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Aliases for CNGA2 Gene

Aliases for CNGA2 Gene

  • Cyclic Nucleotide Gated Channel Alpha 2 2 3 5
  • CNG Channel Alpha-2 3 4
  • CNCA1 3 4
  • CNCA 3 4
  • CNG2 3 4
  • Cyclic-Nucleotide-Gated Cation Channel 2 3
  • Cyclic Nucleotide-Gated Cation Channel 2 4
  • Cyclic Nucleotide-Gated Channel Alpha-2 4
  • OCNCALPHA 3
  • OCNC1 3
  • OCNCa 3
  • CNCG2 4
  • CNG-2 4

External Ids for CNGA2 Gene

Previous HGNC Symbols for CNGA2 Gene

  • CNCA1
  • CNCA

Previous GeneCards Identifiers for CNGA2 Gene

  • GC0XU990031
  • GC0XP148659
  • GC0XP149529
  • GC0XP149520
  • GC0XP150573
  • GC0XP150904
  • GC0XP139760

Summaries for CNGA2 Gene

Entrez Gene Summary for CNGA2 Gene

  • The protein encoded by this gene represents the alpha subunit of a cyclic nucleotide-gated olfactory channel. The encoded protein contains a carboxy-terminal leucine zipper that mediates channel formation. [provided by RefSeq, Jan 2010]

GeneCards Summary for CNGA2 Gene

CNGA2 (Cyclic Nucleotide Gated Channel Alpha 2) is a Protein Coding gene. Diseases associated with CNGA2 include anosmia, isolated congenital and cranial nerve malignant neoplasm. Among its related pathways are cAMP signaling pathway and Organelle biogenesis and maintenance. GO annotations related to this gene include calmodulin binding and voltage-gated potassium channel activity. An important paralog of this gene is KCNH1.

UniProtKB/Swiss-Prot for CNGA2 Gene

  • Odorant signal transduction is probably mediated by a G-protein coupled cascade using cAMP as second messenger. The olfactory channel can be shown to be activated by cyclic nucleotides which leads to a depolarization of olfactory sensory neurons.

Gene Wiki entry for CNGA2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CNGA2 Gene

Genomics for CNGA2 Gene

Regulatory Elements for CNGA2 Gene

Genomic Location for CNGA2 Gene

Chromosome:
X
Start:
151,734,746 bp from pter
End:
151,745,564 bp from pter
Size:
10,819 bases
Orientation:
Plus strand

Genomic View for CNGA2 Gene

Genes around CNGA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CNGA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CNGA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CNGA2 Gene

Proteins for CNGA2 Gene

  • Protein details for CNGA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16280-CNGA2_HUMAN
    Recommended name:
    Cyclic nucleotide-gated olfactory channel
    Protein Accession:
    Q16280
    Secondary Accessions:
    • A0AVD0

    Protein attributes for CNGA2 Gene

    Size:
    664 amino acids
    Molecular mass:
    76048 Da
    Quaternary structure:
    • Heterotetramer composed of two subunits of CNGA2, one of CNGA4 and one of CNGB1b. The complex forms the cyclic nucleotide-gated (CNG) channel of olfactory sensory neurons (By similarity).

neXtProt entry for CNGA2 Gene

Proteomics data for CNGA2 Gene at MOPED

Post-translational modifications for CNGA2 Gene

  • Glycosylation at Asn 379
  • Modification sites at PhosphoSitePlus

Other Protein References for CNGA2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CNGA2 Gene

Domains & Families for CNGA2 Gene

Gene Families for CNGA2 Gene

Suggested Antigen Peptide Sequences for CNGA2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q16280

UniProtKB/Swiss-Prot:

CNGA2_HUMAN :
  • The C-terminal coiled-coil domain mediates trimerization of CNGA subunits.
  • Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGA2 subfamily.
Domain:
  • The C-terminal coiled-coil domain mediates trimerization of CNGA subunits.
  • Contains 1 cyclic nucleotide-binding domain.
Family:
  • Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGA2 subfamily.
genes like me logo Genes that share domains with CNGA2: view

Function for CNGA2 Gene

Molecular function for CNGA2 Gene

UniProtKB/Swiss-Prot Function:
Odorant signal transduction is probably mediated by a G-protein coupled cascade using cAMP as second messenger. The olfactory channel can be shown to be activated by cyclic nucleotides which leads to a depolarization of olfactory sensory neurons.

Gene Ontology (GO) - Molecular Function for CNGA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005216 ion channel activity IEA --
GO:0005223 intracellular cGMP activated cation channel activity IBA --
GO:0030553 cGMP binding IBA --
genes like me logo Genes that share ontologies with CNGA2: view
genes like me logo Genes that share phenotypes with CNGA2: view

Human Phenotype Ontology for CNGA2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for CNGA2 Gene

MGI Knock Outs for CNGA2:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CNGA2 Gene

Localization for CNGA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CNGA2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CNGA2 Gene COMPARTMENTS Subcellular localization image for CNGA2 gene
Compartment Confidence
plasma membrane 5
golgi apparatus 4
cytosol 2
endoplasmic reticulum 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CNGA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0030660 Golgi-associated vesicle membrane TAS --
genes like me logo Genes that share ontologies with CNGA2: view

Pathways & Interactions for CNGA2 Gene

genes like me logo Genes that share pathways with CNGA2: view

Interacting Proteins for CNGA2 Gene

Gene Ontology (GO) - Biological Process for CNGA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006996 organelle organization TAS --
GO:0007608 sensory perception of smell IEA --
GO:0042391 regulation of membrane potential IBA --
GO:0098655 cation transmembrane transport IBA --
genes like me logo Genes that share ontologies with CNGA2: view

No data available for SIGNOR curated interactions for CNGA2 Gene

Drugs & Compounds for CNGA2 Gene

(2) Drugs for CNGA2 Gene - From: Novoseek and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
cyclic amp Experimental Pharma 0
genes like me logo Genes that share compounds with CNGA2: view

Transcripts for CNGA2 Gene

mRNA/cDNA for CNGA2 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CNGA2 Gene

Cyclic nucleotide gated channel alpha 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CNGA2 Gene

No ASD Table

Relevant External Links for CNGA2 Gene

GeneLoc Exon Structure for
CNGA2
ECgene alternative splicing isoforms for
CNGA2

Expression for CNGA2 Gene

mRNA expression in normal human tissues for CNGA2 Gene

mRNA differential expression in normal tissues according to GTEx for CNGA2 Gene

This gene is overexpressed in Testis (x46.3).

Protein differential expression in normal tissues from HIPED for CNGA2 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CNGA2 Gene



SOURCE GeneReport for Unigene cluster for CNGA2 Gene Hs.447360

genes like me logo Genes that share expression patterns with CNGA2: view

Protein tissue co-expression partners for CNGA2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for CNGA2 Gene

Orthologs for CNGA2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CNGA2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CNGA2 35
  • 89.85 (n)
  • 93.79 (a)
CNGA2 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CNGA2 35
  • 90.56 (n)
  • 94.73 (a)
CNGA2 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cnga2 35
  • 88.17 (n)
  • 93.96 (a)
Cnga2 16
Cnga2 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CNGA2 35
  • 99.5 (n)
  • 99.25 (a)
CNGA2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cnga2 35
  • 87.56 (n)
  • 92.9 (a)
oppossum
(Monodelphis domestica)
Mammalia CNGA2 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CNGA2 36
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves CNGA2 35
  • 74.04 (n)
  • 77.57 (a)
CNGA2 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CNGA2 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cnga2 35
  • 67.58 (n)
  • 69.05 (a)
zebrafish
(Danio rerio)
Actinopterygii cnga5 35
  • 66.25 (n)
  • 69.2 (a)
cnga5 36
  • 66 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Cng 36
  • 37 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea che-6 36
  • 30 (a)
ManyToMany
cng-1 36
  • 31 (a)
ManyToMany
cng-2 36
  • 23 (a)
ManyToMany
cng-3 36
  • 22 (a)
ManyToMany
tax-4 36
  • 39 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 57 (a)
OneToMany
Species with no ortholog for CNGA2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CNGA2 Gene

ENSEMBL:
Gene Tree for CNGA2 (if available)
TreeFam:
Gene Tree for CNGA2 (if available)

Paralogs for CNGA2 Gene

(4) SIMAP similar genes for CNGA2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CNGA2: view

Variants for CNGA2 Gene

Sequence variations from dbSNP and Humsavar for CNGA2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
VAR_036603 A breast cancer sample
VAR_036604 A breast cancer sample
rs6627455 - 151,739,710(+) ACAAG(C/G)ATGGC reference, missense
rs714147 - 151,744,490(+) CTGAC(A/G)AGCCA reference, missense
rs35350051 - 151,740,835(+) GGATT(G/T)GTACT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for CNGA2 Gene

Variant ID Type Subtype PubMed ID
nsv518142 CNV Gain 19592680

Variation tolerance for CNGA2 Gene

Residual Variation Intolerance Score: 87.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.12; 80.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CNGA2 Gene

HapMap Linkage Disequilibrium report
CNGA2
Human Gene Mutation Database (HGMD)
CNGA2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CNGA2 Gene

Disorders for CNGA2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for CNGA2 Gene - From: Orphanet and DISEASES

Disorder Aliases PubMed IDs
anosmia, isolated congenital
  • congenital anosmia
cranial nerve malignant neoplasm
  • malignant neoplasm of cranial nerve
olfactory nerve neoplasm
  • neoplasm of olfactory nerve
- elite association - COSMIC cancer census association via MalaCards
Search CNGA2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CNGA2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CNGA2
genes like me logo Genes that share disorders with CNGA2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CNGA2 Gene

Publications for CNGA2 Gene

  1. Expression of cyclic nucleotide-gated cation channels in non-sensory tissues and cells. (PMID: 7532814) Distler M. … Hofmann F. (Neuropharmacology 1994) 2 3 4 67
  2. International Union of Pharmacology. LI. Nomenclature and structure-function relationships of cyclic nucleotide-regulated channels. (PMID: 16382102) Hofmann F. … Kaupp U.B. (Pharmacol. Rev. 2005) 2 3
  3. Expression of olfactory-type cyclic nucleotide-gated channel (CNGA2) in vascular tissues. (PMID: 14618336) Cheng K.T. … Yao X. (Histochem. Cell Biol. 2003) 3 23
  4. An isoform of the rod photoreceptor cyclic nucleotide-gated channel beta subunit expressed in olfactory neurons. (PMID: 9539801) Sautter A. … Biel M. (Proc. Natl. Acad. Sci. U.S.A. 1998) 3 23
  5. Electrophysiology of hyperpolarization-activated cyclic nucleotide-gated cation channel 2 and hyperpolarization-activated cyclic nucleotide-gated cation channel 4 expressed in HEK293 cells. (PMID: 18067793) Li C. … Wang S.Q. (Chin. Med. J. 2007) 23

Products for CNGA2 Gene

Sources for CNGA2 Gene

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