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Aliases for HMGB4 Gene

Aliases for HMGB4 Gene

  • High Mobility Group Box 4 2 3 5
  • High-Mobility Group Box 4 2
  • DJ1007G16.5 3
  • HMG2 Like 3

External Ids for HMGB4 Gene

Previous GeneCards Identifiers for HMGB4 Gene

  • GC01P033996
  • GC01P034098
  • GC01P034326
  • GC01P032442

Summaries for HMGB4 Gene

GeneCards Summary for HMGB4 Gene

HMGB4 (High Mobility Group Box 4) is a Protein Coding gene. GO annotations related to this gene include chromatin binding. An important paralog of this gene is HMGB1.

Gene Wiki entry for HMGB4 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HMGB4 Gene

Genomics for HMGB4 Gene

Regulatory Elements for HMGB4 Gene

Genomic Location for HMGB4 Gene

33,860,475 bp from pter
33,864,791 bp from pter
4,317 bases
Plus strand

Genomic View for HMGB4 Gene

Genes around HMGB4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HMGB4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HMGB4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HMGB4 Gene

Proteins for HMGB4 Gene

  • Protein details for HMGB4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    High mobility group protein B4
    Protein Accession:
    Secondary Accessions:
    • B2R4X7
    • Q0QWA4

    Protein attributes for HMGB4 Gene

    186 amino acids
    Molecular mass:
    22490 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HMGB4 Gene

Proteomics data for HMGB4 Gene at MOPED

Post-translational modifications for HMGB4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HMGB4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HMGB4 Gene

Domains & Families for HMGB4 Gene

Gene Families for HMGB4 Gene

Protein Domains for HMGB4 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 HMG box DNA-binding domains.
  • Belongs to the HMGB family.
  • Contains 2 HMG box DNA-binding domains.
  • Belongs to the HMGB family.
genes like me logo Genes that share domains with HMGB4: view

Function for HMGB4 Gene

Gene Ontology (GO) - Molecular Function for HMGB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with HMGB4: view
genes like me logo Genes that share phenotypes with HMGB4: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HMGB4 Gene

Localization for HMGB4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HMGB4 Gene

Nucleus. Chromosome.

Subcellular locations from

Jensen Localization Image for HMGB4 Gene COMPARTMENTS Subcellular localization image for HMGB4 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for HMGB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005694 chromosome IEA --
genes like me logo Genes that share ontologies with HMGB4: view

Pathways & Interactions for HMGB4 Gene

SuperPathways for HMGB4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for HMGB4 Gene


No data available for Pathways by source and SIGNOR curated interactions for HMGB4 Gene

Drugs & Compounds for HMGB4 Gene

No Compound Related Data Available

Transcripts for HMGB4 Gene

Unigene Clusters for HMGB4 Gene

High mobility group box 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HMGB4 Gene

No ASD Table

Relevant External Links for HMGB4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HMGB4 Gene

mRNA expression in normal human tissues for HMGB4 Gene

mRNA differential expression in normal tissues according to GTEx for HMGB4 Gene

This gene is overexpressed in Testis (x52.6).

Protein differential expression in normal tissues from HIPED for HMGB4 Gene

This gene is overexpressed in Testis (50.9) and Ovary (18.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HMGB4 Gene

SOURCE GeneReport for Unigene cluster for HMGB4 Gene Hs.568628

genes like me logo Genes that share expression patterns with HMGB4: view

Protein tissue co-expression partners for HMGB4 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for HMGB4 Gene

Orthologs for HMGB4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for HMGB4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia HMGB4 35
  • 86.96 (n)
  • 84.36 (a)
HMGB4 36
  • 78 (a)
(Canis familiaris)
Mammalia HMGB4 35
  • 82.87 (n)
  • 82.32 (a)
HMGB4 36
  • 80 (a)
(Mus musculus)
Mammalia Hmgb4 35
  • 78.97 (n)
  • 78.57 (a)
Hmgb4 16
Hmgb4 36
  • 73 (a)
(Pan troglodytes)
Mammalia HMGB4 35
  • 98.75 (n)
  • 96.77 (a)
(Rattus norvegicus)
Mammalia Hmgb4 35
  • 77.44 (n)
  • 75.61 (a)
(Monodelphis domestica)
Mammalia HMGB4 36
  • 54 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 21 (a)
(Danio rerio)
Actinopterygii hmgb2b 36
  • 31 (a)
fruit fly
(Drosophila melanogaster)
Insecta Dsp1 36
  • 15 (a)
(Caenorhabditis elegans)
Secernentea hmg-1.1 36
  • 32 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NHP6A 36
  • 33 (a)
NHP6B 36
  • 32 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3845 36
  • 12 (a)
Species with no ortholog for HMGB4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for HMGB4 Gene

Gene Tree for HMGB4 (if available)
Gene Tree for HMGB4 (if available)

Paralogs for HMGB4 Gene

Paralogs for HMGB4 Gene

(9) SIMAP similar genes for HMGB4 Gene using alignment to 2 proteins: Pseudogenes for HMGB4 Gene

genes like me logo Genes that share paralogs with HMGB4: view

Variants for HMGB4 Gene

Sequence variations from dbSNP and Humsavar for HMGB4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_055951 -
VAR_067467 -
VAR_067468 -

Structural Variations from Database of Genomic Variants (DGV) for HMGB4 Gene

Variant ID Type Subtype PubMed ID
nsv834624 CNV Loss 17160897
nsv871907 CNV Loss 21882294
esv34112 CNV Loss 18971310

Variation tolerance for HMGB4 Gene

Residual Variation Intolerance Score: 78.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.07; 37.86% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HMGB4 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HMGB4 Gene

Disorders for HMGB4 Gene

Relevant External Links for HMGB4

Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for HMGB4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HMGB4 Gene

Publications for HMGB4 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  3. Convergent animal and human evidence suggests a role of PPM1A gene in response to antidepressants. (PMID: 20970119) Malki K. … Schalkwyk L.C. (Biol. Psychiatry 2011) 3
  4. Proteomic characterization of the human sperm nucleus. (PMID: 21630459) de Mateo S. … Oliva R. (Proteomics 2011) 3
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3

Products for HMGB4 Gene

Sources for HMGB4 Gene

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