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Aliases for SLC31A1 Gene

Aliases for SLC31A1 Gene

  • Solute Carrier Family 31 (Copper Transporter), Member 1 2 3
  • COPT1 3 4 6
  • CTR1 3 4 6
  • Solute Carrier Family 31 Member 1 3 4
  • Copper Transporter 1 3 4
  • Solute Carrier Family 31 (Copper Transporters), Member 1 3
  • Copper Transport 1 Homolog (S. Cerevisiae) 2
  • High Affinity Copper Uptake Protein 1 3
  • Copper Transport 1 Homolog 3
  • HCTR1 4

External Ids for SLC31A1 Gene

Previous HGNC Symbols for SLC31A1 Gene

  • COPT1

Previous GeneCards Identifiers for SLC31A1 Gene

  • GC09P106782
  • GC09P107716
  • GC09P109437
  • GC09P111359
  • GC09P113063
  • GC09P115023
  • GC09P115983
  • GC09P085591

Summaries for SLC31A1 Gene

Entrez Gene Summary for SLC31A1 Gene

  • The protein encoded by this gene is a high-affinity copper transporter found in the cell membrane. The encoded protein functions as a homotrimer to effect the uptake of dietary copper. [provided by RefSeq, Aug 2011]

GeneCards Summary for SLC31A1 Gene

SLC31A1 (Solute Carrier Family 31 (Copper Transporter), Member 1) is a Protein Coding gene. Diseases associated with SLC31A1 include ethylmalonic encephalopathy and wilson disease. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Mineral absorption. GO annotations related to this gene include copper ion transmembrane transporter activity. An important paralog of this gene is SLC31A2.

UniProtKB/Swiss-Prot for SLC31A1 Gene

  • High-affinity, saturable copper transporter involved in dietary copper uptake.

Gene Wiki entry for SLC31A1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC31A1 Gene

Genomics for SLC31A1 Gene

Regulatory Elements for SLC31A1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SLC31A1 Gene

Start:
113,221,528 bp from pter
End:
113,264,492 bp from pter
Size:
42,965 bases
Orientation:
Plus strand

Genomic View for SLC31A1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC31A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC31A1 Gene

Proteins for SLC31A1 Gene

  • Protein details for SLC31A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15431-COPT1_HUMAN
    Recommended name:
    High affinity copper uptake protein 1
    Protein Accession:
    O15431
    Secondary Accessions:
    • A8K8Z6
    • Q53GR5
    • Q5T1M4

    Protein attributes for SLC31A1 Gene

    Size:
    190 amino acids
    Molecular mass:
    21091 Da
    Quaternary structure:
    • Homotrimer.

    Three dimensional structures from OCA and Proteopedia for SLC31A1 Gene

neXtProt entry for SLC31A1 Gene

Proteomics data for SLC31A1 Gene at MOPED

Post-translational modifications for SLC31A1 Gene

  • O-Glycosylation at Thr-27 protects from proteolytic cleavage in the N-terminal extracellular domain.
  • Glycosylation at Asn15 and Thr27
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC31A1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC31A1 Gene

Domains for SLC31A1 Gene

Gene Families for SLC31A1 Gene

Protein Domains for SLC31A1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC31A1 Gene

Graphical View of Domain Structure for InterPro Entry

O15431

UniProtKB/Swiss-Prot:

COPT1_HUMAN :
  • O15431
Family:
  • Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.
genes like me logo Genes that share domains with SLC31A1: view

Function for SLC31A1 Gene

Molecular function for SLC31A1 Gene

GENATLAS Biochemistry: solute carrier family 31,copper uptake transport,high affinity,homolog to yeast ctr1,see D9S262,ubiquitously expressed
UniProtKB/Swiss-Prot Function: High-affinity, saturable copper transporter involved in dietary copper uptake.

Gene Ontology (GO) - Molecular Function for SLC31A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005375 copper ion transmembrane transporter activity TAS 9207117
GO:0005515 protein binding --
GO:0015088 copper uptake transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with SLC31A1: view
genes like me logo Genes that share phenotypes with SLC31A1: view

Animal Models for SLC31A1 Gene

MGI Knock Outs for SLC31A1:

Animal Model Products

CRISPR Products

miRNA for SLC31A1 Gene

miRTarBase miRNAs that target SLC31A1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC31A1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SLC31A1 Gene

Localization for SLC31A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC31A1 Gene

Cell membrane; Multi-pass membrane protein. Note=Localizes to the apical membrane in intestinal epithelial cells. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC31A1 Gene COMPARTMENTS Subcellular localization image for SLC31A1 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 1
cytosol 1
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for SLC31A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005770 late endosome IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 9207117
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with SLC31A1: view

Pathways for SLC31A1 Gene

genes like me logo Genes that share pathways with SLC31A1: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for SLC31A1 Gene

Gene Ontology (GO) - Biological Process for SLC31A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006825 copper ion transport TAS 9207117
GO:0006855 drug transmembrane transport IEA --
GO:0006878 cellular copper ion homeostasis IEA --
GO:0015677 copper ion import --
GO:0035434 copper ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC31A1: view

Compounds for SLC31A1 Gene

(1) HMDB Compounds for SLC31A1 Gene

Compound Synonyms Cas Number PubMed IDs
Copper
  • Cu
7440-50-8

(4) Drugbank Compounds for SLC31A1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Bortezomib
179324-69-7 transporter inhibitor
Carboplatin
  • CBDCA
41575-94-4 transporter substrate
Cisplatin
  • CDDP
15663-27-1 transporter substrate
Oxaliplatin
  • Diaminocyclohexane Oxalatoplatinum
61825-94-3 transporter substrate

(6) Novoseek inferred chemical compound relationships for SLC31A1 Gene

Compound -log(P) Hits PubMed IDs
copper 82.5 109
oxaliplatin 72.9 2
cisplatin 71.6 43
platinum 70.8 8
carboplatin 63.8 2

(2) PharmGKB related drug/compound annotations for SLC31A1 Gene

Drug/compound Annotation
carboplatin CA
cisplatin CA
genes like me logo Genes that share compounds with SLC31A1: view

Transcripts for SLC31A1 Gene

mRNA/cDNA for SLC31A1 Gene

Unigene Clusters for SLC31A1 Gene

Solute carrier family 31 (copper transporters), member 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC31A1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC31A1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6
SP1: - -
SP2: -
SP3: - - -
SP4:

Relevant External Links for SLC31A1 Gene

GeneLoc Exon Structure for
SLC31A1
ECgene alternative splicing isoforms for
SLC31A1

Expression for SLC31A1 Gene

mRNA expression in normal human tissues for SLC31A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC31A1 Gene

This gene is overexpressed in Liver (6.0).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for SLC31A1 Gene

SOURCE GeneReport for Unigene cluster for SLC31A1 Gene Hs.532315

genes like me logo Genes that share expressions with SLC31A1: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for SLC31A1 Gene

Orthologs for SLC31A1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC31A1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC31A1 35
  • 99.82 (n)
  • 100 (a)
SLC31A1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC31A1 35
  • 90.81 (n)
  • 94.59 (a)
SLC31A1 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC31A1 35
  • 91.36 (n)
  • 93.12 (a)
SLC31A1 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc31a1 35
  • 90.96 (n)
  • 93.09 (a)
Slc31a1 16
Slc31a1 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC31A1 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC31A1 36
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc31a1 35
  • 90.88 (n)
  • 93.3 (a)
chicken
(Gallus gallus)
Aves SLC31A1 35
  • 77.66 (n)
  • 84.62 (a)
SLC31A1 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC31A1 36
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.1914 35
zebrafish
(Danio rerio)
Actinopterygii Dr.6847 35
slc31a1 35
  • 72.19 (n)
  • 80.47 (a)
slc31a1 36
  • 73 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Ctr1A 35
  • 56.44 (n)
  • 50 (a)
Ctr1A 36
  • 34 (a)
ManyToMany
Ctr1B 36
  • 33 (a)
ManyToMany
Ctr1C 36
  • 21 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CTR2 38
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3417 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8961 36
  • 44 (a)
OneToOne
Species with no ortholog for SLC31A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC31A1 Gene

ENSEMBL:
Gene Tree for SLC31A1 (if available)
TreeFam:
Gene Tree for SLC31A1 (if available)

Paralogs for SLC31A1 Gene

Paralogs for SLC31A1 Gene

Pseudogenes.org Pseudogenes for SLC31A1 Gene

genes like me logo Genes that share paralogs with SLC31A1: view

Variants for SLC31A1 Gene

Sequence variations from dbSNP and Humsavar for SLC31A1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs1141501 -- 113,252,547(-) ctttg(C/G)gaggc intron-variant
rs1143245 -- 113,263,975(+) CATGT(C/G)ATTTA utr-variant-3-prime
rs1804960 -- 113,261,006(+) ctgta(A/G)tccca utr-variant-3-prime
rs2233915 - 113,256,221(+) ATCAC(C/G)CAACC reference, missense
rs2233916 -- 113,258,856(+) CAAAA(C/G)TGTTG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for SLC31A1 Gene

Variant ID Type Subtype PubMed ID
dgv2412e1 CNV Complex 17122850
dgv2416e1 CNV Complex 17122850
nsv893744 CNV Gain 21882294
nsv893745 CNV Loss 21882294
nsv893746 CNV Gain 21882294

Relevant External Links for SLC31A1 Gene

HapMap Linkage Disequilibrium report
SLC31A1
Human Gene Mutation Database (HGMD)
SLC31A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC31A1 Gene

Disorders for SLC31A1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for SLC31A1 Gene including...

Search for SLC31A1 Gene in MalaCards »

(5) Novoseek inferred disease relationships for SLC31A1 Gene

Disease -log(P) Hits PubMed IDs
wilson disease 60.4 1
ovarian carcinoma 51.4 6
tumors 18.4 7
ovarian cancer 3.94 4
prostate cancer 0 2
genes like me logo Genes that share disorders with SLC31A1: view

No data available for UniProtKB/Swiss-Prot for SLC31A1 Gene

Publications for SLC31A1 Gene

  1. hCTR1: a human gene for copper uptake identified by complementation in yeast. (PMID: 9207117) Zhou B. … Gitschier J. (Proc. Natl. Acad. Sci. U.S.A. 1997) 2 3 4 23
  2. Enhanced delivery of cisplatin to intraperitoneal ovarian carcinomas mediated by the effects of bortezomib on the human copper transporter 1. (PMID: 19147760) Jandial D.D. … Howell S.B. (Clin. Cancer Res. 2009) 3 23 25
  3. Protein kinase inhibitors emodin and dichloro-ribofuranosylbenzimidazole modulate the cellular accumulation and cytotoxicity of cisplatin in a schedule-dependent manner. (PMID: 19529937) Kurokawa T. … Siddik Z.H. (Cancer Chemother. Pharmacol. 2010) 3 23 25
  4. The N-terminus of the human copper transporter 1 (hCTR1) is localized extracellularly, and interacts with itself. (PMID: 12466020) Klomp A.E. … Klomp L.W. (Biochem. J. 2003) 3 23
  5. Copper-stimulated endocytosis and degradation of the human copper transporter, hCtr1. (PMID: 12501239) Petris M.J. … Thiele D.J. (J. Biol. Chem. 2003) 3 23

Products for SLC31A1 Gene

  • antibodies-online peptides for SLC31A1
  • antibodies-online antibodies for SLC31A1
  • antibodies-online kits for SLC31A1

Sources for SLC31A1 Gene

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