Aliases for JDP2 Gene
External Ids for JDP2 Gene
Previous GeneCards Identifiers for JDP2 Gene
GeneCards Summary for JDP2 Gene
JDP2 (Jun Dimerization Protein 2) is a Protein Coding gene. Diseases associated with JDP2 include keratitis and skeletal muscle cancer. Among its related pathways are ATF-2 transcription factor network and Tacrolimus/Cyclosporine Pathway, Pharmacodynamics. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and protein heterodimerization activity. An important paralog of this gene is ATF3.
UniProtKB/Swiss-Prot for JDP2 Gene
Component of the AP-1 transcription factor that represses transactivation mediated by the Jun family of proteins. Involved in a variety of transcriptional responses associated with AP-1 such as UV-induced apoptosis, cell differentiation, tumorigenesis and antitumogeneris. Can also function as a repressor by recruiting histone deacetylase 3/HDAC3 to the promoter region of JUN. May control transcription via direct regulation of the modification of histones and the assembly of chromatin.