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Aliases for CCR3 Gene

Aliases for CCR3 Gene

  • Chemokine (C-C Motif) Receptor 3 2 3
  • CMKBR3 3 4 6
  • CKR3 3 4 6
  • Eosinophil Eotaxin Receptor 3 4
  • C-C CKR-3 3 4
  • CC-CKR-3 3 4
  • CCR-3 3 4
  • Eosinophil CC Chemokine Receptor 3 3
  • C-C Chemokine Receptor Type 3 3
  • CC Chemokine Receptor 3 3
  • B-Chemokine Receptor 3
  • CD193 Antigen 4
  • CD193 3

External Ids for CCR3 Gene

Previous Symbols for CCR3 Gene

  • CMKBR3

Summaries for CCR3 Gene

Entrez Gene Summary for CCR3 Gene

  • The protein encoded by this gene is a receptor for C-C type chemokines. It belongs to family 1 of the G protein-coupled receptors. This receptor binds and responds to a variety of chemokines, including eotaxin (CCL11), eotaxin-3 (CCL26), MCP-3 (CCL7), MCP-4 (CCL13), and RANTES (CCL5). It is highly expressed in eosinophils and basophils, and is also detected in TH1 and TH2 cells, as well as in airway epithelial cells. This receptor may contribute to the accumulation and activation of eosinophils and other inflammatory cells in the allergic airway. It is also known to be an entry co-receptor for HIV-1. This gene and seven other chemokine receptor genes form a chemokine receptor gene cluster on the chromosomal region 3p21. Alternatively spliced transcript variants have been described. [provided by RefSeq, Sep 2009]

GeneCards Summary for CCR3 Gene

CCR3 (Chemokine (C-C Motif) Receptor 3) is a Protein Coding gene. Diseases associated with CCR3 include aids dementia complex and erdheim-chester disease. Among its related pathways are Signaling by GPCR and Akt Signaling. GO annotations related to this gene include chemokine receptor activity and C-C chemokine receptor activity. An important paralog of this gene is CCR7.

UniProtKB/Swiss-Prot for CCR3 Gene

  • Receptor for a C-C type chemokine. Binds to eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES and MIP-1 delta. Subsequently transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection

Tocris Summary for CCR3 Gene

  • Chemokines (chemotactic cytokines) belong to a family of chemoattractant molecules involved in the directed migration of immune cells. Over fifty human chemokines have been identified that can be categorised into four groups; CC, CXC, CX3C and C (XCL1 and XCL2); depending on the spacing of their first two cysteine residues. Chemokines exert their effects by binding to G-protein-coupled chemokine receptors on the surface of cells, predominantly leukocytes. Eighteen human chemokine receptors have been identified that are classified according to the class of chemokines that they bind. The major function of chemokines is to regulate leukocyte trafficking in hematopoiesis and in innate and adaptive immunity. Other functions include angiogenic activity, apoptosis, T-cell differentiation and phagocyte activation. Inadvertent activation of chemokine receptors leads to autoimmunity by inappropriately targeting self antigens for destruction by cytotoxic T-cells and macrophages.

Gene Wiki entry for CCR3 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCR3 Gene

Genomics for CCR3 Gene

Genomic Location for CCR3 Gene

Start:
46,163,604 bp from pter
End:
46,266,706 bp from pter
Size:
103,103 bases
Orientation:
Plus strand

Genomic View for CCR3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCR3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCR3 Gene

Regulatory Elements for CCR3 Gene

Proteins for CCR3 Gene

  • Protein details for CCR3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51677-CCR3_HUMAN
    Recommended name:
    C-C chemokine receptor type 3
    Protein Accession:
    P51677
    Secondary Accessions:
    • B3KVQ1
    • F5GWL6
    • Q15748
    • Q2YDB9
    • Q86WD2
    • Q8TDP6
    • Q9ULY8

    Protein attributes for CCR3 Gene

    Size:
    355 amino acids
    Molecular mass:
    41044 Da
    Quaternary structure:
    • Binds to HIV-1 Tat
    Miscellaneous:
    • Overexpression of CCR3 together with its ligands appears to be a characteristic of ulcerative colitis (UC). The production of CCR3 ligands by human colonic epithelial cells suggests further that the epithelium can play a role in modulating pathological T-cell-mediated mucosal inflammation (PubMed:21077277).

    Alternative splice isoforms for CCR3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCR3 Gene

Proteomics data for CCR3 Gene at MOPED

Post-translational modifications for CCR3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCR3 Gene

No data available for DME Specific Peptides for CCR3 Gene

Domains for CCR3 Gene

Gene Families for CCR3 Gene

HGNC:
  • CD :CD molecules
  • CCR :GPCR / Class A : Chemokine receptors : C-C motif
IUPHAR :

Graphical View of Domain Structure for InterPro Entry

P51677

UniProtKB/Swiss-Prot:

CCR3_HUMAN
Family:
  • Belongs to the G-protein coupled receptor 1 family.:
    • P51677
genes like me logo Genes that share domains with CCR3: view

Function for CCR3 Gene

Molecular function for CCR3 Gene

GENATLAS Biochemistry: chemokine CC,beta,receptor 3,expressed in eosinophil,basophil and T helper 2 cell,G protein coupled receptor superfamily,expressed by the thymocytes for the mobilization of lymphocytes within and from the thymus
UniProtKB/Swiss-Prot Function: Receptor for a C-C type chemokine. Binds to eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES and MIP-1 delta. Subsequently transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection

Gene Ontology (GO) - Molecular Function for CCR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity --
GO:0004950 chemokine receptor activity TAS 10415069
GO:0005515 protein binding IPI 23597562
GO:0016493 C-C chemokine receptor activity IEA --
genes like me logo Genes that share ontologies with CCR3: view
genes like me logo Genes that share phenotypes with CCR3: view

Animal Models for CCR3 Gene

MGI Knock Outs for CCR3:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for CCR3 Gene

Localization for CCR3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCR3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCR3 Gene COMPARTMENTS Subcellular localization image for CCR3 gene
Compartment Confidence
plasma membrane 5
extracellular 2
nucleus 1

Gene Ontology (GO) - Cellular Components for CCR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 9302298
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with CCR3: view

Pathways for CCR3 Gene

genes like me logo Genes that share pathways with CCR3: view

Gene Ontology (GO) - Biological Process for CCR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001938 positive regulation of endothelial cell proliferation IEA --
GO:0006935 chemotaxis IEA --
GO:0006954 inflammatory response IEA --
GO:0006968 cellular defense response TAS 10713092
GO:0007155 cell adhesion TAS 10201960
genes like me logo Genes that share ontologies with CCR3: view

Compounds for CCR3 Gene

(5) Tocris Compounds for CCR3 Gene

Compound Action Cas Number
Maraviroc Selective CCR5 antagonist [376348-65-1]
RS 504393 Highly selective CCR2 chemokine receptor antagonist [300816-15-3]
SB 225002 Potent and selective CXCR2 antagonist [182498-32-4]
SB 265610 Potent CXCR2 antagonist [211096-49-0]
TC 14012 CXCR4 antagonist; CXCR7 agonist [368874-34-4]

(1) HMDB Compounds for CCR3 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(28) IUPHAR Ligand for CCR3 Gene

Ligand Type Action Affinity Pubmed IDs
CCL11 Antagonist Antagonist 10
CCL11 Antagonist Antagonist 10
CCL24 Agonist Full agonist 9.4
[125I]CCL7 (human) Agonist Full agonist 9.2
RO116-9132/238 Antagonist Antagonist 9
CCL26 Agonist Full agonist 8.9
banyu (I) Antagonist Inverse agonist 8.5
SB328437 Antagonist Antagonist 8.4
RO320-2947/001 Antagonist Antagonist 8.4
[3H]banyu (I) Antagonist Inverse agonist 8.3
[125I]CCL11 (human) Antagonist Antagonist 8.3
RO330-0802/001 Antagonist Antagonist 8.3
CCL5 Agonist Full agonist 8.2
Met-Ckbeta7 Antagonist Antagonist 8.2
[125I]CCL5 (human) Agonist Full agonist 8.2
CCL7 Agonist Full agonist 8.1
YM-355179 Antagonist Antagonist 8.1
BMS compound 87b Antagonist Antagonist 8.1
CCL15 Agonist Full agonist 7.9
CCL2 Agonist Full agonist 7.8
HIV-Tat Agonist Full agonist 7.2
RO116-4875/608 Antagonist Antagonist 7.2
CCL13 Agonist Agonist
CCL8 Agonist Agonist
CXCL11 Antagonist Antagonist
CCL28 Agonist Full agonist
CXCL9 Antagonist Antagonist
CXCL10 Antagonist Antagonist

(33) Novoseek inferred chemical compound relationships for CCR3 Gene

Compound -log(P) Hits PubMed IDs
rantes 91.1 100
tarc 78.6 5
ccl3 69.1 3
mcp 1 46.7 1
calcium 46.3 31
genes like me logo Genes that share compounds with CCR3: view

Transcripts for CCR3 Gene

Unigene Clusters for CCR3 Gene

Chemokine (C-C motif) receptor 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCR3 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c
SP1: - - - - -
SP2: - - -
SP3: - - -
SP4: - - - -
SP5: - -
SP6: -

Relevant External Links for CCR3 Gene

GeneLoc Exon Structure for
CCR3
ECgene alternative splicing isoforms for
CCR3

Expression for CCR3 Gene

mRNA expression in normal human tissues for CCR3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCR3 Gene

This gene is overexpressed in Whole Blood (40.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CCR3 Gene

SOURCE GeneReport for Unigene cluster for CCR3 Gene Hs.506190

mRNA Expression by UniProt/SwissProt for CCR3 Gene

P51677-CCR3_HUMAN
Tissue specificity: In eosinophils as well as trace amounts in neutrophils and monocytes
genes like me logo Genes that share expressions with CCR3: view

Orthologs for CCR3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CCR3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCR3 35
  • 99.25 (n)
  • 98.59 (a)
CCR3 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CCR3 35
  • 79.47 (n)
  • 74.86 (a)
CCR3 36
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCR3 35
  • 77.62 (n)
  • 70.03 (a)
CCR3 36
  • 68 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccr3 35
  • 77.01 (n)
  • 70.11 (a)
Ccr3 16
Ccr3 36
  • 69 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CCR3 36
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCR3 36
  • 59 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccr3 35
  • 76.53 (n)
  • 69.25 (a)
Species with no ortholog for CCR3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCR3 Gene

ENSEMBL:
Gene Tree for CCR3 (if available)
TreeFam:
Gene Tree for CCR3 (if available)

Paralogs for CCR3 Gene

genes like me logo Genes that share paralogs with CCR3: view

Variants for CCR3 Gene

Sequence variations from dbSNP and Humsavar for CCR3 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs1491962 -- 46,263,115(+) CATCC(C/T)GATCA intron-variant
rs1826341 -- 46,255,633(-) atggt(A/G)ctggg intron-variant
rs1844923 -- 46,255,128(-) gaaat(A/G)caaat intron-variant
rs1907635 -- 46,256,625(-) ctgtt(A/G)taccc intron-variant
rs1907636 -- 46,251,808(-) gtgac(C/T)cccac intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCR3 Gene

Variant ID Type Subtype PubMed ID
nsv876734 CNV Gain 21882294

Relevant External Links for CCR3 Gene

HapMap Linkage Disequilibrium report
CCR3
Human Gene Mutation Database (HGMD)
CCR3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCR3 Gene

Disorders for CCR3 Gene

(48) Novoseek inferred disease relationships for CCR3 Gene

Disease -log(P) Hits PubMed IDs
immunodeficiency 65.1 24
asthma 63.9 47
inflammation 60.7 37
eosinophilia 54.4 6
aids dementia complex 52.7 1

Relevant External Links for CCR3

Genetic Association Database (GAD)
CCR3
Human Genome Epidemiology (HuGE) Navigator
CCR3
genes like me logo Genes that share disorders with CCR3: view

No data available for UniProtKB/Swiss-Prot for CCR3 Gene

Publications for CCR3 Gene

  1. New variations of human CC-chemokine receptors CCR3 and CCR4. (PMID: 11196669) Kato H. … Tokunaga K. (Genes Immun. 1999) 3 4 23 48
  2. Genetic polymorphisms of CC chemokine receptor 3 in Japanese and British asthmatics. (PMID: 11307756) Fukunaga K. … Yamaguchi K. (Eur. Respir. J. 2001) 3 23 48
  3. Cloning, expression, and characterization of the human eosinophil eotaxin receptor. (PMID: 8642344) Daugherty B.L. … Springer M.S. (J. Exp. Med. 1996) 3 4 23
  4. Molecular cloning and characterization of a human eotaxin receptor expressed selectively on eosinophils. (PMID: 8676064) Ponath P.D. … Mackay C.R. (J. Exp. Med. 1996) 3 4 23
  5. Cloning and functional expression of a human eosinophil CC chemokine receptor. (PMID: 7622448) Combadiere C. … Murphy P.M. (J. Biol. Chem. 1995) 3 4 23

Products for CCR3 Gene

Sources for CCR3 Gene

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