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Aliases for KLF17 Gene

Aliases for KLF17 Gene

  • Kruppel-Like Factor 17 2 3 5
  • Zinc Finger Protein 393 2 3 4
  • ZNF393 3 4
  • Novel Zinc-Finger Protein 3
  • Zfp393 3

External Ids for KLF17 Gene

Previous HGNC Symbols for KLF17 Gene

  • ZNF393

Previous GeneCards Identifiers for KLF17 Gene

  • GC01P044357
  • GC01P044584
  • GC01P042699

Summaries for KLF17 Gene

GeneCards Summary for KLF17 Gene

KLF17 (Kruppel-Like Factor 17) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription regulatory region DNA binding. An important paralog of this gene is KLF8.

UniProtKB/Swiss-Prot for KLF17 Gene

  • Transcription repressor that binds to the promoter of target genes and prevents their expression. Acts as a negative regulator of epithelial-mesenchymal transition and metastasis in breast cancer. Specifically binds the 5-CACCC-3 sequence in the promoter of ID1, a key metastasis regulator in breast cancer, and repress its expression. May be a germ cell-specific transcription factor that plays important roles in spermatid differentiation and oocyte development (By similarity).

Gene Wiki entry for KLF17 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLF17 Gene

Genomics for KLF17 Gene

Regulatory Elements for KLF17 Gene

Enhancers for KLF17 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around KLF17 on UCSC Golden Path with GeneCards custom track

Genomic Location for KLF17 Gene

Chromosome:
1
Start:
44,043,927 bp from pter
End:
44,135,140 bp from pter
Size:
91,214 bases
Orientation:
Plus strand

Genomic View for KLF17 Gene

Genes around KLF17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLF17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLF17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLF17 Gene

Proteins for KLF17 Gene

  • Protein details for KLF17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5JT82-KLF17_HUMAN
    Recommended name:
    Krueppel-like factor 17
    Protein Accession:
    Q5JT82
    Secondary Accessions:
    • Q86VQ7
    • Q8N805

    Protein attributes for KLF17 Gene

    Size:
    389 amino acids
    Molecular mass:
    42577 Da
    Quaternary structure:
    No Data Available

neXtProt entry for KLF17 Gene

Proteomics data for KLF17 Gene at MOPED

Post-translational modifications for KLF17 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KLF17 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for KLF17

No data available for DME Specific Peptides for KLF17 Gene

Domains & Families for KLF17 Gene

Protein Domains for KLF17 Gene

Suggested Antigen Peptide Sequences for KLF17 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5JT82

UniProtKB/Swiss-Prot:

KLF17_HUMAN :
  • Belongs to the Sp1 C2H2-type zinc-finger protein family.
  • Contains 3 C2H2-type zinc fingers.
Family:
  • Belongs to the Sp1 C2H2-type zinc-finger protein family.
Similarity:
  • Contains 3 C2H2-type zinc fingers.
genes like me logo Genes that share domains with KLF17: view

Function for KLF17 Gene

Molecular function for KLF17 Gene

UniProtKB/Swiss-Prot Function:
Transcription repressor that binds to the promoter of target genes and prevents their expression. Acts as a negative regulator of epithelial-mesenchymal transition and metastasis in breast cancer. Specifically binds the 5-CACCC-3 sequence in the promoter of ID1, a key metastasis regulator in breast cancer, and repress its expression. May be a germ cell-specific transcription factor that plays important roles in spermatid differentiation and oocyte development (By similarity).

Gene Ontology (GO) - Molecular Function for KLF17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0044212 transcription regulatory region DNA binding IEA,ISS --
genes like me logo Genes that share ontologies with KLF17: view

Phenotypes for KLF17 Gene

GenomeRNAi human phenotypes for KLF17:
genes like me logo Genes that share phenotypes with KLF17: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KLF17 Gene

Localization for KLF17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLF17 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KLF17 Gene COMPARTMENTS Subcellular localization image for KLF17 gene
Compartment Confidence
nucleus 5
cytosol 2
golgi apparatus 2

No data available for Gene Ontology (GO) - Cellular Components for KLF17 Gene

Pathways & Interactions for KLF17 Gene

SuperPathways for KLF17 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KLF17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA,ISS --
genes like me logo Genes that share ontologies with KLF17: view

No data available for Pathways by source and SIGNOR curated interactions for KLF17 Gene

Drugs & Compounds for KLF17 Gene

No Compound Related Data Available

Transcripts for KLF17 Gene

mRNA/cDNA for KLF17 Gene

(7) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KLF17 Gene

Kruppel-like factor 17:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KLF17 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6
SP1: -
SP2: - -
SP3:

Relevant External Links for KLF17 Gene

GeneLoc Exon Structure for
KLF17
ECgene alternative splicing isoforms for
KLF17

Expression for KLF17 Gene

mRNA expression in normal human tissues for KLF17 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KLF17 Gene

This gene is overexpressed in Testis (x29.8).

Protein differential expression in normal tissues from HIPED for KLF17 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KLF17 Gene



SOURCE GeneReport for Unigene cluster for KLF17 Gene Hs.567674

genes like me logo Genes that share expression patterns with KLF17: view

Protein tissue co-expression partners for KLF17 Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for KLF17 Gene

Orthologs for KLF17 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for KLF17 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KLF17 35
  • 75.7 (n)
  • 61.84 (a)
-- 36
  • 55 (a)
OneToMany
-- 36
  • 61 (a)
OneToMany
dog
(Canis familiaris)
Mammalia KLF17 35
  • 78.57 (n)
  • 64.29 (a)
KLF17 36
  • 62 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Klf17 35
  • 65.86 (n)
  • 49.55 (a)
Klf17 16
Klf17 36
  • 49 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia KLF17 35
  • 99.06 (n)
  • 98.2 (a)
KLF17 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Klf17 35
  • 65.84 (n)
  • 52.8 (a)
oppossum
(Monodelphis domestica)
Mammalia KLF17 36
  • 20 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii AL929286.1 36
  • 19 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta btd 36
  • 13 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RIM101 38
Species with no ortholog for KLF17:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KLF17 Gene

ENSEMBL:
Gene Tree for KLF17 (if available)
TreeFam:
Gene Tree for KLF17 (if available)

Paralogs for KLF17 Gene

Paralogs for KLF17 Gene

Pseudogenes.org Pseudogenes for KLF17 Gene

genes like me logo Genes that share paralogs with KLF17: view

Variants for KLF17 Gene

Sequence variations from dbSNP and Humsavar for KLF17 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs2485652 - 44,129,738(-) GCCCA(C/T)TGGGG intron-variant, reference, missense
rs11210969 - 44,129,375(+) GCCCA(A/T)CTTGA reference, missense, utr-variant-5-prime
rs2429051 - 44,129,441(-) GAATG(C/G/T)TTGGT reference, missense
rs6656945 - 44,129,511(+) GGGCA(G/T)AATGT reference, missense
rs548299 -- 44,098,146(+) tTAGt(C/T)AGttt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KLF17 Gene

Variant ID Type Subtype PubMed ID
nsv829704 CNV Loss 17160897

Variation tolerance for KLF17 Gene

Residual Variation Intolerance Score: 66.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.86; 89.66% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for KLF17 Gene

Disorders for KLF17 Gene

Relevant External Links for KLF17

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KLF17

No disorders were found for KLF17 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KLF17 Gene

Publications for KLF17 Gene

  1. Human KLF17 is a new member of the Sp/KLF family of transcription factors. (PMID: 16460907) van Vliet J. … Crossley M. (Genomics 2006) 2 3 4 23 67
  2. KrA1ppel-like factors in hepatocellular carcinoma. (PMID: 25652467) Lu X.J. … Ma S. (Tumour Biol. 2015) 3
  3. Novel FUS-KLF17 and EWSR1-KLF17 fusions in myoepithelial tumors. (PMID: 25706482) Huang S.C. … Antonescu C.R. (Genes Chromosomes Cancer 2015) 3
  4. KLF17 empowers TGF-I^/Smad signaling by targeting Smad3-dependent pathway to suppress tumor growth and metastasis during cancer progression. (PMID: 25766320) Ali A. … Xiao J. (Cell Death Dis 2015) 3
  5. Tumor-suppressive p53 Signaling Empowers Metastatic Inhibitor KLF17-dependent Transcription to Overcome Tumorigenesis in Non-small Cell Lung Cancer. (PMID: 25911104) Ali A. … Ahmad A. (J. Biol. Chem. 2015) 3

Products for KLF17 Gene

Sources for KLF17 Gene

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