Aliases for OSCAR Gene
External Ids for OSCAR Gene
Previous GeneCards Identifiers for OSCAR Gene
Osteoclasts are multinucleated cells that resorb bone and are essential for bone homeostasis. This gene encodes an osteoclast-associated receptor (OSCAR), which is a member of the leukocyte receptor complex protein family that plays critical roles in the regulation of both innate and adaptive immune responses. The encoded protein may play a role in oxidative stress-mediated atherogenesis as well as monocyte adhesion. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2013]
GeneCards Summary for OSCAR Gene
OSCAR (Osteoclast Associated, Immunoglobulin-Like Receptor) is a Protein Coding gene. Diseases associated with OSCAR include Mucinous Tubular And Spindle Renal Cell Carcinoma and Spindle Cell Synovial Sarcoma. Among its related pathways are Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell and Innate Immune System. An important paralog of this gene is IGSF1.
UniProtKB/Swiss-Prot for OSCAR Gene
Regulator of osteoclastogenesis which plays an important bone-specific function in osteoclast differentiation.