain). Interacts (via coiled-coil domains) with BNIP3 (via BH3 domain).
- SequenceCaution:
-
- Sequence=BAC05356.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Protein Expression for SPATA18 Gene
Post-translational modifications for SPATA18 Gene
Other Protein References for SPATA18 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for SPATA18
-
Custom Antibody ServicesOriGene Antibodies for SPATA18
- Novus Biologicals Antibodies for SPATA18
- Abcam antibodies for Spata18
- antibodies-online Antibodies for SPATA18: See all 26
- GeneTex SPATA18 antibody for SPATA18
-
Custom Antibody ServicesProSci Antibodies for SPATA18
-
Santa Cruz Biotechnology (SCBT) Antibodies for SPATA18
Protein Products
-
OriGene Purified Proteins for SPATA18
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- Origene Custom Protein Services for SPATA18
- antibodies-online Proteins for SPATA18: See all 7
- Search antibodies-online for peptides
- Search GeneTex for Proteins for SPATA18
Assay Products
- antibodies-online Kits for SPATA18: See all 6
No data available for DME Specific Peptides for SPATA18 Gene
Domains & Families for SPATA18 Gene
Suggested Antigen Peptide Sequences for SPATA18 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q8TC71- Family:
-
- Belongs to the MIEAP family.
No data available for Gene Families for SPATA18 Gene
Function for SPATA18 Gene
Molecular function for SPATA18 Gene
- UniProtKB/Swiss-Prot Function:
- Key regulator of mitochondrial quality that mediates the repairing or degradation of unhealthy mitochondria in response to mitochondrial damage. Mediator of mitochondrial protein catabolic process (also named MALM) by mediating the degradation of damaged proteins inside mitochondria by promoting the accumulation in the mitochondrial matrix of hydrolases that are characteristic of the lysosomal lumen. Also involved in mitochondrion degradation of damaged mitochondria by promoting the formation of vacuole-like structures (named MIV), which engulf and degrade unhealthy mitochondria by accumulating lysosomes. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix.
- UniProtKB/Swiss-Prot Induction:
- By p53/TP53 and p63/TP63. Directly activated by p53/TP53.
Phenotypes for SPATA18 Gene
- GenomeRNAi human phenotypes for SPATA18:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for SPATA18 gene
-
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- Search ViGene Biosciences for SPATA18
CRISPR Products
-
OriGene CRISPR knockouts for SPATA18
-
Santa Cruz Biotechnology (SCBT) CRISPR for SPATA18
- GenScript: Design CRISPR guide RNA sequences for SPATA18
miRNA for SPATA18 Gene
- miRTarBase miRNAs that target SPATA18
-
- hsa-mir-335-5p (MIRT017774)
- hsa-mir-510-3p (MIRT545163)
- hsa-mir-203a-3p (MIRT545164)
- hsa-mir-7977 (MIRT545165)
- hsa-mir-4726-3p (MIRT545166)
- hsa-mir-6764-5p (MIRT545167)
- hsa-mir-1915-3p (MIRT545168)
- hsa-mir-6840-3p (MIRT545169)
- hsa-mir-665 (MIRT545170)
- hsa-mir-4768-3p (MIRT545171)
- hsa-mir-3938 (MIRT545172)
- hsa-mir-6888-5p (MIRT545174)
miRNA Products
- Search ViGene Biosciences for SPATA18
Inhibitory RNA Products
- Origene siRNA, shRNA, rat_shrna, and RNAi products in human, mouse, rat for SPATA18
- Browse OriGene Inhibitory RNA Products For SPATA18
-
ViGene Biosciences ready-to-package AAV shRNAs for SPATA18 gene
Clone Products
- OriGene clones in human for SPATA18
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- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for SPATA18 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for SPATA18 gene
-
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SPATA18 Gene
Localization for SPATA18 Gene
Subcellular locations from UniProtKB/Swiss-Prot for SPATA18 Gene
- Cytoplasm. Mitochondrion outer membrane. Note=Localizes to the cytoplasm under normal conditions (PubMed:21264228). Relocalizes to mitochondrion outer membrane following cellular stress. Colocalizes with BNIP3 and BNIP3L at the mitochondrion outer membrane (PubMed:22292033). {ECO:0000269 PubMed:21264228, ECO:0000269 PubMed:22292033}.
| Compartment | Confidence |
|---|---|
| mitochondrion | 5 |
| cytosol | 2 |
| lysosome | 2 |
| nucleus | 2 |
| vacuole | 1 |
No data available for Gene Ontology (GO) - Cellular Components for SPATA18 Gene
Pathways & Interactions for SPATA18 Gene
More details on SuperPathways for SPATA18
No Data Available
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0033554 | cellular response to stress | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for SPATA18 Gene
Transcripts for SPATA18 Gene
mRNA/cDNA for SPATA18 Gene
- (9) REFSEQ mRNAs :
- (8) Additional mRNA sequences :
- (71) Selected AceView cDNA sequences:
- (10) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for SPATA18 Gene
CRISPR Products
-
OriGene CRISPR knockouts for SPATA18
-
Santa Cruz Biotechnology (SCBT) CRISPR for SPATA18
- GenScript: Design CRISPR guide RNA sequences for SPATA18
miRNA Products
- Search ViGene Biosciences for SPATA18
Inhibitory RNA Products
- Origene siRNA, shRNA, rat_shrna, and RNAi products in human, mouse, rat for SPATA18
- Browse OriGene Inhibitory RNA Products For SPATA18
-
ViGene Biosciences ready-to-package AAV shRNAs for SPATA18 gene
Clone Products
- OriGene clones in human for SPATA18
- OriGene ORF clones in human,mouse,rat for SPATA18
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- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | · | 6d | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP9: |
Expression for SPATA18 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
mRNA differential expression in normal tissues according to GTEx for SPATA18 Gene
This gene is overexpressed in Testis (x11.8).
This gene is overexpressed in Nasal epithelium (63.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SPATA18 Gene
SOURCE GeneReport for Unigene cluster for SPATA18 Gene Hs.527090
Primer Products
-
OriGene qPCR primer pairs for SPATA18
-
OriGene qPCR primer pairs and template standards for SPATA18
No data available for mRNA Expression by UniProt/SwissProt for SPATA18 Gene
Orthologs for SPATA18 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | SPATA18 35 |
|
||
| SPATA18 36 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | SPATA18 35 |
|
||
| SPATA18 36 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Spata18 35 |
|
||
| Spata18 16 |
|
||||
| Spata18 36 |
|
OneToOne | |||
| chimpanzee (Pan troglodytes) |
Mammalia | SPATA18 35 |
|
||
| SPATA18 36 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | Spata18 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | SPATA18 36 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | SPATA18 36 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | SPATA18 35 |
|
||
| SPATA18 36 |
|
OneToOne | |||
| lizard (Anolis carolinensis) |
Reptilia | SPATA18 36 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | spata18 35 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | Dr.13864 35 |
|
||
| spata18 35 |
|
||||
| spata18 36 |
|
OneToOne | |||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.4160 35 |
|
||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.1722 35 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.3999 36 |
|
OneToOne |
- Species with no ortholog for SPATA18:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for SPATA18 Gene
No data available for Paralogs for SPATA18 Gene
Variants for SPATA18 Gene
| SNP ID | Clin | Chr 04 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs3860707 | - | 52,072,077(+) | CCATG(C/T)CCGAT | nc-transcript-variant, reference, missense | |
| rs11558773 | - | 52,082,479(-) | CTCCC(C/T)TCATA | intron-variant, nc-transcript-variant, reference, missense | |
| rs784942 | -- | 52,055,288(+) | GGAAA(C/G)TTCTT | intron-variant | |
| rs784943 | -- | 52,057,039(+) | CCTCA(C/T)CAGAG | intron-variant | |
| rs784944 | -- | 52,061,063(+) | CAGGT(A/G)GAGAT | intron-variant |
Residual Variation Intolerance Score:
92.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.35;
53.76% of all genes are more intolerant (likely to be disease-causing)
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SPATA18 Gene
Disorders for SPATA18 Gene
Relevant External Links for SPATA18
No disorders were found for SPATA18 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPATA18 Gene
Publications for SPATA18 Gene
- SPATA18, a spermatogenesis-associated gene, is a novel transcriptional target of p53 and p63. (PMID: 21300779) Bornstein C. … Rotter V. (Mol. Cell. Biol. 2011) 2 3 4 67
- A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3
- BNIP3 and NIX mediate Mieap-induced accumulation of lysosomal proteins within mitochondria. (PMID: 22292033) Nakamura Y. … Arakawa H. (PLoS ONE 2012) 3
- Charting the landscape of tandem BRCT domain-mediated protein interactions. (PMID: 22990118) Woods N.T. … Monteiro A.N. (Sci Signal 2012) 3
- Possible existence of lysosome-like organella within mitochondria and its role in mitochondrial quality control. (PMID: 21264221) Miyamoto Y. … Arakawa H. (PLoS ONE 2011) 3
Products for SPATA18 Gene
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- Browse R&D Systems for biochemical assays
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- Custom Antibody ServicesOriGene Antibodies for SPATA18
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- OriGene Purified Proteins for SPATA18
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- OriGene qPCR primer pairs for SPATA18
- OriGene qPCR primer pairs and template standards for SPATA18
- OriGene CRISPR knockouts for SPATA18
- OriGene clones in human for SPATA18
- OriGene ORF clones in human,mouse,rat for SPATA18
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- Novus Biologicals Antibodies for SPATA18
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- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- antibodies-online Antibodies for SPATA18: See all 26
- antibodies-online Kits for SPATA18: See all 6
- antibodies-online Proteins for SPATA18: See all 7
- Search antibodies-online for peptides
- GeneTex SPATA18 antibody for SPATA18
- Search GeneTex for Proteins for SPATA18
- ViGene Biosciences adenoviral particle packaged cDNA for SPATA18 gene
- ViGene Biosciences lentiviral particle packaged cDNA for SPATA18 gene
- ViGene Biosciences lentiviral particle packaged cDNA for SPATA18 gene
- ViGene Biosciences ready-to-package AAV shRNAs for SPATA18 gene
- ViGene Biosciences ready-to-package AAV shRNAs for SPATA18 gene
- ViGene Biosciences ready-to-package AAV shRNAs for SPATA18 gene
- Search ViGene Biosciences for SPATA18
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- Santa Cruz Biotechnology (SCBT) Antibodies for SPATA18
- Search Santa Cruz Biotechnology (SCBT) for SPATA18 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for SPATA18
- Custom Antibody ServicesProSci Antibodies for SPATA18
Sources for SPATA18 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
- (61) MILLIPORE
- (62) miRBase
- (63) DME
- (64) Nature
- (65) NCBI
- (66) OriGene
- (67) PubMed
- (68) R&D Systems
- (69) Salk
- (70) TGDB
- (71) Tufts
- (72) YEDA
- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
- (87) neXtProt
- (88) Reactome
- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
- (91) DISEASES
- (92) SIMAP
- (93) GenomeRNAi
- (94) LifeMap
- (95) miRTarBase
- (96) MalaCards
- (97) Invitrogen
- (98) BitterDB
- (99) Vector BioLabs
- (100) ESI-BIO
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- (102) BioSystems
- (103) MaxQB
- (104) IUPHAR
- (105) BioGPS
- (106) Illumina
- (107) COMPARTMENTS
- (108) HOMER
- (109) PaxDb
- (110) ApexBio
- (111) Addgene
- (112) Advanced Cell Diagnostics
- (113) antibodies-online
- (114) CYP
- (115) NONCODE
- (116) SwitchGear Genomics
- (117) TreeFam
- (118) PathCards
- (119) GeneReviews
- (120) GeneTex
- (121) Taconic Biosciences
- (122) GTEx
- (123) ProteomicsDB
- (124) SCBT
- (125) DGIdb
- (126) ClinicalTrials
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- (130) diseasecard
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- (135) Disease Ontology
- (136) Genetics Home Reference
- (137) MeSH
- (138) MedlinePlus
- (139) CDC
- (140) NINDS
- (141) NCBI Bookshelf
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- (143) Gene Damage Index
- (144) ViGene Biosciences
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- (146) UDN
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- (148) FANTOM5
- (149) ENCODE
- (150) ProSci
- (151) Horizon