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Aliases for CNR2 Gene

Aliases for CNR2 Gene

  • Cannabinoid Receptor 2 2 3 5
  • Cannabinoid Receptor 2 (Macrophage) 2 3
  • CB-2 3 4
  • CB2 3 4
  • CX5 3 4
  • Testis-Dominant CNR2 Isoform CB2 3
  • CB2A 4
  • CB2B 4
  • HCB2 4

External Ids for CNR2 Gene

Previous GeneCards Identifiers for CNR2 Gene

  • GC01M023725
  • GC01M023271
  • GC01M9A0006
  • GC01M9A3945
  • GC01M023945
  • GC01M024069
  • GC01M024197
  • GC01M022452

Summaries for CNR2 Gene

Entrez Gene Summary for CNR2 Gene

  • The cannabinoid delta-9-tetrahydrocannabinol is the principal psychoactive ingredient of marijuana. The proteins encoded by this gene and the cannabinoid receptor 1 (brain) (CNR1) gene have the characteristics of a guanine nucleotide-binding protein (G-protein)-coupled receptor for cannabinoids. They inhibit adenylate cyclase activity in a dose-dependent, stereoselective, and pertussis toxin-sensitive manner. These proteins have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. The cannabinoid receptors are members of family 1 of the G-protein-coupled receptors. [provided by RefSeq, Jul 2008]

GeneCards Summary for CNR2 Gene

CNR2 (Cannabinoid Receptor 2) is a Protein Coding gene. Diseases associated with CNR2 include Cannabis Abuse and Glycerol Kinase Deficiency. Among its related pathways are Peptide ligand-binding receptors and Ibuprofen Pathway, Pharmacodynamics. GO annotations related to this gene include G-protein coupled receptor activity and cannabinoid receptor activity. An important paralog of this gene is CNR1.

UniProtKB/Swiss-Prot for CNR2 Gene

  • Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis.

Tocris Summary for CNR2 Gene

  • The CB2 receptor, also known as the peripheral cannabinoid receptor, is a member of the cannabinoid receptor group of G-protein-coupled receptors that also includes CB1 and GPR55. CB2 receptors are located primarily in immune cells both within and outside the CNS.

Gene Wiki entry for CNR2 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CNR2 Gene

Genomics for CNR2 Gene

Regulatory Elements for CNR2 Gene

Enhancers for CNR2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G023975 2.7 Ensembl ENCODE dbSUPER 11.8 -65.5 -65475 6.4 MLX CREB3L1 AGO1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC ZNF436-AS1 CNR2 SRSF10 PNRC2
GH01G024014 1.9 FANTOM5 Ensembl ENCODE dbSUPER 11.8 -106.0 -106007 9.3 FOXA2 PKNOX1 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SRSF10 PNRC2 CNR2 ENSG00000230703 MYOM3 LOC105376863 ENSG00000225315
GH01G023983 1.3 Ensembl ENCODE dbSUPER 11.8 -71.4 -71411 1.9 BCOR ESRRA FOXA2 NFIB INSM2 ZMYM3 FEZF1 ZBTB40 ZEB1 ZNF121 PNRC2 CNR2 SRSF10 LOC105378615
GH01G023907 1.8 FANTOM5 Ensembl ENCODE dbSUPER 7.1 +2.4 2421 6.4 HDGF PKNOX1 FOXA2 WRNIP1 ZNF143 FOS KDM4B JUNB TBX21 ZNF579 FUCA1 CNR2 NCMAP PNRC2 RPL11 ENSG00000232557
GH01G024028 0.7 Ensembl 11.5 -114.8 -114840 0.4 CTCF SAP130 ARID4B BMI1 RAD21 SMC3 ZSCAN29 MIXL1 ZNF680 RFX1 SRSF10 PNRC2 CNR2 ENSG00000225315 LOC105376863
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CNR2 on UCSC Golden Path with GeneCards custom track

Genomic Location for CNR2 Gene

23,870,526 bp from pter
23,913,362 bp from pter
42,837 bases
Minus strand

Genomic View for CNR2 Gene

Genes around CNR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CNR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CNR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CNR2 Gene

Proteins for CNR2 Gene

  • Protein details for CNR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cannabinoid receptor 2
    Protein Accession:
    Secondary Accessions:
    • C6ES44
    • Q4VBK8
    • Q5JRH7
    • Q6B0G7
    • Q6NSY0

    Protein attributes for CNR2 Gene

    360 amino acids
    Molecular mass:
    39681 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CNR2 Gene

neXtProt entry for CNR2 Gene

Post-translational modifications for CNR2 Gene

  • Constitutively phosphorylated on Ser-352; phosphorylation increases cell internalization and desensitizes the receptor.
  • Glycosylation at Asn11
  • Modification sites at PhosphoSitePlus

Other Protein References for CNR2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CNR2 Gene

Domains & Families for CNR2 Gene

Gene Families for CNR2 Gene

Suggested Antigen Peptide Sequences for CNR2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with CNR2: view

Function for CNR2 Gene

Molecular function for CNR2 Gene

GENATLAS Biochemistry:
cannabinoid receptor 2,peripheral,expressed in spleen,inhibiting adenylate cyclase
UniProtKB/Swiss-Prot Function:
Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis.

Gene Ontology (GO) - Molecular Function for CNR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IEA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004949 cannabinoid receptor activity TAS,IEA --
genes like me logo Genes that share ontologies with CNR2: view
genes like me logo Genes that share phenotypes with CNR2: view

Animal Models for CNR2 Gene

MGI Knock Outs for CNR2:

Animal Model Products

CRISPR Products

miRNA for CNR2 Gene

miRTarBase miRNAs that target CNR2

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CNR2
  • Applied Biological Materials Clones for CNR2
  • R&D Systems cDNA Clones for CNR2 (Cannabinoid R2/CB2/CNR2)

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CNR2 Gene

Localization for CNR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CNR2 Gene

Cell membrane; Multi-pass membrane protein. Cell projection, dendrite. Perikaryon. Note=Localizes to apical dendrite of pyramidal neurons. {ECO:0000250}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CNR2 gene
Compartment Confidence
plasma membrane 5
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for CNR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8679694
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030425 dendrite IEA --
genes like me logo Genes that share ontologies with CNR2: view

Pathways & Interactions for CNR2 Gene

genes like me logo Genes that share pathways with CNR2: view

Pathways by source for CNR2 Gene

Gene Ontology (GO) - Biological Process for CNR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001975 response to amphetamine IEA --
GO:0006954 inflammatory response IEA --
GO:0006955 immune response TAS 7556170
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with CNR2: view

No data available for SIGNOR curated interactions for CNR2 Gene

Drugs & Compounds for CNR2 Gene

(75) Drugs for CNR2 Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dronabinol Approved, Illicit Pharma Target, agonist 144
Nabilone Approved, Investigational Pharma Target, partial agonist 18
Rimonabant Approved, Investigational Pharma Antagonist CB1 receptor antagonist 45
Lasofoxifene Approved, Investigational Pharma Target, inverse agonist 0
AM630 Pharma Antagonist CB2 receptor antagonist,selective and competitive, CB2 selective antagonist/inverse agonist 0

(14) Additional Compounds for CNR2 Gene - From: IUPHAR, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Partial agonist, Agonist
GP 1a
JWH 133
JWH 133 (in Tocrisolve 100)

(5) Tocris Compounds for CNR2 Gene

Compound Action Cas Number
AM 630 CB2 selective antagonist/inverse agonist 164178-33-0
GP 1a Highly selective CB2 agonist 511532-96-0
HU 308 Potent and selective CB2 agonist 256934-39-1
JWH 133 Potent, selective CB2 agonist 259869-55-1
JWH 133 (in Tocrisolve 100) Potent, selective CB2 agonist (in water-soluble emulsion) 259869-55-1

(37) ApexBio Compounds for CNR2 Gene

Compound Action Cas Number
(-)-5'-DMH-CBD 97452-63-6
2-Palmitoylglycerol 23470-00-0
AM 1172 Inhibitor of anandamide uptake and FAAH,potent and selective 251908-92-6
AM1241 Cannabinoid CB2 receptor agonist,potent and selective 444912-48-5
AM251 Potent CB1 antagonist 183232-66-8
AM630 CB2 receptor antagonist,selective and competitive 164178-33-0
Arachidonyl serotonin 187947-37-1
Arvanil 128007-31-8
BML-190 CB2 receptor ligand 2854-32-2
COR 170 1048039-15-1
CP-945598 HCl CB1 antagonist,selective and high affinity 686347-12-6
GW842166X 666260-75-9
Hemopressin (human, mouse) 1314035-51-2
Hemopressin (rat) 568588-77-2
HU 308 CB2-receptor agonist 256934-39-1
JTE 907 282089-49-0
LY 320135 176977-56-3
MAFP 188404-10-6
MJ 15 944154-76-1
MM-22 956605-71-3
N-Arachidonylglycine 179113-91-8
NIDA 41020 502486-89-7
O-1918 536697-79-7
O-2093 439080-01-0
Oleamide 301-02-0
OMDM-2 616884-63-0
Org 27569 Cannabinoid CB1 receptor allosteric modulator 868273-06-7
Palmitoylisopropylamide 189939-61-5
PB-22 Synthetic cannabinoid 1400742-17-7
PF 514273 851728-60-4
Rimonabant CB1 receptor antagonist 168273-06-1
Taranabant 701977-09-5
TC-C 14G 656804-72-7
Tocrifluor T1117 1186195-59-4
UCM 707 390824-20-1
VDM 11 313998-81-1
genes like me logo Genes that share compounds with CNR2: view

Drug Products

Transcripts for CNR2 Gene

mRNA/cDNA for CNR2 Gene

Unigene Clusters for CNR2 Gene

Cannabinoid receptor 2 (macrophage):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CNR2
  • Applied Biological Materials Clones for CNR2
  • R&D Systems cDNA Clones for CNR2 (Cannabinoid R2/CB2/CNR2)

Alternative Splicing Database (ASD) splice patterns (SP) for CNR2 Gene

No ASD Table

Relevant External Links for CNR2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CNR2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CNR2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CNR2 Gene

This gene is overexpressed in Spleen (x19.6), Small Intestine - Terminal Ileum (x7.1), and Whole Blood (x7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CNR2 Gene

NURSA nuclear receptor signaling pathways regulating expression of CNR2 Gene:


SOURCE GeneReport for Unigene cluster for CNR2 Gene:


mRNA Expression by UniProt/SwissProt for CNR2 Gene:

Tissue specificity: Preferentially expressed in cells of the immune system with higher expression in B-cells and NK cells (at protein level). Expressed in skin in suprabasal layers and hair follicles (at protein level). Highly expressed in tonsil and to a lower extent in spleen, peripheral blood mononuclear cells, and thymus. PubMed:14657172 could not detect expression in normal brain. Expressed in brain by perivascular microglial cells and dorsal root ganglion sensory neurons (at protein level). Two isoforms are produced by alternative promoter usage and differ only in the 5 UTR: isoform CB2A is observed predominantly in testis with some expression in brain, while isoform CB2B is predominant in spleen and leukocytes.

Evidence on tissue expression from TISSUES for CNR2 Gene

  • Blood(4.4)
  • Nervous system(4.4)
  • Spleen(4.3)
genes like me logo Genes that share expression patterns with CNR2: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CNR2 Gene

Orthologs for CNR2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CNR2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CNR2 34 35
  • 99.26 (n)
(Canis familiaris)
Mammalia CNR2 34 35
  • 85 (n)
(Bos Taurus)
Mammalia CNR2 34 35
  • 84.22 (n)
(Mus musculus)
Mammalia Cnr2 34 16 35
  • 82.32 (n)
(Rattus norvegicus)
Mammalia Cnr2 34
  • 81.85 (n)
(Monodelphis domestica)
Mammalia CNR2 35
  • 68 (a)
(Ornithorhynchus anatinus)
Mammalia CNR2 35
  • 57 (a)
(Gallus gallus)
Aves CNR2 34 35
  • 56.11 (n)
(Anolis carolinensis)
Reptilia CNR2 35
  • 54 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cnr2 34
  • 54.98 (n)
(Danio rerio)
Actinopterygii cnr2 34 35
  • 51.04 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 23 (a)
-- 35
  • 21 (a)
Species where no ortholog for CNR2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CNR2 Gene

Gene Tree for CNR2 (if available)
Gene Tree for CNR2 (if available)

Paralogs for CNR2 Gene

Paralogs for CNR2 Gene

(1) SIMAP similar genes for CNR2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CNR2: view

Variants for CNR2 Gene

Sequence variations from dbSNP and Humsavar for CNR2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000029053 -- 23,889,975(+) GTGTT(C/T)TTACA intron-variant, upstream-variant-2KB
rs1000317078 -- 23,876,076(+) AATTT(C/T)GGCAA intron-variant
rs1000379759 -- 23,881,403(+) ACCAG(A/C)CTGTC intron-variant
rs1000410652 -- 23,881,198(+) TTGAA(C/T)CCAGG intron-variant
rs1000489968 -- 23,874,539(+) ATCAG(A/C)AATCA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for CNR2 Gene

Variant ID Type Subtype PubMed ID
dgv190n54 CNV loss 21841781
dgv191n54 CNV loss 21841781
dgv29n67 CNV loss 20364138
esv1663042 CNV insertion 17803354
esv2672735 CNV deletion 23128226
esv2745386 CNV deletion 23290073
esv29329 CNV loss 19812545
esv3585494 CNV loss 21293372
esv3585495 CNV loss 21293372
esv3893081 CNV gain 25118596
esv991485 CNV insertion 20482838
nsv1122310 CNV deletion 24896259
nsv1133021 OTHER inversion 24896259
nsv1145326 CNV deletion 24896259
nsv512727 CNV insertion 21212237
nsv545778 CNV loss 21841781

Variation tolerance for CNR2 Gene

Residual Variation Intolerance Score: 39.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.18; 39.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CNR2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CNR2 Gene

Disorders for CNR2 Gene

MalaCards: The human disease database

(5) MalaCards diseases for CNR2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
cannabis abuse
  • marijuana abuse
glycerol kinase deficiency
  • hyperglycerolemia
chromosome xp21 deletion syndrome
  • complex glycerol kinase deficiency
alternating hemiplegia of childhood
  • ahc
multiple sclerosis, disease progression, modifier of
  • multiple sclerosis 1
- elite association - COSMIC cancer census association via MalaCards
Search CNR2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CNR2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CNR2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CNR2 Gene

Publications for CNR2 Gene

  1. Brain neuronal CB2 cannabinoid receptors in drug abuse and depression: from mice to human subjects. (PMID: 18286196) Onaivi E.S. … Uhl G.R. (PLoS ONE 2008) 3 4 22 46 64
  2. Hepatic expression of endocannabinoid receptors and their novel polymorphisms in primary biliary cirrhosis. (PMID: 19730968) Floreani A. … Bergasa N.V. (J. Gastroenterol. 2010) 3 22 46 64
  3. Brain cannabinoid CB2 receptor in schizophrenia. (PMID: 19931854) Ishiguro H. … Arinami T. (Biol. Psychiatry 2010) 3 22 46 64
  4. The cannabinoid receptor type 2 (CNR2) gene is associated with hand bone strength phenotypes in an ethnically homogeneous family sample. (PMID: 19565271) Karsak M. … Livshits G. (Hum. Genet. 2009) 3 22 46 64
  5. Species differences in cannabinoid receptor 2 (CNR2 gene): identification of novel human and rodent CB2 isoforms, differential tissue expression and regulation by cannabinoid receptor ligands. (PMID: 19496827) Liu Q.R. … Uhl G.R. (Genes Brain Behav. 2009) 3 4 22 64

Products for CNR2 Gene

  • Addgene plasmids for CNR2

Sources for CNR2 Gene

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