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Aliases for OR11H6 Gene

Aliases for OR11H6 Gene

  • Olfactory Receptor Family 11 Subfamily H Member 6 2 3 5
  • Olfactory Receptor, Family 11, Subfamily H, Member 6 2
  • Olfactory Receptor OR14-35 4

External Ids for OR11H6 Gene

Previous GeneCards Identifiers for OR11H6 Gene

  • GC14U990444
  • GC14P018682
  • GC14P019761
  • GC14P020691

Summaries for OR11H6 Gene

Entrez Gene Summary for OR11H6 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR11H6 Gene

OR11H6 (Olfactory Receptor Family 11 Subfamily H Member 6) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR11G2.

UniProtKB/Swiss-Prot for OR11H6 Gene

  • Odorant receptor.

Gene Wiki entry for OR11H6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR11H6 Gene

Genomics for OR11H6 Gene

Regulatory Elements for OR11H6 Gene

Genomic Location for OR11H6 Gene

Chromosome:
14
Start:
20,223,632 bp from pter
End:
20,224,805 bp from pter
Size:
1,174 bases
Orientation:
Plus strand

Genomic View for OR11H6 Gene

Genes around OR11H6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR11H6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR11H6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR11H6 Gene

Proteins for OR11H6 Gene

  • Protein details for OR11H6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGC7-O11H6_HUMAN
    Recommended name:
    Olfactory receptor 11H6
    Protein Accession:
    Q8NGC7
    Secondary Accessions:
    • Q6IF08

    Protein attributes for OR11H6 Gene

    Size:
    330 amino acids
    Molecular mass:
    36788 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR11H6 Gene

Proteomics data for OR11H6 Gene at MOPED

Post-translational modifications for OR11H6 Gene

Other Protein References for OR11H6 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR11H6 Gene

Domains & Families for OR11H6 Gene

Gene Families for OR11H6 Gene

Protein Domains for OR11H6 Gene

Suggested Antigen Peptide Sequences for OR11H6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NGC7

UniProtKB/Swiss-Prot:

O11H6_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR11H6: view

Function for OR11H6 Gene

Molecular function for OR11H6 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes for OR11H6 Gene

genes like me logo Genes that share phenotypes with OR11H6: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR11H6 Gene

Localization for OR11H6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR11H6 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR11H6 Gene COMPARTMENTS Subcellular localization image for OR11H6 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR11H6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IBA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR11H6: view

Pathways & Interactions for OR11H6 Gene

genes like me logo Genes that share pathways with OR11H6: view

Pathways by source for OR11H6 Gene

Interacting Proteins for OR11H6 Gene

Gene Ontology (GO) - Biological Process for OR11H6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR11H6: view

No data available for SIGNOR curated interactions for OR11H6 Gene

Drugs & Compounds for OR11H6 Gene

No Compound Related Data Available

Transcripts for OR11H6 Gene

mRNA/cDNA for OR11H6 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR11H6 Gene

No ASD Table

Relevant External Links for OR11H6 Gene

GeneLoc Exon Structure for
OR11H6
ECgene alternative splicing isoforms for
OR11H6

Expression for OR11H6 Gene

mRNA expression in normal human tissues for OR11H6 Gene

mRNA differential expression in normal tissues according to GTEx for OR11H6 Gene

This gene is overexpressed in Testis (x15.0), Esophagus - Gastroesophageal Junction (x4.3), Brain - Nucleus accumbens (basal ganglia) (x4.1), and Brain - Frontal Cortex (BA9) (x4.0).

SOURCE GeneReport for Unigene cluster for OR11H6 Gene Hs.553575

genes like me logo Genes that share expression patterns with OR11H6: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for OR11H6 Gene

Orthologs for OR11H6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR11H6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC740639 35
  • 99.19 (n)
  • 98.79 (a)
OR11H6 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OR11H6 36
  • 88 (a)
OneToOne
LOC514151 35
  • 89.25 (n)
  • 88.6 (a)
dog
(Canis familiaris)
Mammalia LOC482550 35
  • 88.18 (n)
  • 86.97 (a)
OR11H6 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Olfr745 36
  • 82 (a)
OneToOne
Olfr745 16
Olfr745 35
  • 84.3 (n)
  • 82.26 (a)
oppossum
(Monodelphis domestica)
Mammalia OR11H6 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 60 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Olr1621 35
  • 84.51 (n)
  • 83.79 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486213 35
  • 52.15 (n)
  • 44.55 (a)
Species with no ortholog for OR11H6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR11H6 Gene

ENSEMBL:
Gene Tree for OR11H6 (if available)
TreeFam:
Gene Tree for OR11H6 (if available)

Paralogs for OR11H6 Gene

(450) SIMAP similar genes for OR11H6 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for OR11H6 Gene

genes like me logo Genes that share paralogs with OR11H6: view

Variants for OR11H6 Gene

Sequence variations from dbSNP and Humsavar for OR11H6 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs9323693 - 20,223,803(+) TTGTC(C/G)TCCTG reference, missense
rs10140652 - 20,223,729(+) TCATT(A/C)TTTGG reference, missense
rs12891553 - 20,224,029(+) TGAGA(C/T)TAAAA reference, missense
rs17106351 - 20,224,146(+) CTGTC(A/G)TCCAT reference, missense
rs17211285 - 20,224,294(+) CACTT(G/T)GTGTG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for OR11H6 Gene

Variant ID Type Subtype PubMed ID
nsv901299 CNV Gain 21882294
esv2751268 CNV Gain 17911159
nsv832739 CNV Gain 17160897
nsv901466 CNV Loss 21882294
nsv456144 CNV Loss 19166990
nsv901467 CNV Gain 21882294

Variation tolerance for OR11H6 Gene

Residual Variation Intolerance Score: 97.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 19.97; 98.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR11H6 Gene

HapMap Linkage Disequilibrium report
OR11H6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR11H6 Gene

Disorders for OR11H6 Gene

Relevant External Links for OR11H6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR11H6

No disorders were found for OR11H6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR11H6 Gene

Publications for OR11H6 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 67

Products for OR11H6 Gene

Sources for OR11H6 Gene

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