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Aliases for OR10J5 Gene

Aliases for OR10J5 Gene

  • Olfactory Receptor Family 10 Subfamily J Member 5 2 3 5
  • Olfactory Receptor OR1-28 3 4
  • Olfactory Receptor, Family 10, Subfamily J, Member 5 2
  • Olfactory Receptor 10J5 3
  • OR1-28 3

External Ids for OR10J5 Gene

Previous GeneCards Identifiers for OR10J5 Gene

  • GC01U990424
  • GC01M156722
  • GC01M156317
  • GC01M157771
  • GC01M157516

Summaries for OR10J5 Gene

Entrez Gene Summary for OR10J5 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR10J5 Gene

OR10J5 (Olfactory Receptor Family 10 Subfamily J Member 5) is a Protein Coding gene. Among its related pathways are Olfactory Signaling Pathway and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR10J1.

UniProtKB/Swiss-Prot for OR10J5 Gene

  • Odorant receptor.

Gene Wiki entry for OR10J5 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR10J5 Gene

Genomics for OR10J5 Gene

Regulatory Elements for OR10J5 Gene

Enhancers for OR10J5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G159596 0.9 Ensembl ENCODE 10.5 -62.0 -61968 2.7 JUN CEBPB MAX RAD21 EP300 YY1 FOXA1 JUND ATF3 GATA2 OR10J5 OR10J3 OR10J6P DUSP23 SLAMF9 APCS
GH01G159141 1 FANTOM5 Ensembl 7.9 +394.0 394019 0.8 TBP MXI1 SREBF2 SIN3A REST EP300 POLR2H JUND POLR2A POLR3A OR6K3 OR6N1 FCER1A CADM3 ACKR1 CADM3-AS1 OR6N2 OR10J5 AIM2 OR10J1
GH01G159509 0.6 ENCODE 11 +26.2 26224 1.5 ATF3 HNF4G CEBPB HNF4A TRIM24 CEBPG YY1 OR10J5 GC01P159502
GH01G159682 0.3 FANTOM5 6.7 -146.9 -146933 0.2 FCER1A CRP OR10J5 OR10J1 CRPP1 ENSG00000276632
GH01G159172 1.1 FANTOM5 Ensembl ENCODE 1.2 +362.9 362924 1.0 SMARCA4 TEAD4 CTBP2 RBBP5 EBF1 EZH2 ACKR1 CADM3-AS1 AIM2 ENSG00000212161 OR10J3 CADM3 OR6N1 OR6K3 FCER1A OR6N2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OR10J5 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR10J5 Gene

Chromosome:
1
Start:
159,535,078 bp from pter
End:
159,536,007 bp from pter
Size:
930 bases
Orientation:
Minus strand

Genomic View for OR10J5 Gene

Genes around OR10J5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR10J5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR10J5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR10J5 Gene

Proteins for OR10J5 Gene

  • Protein details for OR10J5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NHC4-O10J5_HUMAN
    Recommended name:
    Olfactory receptor 10J5
    Protein Accession:
    Q8NHC4
    Secondary Accessions:
    • B9EH35
    • Q6IFH2

    Protein attributes for OR10J5 Gene

    Size:
    309 amino acids
    Molecular mass:
    34401 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR10J5 Gene

Post-translational modifications for OR10J5 Gene

Other Protein References for OR10J5 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR10J5 Gene

Domains & Families for OR10J5 Gene

Gene Families for OR10J5 Gene

Protein Domains for OR10J5 Gene

Suggested Antigen Peptide Sequences for OR10J5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NHC4

UniProtKB/Swiss-Prot:

O10J5_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR10J5: view

Function for OR10J5 Gene

Molecular function for OR10J5 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR10J5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
GO:0004993 G-protein coupled serotonin receptor activity IBA --
GO:0030594 neurotransmitter receptor activity IBA --
genes like me logo Genes that share ontologies with OR10J5: view
genes like me logo Genes that share phenotypes with OR10J5: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR10J5 Gene

Localization for OR10J5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR10J5 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR10J5 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR10J5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR10J5: view

Pathways & Interactions for OR10J5 Gene

genes like me logo Genes that share pathways with OR10J5: view

Pathways by source for OR10J5 Gene

Interacting Proteins for OR10J5 Gene

Gene Ontology (GO) - Biological Process for OR10J5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR10J5: view

No data available for SIGNOR curated interactions for OR10J5 Gene

Transcripts for OR10J5 Gene

mRNA/cDNA for OR10J5 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR10J5 Gene

No ASD Table

Relevant External Links for OR10J5 Gene

GeneLoc Exon Structure for
OR10J5
ECgene alternative splicing isoforms for
OR10J5

Expression for OR10J5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR10J5 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR10J5 Gene:

OR10J5

SOURCE GeneReport for Unigene cluster for OR10J5 Gene:

Hs.553587
genes like me logo Genes that share expression patterns with OR10J5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR10J5 Gene

Orthologs for OR10J5 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR10J5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC469542 34
  • 99.24 (n)
OR10J5 35
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Or10j5 55 Olfr16 34 16 35
  • 85.11 (n)
rat
(Rattus norvegicus)
Mammalia Olr1576 34
  • 85.01 (n)
cow
(Bos Taurus)
Mammalia OR10J5 34 35
  • 84.97 (n)
dog
(Canis familiaris)
Mammalia OR10J5 34 35
  • 83.77 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 47 (a)
ManyToMany
Species where no ortholog for OR10J5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR10J5 Gene

ENSEMBL:
Gene Tree for OR10J5 (if available)
TreeFam:
Gene Tree for OR10J5 (if available)

Paralogs for OR10J5 Gene

(452) SIMAP similar genes for OR10J5 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for OR10J5 Gene

genes like me logo Genes that share paralogs with OR10J5: view

Variants for OR10J5 Gene

Sequence variations from dbSNP and Humsavar for OR10J5 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1001513521 -- 159,538,004(+) GATAG(-/A)AAAAA upstream-variant-2KB
rs1003358605 -- 159,536,903(+) GAACA(G/T)ACAAT upstream-variant-2KB
rs1006187624 -- 159,537,850(+) TCATT(G/T)GAAGA upstream-variant-2KB
rs1007863129 -- 159,537,454(+) TTGGC(C/T)TCTCT upstream-variant-2KB
rs1008101638 -- 159,534,886(+) TTGTA(C/T)CTGGT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for OR10J5 Gene

Variant ID Type Subtype PubMed ID
esv3578214 CNV loss 25503493
nsv1005195 CNV gain 25217958

Variation tolerance for OR10J5 Gene

Residual Variation Intolerance Score: 72.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.70; 32.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR10J5 Gene

Human Gene Mutation Database (HGMD)
OR10J5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR10J5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR10J5 Gene

Disorders for OR10J5 Gene

Relevant External Links for OR10J5

Genetic Association Database (GAD)
OR10J5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR10J5

No disorders were found for OR10J5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR10J5 Gene

Publications for OR10J5 Gene

  1. Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study. (PMID: 17903294) Yang Q. … O'Donnell C.J. (BMC Med. Genet. 2007) 3 46 64
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 64
  3. Expression of human olfactory receptor 10J5 in heart aorta, coronary artery, and endothelial cells and its functional role in angiogenesis. (PMID: 25791473) Kim S.H. … Park J.H. (Biochem. Biophys. Res. Commun. 2015) 3 64
  4. Genome-wide association and population genetic analysis of C-reactive protein in African American and Hispanic American women. (PMID: 22939635) Reiner A.P. … Tang H. (Am. J. Hum. Genet. 2012) 3 64
  5. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 3 64

Products for OR10J5 Gene

Sources for OR10J5 Gene

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