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CCR3 Gene(Protein Coding)

C-C Motif Chemokine Receptor 3

GCID:
GC03P046227
GIFtS:
66
Genes Participants
UDN Logo

Aliases for CCR3 Gene

Aliases for CCR3 Gene

  • C-C Motif Chemokine Receptor 3 2 3 5
  • Chemokine (C-C Motif) Receptor 3 2 3
  • Eosinophil Eotaxin Receptor 3 4
  • C-C CKR-3 3 4
  • CC-CKR-3 3 4
  • CMKBR3 3 4
  • CCR-3 3 4
  • CKR3 3 4
  • Eosinophil CC Chemokine Receptor 3 3
  • C-C Chemokine Receptor Type 3 3
  • CC Chemokine Receptor 3 3
  • B-Chemokine Receptor 3
  • CD193 Antigen 4
  • CD193 3

External Ids for CCR3 Gene

Previous HGNC Symbols for CCR3 Gene

  • CMKBR3

Previous GeneCards Identifiers for CCR3 Gene

  • GC03P045547
  • GC03P046024
  • GC03P046244

Summaries for CCR3 Gene

Entrez Gene Summary for CCR3 Gene

  • The protein encoded by this gene is a receptor for C-C type chemokines. It belongs to family 1 of the G protein-coupled receptors. This receptor binds and responds to a variety of chemokines, including eotaxin (CCL11), eotaxin-3 (CCL26), MCP-3 (CCL7), MCP-4 (CCL13), and RANTES (CCL5). It is highly expressed in eosinophils and basophils, and is also detected in TH1 and TH2 cells, as well as in airway epithelial cells. This receptor may contribute to the accumulation and activation of eosinophils and other inflammatory cells in the allergic airway. It is also known to be an entry co-receptor for HIV-1. This gene and seven other chemokine receptor genes form a chemokine receptor gene cluster on the chromosomal region 3p21. Alternatively spliced transcript variants have been described. [provided by RefSeq, Sep 2009]

GeneCards Summary for CCR3 Gene

CCR3 (C-C Motif Chemokine Receptor 3) is a Protein Coding gene. Diseases associated with CCR3 include Folliculotropic Mycosis Fungoides and Aids Dementia Complex. Among its related pathways are Peptide ligand-binding receptors and Kit receptor signaling pathway. GO annotations related to this gene include G-protein coupled receptor activity and C-C chemokine receptor activity. An important paralog of this gene is CCR1.

UniProtKB/Swiss-Prot for CCR3 Gene

  • Receptor for a C-C type chemokine. Binds to eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES and MIP-1 delta. Subsequently transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection.

Tocris Summary for CCR3 Gene

  • Chemokine CC receptors (CCRs) predominantly recognize CC chemokines. CC chemokines are distinguished by having four conserved cysteines, with the first two cysteines being adjacent to each other. There are 10 chemokine CC receptors.

Gene Wiki entry for CCR3 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCR3 Gene

Genomics for CCR3 Gene

Products:

  1. Regulatory Element

Regulatory Elements for CCR3 Gene

Enhancers for CCR3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G046236 0.7 FANTOM5 36.2 +72.9 72900 0.2 L3MBTL2 NR2F1 ZNF175 MAX GABPA ZNF766 IKZF1 NR2F6 MYC SPI1 CCR3 CCR2 CCR1 CCRL2 LOC102724297 GC03M046310
GH03G046132 1 FANTOM5 Ensembl dbSUPER 22 -30.9 -30903 1.4 CEBPB CCR1 CCR3 FYCO1 CCRL2 CCR2 SACM1L CCR5 LOC105377067 FLT1P1
GH03G046233 0.4 FANTOM5 35.1 +69.8 69833 0.3 NR2F2 CCR3 CCR1 CCR2 GC03M046310
GH03G046106 2 FANTOM5 Ensembl ENCODE dbSUPER 5.5 -52.0 -51960 9.6 HDGF PKNOX1 ATF1 FOXA2 WRNIP1 ELK1 ZNF207 FOS DEK JUNB CCR1 CCRL2 CXCR6 FYCO1 CCR2 CCR5 LIMD1 XCR1 CCR3 SACM1L
GH03G046130 0.9 Ensembl ENCODE dbSUPER 12 -32.8 -32804 1.6 SPI1 CCR1 FYCO1 CCR3 CCR2 CCDC12 LOC105377067 LOC105377066
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CCR3 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the CCR3 gene promoter:

Genomic Location for CCR3 Gene

Chromosome:
3
Start:
46,163,604 bp from pter
End:
46,266,706 bp from pter
Size:
103,103 bases
Orientation:
Plus strand

Genomic View for CCR3 Gene

Genes around CCR3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCR3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCR3 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CCR3 Gene

Proteins for CCR3 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for CCR3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51677-CCR3_HUMAN
    Recommended name:
    C-C chemokine receptor type 3
    Protein Accession:
    P51677
    Secondary Accessions:
    • B3KVQ1
    • F5GWL6
    • Q15748
    • Q2YDB9
    • Q86WD2
    • Q8TDP6
    • Q9ULY8

    Protein attributes for CCR3 Gene

    Size:
    355 amino acids
    Molecular mass:
    41044 Da
    Quaternary structure:
    • Binds to HIV-1 Tat.
    Miscellaneous:
    • Overexpression of CCR3 together with its ligands appears to be a characteristic of ulcerative colitis (UC). The production of CCR3 ligands by human colonic epithelial cells suggests further that the epithelium can play a role in modulating pathological T-cell-mediated mucosal inflammation (PubMed:21077277).

    Alternative splice isoforms for CCR3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCR3 Gene

Protein Expression for CCR3 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for CCR3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCR3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for CCR3

No data available for DME Specific Peptides for CCR3 Gene

Domains & Families for CCR3 Gene

Gene Families for CCR3 Gene

HGNC:
IUPHAR :

Protein Domains for CCR3 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CCR3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P51677

UniProtKB/Swiss-Prot:

CCR3_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with CCR3: view

Function for CCR3 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for CCR3 Gene

GENATLAS Biochemistry:
chemokine CC,beta,receptor 3,expressed in eosinophil,basophil and T helper 2 cell,G protein coupled receptor superfamily,expressed by the thymocytes for the mobilization of lymphocytes within and from the thymus
UniProtKB/Swiss-Prot Function:
Receptor for a C-C type chemokine. Binds to eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES and MIP-1 delta. Subsequently transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection.

Gene Ontology (GO) - Molecular Function for CCR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IEA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004950 chemokine receptor activity TAS 10415069
GO:0005515 protein binding IPI 23597562
GO:0016493 C-C chemokine receptor activity IEA --
genes like me logo Genes that share ontologies with CCR3: view
genes like me logo Genes that share phenotypes with CCR3: view

Animal Models for CCR3 Gene

MGI Knock Outs for CCR3:

Animal Model Products

  • Taconic Biosciences Mouse Models for CCR3

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CCR3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CCR3 Gene

Localization for CCR3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCR3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCR3 gene
Compartment Confidence
plasma membrane 5
extracellular 2
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for CCR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 9302298
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CCR3: view

Pathways & Interactions for CCR3 Gene

genes like me logo Genes that share pathways with CCR3: view

Gene Ontology (GO) - Biological Process for CCR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001938 positive regulation of endothelial cell proliferation IEA --
GO:0006935 chemotaxis TAS,IEA --
GO:0006954 inflammatory response IEA,TAS --
GO:0006968 cellular defense response TAS 10713092
GO:0007155 cell adhesion TAS 10201960
genes like me logo Genes that share ontologies with CCR3: view

No data available for SIGNOR curated interactions for CCR3 Gene

Drugs & Compounds for CCR3 Gene

Products:

  1. Drug

(60) Drugs for CCR3 Gene - From: ClinicalTrials, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
[<sup>125</sup>I]CCL11 (human) Pharma Antagonist 0
[<sup>125</sup>I]CCL5 (human) Pharma Full agonist, Agonist 0
[<sup>125</sup>I]CCL7 (human) Pharma Full agonist, Agonist 0
[<sup>3</sup>H]banyu (I) Pharma Inverse agonist, Antagonist 0
banyu (I) Pharma Inverse agonist, Antagonist 0

(13) Additional Compounds for CCR3 Gene - From: IUPHAR and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Met-Ckbeta7
Antagonist

(5) Tocris Compounds for CCR3 Gene

Compound Action Cas Number
BMS CCR2 22 High affinity, potent CCR2 antagonist 445479-97-0
C 021 dihydrochloride Potent CCR4 antagonist 864289-85-0
J 113863 Potent CCR1 chemokine receptor antagonist 353791-85-2
RS 102895 hydrochloride CCR2b chemokine receptor antagonist 1173022-16-6
RS 504393 Highly selective CCR2 chemokine receptor antagonist 300816-15-3

(3) ApexBio Compounds for CCR3 Gene

Compound Action Cas Number
SB 297006 58816-69-6
SB 328437 247580-43-4
UCB 35625
genes like me logo Genes that share compounds with CCR3: view

Drug Products

Transcripts for CCR3 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for CCR3 Gene

(8) REFSEQ mRNAs :
(12) Additional mRNA sequences :
(19) Selected AceView cDNA sequences:
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CCR3 Gene

Chemokine (C-C motif) receptor 3:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CCR3

Alternative Splicing Database (ASD) splice patterns (SP) for CCR3 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c
SP1: - - - - -
SP2: - - -
SP3: - - -
SP4: - - - -
SP5: - -
SP6: -

Relevant External Links for CCR3 Gene

GeneLoc Exon Structure for
CCR3
ECgene alternative splicing isoforms for
CCR3

Expression for CCR3 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCR3 Gene

mRNA expression in normal human tissues for CCR3 Gene
mRNA expression by BioGPS for CCR3 GenemRNA expression by GTEx for CCR3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCR3 Gene

This gene is overexpressed in Whole Blood (x40.3).

Protein differential expression in normal tissues from HIPED for CCR3 Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CCR3 Gene



Protein tissue co-expression partners for CCR3 Gene

NURSA nuclear receptor signaling pathways regulating expression of CCR3 Gene:

CCR3

SOURCE GeneReport for Unigene cluster for CCR3 Gene:

Hs.506190

mRNA Expression by UniProt/SwissProt for CCR3 Gene:

P51677-CCR3_HUMAN
Tissue specificity: In eosinophils as well as trace amounts in neutrophils and monocytes.

Evidence on tissue expression from TISSUES for CCR3 Gene

  • Blood(4.6)
  • Skin(2.4)
  • Lung(2.2)
  • Spleen(2.1)
genes like me logo Genes that share expression patterns with CCR3: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CCR3 Gene

Orthologs for CCR3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CCR3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia CCR3 34 35
  • 99.25 (n)
cow
(Bos Taurus)
 Mammalia CCR3 34 35
  • 79.47 (n)
dog
(Canis familiaris)
 Mammalia CCR3 34 35
  • 77.62 (n)
mouse
(Mus musculus)
 Mammalia Ccr3 34 16 35
  • 77.01 (n)
rat
(Rattus norvegicus)
 Mammalia Ccr3 34
  • 76.53 (n)
oppossum
(Monodelphis domestica)
 Mammalia CCR3 35
  • 64 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia CCR3 35
  • 59 (a)
 OneToOne
Species where no ortholog for CCR3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCR3 Gene

ENSEMBL:
Gene Tree for CCR3 (if available)
TreeFam:
Gene Tree for CCR3 (if available)

Paralogs for CCR3 Gene

Variants for CCR3 Gene

Sequence variations from dbSNP and Humsavar for CCR3 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000071842 -- 46,229,633(+) TTGAA(A/T)CTTGA intron-variant
rs1000079016 -- 46,247,544(+) GGACT(A/G)TAAGG intron-variant
rs1000182626 -- 46,224,332(+) TGGCT(C/T)ACACC intron-variant
rs1000184298 -- 46,244,136(+) AGGAA(A/G)TAATT intron-variant
rs1000284988 -- 46,231,127(+) ACCAT(C/G)TTGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCR3 Gene

Variant ID Type Subtype PubMed ID
nsv1109510 CNV deletion 24896259

Variation tolerance for CCR3 Gene

Residual Variation Intolerance Score: 88.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.07; 37.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCR3 Gene

Human Gene Mutation Database (HGMD)
CCR3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCR3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCR3 Gene

Disorders for CCR3 Gene

MalaCards: The human disease database

(20) MalaCards diseases for CCR3 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
folliculotropic mycosis fungoides
  • mycosis fungoides-associated follicular mucinosis
aids dementia complex
  • adc
hiv-1
  • aids, slow progression to
testicular leukemia
smooth muscle tumor
  • smooth muscle tumor nos
- elite association - COSMIC cancer census association via MalaCards
Search CCR3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CCR3

Genetic Association Database (GAD)
CCR3
Human Genome Epidemiology (HuGE) Navigator
CCR3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCR3
genes like me logo Genes that share disorders with CCR3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCR3 Gene

Publications for CCR3 Gene

  1. New variations of human CC-chemokine receptors CCR3 and CCR4. (PMID: 11196669) Kato H. … Tokunaga K. (Genes Immun. 1999) 3 4 22 46 64
  2. Genotypes and haplotypes of CCR2 and CCR3 genes in Japanese cedar pollinosis. (PMID: 17135764) Nakamura H. … Eboshida A. (Int. Arch. Allergy Immunol. 2007) 3 22 46 64
  3. The chemokine (C-C-motif) receptor 3 (CCR3) gene is linked and associated with age at menarche in Caucasian females. (PMID: 17146638) Yang F. … Deng H.W. (Hum. Genet. 2007) 3 22 46 64
  4. The polymorphisms of Eotaxin 1 and CCR3 genes influence on serum IgE, Eotaxin levels and mild asthmatic children in Taiwan. (PMID: 17845580) Wang T.N. … Ko Y.C. (Allergy 2007) 3 22 46 64
  5. Genetic effect of CCR3 and IL5RA gene polymorphisms on eosinophilia in asthmatic patients. (PMID: 17983872) Lee J.H. … Shin H.D. (J. Allergy Clin. Immunol. 2007) 3 22 46 64

Products for CCR3 Gene

  • Addgene plasmids for CCR3

Sources for CCR3 Gene

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