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Aliases for OR7G1 Gene

Aliases for OR7G1 Gene

  • Olfactory Receptor Family 7 Subfamily G Member 1 2 3 5
  • Olfactory Receptor OR19-8 3 4
  • Olfactory Receptor 19-15 3 4
  • OR19-15 3 4
  • OR7G1P 3 4
  • Olfactory Receptor, Family 7, Subfamily G, Member 1 2
  • Olfactory Receptor 7G1 3
  • OR19-8 3

External Ids for OR7G1 Gene

Previous HGNC Symbols for OR7G1 Gene

  • OR7G1P

Previous GeneCards Identifiers for OR7G1 Gene

  • GC19U990182
  • GC19M009088
  • GC19M009225

Summaries for OR7G1 Gene

Entrez Gene Summary for OR7G1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR7G1 Gene

OR7G1 (Olfactory Receptor Family 7 Subfamily G Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR7G2.

UniProtKB/Swiss-Prot for OR7G1 Gene

  • Odorant receptor.

Gene Wiki entry for OR7G1 Gene

Additional gene information for OR7G1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR7G1 Gene

Genomics for OR7G1 Gene

GeneHancer (GH) Regulatory Elements for OR7G1 Gene

Promoters and enhancers for OR7G1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I009074 Enhancer 1.2 Ensembl ENCODE 11.7 +40.2 40226 1.7 PKNOX1 ARNT ZNF2 ZNF766 FOS REST SMARCB1 ZNF592 SMARCA4 GLIS1 MUC16 ZNF414 LOC100419831 ZNF559 ZNF558 HNRNPM ZNF266 OR7G1 ZNF699 ZNF121
GH19I009069 Enhancer 0.5 ENCODE 11.7 +45.7 45660 1.1 SP1 ZNF341 BACH1 EZH2 MUC16 OR7G1 OR7G3 GC19P009058 OR1M4P
GH19I009073 Enhancer 0.2 ENCODE 11.7 +41.9 41877 0.6 OR7G1 OR7G3 MUC16 OR1M4P GC19P009058
GH19I008878 Enhancer 0.7 FANTOM5 1.5 +237.3 237289 0.2 HCFC1 SOX6 SIX5 ELF1 ZBTB40 GABPA MBD2 ZNF366 ZNF512 NFYB PIR31457 ACTL9 MUC16 ZNF177 OR7G1 GC19P008942
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around OR7G1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR7G1 gene promoter:

Genomic Locations for OR7G1 Gene

Genomic Locations for OR7G1 Gene
chr19:9,114,828-9,115,763
(GRCh38/hg38)
Size:
936 bases
Orientation:
Minus strand
chr19:9,225,274-9,226,439
(GRCh37/hg19)

Genomic View for OR7G1 Gene

Genes around OR7G1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR7G1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR7G1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR7G1 Gene

Proteins for OR7G1 Gene

  • Protein details for OR7G1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGA0-OR7G1_HUMAN
    Recommended name:
    Olfactory receptor 7G1
    Protein Accession:
    Q8NGA0
    Secondary Accessions:
    • Q6IFJ5
    • Q96RA1

    Protein attributes for OR7G1 Gene

    Size:
    311 amino acids
    Molecular mass:
    34803 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC06141.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for OR7G1 Gene

Post-translational modifications for OR7G1 Gene

  • Glycosylation at isoforms=5 and Asn89

Other Protein References for OR7G1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR7G1 Gene

Domains & Families for OR7G1 Gene

Gene Families for OR7G1 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR7G1 Gene

Suggested Antigen Peptide Sequences for OR7G1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NGA0

UniProtKB/Swiss-Prot:

OR7G1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR7G1: view

Function for OR7G1 Gene

Molecular function for OR7G1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR7G1 Gene

Gene Ontology (GO) - Molecular Function for OR7G1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR7G1: view
genes like me logo Genes that share phenotypes with OR7G1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR7G1 Gene

Localization for OR7G1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR7G1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR7G1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR7G1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR7G1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR7G1 Gene

Pathways & Interactions for OR7G1 Gene

genes like me logo Genes that share pathways with OR7G1: view

Pathways by source for OR7G1 Gene

Interacting Proteins for OR7G1 Gene

Gene Ontology (GO) - Biological Process for OR7G1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IBA --
genes like me logo Genes that share ontologies with OR7G1: view

No data available for SIGNOR curated interactions for OR7G1 Gene

Drugs & Compounds for OR7G1 Gene

No Compound Related Data Available

Transcripts for OR7G1 Gene

mRNA/cDNA for OR7G1 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR7G1 Gene

No ASD Table

Relevant External Links for OR7G1 Gene

GeneLoc Exon Structure for
OR7G1
ECgene alternative splicing isoforms for
OR7G1

Expression for OR7G1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR7G1 Gene

Protein differential expression in normal tissues from HIPED for OR7G1 Gene

This gene is overexpressed in Brain (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OR7G1 Gene



Protein tissue co-expression partners for OR7G1 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR7G1 Gene:

OR7G1

SOURCE GeneReport for Unigene cluster for OR7G1 Gene:

Hs.553576
genes like me logo Genes that share expression patterns with OR7G1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR7G1 Gene

Orthologs for OR7G1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR7G1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC468707 33
  • 98.29 (n)
PTR211 34
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC484982 33
  • 83.77 (n)
-- 34
  • 77 (a)
OneToMany
-- 34
  • 75 (a)
OneToMany
cow
(Bos Taurus)
Mammalia LOC511678 33
  • 83.28 (n)
-- 34
  • 76 (a)
OneToMany
-- 34
  • 73 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Olfr854 33 16
  • 73.38 (n)
Olfr853 34
  • 67 (a)
ManyToMany
Olfr834 34
  • 61 (a)
ManyToMany
Or7f1-ps 51 Olfr838-ps1
  • chr9:19,153,638-19,154,457
Or7g25 51 Olfr843
  • chr9:19,248,459-19,249,397
rat
(Rattus norvegicus)
Mammalia Olr1149 33
  • 73.01 (n)
Species where no ortholog for OR7G1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR7G1 Gene

ENSEMBL:
Gene Tree for OR7G1 (if available)
TreeFam:
Gene Tree for OR7G1 (if available)

Paralogs for OR7G1 Gene

Paralogs for OR7G1 Gene

(452) SIMAP similar genes for OR7G1 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for OR7G1 Gene

genes like me logo Genes that share paralogs with OR7G1: view

Variants for OR7G1 Gene

Sequence variations from dbSNP and Humsavar for OR7G1 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000414181 -- 9,116,799(-) C/T upstream_transcript_variant
rs1001850876 -- 9,117,701(-) G/A upstream_transcript_variant
rs1002910713 -- 9,114,580(-) G/A downstream_transcript_variant
rs1003120788 -- 9,116,515(-) AAAAAA/AAAAAAA upstream_transcript_variant
rs1003561472 -- 9,116,829(-) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OR7G1 Gene

Variant ID Type Subtype PubMed ID
esv2762024 CNV gain 21179565
nsv1056401 CNV gain 25217958
nsv509720 CNV insertion 20534489

Variation tolerance for OR7G1 Gene

Residual Variation Intolerance Score: 85.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.23; 97.00% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR7G1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR7G1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR7G1 Gene

Disorders for OR7G1 Gene

Additional Disease Information for OR7G1

No disorders were found for OR7G1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR7G1 Gene

Publications for OR7G1 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  2. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4 58
  3. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 4 58

Products for OR7G1 Gene

Sources for OR7G1 Gene

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