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CNR2 Gene(Protein Coding)

Cannabinoid Receptor 2

GCID:
GC01M023870
GIFtS:
67
Genes Participants
UDN Logo

Aliases for CNR2 Gene

Aliases for CNR2 Gene

  • Cannabinoid Receptor 2 2 3 5
  • Cannabinoid Receptor 2 (Macrophage) 2 3
  • CB-2 3 4
  • CB2 3 4
  • CX5 3 4
  • Testis-Dominant CNR2 Isoform CB2 3
  • CB2A 4
  • CB2B 4
  • HCB2 4

External Ids for CNR2 Gene

Previous GeneCards Identifiers for CNR2 Gene

  • GC01M023725
  • GC01M023271
  • GC01M9A0006
  • GC01M9A3945
  • GC01M023945
  • GC01M024069
  • GC01M024197
  • GC01M022452

Summaries for CNR2 Gene

Entrez Gene Summary for CNR2 Gene

  • The cannabinoid delta-9-tetrahydrocannabinol is the principal psychoactive ingredient of marijuana. The proteins encoded by this gene and the cannabinoid receptor 1 (brain) (CNR1) gene have the characteristics of a guanine nucleotide-binding protein (G-protein)-coupled receptor for cannabinoids. They inhibit adenylate cyclase activity in a dose-dependent, stereoselective, and pertussis toxin-sensitive manner. These proteins have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. The cannabinoid receptors are members of family 1 of the G-protein-coupled receptors. [provided by RefSeq, Jul 2008]

GeneCards Summary for CNR2 Gene

CNR2 (Cannabinoid Receptor 2) is a Protein Coding gene. Diseases associated with CNR2 include Cannabis Abuse and Glycerol Kinase Deficiency. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and cannabinoid receptor activity. An important paralog of this gene is LPAR1.

UniProtKB/Swiss-Prot for CNR2 Gene

  • Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis.

Tocris Summary for CNR2 Gene

  • The CB2 receptor, also known as the peripheral cannabinoid receptor, is a member of the cannabinoid receptor group of G-protein-coupled receptors that also includes CB1 and GPR55. CB2 receptors are located primarily in immune cells both within and outside the CNS.

Gene Wiki entry for CNR2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CNR2 Gene

Genomics for CNR2 Gene

Products:

  1. Regulatory Element

Regulatory Elements for CNR2 Gene

Enhancers for CNR2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CNR2 on UCSC Golden Path with GeneCards custom track

Promoters for CNR2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CNR2 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the CNR2 gene promoter:

Genomic Location for CNR2 Gene

Chromosome:
1
Start:
23,870,526 bp from pter
End:
23,913,362 bp from pter
Size:
42,837 bases
Orientation:
Minus strand

Genomic View for CNR2 Gene

Genes around CNR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CNR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CNR2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CNR2 Gene

Proteins for CNR2 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for CNR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P34972-CNR2_HUMAN
    Recommended name:
    Cannabinoid receptor 2
    Protein Accession:
    P34972
    Secondary Accessions:
    • C6ES44
    • Q4VBK8
    • Q5JRH7
    • Q6B0G7
    • Q6NSY0

    Protein attributes for CNR2 Gene

    Size:
    360 amino acids
    Molecular mass:
    39681 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CNR2 Gene

neXtProt entry for CNR2 Gene

Proteomics data for CNR2 Gene at MOPED

Protein Expression for CNR2 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for CNR2 Gene

  • Constitutively phosphorylated on Ser-352; phosphorylation increases cell internalization and desensitizes the receptor.
  • Glycosylation at Asn 11
  • Modification sites at PhosphoSitePlus

Other Protein References for CNR2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for CNR2 (Cannabinoid R2/CB2/CNR2)

No data available for DME Specific Peptides for CNR2 Gene

Domains & Families for CNR2 Gene

Gene Families for CNR2 Gene

HGNC:
IUPHAR :

Protein Domains for CNR2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CNR2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P34972

UniProtKB/Swiss-Prot:

CNR2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with CNR2: view

Function for CNR2 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for CNR2 Gene

GENATLAS Biochemistry:
cannabinoid receptor 2,peripheral,expressed in spleen,inhibiting adenylate cyclase
UniProtKB/Swiss-Prot Function:
Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis.

Phenotypes for CNR2 Gene

MGI mutant phenotypes for CNR2:
inferred from 2 alleles
GenomeRNAi human phenotypes for CNR2:
genes like me logo Genes that share phenotypes with CNR2: view

Animal Models for CNR2 Gene

MGI Knock Outs for CNR2:

Animal Model Products

miRNA for CNR2 Gene

miRTarBase miRNAs that target CNR2

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CNR2 Gene

Localization for CNR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CNR2 Gene

Cell membrane; Multi-pass membrane protein. Cell projection, dendrite. Perikaryon. Note=Localizes to apical dendrite of pyramidal neurons. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CNR2 Gene COMPARTMENTS Subcellular localization image for CNR2 gene
Compartment Confidence
plasma membrane 5
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for CNR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0030425 dendrite IEA --
GO:0043005 neuron projection IEA --
GO:0043025 neuronal cell body IEA --
genes like me logo Genes that share ontologies with CNR2: view

Pathways & Interactions for CNR2 Gene

genes like me logo Genes that share pathways with CNR2: view

Pathways by source for CNR2 Gene

2 BioSystems pathways for CNR2 Gene
1 PharmGKB pathway for CNR2 Gene
1 KEGG pathway for CNR2 Gene
1 Qiagen pathway for CNR2 Gene

Gene Ontology (GO) - Biological Process for CNR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001975 response to amphetamine IEA --
GO:0006954 inflammatory response IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0032229 negative regulation of synaptic transmission, GABAergic IEA --
GO:0032496 response to lipopolysaccharide IEA --
genes like me logo Genes that share ontologies with CNR2: view

No data available for SIGNOR curated interactions for CNR2 Gene

Drugs & Compounds for CNR2 Gene

Products:

  1. Drug

(42) Drugs for CNR2 Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dronabinol Approved, Illicit Pharma Target, agonist 131
Nabilone Approved, Investigational Pharma Target, partial agonist 17
Rimonabant Approved, Investigational Pharma Antagonist CB1 receptor antagonist 45
AM1241 Pharma Agonist Cannabinoid CB2 receptor agonist,potent and selective 0
2-arachidonoylglycerol Pharma Partial agonist, Agonist 0

(18) Additional Compounds for CNR2 Gene - From: Novoseek, IUPHAR, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
AM630
Antagonist
Delta<sup>9</sup>-tetrahydrocannabinol
Partial agonist, Agonist
GW 405833
180002-83-9
JWH 015
155471-08-2
JWH 133
259869-55-1

(4) Tocris Compounds for CNR2 Gene

Compound Action Cas Number
GW 405833 Selective, high affinity CB2 receptor partial agonist 180002-83-9
JWH 015 Selective CB2 agonist 155471-08-2
JWH 133 Potent, selective CB2 agonist 259869-55-1
JWH 133 (in Tocrisolve 100) Potent, selective CB2 agonist (in water-soluble emulsion) 259869-55-1

(7) ApexBio Compounds for CNR2 Gene

Compound Action Cas Number
AM1241 Cannabinoid CB2 receptor agonist,potent and selective 444912-48-5
AM251 Potent CB1 antagonist 183232-66-8
BML-190 CB2 receptor ligand 2854-32-2
CP-945598 HCl CB1 antagonist,selective and high affinity 686347-12-6
GW842166X 666260-75-9
Org 27569 Cannabinoid CB1 receptor allosteric modulator 868273-06-7
Rimonabant CB1 receptor antagonist 168273-06-1
genes like me logo Genes that share compounds with CNR2: view

Drug Products

Transcripts for CNR2 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for CNR2 Gene

(5) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(32) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CNR2 Gene

Cannabinoid receptor 2 (macrophage):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CNR2 Gene

No ASD Table

Relevant External Links for CNR2 Gene

GeneLoc Exon Structure for
CNR2
ECgene alternative splicing isoforms for
CNR2

Expression for CNR2 Gene

Products:

  1. Primer

mRNA expression in normal human tissues for CNR2 Gene

mRNA expression in normal human tissues for CNR2 Gene
mRNA expression by BioGPS for CNR2 GenemRNA expression by GTEx for CNR2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CNR2 Gene

This gene is overexpressed in Spleen (x19.6), Small Intestine - Terminal Ileum (x7.1), and Whole Blood (x7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CNR2 Gene



SOURCE GeneReport for Unigene cluster for CNR2 Gene Hs.73037

mRNA Expression by UniProt/SwissProt for CNR2 Gene

P34972-CNR2_HUMAN
Tissue specificity: Preferentially expressed in cells of the immune system with higher expression in B-cells and NK cells (at protein level). Expressed in skin in suprabasal layers and hair follicles (at protein level). Highly expressed in tonsil and to a lower extent in spleen, peripheral blood mononuclear cells, and thymus. PubMed:14657172 could not detect expression in normal brain. Expressed in brain by perivascular microglial cells and dorsal root ganglion sensory neurons (at protein level). Two isoforms are produced by alternative promoter usage and differ only in the 5 UTR: isoform CB2A is observed predominantly in testis with some expression in brain, while isoform CB2B is predominant in spleen and leukocytes.
genes like me logo Genes that share expression patterns with CNR2: view

Primer Products

No data available for Protein differential expression in normal tissues and Protein tissue co-expression partners for CNR2 Gene

Orthologs for CNR2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CNR2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia CNR2 35
  • 84.22 (n)
  • 82.73 (a)
CNR2 36
  • 82 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia CNR2 35
  • 85 (n)
  • 82.22 (a)
CNR2 36
  • 82 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Cnr2 35
  • 82.32 (n)
  • 82.71 (a)
Cnr2 16
Cnr2 36
  • 83 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia CNR2 35
  • 99.26 (n)
  • 99.72 (a)
CNR2 36
  • 100 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Cnr2 35
  • 81.85 (n)
  • 81.11 (a)
oppossum
(Monodelphis domestica)
 Mammalia CNR2 36
  • 68 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia CNR2 36
  • 57 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves CNR2 35
  • 56.11 (n)
  • 50.44 (a)
CNR2 36
  • 50 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia CNR2 36
  • 54 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia cnr2 35
  • 54.98 (n)
  • 50.57 (a)
zebrafish
(Danio rerio)
 Actinopterygii cnr2 35
  • 51.04 (n)
  • 45.94 (a)
cnr2 36
  • 39 (a)
 OneToOne
sea squirt
(Ciona savignyi)
 Ascidiacea -- 36
  • 21 (a)
 ManyToMany
-- 36
  • 23 (a)
 ManyToMany
Species with no ortholog for CNR2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CNR2 Gene

ENSEMBL:
Gene Tree for CNR2 (if available)
TreeFam:
Gene Tree for CNR2 (if available)

Paralogs for CNR2 Gene

Paralogs for CNR2 Gene

(1) SIMAP similar genes for CNR2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CNR2: view

Variants for CNR2 Gene

Sequence variations from dbSNP and Humsavar for CNR2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs2229579 - 23,874,672(-) TGGCT(A/C/T)ACTGG reference, missense
rs2501432 - 23,875,430(+) GGAGT(C/T)GGTGG reference, missense
rs1105 -- 23,874,310(-) CAGGT(A/G)GGCGA utr-variant-3-prime
rs1106 -- 23,874,282(-) ACAGG(C/G)TCAGT utr-variant-3-prime
rs1130316 -- 23,874,266(-) TCAGG(A/T)CAGGC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CNR2 Gene

Variant ID Type Subtype PubMed ID
esv29329 CNV Loss 19812545
dgv29n67 CNV Loss 20364138
esv991485 CNV Insertion 20482838
nsv512727 CNV Insertion 21212237
esv1663042 CNV Insertion 17803354
esv2672735 CNV Deletion 23128226
esv2745386 CNV Deletion 23290073

Variation tolerance for CNR2 Gene

Residual Variation Intolerance Score: 39.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.18; 39.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CNR2 Gene

Human Gene Mutation Database (HGMD)
CNR2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CNR2 Gene

Disorders for CNR2 Gene

MalaCards: The human disease database

(5) MalaCards diseases for CNR2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
cannabis abuse
  • marijuana abuse
glycerol kinase deficiency
  • glycerol kinase
chromosome xp21 deletion syndrome
  • complex glycerol kinase deficiency
alternating hemiplegia of childhood
  • ahc
multiple sclerosis, disease progression, modifier of
  • multiple sclerosis 1
- elite association - COSMIC cancer census association via MalaCards
Search CNR2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CNR2

Genetic Association Database (GAD)
CNR2
Human Genome Epidemiology (HuGE) Navigator
CNR2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CNR2
genes like me logo Genes that share disorders with CNR2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CNR2 Gene

Publications for CNR2 Gene

  1. Brain neuronal CB2 cannabinoid receptors in drug abuse and depression: from mice to human subjects. (PMID: 18286196) Onaivi E.S. … Uhl G.R. (PLoS ONE 2008) 3 4 23 48 67
  2. Hepatic expression of endocannabinoid receptors and their novel polymorphisms in primary biliary cirrhosis. (PMID: 19730968) Floreani A. … Bergasa N.V. (J. Gastroenterol. 2010) 3 23
  3. Substantially altered expression pattern of cannabinoid receptor 2 and activated endocannabinoid system in patients with severe heart failure. (PMID: 19931541) Weis F. … Kreth S. (J. Mol. Cell. Cardiol. 2010) 3 23
  4. Brain cannabinoid CB2 receptor in schizophrenia. (PMID: 19931854) Ishiguro H. … Arinami T. (Biol. Psychiatry 2010) 3 23
  5. The levels of the endocannabinoid receptor CB2 and its ligand 2-arachidonoylglycerol are elevated in endometrial carcinoma. (PMID: 20133454) Guida M. … Iuvone T. (Endocrinology 2010) 3 23

Products for CNR2 Gene

Sources for CNR2 Gene

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