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Aliases for ADH4 Gene

Aliases for ADH4 Gene

  • Alcohol Dehydrogenase 4 (Class II), Pi Polypeptide 2 3 5
  • Alcohol Dehydrogenase Class II Pi Chain 3 4
  • EC 4 63
  • Epididymis Secretory Protein Li 4 3
  • Aldehyde Reductase 3
  • EC 1.1.1 63
  • HEL-S-4 3
  • ADH-2 3

External Ids for ADH4 Gene

Previous GeneCards Identifiers for ADH4 Gene

  • GC04M100290
  • GC04M100453
  • GC04M100458
  • GC04M100401
  • GC04M100044
  • GC04M095782

Summaries for ADH4 Gene

Entrez Gene Summary for ADH4 Gene

  • This gene encodes class II alcohol dehydrogenase 4 pi subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class II alcohol dehydrogenase is a homodimer composed of 2 pi subunits. It exhibits a high activity for oxidation of long-chain aliphatic alcohols and aromatic alcohols and is less sensitive to pyrazole. This gene is localized to chromosome 4 in the cluster of alcohol dehydrogenase genes. [provided by RefSeq, Jul 2008]

GeneCards Summary for ADH4 Gene

ADH4 (Alcohol Dehydrogenase 4 (Class II), Pi Polypeptide) is a Protein Coding gene. Diseases associated with ADH4 include Substance Dependence and Alcohol Dependence. Among its related pathways are Phase II conjugation and Metabolism of xenobiotics by cytochrome P450. GO annotations related to this gene include oxidoreductase activity and NAD binding. An important paralog of this gene is ADH6.

Gene Wiki entry for ADH4 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADH4 Gene

Genomics for ADH4 Gene

Regulatory Elements for ADH4 Gene

Enhancers for ADH4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ADH4 on UCSC Golden Path with GeneCards custom track

Genomic Location for ADH4 Gene

99,123,657 bp from pter
99,157,792 bp from pter
34,136 bases
Minus strand

Genomic View for ADH4 Gene

Genes around ADH4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADH4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADH4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADH4 Gene

Proteins for ADH4 Gene

  • Protein details for ADH4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Alcohol dehydrogenase 4
    Protein Accession:
    Secondary Accessions:
    • A8K470
    • B4DIE7
    • C9J4A9
    • Q8TCD7

    Protein attributes for ADH4 Gene

    380 amino acids
    Molecular mass:
    40222 Da
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Homodimer.
    • There are 7 different ADHs isozymes in human: three belongs to class-I: alpha, beta, and gamma, one to class-II: pi, one to class-III: chi, one to class-IV: ADH7 and one to class-V: ADH6.

    Three dimensional structures from OCA and Proteopedia for ADH4 Gene

    Alternative splice isoforms for ADH4 Gene


neXtProt entry for ADH4 Gene

Proteomics data for ADH4 Gene at MOPED

Post-translational modifications for ADH4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for ADH4 Gene

Gene Families for ADH4 Gene

Suggested Antigen Peptide Sequences for ADH4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the zinc-containing alcohol dehydrogenase family. Class-II subfamily.
  • Belongs to the zinc-containing alcohol dehydrogenase family. Class-II subfamily.
genes like me logo Genes that share domains with ADH4: view

Function for ADH4 Gene

Molecular function for ADH4 Gene

GENATLAS Biochemistry:
alcohol dehydrogenase (class II),pi polypeptide (see ADH@)
UniProtKB/Swiss-Prot CatalyticActivity:
An alcohol + NAD(+) = an aldehyde or ketone + NADH.

Enzyme Numbers (IUBMB) for ADH4 Gene

Gene Ontology (GO) - Molecular Function for ADH4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004024 alcohol dehydrogenase activity, zinc-dependent IEA,IDA 10407146
GO:0004745 retinol dehydrogenase activity IDA,TAS --
GO:0008270 zinc ion binding IEA,IDA 10407146
GO:0019115 benzaldehyde dehydrogenase activity IDA 3466164
GO:0051287 NAD binding IDA 10407146
genes like me logo Genes that share ontologies with ADH4: view
genes like me logo Genes that share phenotypes with ADH4: view

Animal Model Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ADH4 Gene

Localization for ADH4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADH4 Gene


Subcellular locations from

Jensen Localization Image for ADH4 Gene COMPARTMENTS Subcellular localization image for ADH4 gene
Compartment Confidence
cytosol 5
mitochondrion 2
chloroplast 1
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for ADH4 Gene

Pathways & Interactions for ADH4 Gene

genes like me logo Genes that share pathways with ADH4: view

Gene Ontology (GO) - Biological Process for ADH4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006066 alcohol metabolic process IDA 3466164
GO:0006805 xenobiotic metabolic process TAS --
GO:0055114 oxidation-reduction process IEA --
GO:1901661 quinone metabolic process ISS --
genes like me logo Genes that share ontologies with ADH4: view

No data available for SIGNOR curated interactions for ADH4 Gene

Drugs & Compounds for ADH4 Gene

(10) Drugs for ADH4 Gene - From: DrugBank, ApexBio, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ethanol Approved Pharma Enzyme 1924
Vitamin A Approved Nutra 438
Cyclohexylformamide Experimental Pharma Target 0
1-Butanol Experimental Pharma 0
1-Proponol Experimental Pharma 0

(18) Additional Compounds for ADH4 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 1-Hexanol
  • 1-Hexyl alcohol
  • 1-Hydroxyhexane
  • Alcohol C-6
  • Alcohol(C6)
  • 1-Pentanol
  • 1-Pentol
  • 1-Pentyl alcohol
  • Alcool amylique
  • Alcool amylique (french)
  • (Hydroxymethyl)trichloromethane
  • 2, 2,2-Trichloroethanol
  • 2,2,2-Trichloro-1-ethanol
  • 2,2,2-Trichloro-Ethanol
  • 2,2,2-Trichloroethanol
2-Phenyl-1,3-propanediol monocarbamate
  • 3,4-Dihydroxyphenylglycolaldehyde
  • 3,4-Dihydroxyphenylglycolic aldehyde
  • a,3,4-Trihydroxy-Benzeneacetaldehyde
  • alpha,3,4-Trihydroxy-Benzeneacetaldehyde

(1) ApexBio Compounds for ADH4 Gene

Compound Action Cas Number
Isovaleramide 541-46-8
genes like me logo Genes that share compounds with ADH4: view

Transcripts for ADH4 Gene

Unigene Clusters for ADH4 Gene

Alcohol dehydrogenase 4 (class II), pi polypeptide:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ADH4 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11
SP1: -
SP2: - - -
SP3: - -
SP4: - -
SP5: -

Relevant External Links for ADH4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ADH4 Gene

mRNA expression in normal human tissues for ADH4 Gene

mRNA differential expression in normal tissues according to GTEx for ADH4 Gene

This gene is overexpressed in Liver (x50.9).

Protein differential expression in normal tissues from HIPED for ADH4 Gene

This gene is overexpressed in Liver, secretome (46.4) and Liver (20.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for ADH4 Gene

SOURCE GeneReport for Unigene cluster for ADH4 Gene Hs.1219

genes like me logo Genes that share expression patterns with ADH4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ADH4 Gene

Orthologs for ADH4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ADH4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ADH4 35
  • 84.56 (n)
  • 76.84 (a)
ADH4 36
  • 78 (a)
(Canis familiaris)
Mammalia ADH4 35
  • 86.72 (n)
  • 81 (a)
ADH4 36
  • 81 (a)
(Mus musculus)
Mammalia Adh4 35
  • 78.43 (n)
  • 72.41 (a)
Adh4 16
Adh4 36
  • 72 (a)
(Pan troglodytes)
Mammalia ADH4 35
  • 99.39 (n)
  • 99.47 (a)
ADH4 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Adh4 35
  • 80.19 (n)
  • 73.21 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 60 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia adh4 35
  • 68.68 (n)
  • 68.95 (a)
(Danio rerio)
Actinopterygii adh5 36
  • 64 (a)
adh8a 36
  • 54 (a)
adh8b 36
  • 53 (a)
zgc:63568 36
  • 56 (a)
zgc:77938 36
  • 57 (a)
fruit fly
(Drosophila melanogaster)
Insecta Fdh 36
  • 55 (a)
(Caenorhabditis elegans)
Secernentea H24K24.3 36
  • 51 (a)
Y50D4C.2 36
  • 32 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SFA1 36
  • 46 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons ADH1 35
  • 54.04 (n)
  • 50.13 (a)
(Oryza sativa)
Liliopsida Os11g0210500 35
  • 52.42 (n)
  • 49.73 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1497 36
  • 56 (a)
Species with no ortholog for ADH4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADH4 Gene

Gene Tree for ADH4 (if available)
Gene Tree for ADH4 (if available)

Paralogs for ADH4 Gene

Paralogs for ADH4 Gene

(6) SIMAP similar genes for ADH4 Gene using alignment to 5 proteins: Pseudogenes for ADH4 Gene

genes like me logo Genes that share paralogs with ADH4: view

Variants for ADH4 Gene

Sequence variations from dbSNP and Humsavar for ADH4 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
VAR_023461 -
VAR_023462 -
VAR_023463 -

Structural Variations from Database of Genomic Variants (DGV) for ADH4 Gene

Variant ID Type Subtype PubMed ID
nsv879656 CNV Gain 21882294

Variation tolerance for ADH4 Gene

Residual Variation Intolerance Score: 81.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.14; 51.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADH4 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADH4 Gene

Disorders for ADH4 Gene

MalaCards: The human disease database

(7) MalaCards diseases for ADH4 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
substance dependence
alcohol dependence
  • alcohol dependence, protection against
cluster headache
alcoholic liver cirrhosis
  • alcoholic cirrhosis
alcoholic neuropathy
  • alcohol-related polyneuropathy
- elite association - COSMIC cancer census association via MalaCards
Search ADH4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ADH4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with ADH4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ADH4 Gene

Publications for ADH4 Gene

  1. Cluster headache is associated with the alcohol dehydrogenase 4 (ADH4) gene. (PMID: 19925625) Rainero I. … Pinessi L. (Headache 2010) 3 23 48 67
  2. Identification of a FOXA-dependent enhancer of human alcohol dehydrogenase 4 (ADH4). (PMID: 20363298) Pochareddy S. … Edenberg H.J. (Gene 2010) 3 23
  3. Functional assessment of human alcohol dehydrogenase family in ethanol metabolism: significance of first-pass metabolism. (PMID: 16792560) Lee S.L. … Yin S.J. (Alcohol. Clin. Exp. Res. 2006) 25 26
  4. Association of genetic variants in alcohol dehydrogenase 4 with alcohol dependence in Brazilian patients. (PMID: 15863808) Guindalini C. … Zatz M. (Am J Psychiatry 2005) 3 23
  5. Thirteen single-nucleotide polymorphisms (SNPs) in the alcohol dehydrogenase 4 (ADH4) gene locus. (PMID: 11916005) Iida A. … Nakamura Y. (J. Hum. Genet. 2002) 3 23

Products for ADH4 Gene

Sources for ADH4 Gene