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Aliases for KLF17 Gene

Aliases for KLF17 Gene

  • Kruppel Like Factor 17 2 3 5
  • Zinc Finger Protein 393 2 3 4
  • ZNF393 3 4
  • Novel Zinc-Finger Protein 3
  • Krueppel-Like Factor 17 3
  • Zfp393 3

External Ids for KLF17 Gene

Previous HGNC Symbols for KLF17 Gene

  • ZNF393

Previous GeneCards Identifiers for KLF17 Gene

  • GC01P044357
  • GC01P044584
  • GC01P042699

Summaries for KLF17 Gene

GeneCards Summary for KLF17 Gene

KLF17 (Kruppel Like Factor 17) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription regulatory region DNA binding. An important paralog of this gene is KLF18.

UniProtKB/Swiss-Prot for KLF17 Gene

  • Transcription repressor that binds to the promoter of target genes and prevents their expression. Acts as a negative regulator of epithelial-mesenchymal transition and metastasis in breast cancer. Specifically binds the 5-CACCC-3 sequence in the promoter of ID1, a key metastasis regulator in breast cancer, and repress its expression. May be a germ cell-specific transcription factor that plays important roles in spermatid differentiation and oocyte development (By similarity).

Gene Wiki entry for KLF17 Gene

Additional gene information for KLF17 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLF17 Gene

Genomics for KLF17 Gene

Regulatory Elements for KLF17 Gene

Enhancers for KLF17 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H044034 2.1 VISTA Ensembl ENCODE dbSUPER 5.2 -7.7 -7739 2 HDGF HNRNPUL1 PKNOX1 ARNT ZNF2 ZNF766 ZNF143 DEK ZC3H11A REST SZT2 RPS8 LOC101929609 PTCH2 ENSG00000230615 KLF17 SLC6A9
GH01H044044 0.9 ENCODE 0.7 +0.5 457 0 HDAC1 PKNOX1 TBL1XR1 ZNF473 ARNT TCF12 ZNF766 EGR1 FOS CREM DMAP1 SZT2 IPO13 LOC101929609 KLF17 ENSG00000227163
GH01H044047 1.5 Ensembl ENCODE dbSUPER 0.4 +5.1 5050 3 HDGF PKNOX1 ATF1 ARNT ARID4B TCF12 CBX5 GATA2 ELK1 ZNF143 MED8 IPO13 LOC101929609 KDM4A SZT2 RPS8 ARTN HECTD3 ENSG00000230615 B4GALT2
GH01H044068 0.8 Ensembl ENCODE 0.3 +24.8 24774 0 ZNF766 NR2F1 SMAD4 NR2F6 SPI1 SLC6A9 ARTN ENSG00000227163 KLF17
GH01H044072 0.7 ENCODE 0.3 +28.4 28447 0 JUN KLF17 FOSL1 TCF12 ZNF121 ZFHX2 EGR1 FOS RUNX3 EGR2 ERI3 ENSG00000227163 KLF17
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KLF17 on UCSC Golden Path with GeneCards custom track

Genomic Location for KLF17 Gene

Chromosome:
1
Start:
44,043,927 bp from pter
End:
44,135,140 bp from pter
Size:
91,214 bases
Orientation:
Plus strand

Genomic View for KLF17 Gene

Genes around KLF17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLF17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLF17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLF17 Gene

Proteins for KLF17 Gene

  • Protein details for KLF17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5JT82-KLF17_HUMAN
    Recommended name:
    Krueppel-like factor 17
    Protein Accession:
    Q5JT82
    Secondary Accessions:
    • Q86VQ7
    • Q8N805

    Protein attributes for KLF17 Gene

    Size:
    389 amino acids
    Molecular mass:
    42577 Da
    Quaternary structure:
    No Data Available

neXtProt entry for KLF17 Gene

Post-translational modifications for KLF17 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KLF17 Gene

No data available for DME Specific Peptides for KLF17 Gene

Domains & Families for KLF17 Gene

Gene Families for KLF17 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for KLF17 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KLF17 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5JT82

UniProtKB/Swiss-Prot:

KLF17_HUMAN :
  • Belongs to the Sp1 C2H2-type zinc-finger protein family.
Family:
  • Belongs to the Sp1 C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with KLF17: view

Function for KLF17 Gene

Molecular function for KLF17 Gene

UniProtKB/Swiss-Prot Function:
Transcription repressor that binds to the promoter of target genes and prevents their expression. Acts as a negative regulator of epithelial-mesenchymal transition and metastasis in breast cancer. Specifically binds the 5-CACCC-3 sequence in the promoter of ID1, a key metastasis regulator in breast cancer, and repress its expression. May be a germ cell-specific transcription factor that plays important roles in spermatid differentiation and oocyte development (By similarity).

Phenotypes From GWAS Catalog for KLF17 Gene

Gene Ontology (GO) - Molecular Function for KLF17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IEA --
GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding IEA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding ISS,IEA --
genes like me logo Genes that share ontologies with KLF17: view

Phenotypes for KLF17 Gene

GenomeRNAi human phenotypes for KLF17:
genes like me logo Genes that share phenotypes with KLF17: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for KLF17
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KLF17 Gene

Localization for KLF17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLF17 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KLF17 gene
Compartment Confidence
nucleus 5
cytosol 2
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for KLF17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with KLF17: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for KLF17 Gene

Pathways & Interactions for KLF17 Gene

SuperPathways for KLF17 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KLF17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA,ISS --
GO:0007276 gamete generation IEA --
genes like me logo Genes that share ontologies with KLF17: view

No data available for Pathways by source and SIGNOR curated interactions for KLF17 Gene

Drugs & Compounds for KLF17 Gene

No Compound Related Data Available

Transcripts for KLF17 Gene

mRNA/cDNA for KLF17 Gene

(4) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KLF17 Gene

Kruppel-like factor 17:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for KLF17
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for KLF17 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6
SP1: -
SP2: - -
SP3:

Relevant External Links for KLF17 Gene

GeneLoc Exon Structure for
KLF17
ECgene alternative splicing isoforms for
KLF17

Expression for KLF17 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KLF17 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KLF17 Gene

This gene is overexpressed in Testis (x29.8).

Protein differential expression in normal tissues from HIPED for KLF17 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KLF17 Gene



Protein tissue co-expression partners for KLF17 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of KLF17 Gene:

KLF17

SOURCE GeneReport for Unigene cluster for KLF17 Gene:

Hs.567674

Evidence on tissue expression from TISSUES for KLF17 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with KLF17: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KLF17 Gene

Orthologs for KLF17 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for KLF17 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KLF17 33 34
  • 99.06 (n)
dog
(Canis familiaris)
Mammalia KLF17 33 34
  • 78.57 (n)
cow
(Bos Taurus)
Mammalia KLF17 33
  • 75.7 (n)
-- 34
  • 61 (a)
OneToMany
-- 34
  • 55 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Klf17 33 16 34
  • 65.86 (n)
rat
(Rattus norvegicus)
Mammalia Klf17 33
  • 65.84 (n)
oppossum
(Monodelphis domestica)
Mammalia KLF17 34
  • 20 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii AL929286.1 34
  • 19 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta btd 34
  • 13 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RIM101 36
Species where no ortholog for KLF17 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KLF17 Gene

ENSEMBL:
Gene Tree for KLF17 (if available)
TreeFam:
Gene Tree for KLF17 (if available)

Paralogs for KLF17 Gene

Paralogs for KLF17 Gene

Pseudogenes.org Pseudogenes for KLF17 Gene

genes like me logo Genes that share paralogs with KLF17: view

Variants for KLF17 Gene

Sequence variations from dbSNP and Humsavar for KLF17 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000004265 -- 44,132,209(+) GCTGA(G/T)GCAGG intron-variant
rs1000011096 -- 44,135,182(+) GAATT(A/C)CCCAT downstream-variant-500B
rs1000048994 -- 44,055,072(+) CCATG(A/C)CTGGC intron-variant
rs1000051772 -- 44,047,096(+) TATGC(G/T)TACTT intron-variant
rs1000083723 -- 44,051,260(+) AAGGC(G/T)CTTTT intron-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for KLF17 Gene

Variant ID Type Subtype PubMed ID
nsv829704 CNV loss 17160897

Variation tolerance for KLF17 Gene

Residual Variation Intolerance Score: 66.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.86; 89.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KLF17 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KLF17

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLF17 Gene

Disorders for KLF17 Gene

Relevant External Links for KLF17

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KLF17

No disorders were found for KLF17 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KLF17 Gene

Publications for KLF17 Gene

  1. Human KLF17 is a new member of the Sp/KLF family of transcription factors. (PMID: 16460907) van Vliet J … Crossley M (Genomics 2006) 2 3 4 22 60
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. KLF17 attenuates estrogen receptor α-mediated signaling by impeding ERα function on chromatin and determines response to endocrine therapy. (PMID: 27107895) Ali A … Khan AA (Biochimica et biophysica acta 2016) 3 60

Products for KLF17 Gene

Sources for KLF17 Gene

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