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Aliases for ATP6V1G3 Gene

Aliases for ATP6V1G3 Gene

  • ATPase H+ Transporting V1 Subunit G3 2 3
  • ATPase, H+ Transporting, Lysosomal 13kDa, V1 Subunit G3 2 3 5
  • Vacuolar Proton Pump Subunit G 3 3 4
  • V-ATPase 13 KDa Subunit 3 3 4
  • V-ATPase Subunit G 3 3 4
  • ATP6G3 3 4
  • ATPase, H+ Transporting, Lysosomal (Vacuolar Proton Pump) Subunit G3 3
  • ATPase, H+ Transporting, Lysosomal 13kDa, V1 Subunit G Isoform 3 2
  • ATPase, H+ Transporting, Lysosomal 13kD, V1 Subunit G Isoform 3 2
  • Vacuolar ATP Synthase Subunit G 3 3
  • Vacuolar Proton Pump G Subunit 3 3
  • Vacuolar Proton Pump, Subunit G3 3
  • V-ATPase G Subunit 3 3
  • V-ATPase G3 Subunit 3
  • Vma10 3

External Ids for ATP6V1G3 Gene

Previous GeneCards Identifiers for ATP6V1G3 Gene

  • GC01M196219
  • GC01M193950
  • GC01M194958
  • GC01M195780
  • GC01M195224
  • GC01M196758
  • GC01M169660

Summaries for ATP6V1G3 Gene

Entrez Gene Summary for ATP6V1G3 Gene

  • This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'' and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes one of three G subunit proteins. Transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for ATP6V1G3 Gene

ATP6V1G3 (ATPase H+ Transporting V1 Subunit G3) is a Protein Coding gene. Diseases associated with ATP6V1G3 include chromophobe adenocarcinoma. Among its related pathways are Signaling by GPCR and Metabolism. GO annotations related to this gene include ATPase binding and hydrogen-exporting ATPase activity, phosphorylative mechanism. An important paralog of this gene is ATP6V1G2.

UniProtKB/Swiss-Prot for ATP6V1G3 Gene

  • Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

Tocris Summary for ATP6V1G3 Gene

  • H+-ATPase (also known as vacuolar ATPase, V-ATPase) is a enzyme transporter that functions to acidify intracellular compartments in eukaryotic cells. It is ubiquitously expressed and is present in endomembrane organelles such as vacuoles, lysosomes and endosomes.

Gene Wiki entry for ATP6V1G3 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATP6V1G3 Gene

Genomics for ATP6V1G3 Gene

Regulatory Elements for ATP6V1G3 Gene

Genomic Location for ATP6V1G3 Gene

198,523,222 bp from pter
198,540,945 bp from pter
17,724 bases
Minus strand

Genomic View for ATP6V1G3 Gene

Genes around ATP6V1G3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ATP6V1G3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ATP6V1G3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATP6V1G3 Gene

Proteins for ATP6V1G3 Gene

  • Protein details for ATP6V1G3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    V-type proton ATPase subunit G 3
    Protein Accession:
    Secondary Accessions:
    • Q495K2
    • Q495K4
    • Q5T9L6

    Protein attributes for ATP6V1G3 Gene

    118 amino acids
    Molecular mass:
    13917 Da
    Quaternary structure:
    • V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c, c and d).

    Alternative splice isoforms for ATP6V1G3 Gene


neXtProt entry for ATP6V1G3 Gene

Proteomics data for ATP6V1G3 Gene at MOPED

Post-translational modifications for ATP6V1G3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ATP6V1G3 Gene

No data available for DME Specific Peptides for ATP6V1G3 Gene

Domains & Families for ATP6V1G3 Gene

Gene Families for ATP6V1G3 Gene


Protein Domains for ATP6V1G3 Gene


Suggested Antigen Peptide Sequences for ATP6V1G3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the V-ATPase G subunit family.
  • Belongs to the V-ATPase G subunit family.
genes like me logo Genes that share domains with ATP6V1G3: view

Function for ATP6V1G3 Gene

Molecular function for ATP6V1G3 Gene

UniProtKB/Swiss-Prot Function:
Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

Phenotypes for ATP6V1G3 Gene

genes like me logo Genes that share phenotypes with ATP6V1G3: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ATP6V1G3 Gene

Localization for ATP6V1G3 Gene

Subcellular locations from

Jensen Localization Image for ATP6V1G3 Gene COMPARTMENTS Subcellular localization image for ATP6V1G3 gene
Compartment Confidence
cytosol 5
plasma membrane 5
vacuole 3
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ATP6V1G3 Gene

Pathways & Interactions for ATP6V1G3 Gene

genes like me logo Genes that share pathways with ATP6V1G3: view

Interacting Proteins for ATP6V1G3 Gene

Gene Ontology (GO) - Biological Process for ATP6V1G3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006879 cellular iron ion homeostasis TAS --
GO:0008286 insulin receptor signaling pathway TAS --
GO:0055085 transmembrane transport TAS --
GO:0090383 phagosome acidification TAS --
genes like me logo Genes that share ontologies with ATP6V1G3: view

No data available for SIGNOR curated interactions for ATP6V1G3 Gene

Drugs & Compounds for ATP6V1G3 Gene

(3) Drugs for ATP6V1G3 Gene - From: HMDB and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Disulfiram Approved Pharma Reversibly stimulates SERCA Ca2+-ATPase; displays a range of other activities 34
Bafilomycin A1 Experimental Pharma H+-ATPase (vacuolar) inhibitor 0

(5) Additional Compounds for ATP6V1G3 Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
  • Dihydrogen oxide
  • Steam
Concanamycin A

(4) Tocris Compounds for ATP6V1G3 Gene

Compound Action Cas Number
Bafilomycin A1 H+-ATPase (vacuolar) inhibitor 88899-55-2
Concanamycin A H+-ATPase (vacuolar) inhibitor 80890-47-7
Disulfiram Reversibly stimulates SERCA Ca2+-ATPase; displays a range of other activities 97-77-8
Enterostatin Binds to beta-subunit of F1-ATPase; anorexigenic peptide 117830-79-2
genes like me logo Genes that share compounds with ATP6V1G3: view

Transcripts for ATP6V1G3 Gene

Unigene Clusters for ATP6V1G3 Gene

ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ATP6V1G3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b
SP2: -

Relevant External Links for ATP6V1G3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ATP6V1G3 Gene

mRNA expression in normal human tissues for ATP6V1G3 Gene

mRNA differential expression in normal tissues according to GTEx for ATP6V1G3 Gene

This gene is overexpressed in Kidney - Cortex (x51.8).

Protein differential expression in normal tissues from HIPED for ATP6V1G3 Gene

This gene is overexpressed in Kidney (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ATP6V1G3 Gene

SOURCE GeneReport for Unigene cluster for ATP6V1G3 Gene Hs.127743

mRNA Expression by UniProt/SwissProt for ATP6V1G3 Gene

Tissue specificity: Kidney.
genes like me logo Genes that share expression patterns with ATP6V1G3: view

Protein tissue co-expression partners for ATP6V1G3 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for ATP6V1G3 Gene

Orthologs for ATP6V1G3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ATP6V1G3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ATP6V1G3 35
  • 83.76 (n)
  • 78.63 (a)
ATP6V1G3 36
  • 77 (a)
(Canis familiaris)
Mammalia ATP6V1G3 35
  • 88.14 (n)
  • 88.14 (a)
ATP6V1G3 36
  • 88 (a)
(Mus musculus)
Mammalia Atp6v1g3 35
  • 84.18 (n)
  • 83.9 (a)
Atp6v1g3 16
Atp6v1g3 36
  • 84 (a)
(Pan troglodytes)
Mammalia ATP6V1G3 35
  • 99.72 (n)
  • 99.15 (a)
ATP6V1G3 36
  • 94 (a)
(Rattus norvegicus)
Mammalia Atp6v1g3 35
  • 82.2 (n)
  • 81.36 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 71 (a)
-- 36
  • 62 (a)
(Ornithorhynchus anatinus)
Mammalia ATP6V1G3 36
  • 51 (a)
(Gallus gallus)
Aves ATP6V1G3 35
  • 71.3 (n)
  • 68.7 (a)
ATP6V1G3 36
  • 66 (a)
(Anolis carolinensis)
Reptilia ATP6V1G3 36
  • 61 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia atp6v1g3 35
  • 68.42 (n)
  • 62.28 (a)
Str.15644 35
fruit fly
(Drosophila melanogaster)
Insecta Vha13 36
  • 37 (a)
(Caenorhabditis elegans)
Secernentea vha-10 36
  • 37 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes VMA10 36
  • 34 (a)
VMA10 38
Species with no ortholog for ATP6V1G3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for ATP6V1G3 Gene

Gene Tree for ATP6V1G3 (if available)
Gene Tree for ATP6V1G3 (if available)

Paralogs for ATP6V1G3 Gene

Paralogs for ATP6V1G3 Gene

(3) SIMAP similar genes for ATP6V1G3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ATP6V1G3: view

Variants for ATP6V1G3 Gene

Sequence variations from dbSNP and Humsavar for ATP6V1G3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs16843254 - 198,529,104(+) AAACT(C/G)TTTAT reference, missense, utr-variant-3-prime
rs943132 -- 198,540,915(-) TTATA(C/T)CTCCT upstream-variant-2KB, utr-variant-5-prime
rs1055160 -- 198,523,324(-) TTCGT(A/G)TTTTT utr-variant-3-prime
rs1536317 -- 198,523,965(+) TAAAC(C/T)CACTT intron-variant
rs1536318 -- 198,529,930(+) CGAAA(C/G)TTTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ATP6V1G3 Gene

Variant ID Type Subtype PubMed ID
nsv832259 CNV Gain 17160897
nsv4043 CNV Insertion 18451855

Variation tolerance for ATP6V1G3 Gene

Residual Variation Intolerance Score: 70.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.72; 57.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ATP6V1G3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATP6V1G3 Gene

Disorders for ATP6V1G3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ATP6V1G3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
chromophobe adenocarcinoma
  • chromophobe renal cell carcinoma
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ATP6V1G3

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with ATP6V1G3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ATP6V1G3 Gene

Publications for ATP6V1G3 Gene

  1. Genome-wide association study of hematological and biochemical traits in a Japanese population. (PMID: 20139978) Kamatani Y. … Kamatani N. (Nat. Genet. 2010) 3 48 67
  2. Structure, function and regulation of the vacuolar (H+)-ATPase. (PMID: 9442887) Stevens T.H. … Forgac M. (Annu. Rev. Cell Dev. Biol. 1997) 2 3
  3. HIV latency. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. (PMID: 24968937) Maldarelli F. … Hughes S.H. (Science 2014) 3
  4. HIV/AIDS. Persistence by proliferation? (PMID: 25013050) Margolis D. … Bushman F. (Science 2014) 3
  5. Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan. (PMID: 23648065) Low S.K. … Nakamura Y. (Cancer Sci. 2013) 3

Products for ATP6V1G3 Gene

Sources for ATP6V1G3 Gene

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