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Aliases for RN7SK Gene

Subcategory (RNA class) for RN7SK Gene

7SK RNA

Quality Score for this RNA gene is

13

Aliases for RN7SK Gene

  • RNA, 7SK Small Nuclear 2 3 5
  • RNA, 7SK, Nuclear 2 3
  • 7SK Small Nuclear RNA 3
  • 7SK 3

External Ids for RN7SK Gene

ORGUL Members for RN7SK Gene

Previous GeneCards Identifiers for RN7SK Gene

  • GC06U990106
  • GC06P052907
  • GC06P052968
  • GC06P052860
  • GC06P052691

Summaries for RN7SK Gene

GeneCards Summary for RN7SK Gene

RN7SK (RNA, 7SK Small Nuclear) is an RNA Gene, and is affiliated with the 7SK RNA class.

Gene Wiki entry for RN7SK Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RN7SK Gene

Genomics for RN7SK Gene

Regulatory Elements for RN7SK Gene

Enhancers for RN7SK Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G053009 1.1 ENCODE dbSUPER 0.4 +17.6 17565 7.1 HDAC1 PKNOX1 FOXA2 NFIB SIN3A ZBTB40 RAD21 GATA2 FOS RCOR1 ICK FBXO9 GC06P053016 ENSG00000202198 RN7SK
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RN7SK on UCSC Golden Path with GeneCards custom track

Promoters for RN7SK Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000197975 -320 3401 CREB3L1 ZFP64 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC

Genomic Location for RN7SK Gene

Chromosome:
6
Start:
52,995,620 bp from pter
End:
52,995,951 bp from pter
Size:
332 bases
Orientation:
Plus strand

Genomic View for RN7SK Gene

Genes around RN7SK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RN7SK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RN7SK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RN7SK Gene

Proteins for RN7SK Gene

Post-translational modifications for RN7SK Gene

No Post-translational modifications

No data available for DME Specific Peptides for RN7SK Gene

Domains & Families for RN7SK Gene

Gene Families for RN7SK Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RN7SK: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for RN7SK Gene

Function for RN7SK Gene

Molecular function for RN7SK Gene

GENATLAS Biochemistry:
small nuclear RNA,7SK

Animal Model Products

miRNA for RN7SK Gene

miRTarBase miRNAs that target RN7SK

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RN7SK Gene

Localization for RN7SK Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for RN7SK Gene

Pathways & Interactions for RN7SK Gene

SuperPathways for RN7SK Gene

No Data Available

Interacting Proteins for RN7SK Gene

Gene Ontology (GO) - Biological Process for RN7SK Gene

None

No data available for Pathways by source and SIGNOR curated interactions for RN7SK Gene

Transcripts for RN7SK Gene

mRNA/cDNA for RN7SK Gene

Alternative Splicing Database (ASD) splice patterns (SP) for RN7SK Gene

No ASD Table

Relevant External Links for RN7SK Gene

GeneLoc Exon Structure for
RN7SK
ECgene alternative splicing isoforms for
RN7SK

Expression for RN7SK Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RN7SK Gene

mRNA differential expression in normal tissues according to GTEx for RN7SK Gene

This gene is overexpressed in Kidney - Cortex (x5.1).

NURSA nuclear receptor signaling pathways regulating expression of RN7SK Gene:

RN7SK
genes like me logo Genes that share expression patterns with RN7SK: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for RN7SK Gene

Orthologs for RN7SK Gene

Evolution for RN7SK Gene

ENSEMBL:
Gene Tree for RN7SK (if available)
TreeFam:
Gene Tree for RN7SK (if available)

No data available for Orthologs for RN7SK Gene

Paralogs for RN7SK Gene

No data available for Paralogs for RN7SK Gene

Variants for RN7SK Gene

Sequence variations from dbSNP and Humsavar for RN7SK Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000210850 -- 52,994,666(+) ACTGG(A/C)AGCTC intron-variant, upstream-variant-2KB
rs1000360756 -- 52,995,937(+) TGGCA(A/G)TCTGC nc-transcript-variant, upstream-variant-2KB
rs1000885244 -- 52,996,159(+) TTCTA(G/T)TTTTA downstream-variant-500B, upstream-variant-2KB
rs1001172400 -- 52,993,837(+) ATTTA(C/T)CCTGA intron-variant, upstream-variant-2KB
rs1002126456 -- 52,994,698(+) ATACA(A/T)CATCA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RN7SK Gene

Variant ID Type Subtype PubMed ID
esv2759430 CNV loss 17122850

Relevant External Links for RN7SK Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RN7SK

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for RN7SK Gene

Disorders for RN7SK Gene

Relevant External Links for RN7SK

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RN7SK

No disorders were found for RN7SK Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RN7SK Gene

Publications for RN7SK Gene

  1. 7SK RNA, a non-coding RNA regulating P-TEFb, a general transcription factor. (PMID: 19246988) Diribarne G. … Bensaude O. (RNA Biol 2009) 2 3 64
  2. Regulation of two key nuclear enzymatic activities by the 7SK small nuclear RNA. (PMID: 17381310) He W.J. … Zhou Q. (Cold Spring Harb. Symp. Quant. Biol. 2006) 3 22 64
  3. Recruitment of P-TEFb for stimulation of transcriptional elongation by the bromodomain protein Brd4. (PMID: 16109377) Yang Z. … Zhou Q. (Mol. Cell 2005) 3 22 64
  4. Phosphorylated positive transcription elongation factor b (P-TEFb) is tagged for inhibition through association with 7SK snRNA. (PMID: 14627702) Chen R. … Zhou Q. (J. Biol. Chem. 2004) 3 22 64
  5. A human immunodeficiency virus type 1 Tat-like arginine-rich RNA- binding domain is essential for HEXIM1 to inhibit RNA polymerase II transcription through 7SK snRNA-mediated inactivation of P-TEFb. (PMID: 15169877) Yik J.H.N. … Zhou Q. (Mol. Cell. Biol. 2004) 3 22 64

Products for RN7SK Gene

Sources for RN7SK Gene

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