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Aliases for CNR1 Gene

Aliases for CNR1 Gene

  • Cannabinoid Receptor 1 2 3 5
  • Cannabinoid Receptor 1 (Brain) 2 3
  • CANN6 3 4
  • CB-R 3 4
  • CNR 3 4
  • CB1 3 4
  • Central Cannabinoid Receptor 3
  • CB1K5 3
  • CB1A 3
  • CB1R 3

External Ids for CNR1 Gene

Previous HGNC Symbols for CNR1 Gene

  • CNR

Previous GeneCards Identifiers for CNR1 Gene

  • GC06M088795
  • GC06M088845
  • GC06M088906
  • GC06M086064
  • GC06M088850

Summaries for CNR1 Gene

Entrez Gene Summary for CNR1 Gene

  • This gene encodes one of two cannabinoid receptors. The cannabinoids, principally delta-9-tetrahydrocannabinol and synthetic analogs, are psychoactive ingredients of marijuana. The cannabinoid receptors are members of the guanine-nucleotide-binding protein (G-protein) coupled receptor family, which inhibit adenylate cyclase activity in a dose-dependent, stereoselective and pertussis toxin-sensitive manner. The two receptors have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. Multiple transcript variants encoding two different protein isoforms have been described for this gene. [provided by RefSeq, May 2009]

GeneCards Summary for CNR1 Gene

CNR1 (Cannabinoid Receptor 1) is a Protein Coding gene. Diseases associated with CNR1 include Cannabis Dependence and Chronic Pain. Among its related pathways are Eicosanoid ligand-binding receptors and Cell-type Dependent Selectivity of CCK2R Signaling. GO annotations related to this gene include G-protein coupled receptor activity and cannabinoid receptor activity. An important paralog of this gene is CNR2.

UniProtKB/Swiss-Prot for CNR1 Gene

  • G-protein coupled receptor for endogenous cannabinoids (eCBs), including N-arachidonoylethanolamide (also called anandamide or AEA) and 2-arachidonoylglycerol (2-AG), as well as phytocannabinoids, such as delta(9)-tetrahydrocannabinol (THC) (PubMed:15620723, PubMed:27768894, PubMed:27851727). Mediates many cannabinoid-induced effects, acting, among others, on food intake, memory loss, gastrointestinal motility, catalepsy, ambulatory activity, anxiety, chronic pain. Signaling typically involves reduction in cyclic AMP (PubMed:1718258, PubMed:21895628, PubMed:27768894). In the hypothalamus, may have a dual effect on mitochondrial respiration depending upon the agonist dose and possibly upon the cell type. Increases respiration at low doses, while decreases respiration at high doses. At high doses, CNR1 signal transduction involves G-protein alpha-i protein activation and subsequent inhibition of mitochondrial soluble adenylate cyclase, decrease in cyclic AMP concentration, inhibition of protein kinase A (PKA)-dependent phosphorylation of specific subunits of the mitochondrial electron transport system, including NDUFS2. In the hypothalamus, inhibits leptin-induced reactive oxygen species (ROS) formation and mediates cannabinoid-induced increase in SREBF1 and FASN gene expression. In response to cannabinoids, drives the release of orexigenic beta-endorphin, but not that of melanocyte-stimulating hormone alpha/alpha-MSH, from hypothalamic POMC neurons, hence promoting food intake. In the hippocampus, regulates cellular respiration and energy production in response to cannabinoids. Involved in cannabinoid-dependent depolarization-induced suppression of inhibition (DSI), a process in which depolarization of CA1 postsynaptic pyramidal neurons mobilizes eCBs, which retrogradely activate presynaptic CB1 receptors, transiently decreasing GABAergic inhibitory neurotransmission. Also reduces excitatory synaptic transmission (By similarity). In superior cervical ganglions and cerebral vascular smooth muscle cells, inhibits voltage-gated Ca(2+) channels in a constitutive, as well as agonist-dependent manner (PubMed:17895407). In cerebral vascular smooth muscle cells, cannabinoid-induced inhibition of voltage-gated Ca(2+) channels leads to vasodilation and decreased vascular tone (By similarity). Induces leptin production in adipocytes and reduces LRP2-mediated leptin clearance in the kidney, hence participating in hyperleptinemia. In adipose tissue, CNR1 signaling leads to increased expression of SREBF1, ACACA and FASN genes (By similarity). In the liver, activation by endocannabinoids leads to increased de novo lipogenesis and reduced fatty acid catabolism, associated with increased expression of SREBF1/SREBP-1, GCK, ACACA, ACACB and FASN genes. May also affect de novo cholesterol synthesis and HDL-cholesteryl ether uptake. Peripherally modulates energy metabolism (By similarity). In high carbohydrate diet-induced obesity, may decrease the expression of mitochondrial dihydrolipoyl dehydrogenase/DLD in striated muscles, as well as that of selected glucose/ pyruvate metabolic enzymes, hence affecting energy expenditure through mitochondrial metabolism (By similarity). In response to cannabinoid anandamide, elicits a proinflammatory response in macrophages, which involves NLRP3 inflammasome activation and IL1B and IL18 secretion (By similarity). In macrophages infiltrating pancreatic islets, this process may participate in the progression of type-2 diabetes and associated loss of pancreatic beta-cells (PubMed:23955712).

  • Isoform 1: Binds both 2-AG and anandamide.

  • Isoform 2: Only binds 2-AG with high affinity. Contrary to its effect on isoform 1, 2-AG behaves as an inverse agonist on isoform 2 in assays measuring GTP binding to membranes.

  • Isoform 3: Only binds 2-AG with high affinity. Contrary to its effect on isoform 1, 2-AG behaves as an inverse agonist on isoform 3 in assays measuring GTP binding to membranes.

Tocris Summary for CNR1 Gene

  • The CB1 receptor, also known as the central cannabinoid receptor, is a member of the cannabinoid receptor group of G-protein-coupled receptors that also includes CB2 and GPR55. CB1 receptors are found mainly in the terminals of central and peripheral neurons.

Gene Wiki entry for CNR1 Gene

Additional gene information for CNR1 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CNR1 Gene

Genomics for CNR1 Gene

Regulatory Elements for CNR1 Gene

Enhancers for CNR1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06H088008 0.8 Ensembl ENCODE 9.6 +157.7 157695 1 TSHZ1 FOS PRDM10 TRIM28 SPACA1 CNR1 LOC105377882
GH06H088359 0.6 ENCODE 6.9 -193.6 -193585 1 NFIL3 JUND JUN HLF HNF4A NFE2 CNR1 ACTBP8 GC06P088328 ENSG00000234426
GH06H088376 0.5 ENCODE 5.2 -210.0 -210031 0 JUND POLR2A JUN REST NR2F2 CNR1 ACTBP8 ENSG00000234426 GC06P088328
GH06H088379 0.9 FANTOM5 ENCODE 2.2 -213.6 -213589 1 FOSL1 JUND JUN CEBPB NFE2 FOS ACTBP8 CNR1 ENSG00000234426 GC06P088328
GH06H088490 0.4 ENCODE 4.9 -324.6 -324594 1 ZNF316 CNR1 LOC105377885 LOC101928936
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CNR1 on UCSC Golden Path with GeneCards custom track

Promoters for CNR1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000199822 545 401 ZSCAN4 KLF17 GLI4 RAD21 ZNF2 GLIS2 ZNF143 KLF7 ZNF391 IKZF2

Genomic Location for CNR1 Gene

Chromosome:
6
Start:
88,139,864 bp from pter
End:
88,166,745 bp from pter
Size:
26,882 bases
Orientation:
Minus strand

Genomic View for CNR1 Gene

Genes around CNR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CNR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CNR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CNR1 Gene

Proteins for CNR1 Gene

  • Protein details for CNR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P21554-CNR1_HUMAN
    Recommended name:
    Cannabinoid receptor 1
    Protein Accession:
    P21554
    Secondary Accessions:
    • B2R9T4
    • E1P512
    • Q13949
    • Q495Z0
    • Q4PLI4
    • Q4VBM6
    • Q5JVL5
    • Q5UB37
    • Q9UNN0

    Protein attributes for CNR1 Gene

    Size:
    472 amino acids
    Molecular mass:
    52858 Da
    Quaternary structure:
    • Interacts (via C-terminus) with CNRIP1; this interaction attenuates constitutive, but not agonist-dependent, inhibition of voltage-gated Ca(2+) channels in neurons (PubMed:17895407). Associates with G protein alpha subunits, including G(i) alpha-1/GNAI1, G(i) alpha-3/GNAI3 and G(o) alpha/GNAO1; palmitoylation is important for interaction with GNAI3 and GNAO1 (PubMed:12237474).
    Miscellaneous:
    • High-fat diet also increases the hepatic levels of CNR1 ligand anandamide, but not that of 2-arachidonoylglycerol.

    Three dimensional structures from OCA and Proteopedia for CNR1 Gene

    Alternative splice isoforms for CNR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CNR1 Gene

Post-translational modifications for CNR1 Gene

  • Palmitoylation at Cys-415 is important for recruitment at plasma membrane and lipid rafts and association with G protein alpha subunits.
  • Glycosylation at Asn77 and posLast=8383
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for CNR1 (Cannabinoid R1/CB1/CNR1)
  • Cell Signaling Technology (CST) Antibodies for CNR1 (CNR1)
  • Santa Cruz Biotechnology (SCBT) Antibodies for CNR1

No data available for DME Specific Peptides for CNR1 Gene

Domains & Families for CNR1 Gene

Gene Families for CNR1 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • FDA approved drug targets
  • G-protein coupled receptors
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Suggested Antigen Peptide Sequences for CNR1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P21554

UniProtKB/Swiss-Prot:

CNR1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with CNR1: view

Function for CNR1 Gene

Molecular function for CNR1 Gene

GENATLAS Biochemistry:
cannabinoid receptor 1,expressed in brain,testis,located in the eye-ciliary epithelium,corneal epithelium,endothelium of anterior eye retina,inhibiting adenylate cyclaselocated in and/or one cone pedicles and rod spherules,also inhibiting voltage-gated L-type calcium channel current in retinal bipolar cells,putatively involved for endogenouscannaloid system in retinal physiology,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
G-protein coupled receptor for endogenous cannabinoids (eCBs), including N-arachidonoylethanolamide (also called anandamide or AEA) and 2-arachidonoylglycerol (2-AG), as well as phytocannabinoids, such as delta(9)-tetrahydrocannabinol (THC) (PubMed:15620723, PubMed:27768894, PubMed:27851727). Mediates many cannabinoid-induced effects, acting, among others, on food intake, memory loss, gastrointestinal motility, catalepsy, ambulatory activity, anxiety, chronic pain. Signaling typically involves reduction in cyclic AMP (PubMed:1718258, PubMed:21895628, PubMed:27768894). In the hypothalamus, may have a dual effect on mitochondrial respiration depending upon the agonist dose and possibly upon the cell type. Increases respiration at low doses, while decreases respiration at high doses. At high doses, CNR1 signal transduction involves G-protein alpha-i protein activation and subsequent inhibition of mitochondrial soluble adenylate cyclase, decrease in cyclic AMP concentration, inhibition of protein kinase A (PKA)-dependent phosphorylation of specific subunits of the mitochondrial electron transport system, including NDUFS2. In the hypothalamus, inhibits leptin-induced reactive oxygen species (ROS) formation and mediates cannabinoid-induced increase in SREBF1 and FASN gene expression. In response to cannabinoids, drives the release of orexigenic beta-endorphin, but not that of melanocyte-stimulating hormone alpha/alpha-MSH, from hypothalamic POMC neurons, hence promoting food intake. In the hippocampus, regulates cellular respiration and energy production in response to cannabinoids. Involved in cannabinoid-dependent depolarization-induced suppression of inhibition (DSI), a process in which depolarization of CA1 postsynaptic pyramidal neurons mobilizes eCBs, which retrogradely activate presynaptic CB1 receptors, transiently decreasing GABAergic inhibitory neurotransmission. Also reduces excitatory synaptic transmission (By similarity). In superior cervical ganglions and cerebral vascular smooth muscle cells, inhibits voltage-gated Ca(2+) channels in a constitutive, as well as agonist-dependent manner (PubMed:17895407). In cerebral vascular smooth muscle cells, cannabinoid-induced inhibition of voltage-gated Ca(2+) channels leads to vasodilation and decreased vascular tone (By similarity). Induces leptin production in adipocytes and reduces LRP2-mediated leptin clearance in the kidney, hence participating in hyperleptinemia. In adipose tissue, CNR1 signaling leads to increased expression of SREBF1, ACACA and FASN genes (By similarity). In the liver, activation by endocannabinoids leads to increased de novo lipogenesis and reduced fatty acid catabolism, associated with increased expression of SREBF1/SREBP-1, GCK, ACACA, ACACB and FASN genes. May also affect de novo cholesterol synthesis and HDL-cholesteryl ether uptake. Peripherally modulates energy metabolism (By similarity). In high carbohydrate diet-induced obesity, may decrease the expression of mitochondrial dihydrolipoyl dehydrogenase/DLD in striated muscles, as well as that of selected glucose/ pyruvate metabolic enzymes, hence affecting energy expenditure through mitochondrial metabolism (By similarity). In response to cannabinoid anandamide, elicits a proinflammatory response in macrophages, which involves NLRP3 inflammasome activation and IL1B and IL18 secretion (By similarity). In macrophages infiltrating pancreatic islets, this process may participate in the progression of type-2 diabetes and associated loss of pancreatic beta-cells (PubMed:23955712).
UniProtKB/Swiss-Prot Function:
Isoform 1: Binds both 2-AG and anandamide.
UniProtKB/Swiss-Prot Function:
Isoform 2: Only binds 2-AG with high affinity. Contrary to its effect on isoform 1, 2-AG behaves as an inverse agonist on isoform 2 in assays measuring GTP binding to membranes.
UniProtKB/Swiss-Prot Function:
Isoform 3: Only binds 2-AG with high affinity. Contrary to its effect on isoform 1, 2-AG behaves as an inverse agonist on isoform 3 in assays measuring GTP binding to membranes.
UniProtKB/Swiss-Prot Induction:
Up-regulated by endocannabinoid anandamide.

Phenotypes From GWAS Catalog for CNR1 Gene

Gene Ontology (GO) - Molecular Function for CNR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IEA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004949 cannabinoid receptor activity IDA,IEA 18761332
GO:0008144 drug binding IEA --
genes like me logo Genes that share ontologies with CNR1: view
genes like me logo Genes that share phenotypes with CNR1: view

Animal Models for CNR1 Gene

MGI Knock Outs for CNR1:

Animal Model Products

  • Taconic Biosciences Mouse Models for CNR1

CRISPR Products

miRNA for CNR1 Gene

miRTarBase miRNAs that target CNR1

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CNR1
  • Applied Biological Materials Clones for CNR1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
  • R&D Systems cDNA Clones for CNR1 (Cannabinoid R1/CB1/CNR1)

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CNR1 Gene

Localization for CNR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CNR1 Gene

Cell membrane; Multi-pass membrane protein. Membrane raft. Mitochondrion outer membrane. Cell projection, axon. Note=Unexpectedly, in the mitochondria, the C-terminus is located in the mitochondrial intermembrane space, a compartment topologically considered as extracellular. In canonical seven-transmembrane G-protein coupled receptors, the C-terminus is cytosolic (By similarity). Found on presynaptic axon terminals in some GABAergic neurons in the somatosensory cortex (By similarity). {ECO:0000250 UniProtKB:P20272, ECO:0000250 UniProtKB:P47746}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CNR1 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 5
extracellular 2
mitochondrion 2
peroxisome 2
nucleus 2
endoplasmic reticulum 2
cytosol 2
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
  • Actin filaments (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CNR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005741 mitochondrial outer membrane IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 1718258
GO:0015629 actin cytoskeleton IDA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with CNR1: view

Pathways & Interactions for CNR1 Gene

genes like me logo Genes that share pathways with CNR1: view

Gene Ontology (GO) - Biological Process for CNR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002866 positive regulation of acute inflammatory response to antigenic stimulus IEA --
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS 1718258
GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway IDA 18761332
genes like me logo Genes that share ontologies with CNR1: view

No data available for SIGNOR curated interactions for CNR1 Gene

Drugs & Compounds for CNR1 Gene

(133) Drugs for CNR1 Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Rimonabant Approved, Investigational Pharma Antagonist, antagonist, Target CB1 receptor antagonist 46
Dronabinol Approved, Illicit Pharma agonist, Target 157
Nabilone Approved, Investigational Pharma Target, partial agonist 20
Cocaine Approved, Illicit Pharma 524
Aripiprazole Approved, Investigational Pharma Antagonist Antipsychotic, High affinity D2 and 5-HT1A receptor partial agonist; also 5-HT2A antagonist 366

(26) Additional Compounds for CNR1 Gene - From: Novoseek, IUPHAR, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Delta<sup>9</sup>-tetrahydrocannabinol
Partial agonist, Agonist
(R)-(+)-Methanandamide (in Tocrisolve 100)
157182-49-5
ACEA
220556-69-4
SR 141716A
158681-13-1

(5) Tocris Compounds for CNR1 Gene

Compound Action Cas Number
(R)-(+)-Methanandamide (in Tocrisolve 100) Potent and selective CB1 agonist (in water-soluble emulsion) 157182-49-5
ACEA Potent, highly selective CB1 agonist 220556-69-4
AM 251 Potent CB1 antagonist; also GPR55 agonist 183232-66-8
AM 281 Potent, selective CB1 antagonist/inverse agonist 202463-68-1
SR 141716A Selective CB1 receptor antagonist 158681-13-1

(41) ApexBio Compounds for CNR1 Gene

Compound Action Cas Number
(-)-5'-DMH-CBD 97452-63-6
(±)-SLV 319 CB1 receptor antagonist,potent and selective 362519-49-1
2-Palmitoylglycerol 23470-00-0
AM 1172 Inhibitor of anandamide uptake and FAAH,potent and selective 251908-92-6
AM 281 CB1 antagonist 202463-68-1
AM 404 Anandamide transport inhibitor 198022-70-7
AM1241 Cannabinoid CB2 receptor agonist,potent and selective 444912-48-5
AM251 Potent CB1 antagonist 183232-66-8
Arachidonyl serotonin 187947-37-1
Arvanil 128007-31-8
BML-190 CB2 receptor ligand 2854-32-2
COR 170 1048039-15-1
CP-945598 HCl CB1 antagonist,selective and high affinity 686347-12-6
GW842166X 666260-75-9
Hemopressin (human, mouse) 1314035-51-2
Hemopressin (rat) 568588-77-2
JTE 907 282089-49-0
JWH 073 CB1 receptor agonist 208987-48-8
LY 320135 176977-56-3
MAFP 188404-10-6
MJ 15 944154-76-1
MM-22 956605-71-3
N-Arachidonylglycine 179113-91-8
NIDA 41020 502486-89-7
O-1918 536697-79-7
O-2050
O-2093 439080-01-0
Oleamide 301-02-0
OMDM-2 616884-63-0
Org 27569 Cannabinoid CB1 receptor allosteric modulator 868273-06-7
Otenabant CB1 receptor antagonist 686344-29-6
Palmitoylisopropylamide 189939-61-5
PB-22 Synthetic cannabinoid 1400742-17-7
PF 514273 851728-60-4
Rimonabant CB1 receptor antagonist 168273-06-1
Rimonabant hydrochloride CB1 receptor inverse agonist 158681-13-1
Taranabant 701977-09-5
TC-C 14G 656804-72-7
Tocrifluor T1117 1186195-59-4
UCM 707 390824-20-1
VDM 11 313998-81-1
genes like me logo Genes that share compounds with CNR1: view

Drug Products

Transcripts for CNR1 Gene

Unigene Clusters for CNR1 Gene

Cannabinoid receptor 1 (brain):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CNR1
  • Applied Biological Materials Clones for CNR1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
  • R&D Systems cDNA Clones for CNR1 (Cannabinoid R1/CB1/CNR1)

Alternative Splicing Database (ASD) splice patterns (SP) for CNR1 Gene

ExUns: 1a · 1b ^ 2a · 2b
SP1: -
SP2: -

Relevant External Links for CNR1 Gene

GeneLoc Exon Structure for
CNR1
ECgene alternative splicing isoforms for
CNR1

Expression for CNR1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CNR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CNR1 Gene

This gene is overexpressed in Fetal Brain (35.8) and Frontal cortex (33.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CNR1 Gene



Protein tissue co-expression partners for CNR1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CNR1 Gene:

CNR1

SOURCE GeneReport for Unigene cluster for CNR1 Gene:

Hs.75110

mRNA Expression by UniProt/SwissProt for CNR1 Gene:

P21554-CNR1_HUMAN
Tissue specificity: Widely expressed, with highest levels in fetal and adult brain. Expression levels of isoform 2 and isoform 3 are much lower than those of isoform 1.

Evidence on tissue expression from TISSUES for CNR1 Gene

  • Nervous system(4.9)
  • Lung(4.3)
  • Blood(2.1)
  • Intestine(2)
  • Muscle(2)
genes like me logo Genes that share expression patterns with CNR1: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CNR1 Gene

Orthologs for CNR1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CNR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CNR1 33 34
  • 99.58 (n)
oppossum
(Monodelphis domestica)
Mammalia CNR1 34
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CNR1 34
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CNR1 33 34
  • 92.66 (n)
cow
(Bos Taurus)
Mammalia CNR1 33 34
  • 91.17 (n)
mouse
(Mus musculus)
Mammalia Cnr1 33 16 34
  • 90.54 (n)
rat
(Rattus norvegicus)
Mammalia Cnr1 33
  • 90.54 (n)
chicken
(Gallus gallus)
Aves CNR1 33 34
  • 81.95 (n)
lizard
(Anolis carolinensis)
Reptilia CNR1 34
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cnr1 33
  • 74.12 (n)
African clawed frog
(Xenopus laevis)
Amphibia cnr1-A 33
zebrafish
(Danio rerio)
Actinopterygii cnr1 33 34
  • 70.61 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 24 (a)
ManyToMany
-- 34
  • 23 (a)
ManyToMany
Species where no ortholog for CNR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CNR1 Gene

ENSEMBL:
Gene Tree for CNR1 (if available)
TreeFam:
Gene Tree for CNR1 (if available)

Paralogs for CNR1 Gene

Paralogs for CNR1 Gene

(4) SIMAP similar genes for CNR1 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with CNR1: view

Variants for CNR1 Gene

Sequence variations from dbSNP and Humsavar for CNR1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000139586 -- 88,166,546(+) AGAGG(A/G)GACAA intron-variant, upstream-variant-2KB
rs1000225400 -- 88,154,370(+) CTTCA(C/T)TGGGT intron-variant
rs1000453745 -- 88,158,888(+) AATAA(C/T)GTCAT intron-variant
rs1000600398 -- 88,150,201(+) TCCCC(C/G)TTTAC intron-variant, utr-variant-5-prime
rs1000703054 -- 88,165,045(+) AAACA(-/TTTCT)TTTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CNR1 Gene

Variant ID Type Subtype PubMed ID
dgv6086n100 CNV gain 25217958
dgv775n27 CNV gain 19166990
esv2763586 CNV gain 21179565
esv3609879 CNV gain 21293372
nsv519365 CNV gain 19592680
nsv604120 CNV loss 21841781
nsv604121 CNV gain 21841781
nsv830723 CNV loss 17160897

Variation tolerance for CNR1 Gene

Residual Variation Intolerance Score: 15.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.43; 9.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CNR1 Gene

Human Gene Mutation Database (HGMD)
CNR1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CNR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CNR1 Gene

Disorders for CNR1 Gene

MalaCards: The human disease database

(34) MalaCards diseases for CNR1 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
cannabis dependence
  • marijuana abuse
chronic pain
  • pain - chronic
cannabis abuse
  • marijuana abuse
hallucinogen dependence
substance dependence
- elite association - COSMIC cancer census association via MalaCards
Search CNR1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

CNR1_HUMAN
  • Obesity (OBESITY) [MIM:601665]: A condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat. {ECO:0000269 PubMed:18177726}. Note=The protein represented in this entry may be involved in disease pathogenesis. May contribute to the development of diet-induced obesity and several obesity-associated features, such as dyslipidemia and liver steatosis, regulating peripheral lipogenesis, energy expenditure and feeding behavior. CNR1 inverse agonists have been shown to reduce body weight and improve metabolic abnormalities in obese subjects, although adverse neuropsychiatric effects, including anxiety, irritability, and depressed mood, halted their therapeutic development (PubMed:18177726). In obese mice, peripherally restricted CNR1 inverse agonists have been shown to normalize metabolic abnormalities, including insulin resistance and fatty liver, and to reverse leptin resistance. {ECO:0000269 PubMed:18177726}.

Relevant External Links for CNR1

Genetic Association Database (GAD)
CNR1
Human Genome Epidemiology (HuGE) Navigator
CNR1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CNR1
genes like me logo Genes that share disorders with CNR1: view

No data available for Genatlas for CNR1 Gene

Publications for CNR1 Gene

  1. Hepatic expression of endocannabinoid receptors and their novel polymorphisms in primary biliary cirrhosis. (PMID: 19730968) Floreani A … Bergasa NV (Journal of gastroenterology 2010) 3 22 45 60
  2. Association of polymorphisms of the cannabinoid receptor (CNR1) and fatty acid amide hydrolase (FAAH) genes with heroin addiction: impact of long repeats of CNR1. (PMID: 20010914) Proudnikov D … Kreek MJ (The pharmacogenomics journal 2010) 3 22 45 60
  3. A common polymorphism in the cannabinoid receptor 1 (CNR1) gene is associated with antipsychotic-induced weight gain in Schizophrenia. (PMID: 20107430) Tiwari AK … Müller DJ (Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2010) 3 22 45 60
  4. Evidence for association between polymorphisms in the cannabinoid receptor 1 (CNR1) gene and cannabis dependence. (PMID: 19016476) Agrawal A … Foroud T (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2009) 3 22 45 60
  5. Interaction between two independent CNR1 variants increases risk for cocaine dependence in European Americans: a replication study in family-based sample and population-based sample. (PMID: 19052543) Zuo L … Gelernter J (Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2009) 3 22 45 60

Products for CNR1 Gene

  • Addgene plasmids for CNR1

Sources for CNR1 Gene

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