Aliases for CNR2 Gene
Aliases for CNR2 Gene
External Ids for CNR2 Gene
- HGNC: 2160
- Entrez Gene: 1269
- Ensembl: ENSG00000188822
- OMIM: 605051
- UniProtKB: P34972
Previous GeneCards Identifiers for CNR2 Gene
- GC01M023725
- GC01M023271
- GC01M9A0006
- GC01M9A3945
- GC01M023945
- GC01M024069
- GC01M024197
- GC01M022452
Summaries for CNR2 Gene
-
The cannabinoid delta-9-tetrahydrocannabinol is the principal psychoactive ingredient of marijuana. The proteins encoded by this gene and the cannabinoid receptor 1 (brain) (CNR1) gene have the characteristics of a guanine nucleotide-binding protein (G-protein)-coupled receptor for cannabinoids. They inhibit adenylate cyclase activity in a dose-dependent, stereoselective, and pertussis toxin-sensitive manner. These proteins have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. The cannabinoid receptors are members of family 1 of the G-protein-coupled receptors. [provided by RefSeq, Jul 2008]
GeneCards Summary for CNR2 Gene
CNR2 (Cannabinoid Receptor 2) is a Protein Coding gene. Diseases associated with CNR2 include Cannabis Abuse and Glycerol Kinase Deficiency. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and cannabinoid receptor activity. An important paralog of this gene is CNR1.
UniProtKB/Swiss-Prot for CNR2 Gene
-
Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis.
-
The CB2 receptor, also known as the peripheral cannabinoid receptor, is a member of the cannabinoid receptor group of G-protein-coupled receptors that also includes CB1 and GPR55. CB2 receptors are located primarily in immune cells both within and outside the CNS.
Additional gene information for CNR2 Gene
- Monarch Initiative
- Search for CNR2 at DataMed
- Search for CNR2 at HumanCyc
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CNR2 Gene
Genomics for CNR2 Gene
GeneHancer (GH) Regulatory Elements for CNR2 Gene
Promoters and enhancers for CNR2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around CNR2 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for CNR2 Gene
Genomic Locations for CNR2 Gene
- chr1:23,870,526-23,913,362
- (GRCh38/hg38)
- Size:
- 42,837 bases
- Orientation:
- Minus strand
- chr1:24,197,016-24,285,549
- (GRCh37/hg19)
Genomic View for CNR2 Gene
Genes around CNR2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p36.11 by Ensembl
- 1p36.11 by Entrez Gene
- 1p36.11 by HGNC
CNR2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CNR2 Gene
Proteins for CNR2 Gene
-
Protein details for CNR2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P34972-CNR2_HUMAN
- Recommended name:
- Cannabinoid receptor 2
- Protein Accession:
- P34972
- C6ES44
- Q4VBK8
- Q5JRH7
- Q6B0G7
- Q6NSY0
Protein attributes for CNR2 Gene
- Size:
- 360 amino acids
- Molecular mass:
- 39681 Da
- Quaternary structure:
- No Data Available
Protein Expression for CNR2 Gene
Post-translational modifications for CNR2 Gene
- Constitutively phosphorylated on Ser-352; phosphorylation increases cell internalization and desensitizes the receptor.
- Glycosylation at posLast=1111
Other Protein References for CNR2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for CNR2 (Cannabinoid R2/CB2/CNR2)
-
Custom Antibody ServicesOriGene Antibodies for CNR2
- Novus Biologicals Antibodies for CNR2
-
Abcam antibodies for CNR2
- Invitrogen Antibodies for CNR2
- GeneTex CNR2 antibody for CNR2
-
Santa Cruz Biotechnology (SCBT) Antibodies for CNR2
- Sino Biological Antibodies for CNR2
Protein Products
-
OriGene Purified Proteins for CNR2
- Search Origene for MassSpec and Protein Over-expression Lysates for CNR2
- Origene Custom Protein Services for CNR2
- antibodies-online: Search results for 6 available CNR2 Proteins ranked by validation data
- Compare Top CNR2 Proteins
-
Quality Products:
- Search GeneTex for Proteins for CNR2
-
Abcam proteins for CNR2
Assay Products
- antibodies-online: Search results for 13 available CNR2 Elisa Kits ranked by validation data
- Compare Top CNR2 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for CNR2 Gene
Domains & Families for CNR2 Gene
Gene Families for CNR2 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- FDA approved drug targets
- G-protein coupled receptors
- Predicted membrane proteins
- Transporters
Protein Domains for CNR2 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for CNR2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P34972- Family:
-
- Belongs to the G-protein coupled receptor 1 family.
Function for CNR2 Gene
Molecular function for CNR2 Gene
- GENATLAS Biochemistry:
- cannabinoid receptor 2,peripheral,expressed in spleen,inhibiting adenylate cyclase
- UniProtKB/Swiss-Prot Function:
- Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis.
- UniProtKB/Swiss-Prot Induction:
- In macrophages, down-regulated by endocannabinoid anandamide/AEA.
Phenotypes From GWAS Catalog for CNR2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004871 | signal transducer activity | IEA | -- |
| GO:0004930 | G-protein coupled receptor activity | IEA | -- |
| GO:0004949 | cannabinoid receptor activity | IEA,TAS | -- |
Phenotypes for CNR2 Gene
- MGI mutant phenotypes for CNR2:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for CNR2:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for CNR2
-
-
ViGene Biosciences lentiviral particle packaged cDNA for CNR2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CNR2 gene
- Search ViGene Biosciences for CNR2
CRISPR Products
-
OriGene CRISPR knockouts for CNR2
- genomics-online: gRNA clones - Search results for 101 available CNR2 gene related products
- Overview of 101 available CNR2 gene related products
- Applied Biological Materials CRISPR for CNR2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CNR2
- GenScript: Design CRISPR guide RNA sequences for CNR2
miRNA for CNR2 Gene
- miRTarBase miRNAs that target CNR2
miRNA Products
- Search ViGene Biosciences for CNR2
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CNR2
- Browse OriGene Inhibitory RNA Products For CNR2
- genomics-online: shRNA clones - Search results for 101 available CNR2 gene related products
- Overview of 101 available CNR2 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for CNR2 gene
Clone Products
- Sino Biological Human cDNA Clone for CNR2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CNR2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CNR2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for CNR2
- Applied Biological Materials Clones for CNR2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for CNR2 (Cannabinoid R2/CB2/CNR2)
Cell Line Products
-
Horizon Cell Lines for CNR2
-
ViGene Biosciences adenoviral particle packaged cDNA for CNR2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for CNR2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CNR2 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CNR2 Gene
Localization for CNR2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CNR2 Gene
- Cell membrane; Multi-pass membrane protein. Cell projection, dendrite. Perikaryon. Note=Localizes to apical dendrite of pyramidal neurons. {ECO:0000250}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 1 |
| nucleus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005887 | integral component of plasma membrane | TAS | 8679694 |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
| GO:0030425 | dendrite | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for CNR2 Gene
Pathways & Interactions for CNR2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Peptide ligand-binding receptors | ||
| 2 | Signaling by GPCR | ||
| 3 | Ibuprofen Pathway, Pharmacodynamics | ||
| 4 | Reelin Pathway (Cajal-Retzius cells) | ||
| 5 | Eicosanoid ligand-binding receptors | ||
Pathways by source for CNR2 Gene
2 BioSystems pathways for CNR2 Gene
6 Reactome pathways for CNR2 Gene
1 PharmGKB pathway for CNR2 Gene
1 KEGG pathway for CNR2 Gene
1 Qiagen pathway for CNR2 Gene
Interacting Proteins for CNR2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001975 | response to amphetamine | IEA | -- |
| GO:0006954 | inflammatory response | IEA | -- |
| GO:0006955 | immune response | TAS | 7556170 |
| GO:0007165 | signal transduction | IEA | -- |
| GO:0007186 | G-protein coupled receptor signaling pathway | TAS | -- |
No data available for SIGNOR curated interactions for CNR2 Gene
Drugs & Compounds for CNR2 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Dronabinol | Approved, Illicit | Pharma | Target, agonist | 160 | ||
| Nabilone | Approved, Investigational | Pharma | Target, partial agonist | 21 | ||
| cannabidiol | Approved, Investigational | Pharma | Partial agonist, Agonist, Target, antagonist | 0 | ||
| Rimonabant | Approved, Investigational | Pharma | Antagonist | CB1 receptor antagonist | 46 | |
| Lasofoxifene | Approved, Investigational | Pharma | Target, inverse agonist | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| Delta<sup>9</sup>-tetrahydrocannabinol |
|
Partial agonist, Agonist |
|
|||
| JWH 133 |
|
259869-55-1 |
|
|
||
| JWH 133 (in Tocrisolve 100) |
|
259869-55-1 |
|
|
(5) Tocris Compounds for CNR2 Gene
| Compound | Action | Cas Number |
|---|---|---|
| GW 405833 | Selective, high affinity CB2 receptor partial agonist | 180002-83-9 |
| JWH 015 | Selective CB2 agonist | 155471-08-2 |
| JWH 133 | Potent, selective CB2 agonist | 259869-55-1 |
| JWH 133 (in Tocrisolve 100) | Potent, selective CB2 agonist (in water-soluble emulsion) | 259869-55-1 |
| L-759,633 | High affinity, selective CB2 agonist | 174627-50-0 |
(37) ApexBio Compounds for CNR2 Gene
| Compound | Action | Cas Number |
|---|---|---|
| (-)-5'-DMH-CBD | 97452-63-6 | |
| 2-Palmitoylglycerol | 23470-00-0 | |
| AM 1172 | Inhibitor of anandamide uptake and FAAH,potent and selective | 251908-92-6 |
| AM1241 | Cannabinoid CB2 receptor agonist,potent and selective | 444912-48-5 |
| AM251 | Potent CB1 antagonist | 183232-66-8 |
| AM630 | CB2 receptor antagonist,selective and competitive | 164178-33-0 |
| Arachidonyl serotonin | 187947-37-1 | |
| Arvanil | 128007-31-8 | |
| BML-190 | CB2 receptor ligand | 2854-32-2 |
| COR 170 | 1048039-15-1 | |
| CP-945598 HCl | CB1 antagonist,selective and high affinity | 686347-12-6 |
| GW842166X | 666260-75-9 | |
| Hemopressin (human, mouse) | 1314035-51-2 | |
| Hemopressin (rat) | 568588-77-2 | |
| HU 308 | CB2-receptor agonist | 256934-39-1 |
| JTE 907 | 282089-49-0 | |
| LY 320135 | 176977-56-3 | |
| MAFP | 188404-10-6 | |
| MJ 15 | 944154-76-1 | |
| MM-22 | 956605-71-3 | |
| N-Arachidonylglycine | 179113-91-8 | |
| NIDA 41020 | 502486-89-7 | |
| O-1918 | 536697-79-7 | |
| O-2050 | ||
| O-2093 | 439080-01-0 | |
| Oleamide | 301-02-0 | |
| OMDM-2 | 616884-63-0 | |
| Org 27569 | Cannabinoid CB1 receptor allosteric modulator | 868273-06-7 |
| Palmitoylisopropylamide | 189939-61-5 | |
| PB-22 | Synthetic cannabinoid | 1400742-17-7 |
| PF 514273 | 851728-60-4 | |
| Rimonabant | CB1 receptor antagonist | 168273-06-1 |
| Taranabant | 701977-09-5 | |
| TC-C 14G | 656804-72-7 | |
| Tocrifluor T1117 | 1186195-59-4 | |
| UCM 707 | 390824-20-1 | |
| VDM 11 | 313998-81-1 |
Transcripts for CNR2 Gene
mRNA/cDNA for CNR2 Gene
- (3) REFSEQ mRNAs :
- (10) Additional mRNA sequences :
- (32) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for CNR2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for CNR2
- genomics-online: gRNA clones - Search results for 101 available CNR2 gene related products
- Overview of 101 available CNR2 gene related products
- Applied Biological Materials CRISPR for CNR2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CNR2
- GenScript: Design CRISPR guide RNA sequences for CNR2
miRNA Products
- Search ViGene Biosciences for CNR2
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CNR2
- Browse OriGene Inhibitory RNA Products For CNR2
- genomics-online: shRNA clones - Search results for 101 available CNR2 gene related products
- Overview of 101 available CNR2 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for CNR2 gene
Clone Products
- Sino Biological Human cDNA Clone for CNR2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CNR2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CNR2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for CNR2
- Applied Biological Materials Clones for CNR2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for CNR2 (Cannabinoid R2/CB2/CNR2)
Expression for CNR2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Brain (Nervous System)
- Mature Endothelial Cells Blood Brain Barrier
-
Endothelium (Cardiovascular System)
- Mature Endothelial Cells Blood Brain Barrier
mRNA differential expression in normal tissues according to GTEx for CNR2 Gene
This gene is overexpressed in Spleen (x19.6), Small Intestine - Terminal Ileum (x7.1), and Whole Blood (x7.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CNR2 Gene
NURSA nuclear receptor signaling pathways regulating expression of CNR2 Gene:
CNR2SOURCE GeneReport for Unigene cluster for CNR2 Gene:
Hs.73037mRNA Expression by UniProt/SwissProt for CNR2 Gene:
P34972-CNR2_HUMAN
Tissue specificity:
Preferentially expressed in cells of the immune system with higher expression in B-cells and NK cells (at protein level). Expressed in skin in suprabasal layers and hair follicles (at protein level). Highly expressed in tonsil and to a lower extent in spleen, peripheral blood mononuclear cells, and thymus. PubMed:14657172 could not detect expression in normal brain. Expressed in brain by perivascular microglial cells and dorsal root ganglion sensory neurons (at protein level). Two isoforms are produced by alternative promoter usage and differ only in the 5 UTR: isoform CB2A is observed predominantly in testis with some expression in brain, while isoform CB2B is predominant in spleen and leukocytes.
Evidence on tissue expression from TISSUES for CNR2 Gene
- Blood(4.4)
- Nervous system(4.4)
- Spleen(4.3)
Primer Products
-
OriGene qPCR primer pairs and template standards for CNR2
-
OriGene qPCR primer pairs for CNR2
- genomics-online: primer clones - Search results for 101 available CNR2 gene related products
- Overview of 101 available CNR2 gene related products
No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CNR2 Gene
Orthologs for CNR2 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CNR2 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | CNR2 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | CNR2 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Cnr2 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Cnr2 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | CNR2 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | CNR2 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | CNR2 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | CNR2 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | cnr2 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | cnr2 33 34 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
ManyToMany | |
| -- 34 |
|
ManyToMany |
- Species where no ortholog for CNR2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for CNR2 Gene
Variants for CNR2 Gene
| SNP ID | Clin | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000029053 | -- | 23,889,975(-) | C/T | genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant | |
| rs1000317078 | -- | 23,876,076(-) | C/T | intron_variant | |
| rs1000379759 | -- | 23,881,403(-) | C/A | intron_variant | |
| rs1000410652 | -- | 23,881,198(-) | C/T | intron_variant | |
| rs1000489968 | -- | 23,874,539(-) | C/A | coding_sequence_variant, missense_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv190n54 | CNV | loss | 21841781 |
| dgv191n54 | CNV | loss | 21841781 |
| dgv29n67 | CNV | loss | 20364138 |
| esv1663042 | CNV | insertion | 17803354 |
| esv2672735 | CNV | deletion | 23128226 |
| esv2745386 | CNV | deletion | 23290073 |
| esv29329 | CNV | loss | 19812545 |
| esv3585494 | CNV | loss | 21293372 |
| esv3585495 | CNV | loss | 21293372 |
| esv3893081 | CNV | gain | 25118596 |
| esv991485 | CNV | insertion | 20482838 |
| nsv1122310 | CNV | deletion | 24896259 |
| nsv1133021 | OTHER | inversion | 24896259 |
| nsv1145326 | CNV | deletion | 24896259 |
| nsv512727 | CNV | insertion | 21212237 |
| nsv545778 | CNV | loss | 21841781 |
Residual Variation Intolerance Score:
39.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.18;
39.42% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CNR2 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CNR2 Gene
Disorders for CNR2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| cannabis abuse |
|
|
| glycerol kinase deficiency |
|
|
| chromosome xp21 deletion syndrome |
|
|
| alternating hemiplegia of childhood |
|
|
| multiple sclerosis |
|
Search CNR2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CNR2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for CNR2 Gene
Publications for CNR2 Gene
- Brain neuronal CB2 cannabinoid receptors in drug abuse and depression: from mice to human subjects. (PMID: 18286196) Onaivi ES … Uhl GR (PloS one 2008) 3 4 22 44 58
- Hepatic expression of endocannabinoid receptors and their novel polymorphisms in primary biliary cirrhosis. (PMID: 19730968) Floreani A … Bergasa NV (Journal of gastroenterology 2010) 3 22 44 58
- Brain cannabinoid CB2 receptor in schizophrenia. (PMID: 19931854) Ishiguro H … Arinami T (Biological psychiatry 2010) 3 22 44 58
- Species differences in cannabinoid receptor 2 (CNR2 gene): identification of novel human and rodent CB2 isoforms, differential tissue expression and regulation by cannabinoid receptor ligands. (PMID: 19496827) Liu QR … Uhl GR (Genes, brain, and behavior 2009) 3 4 22 58
- The cannabinoid receptor type 2 (CNR2) gene is associated with hand bone strength phenotypes in an ethnically homogeneous family sample. (PMID: 19565271) Karsak M … Livshits G (Human genetics 2009) 3 22 44 58
Products for CNR2 Gene
- R&D Systems Antibodies for CNR2 (Cannabinoid R2/CB2/CNR2)
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- R&D Systems cDNA Clones for CNR2 (Cannabinoid R2/CB2/CNR2)
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for CNR2
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for CNR2
- Search Origene for MassSpec and Protein Over-expression Lysates for CNR2
- Origene Custom Protein Services for CNR2
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CNR2
- Browse OriGene Inhibitory RNA Products For CNR2
- OriGene qPCR primer pairs and template standards for CNR2
- OriGene qPCR primer pairs for CNR2
- OriGene CRISPR knockouts for CNR2
- OriGene ORF clones in human for CNR2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CNR2
- GenScript: Next-day shipping of latest version cDNA ORF clones for CNR2 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for CNR2
- GenScript Activity-based Kinase Assay for Compound Screening for CNR2
- GenScript Custom Assay Services for CNR2
- GenScript CNR2 - overexpressing Cell Line for Assay
- GenScript Custom overexpressing Cell Line Services for CNR2
- GenScript: Design CRISPR guide RNA sequences for CNR2
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for CNR2
- Sino Biological Human cDNA Clone for CNR2
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Recombinant Proteins
- Sino Biological Antibodies for CNR2
- Browse Sino Biological Assays
- Browse Sino Biological ELISA Kits
- Browse Sino Biological ELISA Pair Sets
- Browse Sino Biological CRO Services
- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for CNR2
- Novus Biologicals proteins and lysates for CNR2
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for CNR2
- Abcam proteins for CNR2
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
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- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
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- Browse Antibodies at Cloud-Clone Corp.
- Browse Proteins at Cloud-Clone Corp.
- Browse Assay Kits at Cloud-Clone Corp.
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for CNR2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- ApexBio compounds for CNR2
- Cyagen custom Knockout/knockin (KOKI) mouse models for CNR2
- VectorBuilder custom plasmid, inducible vectors for CNR2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CNR2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for CNR2
- antibodies-online: Search results for 134 available CNR2 Antibodies ranked by validation data
- Compare Top CNR2 Antibodies
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- antibodies-online: Search results for 13 available CNR2 Elisa Kits ranked by validation data
- Compare Top CNR2 Elisa Kits
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- antibodies-online: Search results for 6 available CNR2 Proteins ranked by validation data
- Compare Top CNR2 Proteins
- Quality Products:
- GeneTex CNR2 antibody for CNR2
- Search GeneTex for Proteins for CNR2
- ViGene Biosciences adenoviral particle packaged cDNA for CNR2 gene
- ViGene Biosciences lentiviral particle packaged cDNA for CNR2 gene
- ViGene Biosciences ready-to-package AAV shRNAs for CNR2 gene
- Search ViGene Biosciences for CNR2
- Santa Cruz Biotechnology (SCBT) Antibodies for CNR2
- Search Santa Cruz Biotechnology (SCBT) for CNR2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CNR2
- Horizon Cell Lines for CNR2
- genomics-online: cdna clones - Search results for 101 available CNR2 gene related products
- Overview of 101 available CNR2 gene related products
- orf clones - Search results for 101 available CNR2 gene related products
- Overview of 101 available CNR2 gene related products
- genomics-online: gRNA clones - Search results for 101 available CNR2 gene related products
- Overview of 101 available CNR2 gene related products
- genomics-online: primer clones - Search results for 101 available CNR2 gene related products
- Overview of 101 available CNR2 gene related products
- genomics-online: shRNA clones - Search results for 101 available CNR2 gene related products
- Overview of 101 available CNR2 gene related products
Sources for CNR2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew