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Aliases for JDP2 Gene

Aliases for JDP2 Gene

  • Jun Dimerization Protein 2 2 3 5
  • Progesterone Receptor Co-Activator 2 3
  • JUNDM2 3

External Ids for JDP2 Gene

Previous HGNC Symbols for JDP2 Gene

  • JUNDM2

Previous GeneCards Identifiers for JDP2 Gene

  • GC14P073410
  • GC14P069722
  • GC14P073884
  • GC14P073888
  • GC14P074964
  • GC14P075894
  • GC14P056063

Summaries for JDP2 Gene

GeneCards Summary for JDP2 Gene

JDP2 (Jun Dimerization Protein 2) is a Protein Coding gene. Diseases associated with JDP2 include Keratitis and Skeletal Muscle Cancer. Among its related pathways are Tacrolimus/Cyclosporine Pathway, Pharmacodynamics and ATF-2 transcription factor network. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and protein heterodimerization activity. An important paralog of this gene is ATF3.

UniProtKB/Swiss-Prot for JDP2 Gene

  • Component of the AP-1 transcription factor that represses transactivation mediated by the Jun family of proteins. Involved in a variety of transcriptional responses associated with AP-1 such as UV-induced apoptosis, cell differentiation, tumorigenesis and antitumogeneris. Can also function as a repressor by recruiting histone deacetylase 3/HDAC3 to the promoter region of JUN. May control transcription via direct regulation of the modification of histones and the assembly of chromatin.

Gene Wiki entry for JDP2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for JDP2 Gene

Genomics for JDP2 Gene

Regulatory Elements for JDP2 Gene

Enhancers for JDP2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14G075293 1.7 FANTOM5 ENCODE dbSUPER 29.1 -131.3 -131279 6.9 HDGF PKNOX1 ARID4B SIN3A FEZF1 YBX1 ZNF2 YY1 ZNF766 ZNF143 JDP2 TMED10 NEK9 LINC01220 BATF FOS DPPA5P4 SYNDIG1L FLVCR2
GH14G075448 1.8 FANTOM5 Ensembl ENCODE dbSUPER 20.8 +24.6 24636 7.1 PKNOX1 FOXA2 ARID4B SIN3A DMAP1 BRCA1 ZNF48 ZBTB7B YY1 ZNF143 JDP2 BATF ZC2HC1C LOC102724153 LOC101928377 LOC105370572
GH14G075236 2 VISTA FANTOM5 Ensembl ENCODE dbSUPER 9.7 -189.5 -189475 3.7 MXI1 ZBTB21 ZSCAN4 CEBPG ZFHX2 POLR2A EGR2 HLF BHLHE40 ATF2 TMED10 JDP2 ENSG00000258740 LOC105370571 RNU4ATAC14P
GH14G075399 1.5 Ensembl ENCODE dbSUPER 12.5 -26.3 -26319 3.6 PKNOX1 SIN3A FEZF1 ZNF2 YY1 ZNF121 GLIS2 GATA2 ZNF143 FOS JDP2 NEK9 ENSG00000259005 NPC2 LINC01220
GH14G075340 1.4 FANTOM5 Ensembl ENCODE 12.9 -86.4 -86416 3.8 USF1 ZNF175 MAX RAD21 ZNF316 NFE2 MAFK MAFG USF2 CEBPB BATF JDP2 FLVCR2 FOS LINC01220
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around JDP2 on UCSC Golden Path with GeneCards custom track

Promoters for JDP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000070920 384 1801 ATF1 ARID4B SIN3A DMAP1 ZNF48 GLIS2 ZNF263 SP3 KAT8 ATF4

Genomic Location for JDP2 Gene

Chromosome:
14
Start:
75,427,716 bp from pter
End:
75,474,111 bp from pter
Size:
46,396 bases
Orientation:
Plus strand

Genomic View for JDP2 Gene

Genes around JDP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
JDP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for JDP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for JDP2 Gene

Proteins for JDP2 Gene

  • Protein details for JDP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WYK2-JDP2_HUMAN
    Recommended name:
    Jun dimerization protein 2
    Protein Accession:
    Q8WYK2
    Secondary Accessions:
    • J3KN58
    • O95430
    • Q9UIE4

    Protein attributes for JDP2 Gene

    Size:
    163 amino acids
    Molecular mass:
    18704 Da
    Quaternary structure:
    • Forms a homodimer or heterodimer with JUN, JUNB, JUND, CEBPG and ATF2 thereby inhibiting transactivation by JUN, ATF2 and CEBPG (By similarity). Binds multiple DNA elements such as cAMP-response element (CRE) and TPA response element (TRE) either as homodimer or heterodimer (By similarity). Interacts with IRF2BP1.

    Alternative splice isoforms for JDP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for JDP2 Gene

Post-translational modifications for JDP2 Gene

  • Phosphorylation of Thr-148 by MAPK8 in response to different stress conditions such as, UV irradiation, oxidatives stress and anisomycin treatments.
  • Polyubiquitinated; probably by IRF2BP1.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Abcam antibodies for JDP2
  • Santa Cruz Biotechnology (SCBT) Antibodies for JDP2

No data available for DME Specific Peptides for JDP2 Gene

Domains & Families for JDP2 Gene

Gene Families for JDP2 Gene

Protein Domains for JDP2 Gene

Suggested Antigen Peptide Sequences for JDP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WYK2

UniProtKB/Swiss-Prot:

JDP2_HUMAN :
  • Belongs to the bZIP family. ATF subfamily.
Family:
  • Belongs to the bZIP family. ATF subfamily.
genes like me logo Genes that share domains with JDP2: view

Function for JDP2 Gene

Molecular function for JDP2 Gene

UniProtKB/Swiss-Prot Function:
Component of the AP-1 transcription factor that represses transactivation mediated by the Jun family of proteins. Involved in a variety of transcriptional responses associated with AP-1 such as UV-induced apoptosis, cell differentiation, tumorigenesis and antitumogeneris. Can also function as a repressor by recruiting histone deacetylase 3/HDAC3 to the promoter region of JUN. May control transcription via direct regulation of the modification of histones and the assembly of chromatin.

Gene Ontology (GO) - Molecular Function for JDP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IEA --
GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding IEA --
GO:0003677 DNA binding IEA --
GO:0003682 chromatin binding IEA --
GO:0003690 double-stranded DNA binding IEA --
genes like me logo Genes that share ontologies with JDP2: view
genes like me logo Genes that share phenotypes with JDP2: view

Animal Models for JDP2 Gene

MGI Knock Outs for JDP2:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for JDP2 Gene

Localization for JDP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for JDP2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for JDP2 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for JDP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with JDP2: view

Pathways & Interactions for JDP2 Gene

genes like me logo Genes that share pathways with JDP2: view

Pathways by source for JDP2 Gene

1 BioSystems pathway for JDP2 Gene
1 PharmGKB pathway for JDP2 Gene

Gene Ontology (GO) - Biological Process for JDP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA --
GO:0031063 regulation of histone deacetylation IEA --
genes like me logo Genes that share ontologies with JDP2: view

No data available for SIGNOR curated interactions for JDP2 Gene

Drugs & Compounds for JDP2 Gene

(3) Drugs for JDP2 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pseudoephedrine Approved Pharma Target 628
cyclic amp Experimental Pharma 0

(2) Additional Compounds for JDP2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with JDP2: view

Transcripts for JDP2 Gene

Unigene Clusters for JDP2 Gene

Jun dimerization protein 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for JDP2 Gene

No ASD Table

Relevant External Links for JDP2 Gene

GeneLoc Exon Structure for
JDP2
ECgene alternative splicing isoforms for
JDP2

Expression for JDP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for JDP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for JDP2 Gene

This gene is overexpressed in Whole Blood (x4.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for JDP2 Gene



NURSA nuclear receptor signaling pathways regulating expression of JDP2 Gene:

JDP2

SOURCE GeneReport for Unigene cluster for JDP2 Gene:

Hs.196482

Evidence on tissue expression from TISSUES for JDP2 Gene

  • Intestine(4.3)
genes like me logo Genes that share expression patterns with JDP2: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for JDP2 Gene

Orthologs for JDP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for JDP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia JDP2 34 35
  • 99.23 (n)
oppossum
(Monodelphis domestica)
Mammalia JDP2 35
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia JDP2 34 35
  • 91.42 (n)
cow
(Bos Taurus)
Mammalia JDP2 34 35
  • 91 (n)
mouse
(Mus musculus)
Mammalia Jdp2 34 16 35
  • 89.98 (n)
rat
(Rattus norvegicus)
Mammalia Jdp2 34
  • 89.37 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia JDP2 35
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves JDP2 34 35
  • 85.07 (n)
lizard
(Anolis carolinensis)
Reptilia JDP2 35
  • 76 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii LOC570258 34
  • 74.12 (n)
JDP2 35
  • 64 (a)
OneToOne
wufb12f11 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 23 (a)
OneToMany
Species where no ortholog for JDP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for JDP2 Gene

ENSEMBL:
Gene Tree for JDP2 (if available)
TreeFam:
Gene Tree for JDP2 (if available)

Paralogs for JDP2 Gene

Paralogs for JDP2 Gene

(6) SIMAP similar genes for JDP2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with JDP2: view

Variants for JDP2 Gene

Sequence variations from dbSNP and Humsavar for JDP2 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000083125 -- 75,469,972(+) TGCTG(C/T)GGGGC utr-variant-3-prime
rs1000120623 -- 75,439,871(+) AGCCA(A/G)TAGCT intron-variant
rs1000162992 -- 75,427,889(+) TCCTC(C/G/T)CCGGT intron-variant, upstream-variant-2KB
rs1000202338 -- 75,447,681(+) TTGAG(C/T)TGGAG intron-variant
rs1000235926 -- 75,453,217(+) CCCTG(C/T)TTATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for JDP2 Gene

Variant ID Type Subtype PubMed ID
esv22667 CNV loss 19812545
nsv1037822 CNV gain 25217958
nsv1070228 CNV deletion 25765185
nsv1126368 CNV deletion 24896259
nsv1151066 CNV insertion 26484159

Variation tolerance for JDP2 Gene

Residual Variation Intolerance Score: 41.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.56; 30.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for JDP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
JDP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for JDP2 Gene

Disorders for JDP2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for JDP2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
keratitis
  • keratitis, hereditary
skeletal muscle cancer
  • malignant tumor of skeletal muscle
- elite association - COSMIC cancer census association via MalaCards
Search JDP2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for JDP2

Genetic Association Database (GAD)
JDP2
Human Genome Epidemiology (HuGE) Navigator
JDP2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
JDP2
genes like me logo Genes that share disorders with JDP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for JDP2 Gene

Publications for JDP2 Gene

  1. Phosphorylation of two eukaryotic transcription factors, Jun dimerization protein 2 and activation transcription factor 2, in Escherichia coli by Jun N-terminal kinase 1. (PMID: 18307971) Murata T. … Yokoyama K.K. (Anal. Biochem. 2008) 3 4 22 64
  2. IRF2-binding protein-1 is a JDP2 ubiquitin ligase and an inhibitor of ATF2-dependent transcription. (PMID: 18671972) Kimura M. (FEBS Lett. 2008) 3 4 22 64
  3. Depletion of the AP-1 repressor JDP2 induces cell death similar to apoptosis. (PMID: 16026868) Lerdrup M. … Kallunki T. (Biochim. Biophys. Acta 2005) 3 4 22 64
  4. Association of the Jun dimerization protein 2 gene with intracranial aneurysms in Japanese and Korean cohorts as compared to a Dutch cohort. (PMID: 20452405) Krischek B. … Inoue I. (Neuroscience 2010) 3 46 64
  5. A progesterone receptor co-activator (JDP2) mediates activity through interaction with residues in the carboxyl-terminal extension of the DNA binding domain. (PMID: 19553667) Hill K.K. … Edwards D.P. (J. Biol. Chem. 2009) 3 22 64

Products for JDP2 Gene

Sources for JDP2 Gene

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