Free for academic non-profit institutions. Other users need a Commercial license

Aliases for KLF17 Gene

Aliases for KLF17 Gene

  • Kruppel-Like Factor 17 2 3
  • Zinc Finger Protein 393 2 3 4
  • ZNF393 3 4 6
  • Novel Zinc-Finger Protein 3
  • Krueppel-Like Factor 17 3
  • Zfp393 3

External Ids for KLF17 Gene

Previous Symbols for KLF17 Gene

  • ZNF393

Summaries for KLF17 Gene

GeneCards Summary for KLF17 Gene

KLF17 (Kruppel-Like Factor 17) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and transcription regulatory region DNA binding. An important paralog of this gene is KLF2.

UniProtKB/Swiss-Prot for KLF17 Gene

  • Transcription repressor that binds to the promoter of target genes and prevents their expression. Acts as a negative regulator of epithelial-mesenchymal transition and metastasis in breast cancer. Specifically binds the 5-CACCC-3 sequence in the promoter of ID1, a key metastasis regulator in breast cancer, and repress its expression. May be a germ cell-specific transcription factor that plays important roles in spermatid differentiation and oocyte development (By similarity).

Gene Wiki entry for KLF17 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLF17 Gene

Genomics for KLF17 Gene

Genomic Location for KLF17 Gene

Start:
44,048,316 bp from pter
End:
44,135,140 bp from pter
Size:
86,825 bases
Orientation:
Plus strand

Genomic View for KLF17 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KLF17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLF17 Gene

Regulatory Elements for KLF17 Gene

Proteins for KLF17 Gene

  • Protein details for KLF17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5JT82-KLF17_HUMAN
    Recommended name:
    Krueppel-like factor 17
    Protein Accession:
    Q5JT82
    Secondary Accessions:
    • Q86VQ7
    • Q8N805

    Protein attributes for KLF17 Gene

    Size:
    389 amino acids
    Molecular mass:
    42577 Da
    Quaternary structure:
    No Data Available

neXtProt entry for KLF17 Gene

Proteomics data for KLF17 Gene at MOPED

Post-translational modifications for KLF17 Gene

No Post-translational modifications

Other Protein References for KLF17 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KLF17 Gene

Domains for KLF17 Gene

Gene Families for KLF17 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type
  • KLF :Kruppel-like transcription factors

Protein Domains for KLF17 Gene

Suggested Antigen Peptide Sequences for KLF17 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5JT82

UniProtKB/Swiss-Prot:

KLF17_HUMAN
Family:
  • Belongs to the Sp1 C2H2-type zinc-finger protein family.:
    • Q5JT82
Similarity:
  • Contains 3 C2H2-type zinc fingers.:
    • Q5JT82
genes like me logo Genes that share domains with KLF17: view

Function for KLF17 Gene

Molecular function for KLF17 Gene

UniProtKB/Swiss-Prot Function: Transcription repressor that binds to the promoter of target genes and prevents their expression. Acts as a negative regulator of epithelial-mesenchymal transition and metastasis in breast cancer. Specifically binds the 5-CACCC-3 sequence in the promoter of ID1, a key metastasis regulator in breast cancer, and repress its expression. May be a germ cell-specific transcription factor that plays important roles in spermatid differentiation and oocyte development (By similarity).

Gene Ontology (GO) - Molecular Function for KLF17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 sequence-specific DNA binding transcription factor activity ISS --
GO:0005515 protein binding IPI 25416956
GO:0044212 transcription regulatory region DNA binding ISS --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with KLF17: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for KLF17 Gene

Localization for KLF17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLF17 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KLF17 Gene COMPARTMENTS Subcellular localization image for KLF17 gene
Compartment Confidence
nucleus 3
cytosol 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for KLF17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with KLF17: view

Pathways for KLF17 Gene

SuperPathways for KLF17 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KLF17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter ISS --
GO:0007276 gamete generation IEA --
genes like me logo Genes that share ontologies with KLF17: view

No data available for Pathways by source for KLF17 Gene

Transcripts for KLF17 Gene

mRNA/cDNA for KLF17 Gene

(7) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KLF17 Gene

Kruppel-like factor 17:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KLF17 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6
SP1: -
SP2: - -
SP3:

Relevant External Links for KLF17 Gene

GeneLoc Exon Structure for
KLF17
ECgene alternative splicing isoforms for
KLF17

Expression for KLF17 Gene

mRNA expression in normal human tissues for KLF17 Gene

mRNA differential expression in normal tissues according to GTEx for KLF17 Gene

This gene is overexpressed in Testis (29.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for KLF17 Gene

SOURCE GeneReport for Unigene cluster for KLF17 Gene Hs.567674

genes like me logo Genes that share expressions with KLF17: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for KLF17 Gene

Orthologs for KLF17 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for KLF17 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KLF17 35
  • 99.06 (n)
  • 98.2 (a)
KLF17 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 55 (a)
OneToMany
-- 36
  • 61 (a)
OneToMany
KLF17 35
  • 75.7 (n)
  • 61.84 (a)
dog
(Canis familiaris)
Mammalia KLF17 35
  • 78.57 (n)
  • 64.29 (a)
KLF17 36
  • 62 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Klf17 35
  • 65.86 (n)
  • 49.55 (a)
Klf17 16
Klf17 36
  • 49 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KLF17 36
  • 20 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Klf17 35
  • 65.84 (n)
  • 52.8 (a)
zebrafish
(Danio rerio)
Actinopterygii AL929286.1 36
  • 19 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta btd 36
  • 13 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RIM101 38
Species with no ortholog for KLF17:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KLF17 Gene

ENSEMBL:
Gene Tree for KLF17 (if available)
TreeFam:
Gene Tree for KLF17 (if available)

Paralogs for KLF17 Gene

Pseudogenes.org Pseudogenes for KLF17 Gene

genes like me logo Genes that share paralogs with KLF17: view

Variants for KLF17 Gene

Sequence variations from dbSNP and Humsavar for KLF17 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs509261 -- 44,102,650(+) TCATA(A/G)CACGa intron-variant
rs511018 -- 44,096,398(+) tattt(A/T)ttttt intron-variant
rs548299 -- 44,098,146(+) tTAGt(C/T)AGttt intron-variant
rs561842 -- 44,100,997(+) aaaaa(C/T)acaac intron-variant
rs586054 -- 44,115,205(+) tggga(G/T)gccga intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KLF17 Gene

Variant ID Type Subtype PubMed ID
nsv829704 CNV Loss 17160897

Relevant External Links for KLF17 Gene

HapMap Linkage Disequilibrium report
KLF17

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLF17 Gene

Disorders for KLF17 Gene

No disorders were found for KLF17 Gene.

No data available for UniProtKB/Swiss-Prot for KLF17 Gene

Publications for KLF17 Gene

  1. Human KLF17 is a new member of the Sp/KLF family of transcription factors. (PMID: 16460907) van Vliet J. … Crossley M. (Genomics 2006) 2 3 4 23
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  5. KLF17 is a negative regulator of epithelial-mesenchymal transition and metastasis in breast cancer. (PMID: 19801974) Gumireddy K. … Huang Q. (Nat. Cell Biol. 2009) 3

Products for KLF17 Gene

Sources for KLF17 Gene

Back to Top

Content