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Aliases for HEXIM2 Gene

Aliases for HEXIM2 Gene

  • Hexamethylene Bisacetamide Inducible 2 2 3
  • Hexamethylene Bis-Acetamide Inducible 2 2 3 5
  • Hexamethylene Bis-Acetamide-Inducible Protein 2 3 4
  • Hexamethylene-Bis-Acetamide-Inducible Transcript 2 3
  • MAQ1 Paralog 3
  • L3 3

External Ids for HEXIM2 Gene

Previous GeneCards Identifiers for HEXIM2 Gene

  • GC17P040595
  • GC17P043238
  • GC17P039001

Summaries for HEXIM2 Gene

Entrez Gene Summary for HEXIM2 Gene

  • This gene encodes a member of the HEXIM family of proteins. This protein is a component of the 7SK small nuclear ribonucleoprotein. This protein has been found to negatively regulate the kinase activity of the cyclin-dependent kinase P-TEFb, which phosphorylates multiple target proteins to promote transcriptional elongation. This gene is located approximately 7 kb downstream from related family member HEXIM1 on chromosome 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

GeneCards Summary for HEXIM2 Gene

HEXIM2 (Hexamethylene Bisacetamide Inducible 2) is a Protein Coding gene. GO annotations related to this gene include cyclin-dependent protein serine/threonine kinase inhibitor activity and snRNA binding. An important paralog of this gene is HEXIM1.

UniProtKB/Swiss-Prot for HEXIM2 Gene

  • Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation.

Gene Wiki entry for HEXIM2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HEXIM2 Gene

Genomics for HEXIM2 Gene

Regulatory Elements for HEXIM2 Gene

Enhancers for HEXIM2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around HEXIM2 on UCSC Golden Path with GeneCards custom track

Promoters for HEXIM2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HEXIM2 on UCSC Golden Path with GeneCards custom track

Genomic Location for HEXIM2 Gene

Chromosome:
17
Start:
45,160,026 bp from pter
End:
45,170,040 bp from pter
Size:
10,015 bases
Orientation:
Plus strand

Genomic View for HEXIM2 Gene

Genes around HEXIM2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HEXIM2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HEXIM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HEXIM2 Gene

Proteins for HEXIM2 Gene

  • Protein details for HEXIM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96MH2-HEXI2_HUMAN
    Recommended name:
    Protein HEXIM2
    Protein Accession:
    Q96MH2
    Secondary Accessions:
    • D3DX66

    Protein attributes for HEXIM2 Gene

    Size:
    286 amino acids
    Molecular mass:
    32419 Da
    Quaternary structure:
    • Homooligomer and heterooligomer with HEXIM1; probably dimeric (PubMed:15713661, PubMed:15994294). Component of the 7SK snRNP complex at least composed of P-TEFb (composed of CDK9 and CCNT1/cyclin-T1), HEXIM1, HEXIM2, BCDIN3, SART3 proteins and 7SK and U6 snRNAs (PubMed:15713661, PubMed:15713662, PubMed:15994294). Interacts with CCNT2 (PubMed:19883659).

neXtProt entry for HEXIM2 Gene

Proteomics data for HEXIM2 Gene at MOPED

Post-translational modifications for HEXIM2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for HEXIM2 Gene

Domains & Families for HEXIM2 Gene

Protein Domains for HEXIM2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for HEXIM2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96MH2

UniProtKB/Swiss-Prot:

HEXI2_HUMAN :
  • The coiled-coil domain mediates oligomerization.
  • Belongs to the HEXIM family.
Domain:
  • The coiled-coil domain mediates oligomerization.
Family:
  • Belongs to the HEXIM family.
genes like me logo Genes that share domains with HEXIM2: view

No data available for Gene Families for HEXIM2 Gene

Function for HEXIM2 Gene

Molecular function for HEXIM2 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation.
UniProtKB/Swiss-Prot Induction:
Up-regulated by HMBA (hexamethylene bisacetamide) (at protein level).

Phenotypes for HEXIM2 Gene

genes like me logo Genes that share phenotypes with HEXIM2: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HEXIM2 Gene

Localization for HEXIM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HEXIM2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HEXIM2 Gene COMPARTMENTS Subcellular localization image for HEXIM2 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for HEXIM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,ISS --
genes like me logo Genes that share ontologies with HEXIM2: view

Pathways & Interactions for HEXIM2 Gene

SuperPathways for HEXIM2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for HEXIM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity IDA 15713662
GO:0045892 negative regulation of transcription, DNA-templated IDA 15713662
GO:0071901 negative regulation of protein serine/threonine kinase activity IEA --
genes like me logo Genes that share ontologies with HEXIM2: view

No data available for Pathways by source and SIGNOR curated interactions for HEXIM2 Gene

Drugs & Compounds for HEXIM2 Gene

No Compound Related Data Available

Transcripts for HEXIM2 Gene

Unigene Clusters for HEXIM2 Gene

Hexamethylene bis-acetamide inducible 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HEXIM2 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g · 6h
SP1: - - - - - - -
SP2:
SP3: -
SP4: - - - - - - - -
SP5: - - - - - -
SP6: - - - - -
SP7: - -
SP8: -

Relevant External Links for HEXIM2 Gene

GeneLoc Exon Structure for
HEXIM2
ECgene alternative splicing isoforms for
HEXIM2

Expression for HEXIM2 Gene

mRNA expression in normal human tissues for HEXIM2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HEXIM2 Gene

This gene is overexpressed in Muscle - Skeletal (x6.1) and Testis (x4.5).

Protein differential expression in normal tissues from HIPED for HEXIM2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (42.3), Retina (8.2), and Testis (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HEXIM2 Gene



SOURCE GeneReport for Unigene cluster for HEXIM2 Gene Hs.56382

mRNA Expression by UniProt/SwissProt for HEXIM2 Gene

Q96MH2-HEXI2_HUMAN
Tissue specificity: Ubiquitously expressed with higher expression in testis. HEXIM1 and HEXIM2 are differentially expressed.
genes like me logo Genes that share expression patterns with HEXIM2: view

Protein tissue co-expression partners for HEXIM2 Gene

Primer Products

Orthologs for HEXIM2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HEXIM2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HEXIM2 35
  • 84.64 (n)
  • 82.86 (a)
HEXIM2 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HEXIM2 35
  • 85.73 (n)
  • 83.8 (a)
HEXIM2 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hexim2 35
  • 81.8 (n)
  • 78.01 (a)
Hexim2 16
Hexim2 36
  • 70 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HEXIM2 35
  • 99.88 (n)
  • 100 (a)
HEXIM2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hexim2 35
  • 82.39 (n)
  • 77.66 (a)
oppossum
(Monodelphis domestica)
Mammalia HEXIM2 36
  • 58 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 36 (a)
OneToMany
Species with no ortholog for HEXIM2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for HEXIM2 Gene

ENSEMBL:
Gene Tree for HEXIM2 (if available)
TreeFam:
Gene Tree for HEXIM2 (if available)

Paralogs for HEXIM2 Gene

Paralogs for HEXIM2 Gene

(1) SIMAP similar genes for HEXIM2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with HEXIM2: view

Variants for HEXIM2 Gene

Sequence variations from dbSNP and Humsavar for HEXIM2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1105858 -- 45,161,912(-) TCTGG(G/T)CAAGC intron-variant, utr-variant-5-prime
rs4383190 -- 45,161,308(-) CTCAA(A/G/T)CCGTC intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs4792858 -- 45,167,333(+) ACACA(A/C)AAAAA intron-variant
rs4627401 -- 45,166,667(-) cctaa(A/T)gtaga intron-variant
rs6503425 -- 45,164,593(+) gatca(C/T)gccac intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HEXIM2 Gene

Variant ID Type Subtype PubMed ID
nsv527788 CNV Loss 19592680
nsv908297 CNV Loss 21882294
dgv3179n71 CNV Loss 21882294
nsv908300 CNV Loss 21882294
nsv2062 CNV Insertion 18451855
esv994531 CNV Deletion 20482838

Variation tolerance for HEXIM2 Gene

Residual Variation Intolerance Score: 25.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.16; 39.20% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for HEXIM2 Gene

Disorders for HEXIM2 Gene

Relevant External Links for HEXIM2

Genetic Association Database (GAD)
HEXIM2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HEXIM2

No disorders were found for HEXIM2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HEXIM2 Gene

Publications for HEXIM2 Gene

  1. HEXIM2, a HEXIM1-related protein, regulates positive transcription elongation factor b through association with 7SK. (PMID: 15713662) Byers S.A. … Price D.H. (J. Biol. Chem. 2005) 3 4 23 67
  2. The transcription-dependent dissociation of P-TEFb-HEXIM1-7SK RNA relies upon formation of hnRNP-7SK RNA complexes. (PMID: 17709395) Barrandon C. … Bensaude O. (Mol. Cell. Biol. 2007) 3 23
  3. Compensatory contributions of HEXIM1 and HEXIM2 in maintaining the balance of active and inactive positive transcription elongation factor b complexes for control of transcription. (PMID: 15713661) Yik J.H.N. … Zhou Q. (J. Biol. Chem. 2005) 3 23
  4. Analysis of the large inactive P-TEFb complex indicates that it contains one 7SK molecule, a dimer of HEXIM1 or HEXIM2, and two P-TEFb molecules containing Cdk9 phosphorylated at threonine 186. (PMID: 15965233) Li Q. … Price D.H. (J. Biol. Chem. 2005) 3 23
  5. MAQ1 and 7SK RNA interact with CDK9/cyclin T complexes in a transcription-dependent manner. (PMID: 12832472) Michels A.A. … Bensaude O. (Mol. Cell. Biol. 2003) 2 3

Products for HEXIM2 Gene

Sources for HEXIM2 Gene

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