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Aliases for CCR7 Gene

Aliases for CCR7 Gene

  • Chemokine (C-C Motif) Receptor 7 2 3
  • CMKBR7 3 4 6
  • EBI1 3 4 6
  • Epstein-Barr Virus-Induced G-Protein Coupled Receptor 1 3 4
  • MIP-3 Beta Receptor 3 4
  • CC-CKR-7 3 4
  • CDw197 3 4
  • CCR-7 3 4
  • BLR2 3 4
  • Lymphocyte-Specific G Protein-Coupled Peptide Receptor 3
  • EBV-Induced G Protein-Coupled Receptor 1 3
  • EBV-Induced G-Protein Coupled Receptor 1 4
  • Epstein-Barr Virus Induced Gene 1 3
  • C-C Chemokine Receptor Type 7 3
  • Bukitts Lymphoma Receptor 2 3
  • CC Chemokine Receptor 7 3
  • CD197 Antigen 4
  • C-C CKR-7 4
  • CD197 3
  • EVI1 4

External Ids for CCR7 Gene

Previous HGNC Symbols for CCR7 Gene

  • CMKBR7
  • EBI1

Previous GeneCards Identifiers for CCR7 Gene

  • GC17M038210
  • GC17M040885
  • GC17M038618
  • GC17M039083
  • GC17M035963
  • GC17M038710
  • GC17M034504

Summaries for CCR7 Gene

Entrez Gene Summary for CCR7 Gene

  • The protein encoded by this gene is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. It has been shown to control the migration of memory T cells to inflamed tissues, as well as stimulate dendritic cell maturation. The chemokine (C-C motif) ligand 19 (CCL19/ECL) has been reported to be a specific ligand of this receptor. Signals mediated by this receptor regulate T cell homeostasis in lymph nodes, and may also function in the activation and polarization of T cells, and in chronic inflammation pathogenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2014]

GeneCards Summary for CCR7 Gene

CCR7 (Chemokine (C-C Motif) Receptor 7) is a Protein Coding gene. Diseases associated with CCR7 include chronic actinic dermatitis and erdheim-chester disease. Among its related pathways are Signaling by GPCR and Akt Signaling. GO annotations related to this gene include G-protein coupled receptor activity and chemokine (C-C motif) ligand 19 binding. An important paralog of this gene is CCR1.

UniProtKB/Swiss-Prot for CCR7 Gene

  • Receptor for the MIP-3-beta chemokine. Probable mediator of EBV effects on B-lymphocytes or of normal lymphocyte functions

Gene Wiki entry for CCR7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCR7 Gene

Genomics for CCR7 Gene

Regulatory Elements for CCR7 Gene

Genomic Location for CCR7 Gene

40,553,769 bp from pter
40,565,484 bp from pter
11,716 bases
Minus strand

Genomic View for CCR7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCR7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCR7 Gene

Proteins for CCR7 Gene

  • Protein details for CCR7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    C-C chemokine receptor type 7
    Protein Accession:
    Secondary Accessions:

    Protein attributes for CCR7 Gene

    378 amino acids
    Molecular mass:
    42874 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CCR7 Gene

Proteomics data for CCR7 Gene at MOPED

Post-translational modifications for CCR7 Gene

  • Glycosylation at Asn36
  • Modification sites at PhosphoSitePlus

Other Protein References for CCR7 Gene

Antibody Products

No data available for DME Specific Peptides for CCR7 Gene

Domains for CCR7 Gene

Gene Families for CCR7 Gene

Suggested Antigen Peptide Sequences for CCR7 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with CCR7: view

Function for CCR7 Gene

Molecular function for CCR7 Gene

GENATLAS Biochemistry:
chemokine CC,beta receptor 7,G protein coupled receptor,lymphocyte specific,homologous to mouse Ebi-1
UniProtKB/Swiss-Prot Function:
Receptor for the MIP-3-beta chemokine. Probable mediator of EBV effects on B-lymphocytes or of normal lymphocyte functions
UniProtKB/Swiss-Prot Induction:
By Epstein-Barr virus (EBV)

Gene Ontology (GO) - Molecular Function for CCR7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity TAS 16621978
GO:0005515 protein binding --
GO:0016493 C-C chemokine receptor activity ISS --
GO:0035757 chemokine (C-C motif) ligand 19 binding IPI 9507024
GO:0035758 chemokine (C-C motif) ligand 21 binding IPI 9507024
genes like me logo Genes that share ontologies with CCR7: view
genes like me logo Genes that share phenotypes with CCR7: view

Animal Models for CCR7 Gene

MGI Knock Outs for CCR7:

Animal Model Products

miRNA for CCR7 Gene

miRTarBase miRNAs that target CCR7

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CCR7

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CCR7 Gene

Localization for CCR7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCR7 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for CCR7 Gene COMPARTMENTS Subcellular localization image for CCR7 gene
Compartment Confidence
plasma membrane 5
extracellular 2
nucleus 2
cytoskeleton 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for CCR7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA 21051556
GO:0005886 plasma membrane TAS --
GO:0009897 external side of plasma membrane IEA --
GO:0009986 cell surface IDA 18308860
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CCR7: view

Pathways for CCR7 Gene

genes like me logo Genes that share pathways with CCR7: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for CCR7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001768 establishment of T cell polarity IC 12729902
GO:0001954 positive regulation of cell-matrix adhesion IC 15569314
GO:0002407 dendritic cell chemotaxis IC 15778365
GO:0002408 myeloid dendritic cell chemotaxis IDA 11602640
GO:0002606 positive regulation of dendritic cell antigen processing and presentation ISS --
genes like me logo Genes that share ontologies with CCR7: view

Compounds for CCR7 Gene

(4) IUPHAR Ligand for CCR7 Gene

Ligand Type Action Affinity Pubmed IDs
CCL19 Agonist Agonist 9.1
CCL21 Agonist Agonist 6.9
[125I]CCL19 Agonist Full agonist
[125I]CCL21 Agonist Full agonist

(24) Novoseek inferred chemical compound relationships for CCR7 Gene

Compound -log(P) Hits PubMed IDs
mip-3beta 84.4 1
ccl3 63.9 2
larc 61.9 3
rantes 61.5 10
peg-10 51.7 3
genes like me logo Genes that share compounds with CCR7: view

Transcripts for CCR7 Gene

Unigene Clusters for CCR7 Gene

Chemokine (C-C motif) receptor 7:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CCR7

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCR7 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c
SP1: -
SP3: - -

Relevant External Links for CCR7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CCR7 Gene

mRNA expression in normal human tissues for CCR7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCR7 Gene

This gene is overexpressed in Whole Blood (12.1) and Spleen (4.1).

Protein differential expression in normal tissues for CCR7 Gene

This gene is overexpressed in CD4 Tcells (40.9), Blymphocyte (20.3), and CD8 Tcells (7.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CCR7 Gene

SOURCE GeneReport for Unigene cluster for CCR7 Gene Hs.370036

mRNA Expression by UniProt/SwissProt for CCR7 Gene

Tissue specificity: Expressed in various lymphoid tissues and activated B- and T-lymphocytes, strongly up-regulated in B-cells infected with Epstein-Barr virus and T-cells infected with herpesvirus 6 or 7
genes like me logo Genes that share expressions with CCR7: view

Expression partners for CCR7 Gene

* - Elite partner

Primer Products

In Situ Assay Products

Orthologs for CCR7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCR7 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CCR7 35
  • 90.83 (n)
  • 92.33 (a)
CCR7 36
  • 92 (a)
(Canis familiaris)
Mammalia CCR7 35
  • 90.04 (n)
  • 91.27 (a)
CCR7 36
  • 91 (a)
(Mus musculus)
Mammalia Ccr7 35
  • 85.8 (n)
  • 87.04 (a)
Ccr7 16
Ccr7 36
  • 87 (a)
(Pan troglodytes)
Mammalia CCR7 35
  • 99.56 (n)
  • 99.74 (a)
CCR7 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Ccr7 35
  • 85.54 (n)
  • 86.24 (a)
(Monodelphis domestica)
Mammalia CCR7 36
  • 76 (a)
(Gallus gallus)
Aves CCR7 35
  • 69.88 (n)
  • 68.1 (a)
CCR7 36
  • 68 (a)
(Anolis carolinensis)
Reptilia CCR7 36
  • 60 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ccr7 35
  • 64.8 (n)
  • 60.77 (a)
(Danio rerio)
Actinopterygii ccr7 35
  • 60.31 (n)
  • 53.08 (a)
ccr7 36
  • 48 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11674 35
Species with no ortholog for CCR7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCR7 Gene

Gene Tree for CCR7 (if available)
Gene Tree for CCR7 (if available)

Paralogs for CCR7 Gene

genes like me logo Genes that share paralogs with CCR7: view

Variants for CCR7 Gene

Sequence variations from dbSNP and Humsavar for CCR7 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs588019 -- 40,558,855(+) GTGTG(A/G)AGAAG intron-variant
rs1018953 -- 40,562,943(+) CCTCT(A/T)TTACC intron-variant
rs1042490 -- 40,554,591(-) AGAAG(A/T)TAGCT utr-variant-3-prime
rs1042491 -- 40,554,553(-) ATGCC(A/G)AAAAA utr-variant-3-prime
rs1666262 -- 40,565,471(+) CCTGT(C/T)TGGGG utr-variant-5-prime

Relevant External Links for CCR7 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CCR7 Gene

Disorders for CCR7 Gene

(1) University of Copenhagen DISEASES for CCR7 Gene

(59) Novoseek inferred disease relationships for CCR7 Gene

Disease -log(P) Hits PubMed IDs
metastasis 44.5 98
leukemia lymphocytic chronic 43 3
inflammation 42 10
b-all 41.7 5
tumors 41 79

Relevant External Links for CCR7

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with CCR7: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for CCR7 Gene

Publications for CCR7 Gene

  1. Cloning of human and mouse EBI1, a lymphoid-specific G-protein- coupled receptor encoded on human chromosome 17q12-q21.2. (PMID: 7851893) Schweickart V.L. … Gray P.W. (Genomics 1994) 3 4 23
  2. Genetic variants of chemokine receptor CCR7 in patients with systemic lupus erythematosus, Sjogren's syndrome and systemic sclerosis. (PMID: 17587445) Kahlmann D. … FAPrster R. (BMC Genet. 2007) 3 23 48
  3. Epstein-Barr virus-induced genes: first lymphocyte-specific G protein-coupled peptide receptors. (PMID: 8383238) Birkenbach M.P. … Kieff E. (J. Virol. 1993) 2 3 4
  4. Altered chemokine receptor expression in papillary thyroid cancer. (PMID: 19731977) GonzA!lez H.E. … Riedel C.A. (Thyroid 2009) 3 23
  5. Uptake of CCR7 and acquisition of migratory properties by human KIR+ NK cells interacting with monocyte-derived DC or EBV cell lines: regulation by KIR/HLA-class I interaction. (PMID: 19749090) Marcenaro E. … Moretta A. (Blood 2009) 3 23

Products for CCR7 Gene

Sources for CCR7 Gene

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