Aliases for CMA1 Gene
External Ids for CMA1 Gene
Previous GeneCards Identifiers for CMA1 Gene
This gene product is a chymotryptic serine proteinase that belongs to the peptidase family S1. It is expressed in mast cells and thought to function in the degradation of the extracellular matrix, the regulation of submucosal gland secretion, and the generation of vasoactive peptides. In the heart and blood vessels, this protein, rather than angiotensin converting enzyme, is largely responsible for converting angiotensin I to the vasoactive peptide angiotensin II. Angiotensin II has been implicated in blood pressure control and in the pathogenesis of hypertension, cardiac hypertrophy, and heart failure. Thus, this gene product is a target for cardiovascular disease therapies. This gene maps to 14q11.2 in a cluster of genes encoding other proteases. [provided by RefSeq, Jul 2008]
GeneCards Summary for CMA1 Gene
CMA1 (Chymase 1, Mast Cell) is a Protein Coding gene. Diseases associated with CMA1 include idiopathic interstitial pneumonia and vernal keratoconjunctivitis. Among its related pathways are PI-3K cascade and Signaling by GPCR. GO annotations related to this gene include serine-type endopeptidase activity and peptide binding. An important paralog of this gene is ELANE.
UniProtKB/Swiss-Prot for CMA1 Gene
Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion