Aliases for CNR2 Gene
External Ids for CNR2 Gene
Previous GeneCards Identifiers for CNR2 Gene
The cannabinoid delta-9-tetrahydrocannabinol is the principal psychoactive ingredient of marijuana. The proteins encoded by this gene and the cannabinoid receptor 1 (brain) (CNR1) gene have the characteristics of a guanine nucleotide-binding protein (G-protein)-coupled receptor for cannabinoids. They inhibit adenylate cyclase activity in a dose-dependent, stereoselective, and pertussis toxin-sensitive manner. These proteins have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. The cannabinoid receptors are members of family 1 of the G-protein-coupled receptors. [provided by RefSeq, Jul 2008]
GeneCards Summary for CNR2 Gene
CNR2 (Cannabinoid Receptor 2 (Macrophage)) is a Protein Coding gene. Diseases associated with CNR2 include pertussis and chronic pain. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include cannabinoid receptor activity. An important paralog of this gene is LPAR1.
UniProtKB/Swiss-Prot for CNR2 Gene
Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis.
The CB2 receptor, also known as the peripheral cannabinoid receptor, is a member of the cannabinoid receptor group of G-protein-coupled receptors that also includes CB1 and GPR55. They are located primarily in immune cells both within & outside the central nervous system. The function of these receptors includes modulation of cytokine release and immune cell migration. In the brain CB2 receptors are expressed by microglia, blood vessels & some neurons.