Aliases for OR11H6 Gene
Aliases for OR11H6 Gene
External Ids for OR11H6 Gene
- HGNC: 15349
- Entrez Gene: 122748
- Ensembl: ENSG00000176219
- UniProtKB: Q8NGC7
- HORDE: OR11H6
Previous GeneCards Identifiers for OR11H6 Gene
- GC14U990444
- GC14P018682
- GC14P019761
- GC14P020691
Summaries for OR11H6 Gene
-
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
GeneCards Summary for OR11H6 Gene
OR11H6 (Olfactory Receptor Family 11 Subfamily H Member 6) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR11G2.
UniProtKB/Swiss-Prot for OR11H6 Gene
-
Odorant receptor.
No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR11H6 Gene
Genomics for OR11H6 Gene
Regulatory Elements for OR11H6 Gene
Enhancers for OR11H6 Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around OR11H6 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the OR11H6 gene promoter:
Regulatory Element Products
Genomic Location for OR11H6 Gene
- Chromosome:
- 14
- Start:
- 20,223,632 bp from pter
- End:
- 20,224,805 bp from pter
- Size:
- 1,174 bases
- Orientation:
- Plus strand
Genomic View for OR11H6 Gene
Genes around OR11H6 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 14q11.2 by Ensembl
- 14q11.2 by Entrez Gene
- 14q11.2 by HGNC
OR11H6 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for OR11H6 Gene
Proteins for OR11H6 Gene
-
Protein details for OR11H6 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8NGC7-O11H6_HUMAN
- Recommended name:
- Olfactory receptor 11H6
- Protein Accession:
- Q8NGC7
- Q6IF08
Protein attributes for OR11H6 Gene
- Size:
- 330 amino acids
- Molecular mass:
- 36788 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for OR11H6 Gene
- Glycosylation at Asn 21
Other Protein References for OR11H6 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
- HORDE protein sequence:
Antibody Products
- Search GeneTex for Antibodies for OR11H6
-
Santa Cruz Biotechnology (SCBT) Antibodies for OR11H6
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for OR11H6
- Origene Custom Protein Services for OR11H6
- Search GeneTex for Proteins for OR11H6
Assay Products
- antibodies-online Kits for OR11H6: See all 19
No data available for DME Specific Peptides for OR11H6 Gene
Domains & Families for OR11H6 Gene
Gene Families for OR11H6 Gene
Protein Domains for OR11H6 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for OR11H6 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q8NGC7- Family:
-
- Belongs to the G-protein coupled receptor 1 family.
Function for OR11H6 Gene
Molecular function for OR11H6 Gene
- UniProtKB/Swiss-Prot Function:
- Odorant receptor.
Phenotypes for OR11H6 Gene
- GenomeRNAi human phenotypes for OR11H6:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for OR11H6 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for OR11H6 gene
- Search ViGene Biosciences for OR11H6
CRISPR Products
-
OriGene CRISPR knockouts for OR11H6
-
Santa Cruz Biotechnology (SCBT) CRISPR for OR11H6
- GenScript: Design CRISPR guide RNA sequences for OR11H6
miRNA Products
- Search ViGene Biosciences for OR11H6
Inhibitory RNA Products
- Origene RNAi, shRNA, and siRNA products in human, mouse, rat for OR11H6
- Browse OriGene Inhibitory RNA Products For OR11H6
-
ViGene Biosciences ready-to-package AAV shRNAs for OR11H6 gene
Clone Products
- OriGene clones in human for OR11H6
- OriGene ORF clones in human for OR11H6
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for OR11H6 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for OR11H6 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for OR11H6 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR11H6 Gene
Localization for OR11H6 Gene
Subcellular locations from UniProtKB/Swiss-Prot for OR11H6 Gene
- Cell membrane; Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005887 | integral component of plasma membrane | IBA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
Pathways & Interactions for OR11H6 Gene
More details on SuperPathways for OR11H6| Superpath | Contained pathways | ||
|---|---|---|---|
| 1 | Signaling by GPCR | ||
| 2 | Olfactory Signaling Pathway |
Pathways by source for OR11H6 Gene
4 Reactome pathways for OR11H6 Gene
1 KEGG pathway for OR11H6 Gene
Interacting Proteins for OR11H6 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0050911 | detection of chemical stimulus involved in sensory perception of smell | IEA | -- |
No data available for SIGNOR curated interactions for OR11H6 Gene
Transcripts for OR11H6 Gene
mRNA/cDNA for OR11H6 Gene
- (1) REFSEQ mRNAs :
- (1) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for OR11H6
-
Santa Cruz Biotechnology (SCBT) CRISPR for OR11H6
- GenScript: Design CRISPR guide RNA sequences for OR11H6
miRNA Products
- Search ViGene Biosciences for OR11H6
Inhibitory RNA Products
- Origene RNAi, shRNA, and siRNA products in human, mouse, rat for OR11H6
- Browse OriGene Inhibitory RNA Products For OR11H6
-
ViGene Biosciences ready-to-package AAV shRNAs for OR11H6 gene
Clone Products
- OriGene clones in human for OR11H6
- OriGene ORF clones in human for OR11H6
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
Flow Cytometry Products
Expression for OR11H6 Gene
mRNA differential expression in normal tissues according to GTEx for OR11H6 Gene
This gene is overexpressed in Testis (x15.0), Esophagus - Gastroesophageal Junction (x4.3), Brain - Nucleus accumbens (basal ganglia) (x4.1), and Brain - Frontal Cortex (BA9) (x4.0).
SOURCE GeneReport for Unigene cluster for OR11H6 Gene Hs.553575
Primer Products
-
OriGene qPCR primer pairs for OR11H6
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for OR11H6 Gene
Orthologs for OR11H6 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | LOC514151 35 |
|
||
| OR11H6 36 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | LOC482550 35 |
|
||
| OR11H6 36 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Olfr745 35 |
|
||
| Olfr745 16 |
|
||||
| Olfr745 36 |
|
OneToOne | |||
| chimpanzee (Pan troglodytes) |
Mammalia | LOC740639 35 |
|
||
| OR11H6 36 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | Olr1621 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | OR11H6 36 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 36 |
|
OneToMany | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | LOC100486213 35 |
|
- Species with no ortholog for OR11H6:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for OR11H6 Gene
Paralogs for OR11H6 Gene
(450) SIMAP similar genes for OR11H6 Gene using alignment to 1 proteins:
- OR11H7
- OR11H4
- OR11H2
- OR11H13P
- OR11H12
- OR11H1
- OR11G2
- OR6N1
- OR6N2
- FKSG35
- OR2A12
- OR6M1
- OR6C70
- OR2A5
- OR11A1
- OR2W3
- OR6C74
- OR6B1
- OR1M1
- OR1L8
- OR13C2
- OR6F1
- OR6C4
- OR6C3
- OR6C1
- OR5AP2
- OR1D2
- OR13C3
- OR6Q1
- OR8I2
- OR8H2
- OR6S1
- OR6C6
- OR5R1
- OR5AR1
- OR2W1
- OR2B2
- OR2AP1
- OR2A2
- OR1E1
- OR13C9
- OR13C4
- OR8U9
- OR8A1
- OR6Y1
- OR6P1
- OR6C76
- OR6C75
- OR2J4P
- OR2G6
- OR2A42
- OR2A14
- OR1L1
- OR1F12
- OR13C5
- OR10R3P
- OR2A1
- OR1D5
- OR6B3
- OR11L1
- OR9A4
- OR8H3
- OR8H1
- OR7D4
- OR6X1
- OR6J1
- OR6A2
- OR5F1
- OR5B21
- OR5B2
- OR5AS1
- OR4M1
- OR4K17
- OR4K1
- OR4F15
- OR4D1
- OR2J3
- OR2J2
- OR2F1
- OR2C3
- OR2B6
- OR1S2
- OR1S1
- OR1L6
- OR1L3
- OR1K1
- OR1G1
- OR1F1
- OR1D4
- OR13C8
- OR8U1
- OR6B2
- OR5G3
- OR5D16
- OR5AN1
- OR5A2
- OR4Q3
- OR4Q2
- OR4E1
- OR4B1
- OR2W6P
- OR2K2
- OR2D3
- OR2B8P
- OR2A25
- OR1L4
- OR1C1
- OR10G9
- OR10G7
- OR10G4
- OR10A7
- OR2AG2
- OR13F1
- OR9Q2
- OR8K1
- OR8B8
- OR7G3
- OR7C1
- OR7A5
- OR7A10
- OR5V1
- OR5M10
- OR5L2
- OR5I1
- OR5H2
- OR4N5
- OR4F6
- OR4E2
- OR4D2
- OR4C12
- OR2S2
- OR2M4
- OR2G3
- OR2D2
- OR2AG1
- OR1N2
- OR1J2
- OR1F2P
- OR1E2
- OR13D1
- OR12D3
- OR8U8
- OR7E24
- OR6K3
- OR5K1
- OR5H15
- OR5A1
- OR4N4
- OR4N2
- OR4D11
- OR4A15
- OR2J1
- OR2G2
- OR2C1
- OR2AK2
- OR2A7
- OR10R2
- OR10P1
- OR10J4
- OR10A4
- OR10A2
- 6M1-16
- OR10T2
- OR10G2
- OR10A3
- OR8G1
- OR9Q1
- OR9G4
- OR8D1
- OR8B3
- OR8B12
- OR7C2
- OR7A2P
- OR6V1
- OR6T1
- OR6C2
- OR5W2
- OR5T1
- OR5M9
- OR5M3
- OR5M11
- OR5M1
- OR5J2
- OR5B12
- OR4S1
- OR4M2
- OR4K14
- OR4F4
- OR4F17
- OR2T33
- OR2H1
- OR2F2
- OR2B3
- OR2A4
- OR1N1
- OR13G1
- OR8K3
- OR8D4
- OR8D2
- OR6K2
- OR6C68
- OR6C65
- OR5M8
- OR5L1
- OR5K2
- OR5H1
- OR5AU1
- OR5AC1
- OR4S2
- OR4K5
- OR4K3
- OR4K2
- OR4F5
- OR4D9
- OR4D10
- OR4C6
- OR2T1
- OR2M2
- OR2B11
- OR1P1
- OR1J1
- OR1E3
- OR1A1
- OR17-130
- OR16-89
- OR16-37
- OR10X1
- OR10J1
- OR10G8
- OR10J5
- OR10C1
- OR10A6
- OR10A5
- OR8G5
- OR8G2
- OLFR 42A
- OR9I1
- OR8K5
- OR8J3
- OR7G2
- OR7D2
- OR7A17
- OR5T3
- OR5D18
- OR5B3
- OR4L1
- OR4F3
- OR4F29
- OR4F21
- OR4F16
- OR4D5
- OR4C46
- OR2T12
- OR2M3
- OR2AE1
- OR1Q1
- OR1J4
- OR1I1
- OR13J1
- OR13H1
- OR12D2
- OR9G9
- OR9G1
- OR8B2
- OR7-139
- OR5D13
- OR5AL1
- OR56A3
- OR4K15
- OR4C3
- OR4A47
- OR2V2
- OR2T8
- OR2T7
- OR2T3
- OR2T27
- OR2T11
- OR2M5
- OR2H2
- OR16-90
- OR16-88
- OR16-36
- OR14L1P
- OR10AD1
- OR10V1
- OR10K1
- OR10G3
- OR5H14
- OR9A2
- OR7G1
- OR5T2
- OR5K3
- OR5D14
- OR5AK2
- OR4C5
- OR4C15
- OR4C11
- OR2Y1
- OR2M7
- OR2L3
- OR2L13
- OR1E3P
- OR1A2
- OR14A2
- OR9A1P
- OR8J2
- OR7-140
- OR5K4
- OR5C1
- OR5B17
- OR5AC2
- OR56A4
- OR56A1
- OR4P4
- OR4K13
- OR4D6
- OR4C13
- OR4A4P
- OR3A3
- OR2W5
- OR2T6
- OR2T35
- OR2T34
- OR2T2
- OR2L2
- OR14I1
- OR13A1
- OR10Z1
- OR10D4P
- OR10AG1
- OR10W1
- OR10Q1
- OR10H5
- OR10H2
- OR10H1
- OR4A16
- olfr89
- OR8S1
- OR8B4
- OR5P3
- OR4X1
- OR2Z1
- OR2T4
- OR2L8
- OR2L5
- OR9K2
- OR8J1
- OR6K6
- OR5H6
- OR4X2
- OR4C45
- OR4A8P
- OR4A5
- OR3A4P
- OR3A1
- OR2V1
- OR2T5
- OR2T29
- OR2T10
- OR2I1P
- OR2AJ1
- OR1B1
- OR10J3
- OR10G6
- OR10H3
- OR10D3
- OR7E5P
- OR5P2
- OR5E1P
- OR5AK3P
- OR14J1
- PJCG1
- OR7E85P
- OR5D3
- OR56A5
- OR3A2
- OR2AT4
- OR17-16
- OR14A16
- OR10S1
- OLFR 42B
- OR10H4
- OR10K2
- PJCG2
- OR7E35P
- OR2H5P
- OR17-137
- OR14C36
- OR10J6P
- OR56B4
- OR52M1
- OR52E8
- OR52E4
- OR4C16
- OR56B1
- OR52E6
- OR52B2
- OR51E2
- OR56B2P
- OR52R1
- OR52K2
- OR52J3
- OR17-15
- OR52K3P
- OR51I2
- OR51I1
- OR51E1
- OR51A1P
- OR14K1
- OR52N4
- OR52L1
- OR51G2
- OR7E18P
- OR56B3P
- OR52N2
- OR52I1
- OR52D1
- OR51V1
- OR51L1
- OR51D1
- OR51B6
- OR52Z1
- OR52N5
- OR52L2P
- OR52K1
- OR52I2
- OR51B5
- OR52A5
- OR51M1
- OR51A4
- OR52P1P
- OR52N1
- OR52E5
- OR52E2
- OR52B6
- OR51Q1
- OR51B4
- OR51B2
- OR10AC1P
- OR52W1
- OR52H1
- OR52E1
- OR51T1
- OR51H1P
- OR51F2
- OR51A2
- OR52B4
- OR51S1
- OR51F1
- OR51G1
Pseudogenes.org Pseudogenes for OR11H6 Gene
Variants for OR11H6 Gene
| SNP ID | Clin | Chr 14 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs9323693 | - | 20,223,803(+) | TTGTC(C/G)TCCTG | reference, missense | |
| rs10140652 | - | 20,223,729(+) | TCATT(A/C)TTTGG | reference, missense | |
| rs12891553 | - | 20,224,029(+) | TGAGA(C/T)TAAAA | reference, missense | |
| rs17106351 | - | 20,224,146(+) | CTGTC(A/G)TCCAT | reference, missense | |
| rs17211285 | - | 20,224,294(+) | CACTT(G/T)GTGTG | reference, missense |
Residual Variation Intolerance Score:
97.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
19.97;
98.99% of all genes are more intolerant (likely to be disease-causing)
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for OR11H6 Gene
Disorders for OR11H6 Gene
Relevant External Links for OR11H6
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- OR11H6
No disorders were found for OR11H6 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR11H6 Gene
Publications for OR11H6 Gene
- The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 67
Products for OR11H6 Gene
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- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for OR11H6
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- Origene siRNA, shRNA, and RNAi products in human, mouse, rat for OR11H6
- Browse OriGene Inhibitory RNA Products For OR11H6
- OriGene qPCR primer pairs for OR11H6
- OriGene CRISPR knockouts for OR11H6
- OriGene clones in human for OR11H6
- OriGene ORF clones in human for OR11H6
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- GenScript: Next-day shipping cDNA clones in your preferred vector
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- GenScript: Design CRISPR guide RNA sequences for OR11H6
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- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for OR11H6
- ViGene Biosciences adenoviral particle packaged cDNA for OR11H6 gene
- ViGene Biosciences lentiviral particle packaged cDNA for OR11H6 gene
- ViGene Biosciences lentiviral particle packaged cDNA for OR11H6 gene
- ViGene Biosciences ready-to-package AAV shRNAs for OR11H6 gene
- ViGene Biosciences ready-to-package AAV shRNAs for OR11H6 gene
- ViGene Biosciences ready-to-package AAV shRNAs for OR11H6 gene
- Search ViGene Biosciences for OR11H6
- Search ViGene Biosciences for OR11H6
- Santa Cruz Biotechnology (SCBT) Antibodies for OR11H6
- Search Santa Cruz Biotechnology (SCBT) for OR11H6 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for OR11H6
Sources for OR11H6 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
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