Aliases for SP7 Gene
External Ids for SP7 Gene
This gene encodes a member of the Sp subfamily of Sp/XKLF transcription factors. Sp family proteins are sequence-specific DNA-binding proteins characterized by an amino-terminal trans-activation domain and three carboxy-terminal zinc finger motifs. This protein is a bone specific transcription factor and is required for osteoblast differentiation and bone formation.[provided by RefSeq, Jul 2010]
GeneCards Summary for SP7 Gene
SP7 (Sp7 Transcription Factor) is a Protein Coding gene. Diseases associated with SP7 include osteogenesis imperfecta, type xii and sp7-related osteogenesis imperfecta. GO annotations related to this gene include DEAD/H-box RNA helicase binding. An important paralog of this gene is KLF2.
UniProtKB/Swiss-Prot for SP7 Gene
Transcriptional activator essential for osteoblast differentiation. Binds to SP1 and EKLF consensus sequences and to other G/C-rich sequences (By similarity).