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Aliases for CNTF Gene

Aliases for CNTF Gene

  • Ciliary Neurotrophic Factor 2 3 5
  • HCNTF 3

External Ids for CNTF Gene

Previous GeneCards Identifiers for CNTF Gene

  • GC11P060741
  • GC11P059903
  • GC11P058165
  • GC11P058146
  • GC11P058390
  • GC11P054738

Summaries for CNTF Gene

Entrez Gene Summary for CNTF Gene

  • The protein encoded by this gene is a polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. The protein is a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks. A mutation in this gene, which results in aberrant splicing, leads to ciliary neurotrophic factor deficiency, but this phenotype is not causally related to neurologic disease. A read-through transcript variant composed of the upstream ZFP91 gene and CNTF sequence has been identified, but it is thought to be non-coding. Read-through transcription of ZFP91 and CNTF has also been observed in mouse. [provided by RefSeq, Oct 2010]

GeneCards Summary for CNTF Gene

CNTF (Ciliary Neurotrophic Factor) is a Protein Coding gene. Diseases associated with CNTF include motor neuron disease and amyotrophic lateral sclerosis 19. Among its related pathways are Immune System and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include growth factor activity and ciliary neurotrophic factor receptor binding.

UniProtKB/Swiss-Prot for CNTF Gene

  • CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.

Gene Wiki entry for CNTF Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CNTF Gene

Genomics for CNTF Gene

Regulatory Elements for CNTF Gene

Genomic Location for CNTF Gene

Chromosome:
11
Start:
58,622,673 bp from pter
End:
58,625,733 bp from pter
Size:
3,061 bases
Orientation:
Plus strand

Genomic View for CNTF Gene

Genes around CNTF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CNTF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CNTF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CNTF Gene

Proteins for CNTF Gene

  • Protein details for CNTF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P26441-CNTF_HUMAN
    Recommended name:
    Ciliary neurotrophic factor
    Protein Accession:
    P26441
    Secondary Accessions:
    • B2RAB2

    Protein attributes for CNTF Gene

    Size:
    200 amino acids
    Molecular mass:
    22931 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for CNTF Gene

neXtProt entry for CNTF Gene

Proteomics data for CNTF Gene at MOPED

Post-translational modifications for CNTF Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CNTF Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CNTF Gene

Domains & Families for CNTF Gene

Gene Families for CNTF Gene

Suggested Antigen Peptide Sequences for CNTF Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P26441

UniProtKB/Swiss-Prot:

CNTF_HUMAN :
  • Belongs to the CNTF family.
Family:
  • Belongs to the CNTF family.
genes like me logo Genes that share domains with CNTF: view

Function for CNTF Gene

Molecular function for CNTF Gene

GENATLAS Biochemistry:
ciliary neurotrophic factor,interleukin-6 cytokine family member,cytosolic protein,expressed in myelinating Schwann cells and astrocyte subpopulation,involved in axon out growth in retinal ganglion cells and in the spinal cord,with decreased expression in the lateral corticospinal tract of amyotrophic lateral sclerosis (ALS)
UniProtKB/Swiss-Prot Function:
CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.

LifeMap Function Summary for CNTF Gene

CNTF as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:

Gene Ontology (GO) - Molecular Function for CNTF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with CNTF: view
genes like me logo Genes that share phenotypes with CNTF: view

Animal Models for CNTF Gene

MGI Knock Outs for CNTF:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CNTF Gene

Localization for CNTF Gene

Subcellular locations from UniProtKB/Swiss-Prot for CNTF Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CNTF Gene COMPARTMENTS Subcellular localization image for CNTF gene
Compartment Confidence
extracellular 5
cytoskeleton 2
nucleus 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CNTF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
genes like me logo Genes that share ontologies with CNTF: view

Pathways & Interactions for CNTF Gene

genes like me logo Genes that share pathways with CNTF: view

Pathways by source for CNTF Gene

SIGNOR curated interactions for CNTF Gene

Activates:

Gene Ontology (GO) - Biological Process for CNTF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008284 positive regulation of cell proliferation IEA,IBA --
GO:0040007 growth IEA --
GO:0043524 negative regulation of neuron apoptotic process IDA 10966616
GO:0046533 negative regulation of photoreceptor cell differentiation IEA --
GO:0046668 regulation of retinal cell programmed cell death IEA --
genes like me logo Genes that share ontologies with CNTF: view

Drugs & Compounds for CNTF Gene

(31) Drugs for CNTF Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(28) Additional Compounds for CNTF Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CNTF: view

Transcripts for CNTF Gene

mRNA/cDNA for CNTF Gene

(1) REFSEQ mRNAs :
(14) Additional mRNA sequences :
(493) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CNTF Gene

Ciliary neurotrophic factor:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CNTF Gene

No ASD Table

Relevant External Links for CNTF Gene

GeneLoc Exon Structure for
CNTF
ECgene alternative splicing isoforms for
CNTF

Expression for CNTF Gene

mRNA expression in normal human tissues for CNTF Gene

Protein differential expression in normal tissues from HIPED for CNTF Gene

This gene is overexpressed in Spinal cord (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CNTF Gene



SOURCE GeneReport for Unigene cluster for CNTF Gene Hs.524920

mRNA Expression by UniProt/SwissProt for CNTF Gene

P26441-CNTF_HUMAN
Tissue specificity: Nervous system.
genes like me logo Genes that share expression patterns with CNTF: view

Protein tissue co-expression partners for CNTF Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for CNTF Gene

Orthologs for CNTF Gene

This gene was present in the common ancestor of chordates.

Orthologs for CNTF Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CNTF 35
  • 76.72 (n)
  • 73.87 (a)
CNTF 36
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CNTF 35
  • 88.94 (n)
  • 86.43 (a)
CNTF 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cntf 35
  • 84.09 (n)
  • 82.23 (a)
Cntf 16
Cntf 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CNTF 35
  • 99.33 (n)
  • 98.5 (a)
CNTF 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cntf 35
  • 85.17 (n)
  • 84 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia CNTF 36
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves CNTF 35
  • 55.98 (n)
  • 45.11 (a)
CNTF 36
  • 43 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CNTF 36
  • 45 (a)
OneToOne
Species with no ortholog for CNTF:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CNTF Gene

ENSEMBL:
Gene Tree for CNTF (if available)
TreeFam:
Gene Tree for CNTF (if available)

Paralogs for CNTF Gene

No data available for Paralogs for CNTF Gene

Variants for CNTF Gene

Sequence variations from dbSNP and Humsavar for CNTF Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
VAR_013924 -
VAR_033777 -

Variation tolerance for CNTF Gene

Residual Variation Intolerance Score: 86% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.17; 51.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CNTF Gene

HapMap Linkage Disequilibrium report
CNTF
Human Gene Mutation Database (HGMD)
CNTF

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CNTF Gene

Disorders for CNTF Gene

MalaCards: The human disease database

(12) MalaCards diseases for CNTF Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
motor neuron disease
  • motor neuron diseases
amyotrophic lateral sclerosis 19
  • amyotrophic lateral sclerosis type 19
diabetic neuropathy
  • diabetic neuropathies
cold-induced sweating syndrome
  • crisponi syndrome
tetanus neonatorum
  • neonatal tetanus
- elite association - COSMIC cancer census association via MalaCards
Search CNTF in MalaCards View complete list of genes associated with diseases

Relevant External Links for CNTF

Genetic Association Database (GAD)
CNTF
Human Genome Epidemiology (HuGE) Navigator
CNTF
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CNTF
genes like me logo Genes that share disorders with CNTF: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CNTF Gene

Publications for CNTF Gene

  1. Sequence and structural organization of the human gene encoding ciliary neurotrophic factor. (PMID: 1840538) Lam A. … Cordell B. (Gene 1991) 2 3 4 23 67
  2. Sex-specific effects of CNTF, IL6 and UCP2 polymorphisms on weight gain. (PMID: 19833146) Heidema A.G. … Mariman E.C. (Physiol. Behav. 2010) 3 23
  3. Leptin but not ciliary neurotrophic factor (CNTF) induces phosphotyrosine phosphatase-1B expression in human neuronal cells (SH-SY5Y): putative explanation of CNTF efficacy in leptin-resistant state. (PMID: 19008309) Benomar Y. … Taouis M. (Endocrinology 2009) 3 23
  4. Impaired expression of ciliary neurotrophic factor in Charcot-Marie-Tooth type 1A neuropathy. (PMID: 19525893) Nobbio L. … Schenone A. (J. Neuropathol. Exp. Neurol. 2009) 3 23
  5. Sustained striatal ciliary neurotrophic factor expression negatively affects behavior and gene expression in normal and R6/1 mice. (PMID: 18293418) Denovan-Wright E.M. … Mandel R.J. (J. Neurosci. Res. 2008) 3 23

Products for CNTF Gene

Sources for CNTF Gene

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