Aliases for CNR1 Gene
External Ids for CNR1 Gene
Previous HGNC Symbols for CNR1 Gene
Previous GeneCards Identifiers for CNR1 Gene
This gene encodes one of two cannabinoid receptors. The cannabinoids, principally delta-9-tetrahydrocannabinol and synthetic analogs, are psychoactive ingredients of marijuana. The cannabinoid receptors are members of the guanine-nucleotide-binding protein (G-protein) coupled receptor family, which inhibit adenylate cyclase activity in a dose-dependent, stereoselective and pertussis toxin-sensitive manner. The two receptors have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. Multiple transcript variants encoding two different protein isoforms have been described for this gene. [provided by RefSeq, May 2009]
GeneCards Summary for CNR1 Gene
CNR1 (Cannabinoid Receptor 1 (Brain)) is a Protein Coding gene. Diseases associated with CNR1 include cannabis dependence and cannabis abuse. Among its related pathways are Signaling by GPCR and Circadian entrainment. GO annotations related to this gene include G-protein coupled receptor activity and cannabinoid receptor activity. An important paralog of this gene is LPAR1.
UniProtKB/Swiss-Prot for CNR1 Gene
Involved in cannabinoid-induced CNS effects. Acts by inhibiting adenylate cyclase. Could be a receptor for anandamide. Inhibits L-type Ca(2+) channel current. Isoform 2 and isoform 3 have altered ligand binding.
The CB1 receptor, also known as the central cannabinoid receptor, is a member of the cannabinoid receptor group of G-protein-coupled receptors that also includes CB2 and GPR55. CB1 receptors are found mainly in the terminals of central and peripheral neurons.