Aliases for CLTC Gene
External Ids for CLTC Gene
Previous HGNC Symbols for CLTC Gene
Previous GeneCards Identifiers for CLTC Gene
Clathrin is a major protein component of the cytoplasmic face of intracellular organelles, called coated vesicles and coated pits. These specialized organelles are involved in the intracellular trafficking of receptors and endocytosis of a variety of macromolecules. The basic subunit of the clathrin coat is composed of three heavy chains and three light chains. [provided by RefSeq, Jul 2008]
GeneCards Summary for CLTC Gene
CLTC (Clathrin Heavy Chain) is a Protein Coding gene. Diseases associated with CLTC include inflammatory myofibroblastic tumor and translocation renal cell carcinoma. Among its related pathways are Signaling by GPCR and Immune System. GO annotations related to this gene include poly(A) RNA binding and protein kinase binding. An important paralog of this gene is CLTCL1.
UniProtKB/Swiss-Prot for CLTC Gene
Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network.