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Aliases for OR9A4 Gene

Aliases for OR9A4 Gene

  • Olfactory Receptor Family 9 Subfamily A Member 4 2 3 5
  • Olfactory Receptor, Family 9, Subfamily A, Member 4 2
  • Olfactory Receptor OR7-1 4

External Ids for OR9A4 Gene

Previous GeneCards Identifiers for OR9A4 Gene

  • GC07U990309
  • GC07P141026
  • GC07P141071
  • GC07P141265
  • GC07P141619
  • GC07P141622
  • GC07P142619
  • GC07P142928
  • GC07P143072
  • GC07P143221
  • GC07P143416
  • GC07P143567

Summaries for OR9A4 Gene

Entrez Gene Summary for OR9A4 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR9A4 Gene

OR9A4 (Olfactory Receptor Family 9 Subfamily A Member 4) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR9A2.

UniProtKB/Swiss-Prot for OR9A4 Gene

  • Odorant receptor.

Gene Wiki entry for OR9A4 Gene

Additional gene information for OR9A4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR9A4 Gene

Genomics for OR9A4 Gene

Regulatory Elements for OR9A4 Gene

Enhancers for OR9A4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07H141960 1.3 FANTOM5 Ensembl ENCODE 13.1 +87.5 87516 0 ZBED1 JUNB CEBPG ATF2 IKZF1 ETV6 ATF7 RUNX3 IKZF2 CREM CLEC5A WEE2-AS1 OR9A4 TAS2R38
GH07H141944 1.1 FANTOM5 Ensembl ENCODE 13.9 +72.3 72322 2 CTCF POLR2A MAX MYC CLEC5A WEE2-AS1 OR9A4 TAS2R38 OR9N1P
GH07H141074 0.9 ENCODE 14.6 -798.9 -798914 0 ZSCAN4 SIN3A ZNF76 ZNF2 ZNF391 EGR2 YY2 ELF1 REST ZEB2 RNU4-74P TMEM178B CCT4P1 OR9A4 WEE2-AS1 ENSG00000261778
GH07H141955 0.7 Ensembl ENCODE 13.4 +82.8 82802 0 POLR2A MAX MYC OR9A4 CLEC5A TAS2R38
GH07H141915 0.6 ENCODE 15.2 +42.3 42304 1 PKNOX1 POLR2A BACH1 MNT FOS NFE2 SPI1 WEE2-AS1 OR9A4 CLEC5A OR9N1P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OR9A4 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR9A4 Gene

Chromosome:
7
Start:
141,873,479 bp from pter
End:
141,986,420 bp from pter
Size:
112,942 bases
Orientation:
Plus strand

Genomic View for OR9A4 Gene

Genes around OR9A4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR9A4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR9A4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR9A4 Gene

Proteins for OR9A4 Gene

  • Protein details for OR9A4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGU2-OR9A4_HUMAN
    Recommended name:
    Olfactory receptor 9A4
    Protein Accession:
    Q8NGU2
    Secondary Accessions:
    • B9EGV6
    • Q6IFI4

    Protein attributes for OR9A4 Gene

    Size:
    314 amino acids
    Molecular mass:
    35758 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR9A4 Gene

Post-translational modifications for OR9A4 Gene

  • Glycosylation at Asn4 and posLast=190190
  • Modification sites at PhosphoSitePlus

Other Protein References for OR9A4 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR9A4 Gene

Domains & Families for OR9A4 Gene

Gene Families for OR9A4 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR9A4 Gene

Suggested Antigen Peptide Sequences for OR9A4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NGU2

UniProtKB/Swiss-Prot:

OR9A4_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR9A4: view

Function for OR9A4 Gene

Molecular function for OR9A4 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR9A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR9A4: view
genes like me logo Genes that share phenotypes with OR9A4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for OR9A4
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR9A4 Gene

Localization for OR9A4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR9A4 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR9A4 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR9A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR9A4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR9A4 Gene

Pathways & Interactions for OR9A4 Gene

genes like me logo Genes that share pathways with OR9A4: view

Pathways by source for OR9A4 Gene

Interacting Proteins for OR9A4 Gene

Gene Ontology (GO) - Biological Process for OR9A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR9A4: view

No data available for SIGNOR curated interactions for OR9A4 Gene

Drugs & Compounds for OR9A4 Gene

No Compound Related Data Available

Transcripts for OR9A4 Gene

mRNA/cDNA for OR9A4 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR9A4 Gene

Olfactory receptor, family 9, subfamily A, member 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for OR9A4
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for OR9A4 Gene

No ASD Table

Relevant External Links for OR9A4 Gene

GeneLoc Exon Structure for
OR9A4
ECgene alternative splicing isoforms for
OR9A4

Expression for OR9A4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR9A4 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR9A4 Gene:

OR9A4

SOURCE GeneReport for Unigene cluster for OR9A4 Gene:

Hs.690171
genes like me logo Genes that share expression patterns with OR9A4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR9A4 Gene

Orthologs for OR9A4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR9A4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC472536 33
  • 99.15 (n)
OR9A4 34
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 34
  • 89 (a)
OneToMany
-- 34
  • 89 (a)
OneToMany
LOC100855949 33
  • 86.62 (n)
-- 34
  • 85 (a)
OneToMany
-- 34
  • 85 (a)
OneToMany
cow
(Bos Taurus)
Mammalia OR9A4 33 34
  • 86.84 (n)
mouse
(Mus musculus)
Mammalia Or9a4 52 Olfr460 33 16 34
  • 84.39 (n)
rat
(Rattus norvegicus)
Mammalia Olr799 33
  • 84.18 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 69 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii or101-1 34
  • 35 (a)
OneToMany
Species where no ortholog for OR9A4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OR9A4 Gene

ENSEMBL:
Gene Tree for OR9A4 (if available)
TreeFam:
Gene Tree for OR9A4 (if available)

Paralogs for OR9A4 Gene

Paralogs for OR9A4 Gene

(440) SIMAP similar genes for OR9A4 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for OR9A4 Gene

genes like me logo Genes that share paralogs with OR9A4: view

Variants for OR9A4 Gene

Sequence variations from dbSNP and Humsavar for OR9A4 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1002289540 -- 141,920,142(+) ATAGA(C/G)TAGTG downstream-variant-500B
rs1004248973 -- 141,917,623(+) CAGAG(C/G)ATAAG upstream-variant-2KB
rs1004280106 -- 141,917,368(+) ATACC(G/T)GAATG upstream-variant-2KB
rs1005305076 -- 141,918,843(+) CTCTC(C/T)AGATT upstream-variant-2KB
rs1011085162 -- 141,918,104(+) TAACC(A/G)TGCCT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR9A4 Gene

Variant ID Type Subtype PubMed ID
nsv5974 CNV deletion 18451855
nsv831161 CNV loss 17160897

Variation tolerance for OR9A4 Gene

Residual Variation Intolerance Score: 73.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.53; 44.19% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR9A4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR9A4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR9A4 Gene

Disorders for OR9A4 Gene

Relevant External Links for OR9A4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR9A4

No disorders were found for OR9A4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR9A4 Gene

Publications for OR9A4 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 60
  2. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer SW … Tsui LC (Science (New York, N.Y.) 2003) 3 4 60
  3. Genetic variants associated with disordered eating. (PMID: 23568457) Wade TD … Martin NG (The International journal of eating disorders 2013) 3 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 60
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 60

Products for OR9A4 Gene

Sources for OR9A4 Gene

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