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Aliases for DBX1 Gene

Aliases for DBX1 Gene

  • Developing Brain Homeobox 1 2 3
  • Developing Brain Homeobox Protein 1 4

External Ids for DBX1 Gene

Previous GeneCards Identifiers for DBX1 Gene

  • GC11M020135
  • GC11M019861

Summaries for DBX1 Gene

GeneCards Summary for DBX1 Gene

DBX1 (Developing Brain Homeobox 1) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and transcription regulatory region sequence-specific DNA binding. An important paralog of this gene is DBX2.

UniProtKB/Swiss-Prot for DBX1 Gene

  • Could have a role in patterning the central nervous system during embryogenesis. Has a key role in regulating the distinct phenotypic features that distinguish two major classes of ventral interneurons, V0 and V1 neurons. Regulates the transcription factor profile, neurotransmitter phenotype, intraspinal migratory path and axonal trajectory of V0 neurons, features that differentiate them from an adjacent set of V1 neurons (By similarity).

Gene Wiki entry for DBX1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DBX1 Gene

Genomics for DBX1 Gene

Regulatory Elements for DBX1 Gene

Genomic Location for DBX1 Gene

Start:
20,156,155 bp from pter
End:
20,160,613 bp from pter
Size:
4,459 bases
Orientation:
Minus strand

Genomic View for DBX1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DBX1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DBX1 Gene

Proteins for DBX1 Gene

  • Protein details for DBX1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NMT0-DBX1_HUMAN
    Recommended name:
    Homeobox protein DBX1
    Protein Accession:
    A6NMT0
    Secondary Accessions:

    Protein attributes for DBX1 Gene

    Size:
    343 amino acids
    Molecular mass:
    37283 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DBX1 Gene

Proteomics data for DBX1 Gene at MOPED

Post-translational modifications for DBX1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DBX1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DBX1 Gene

Domains for DBX1 Gene

Gene Families for DBX1 Gene

HGNC:
  • NKL :Homeoboxes / ANTP class : NKL subclass

Protein Domains for DBX1 Gene

Suggested Antigen Peptide Sequences for DBX1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NMT0

UniProtKB/Swiss-Prot:

DBX1_HUMAN :
  • A6NMT0
Domain:
  • Contains 1 homeobox DNA-binding domain.
Family:
  • Belongs to the H2.0 homeobox family.
genes like me logo Genes that share domains with DBX1: view

Function for DBX1 Gene

Molecular function for DBX1 Gene

UniProtKB/Swiss-Prot Function: Could have a role in patterning the central nervous system during embryogenesis. Has a key role in regulating the distinct phenotypic features that distinguish two major classes of ventral interneurons, V0 and V1 neurons. Regulates the transcription factor profile, neurotransmitter phenotype, intraspinal migratory path and axonal trajectory of V0 neurons, features that differentiate them from an adjacent set of V1 neurons (By similarity).

Gene Ontology (GO) - Molecular Function for DBX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding --
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with DBX1: view
genes like me logo Genes that share phenotypes with DBX1: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for DBX1 Gene

Localization for DBX1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DBX1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DBX1 Gene COMPARTMENTS Subcellular localization image for DBX1 gene
Compartment Confidence
nucleus 3
cytosol 2
mitochondrion 2

Gene Ontology (GO) - Cellular Components for DBX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with DBX1: view

Pathways for DBX1 Gene

SuperPathways for DBX1 Gene

No Data Available

Interacting Proteins for DBX1 Gene

Gene Ontology (GO) - Biological Process for DBX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA --
GO:0021521 ventral spinal cord interneuron specification IEA --
genes like me logo Genes that share ontologies with DBX1: view

No data available for Pathways by source for DBX1 Gene

Transcripts for DBX1 Gene

mRNA/cDNA for DBX1 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DBX1 Gene

Developing brain homeobox 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DBX1 Gene

No ASD Table

Relevant External Links for DBX1 Gene

GeneLoc Exon Structure for
DBX1
ECgene alternative splicing isoforms for
DBX1

Expression for DBX1 Gene

mRNA expression in normal human tissues for DBX1 Gene

mRNA differential expression in normal tissues according to GTEx for DBX1 Gene

This gene is overexpressed in Testis (26.0) and Pituitary (7.9).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for DBX1 Gene

SOURCE GeneReport for Unigene cluster for DBX1 Gene Hs.558604

genes like me logo Genes that share expressions with DBX1: view

No data available for mRNA Expression by UniProt/SwissProt for DBX1 Gene

Orthologs for DBX1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DBX1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DBX1 35
  • 97.84 (n)
  • 97.52 (a)
DBX1 36
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DBX1 35
  • 90.36 (n)
  • 92 (a)
DBX1 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DBX1 35
  • 82.49 (n)
  • 84 (a)
DBX1 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dbx1 35
  • 83.78 (n)
  • 88.66 (a)
Dbx1 16
Dbx1 36
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DBX1 36
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dbx1 35
  • 83.48 (n)
  • 89.85 (a)
chicken
(Gallus gallus)
Aves DBX1 35
  • 76.21 (n)
  • 80.82 (a)
DBX1 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DBX1 36
  • 81 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia dbx-A 35
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495433 35
  • 72.63 (n)
  • 77.96 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
dbx1a 36
  • 63 (a)
OneToMany
dbx1b 35
  • 64.31 (n)
  • 70.63 (a)
dbx1b 36
  • 65 (a)
OneToMany
Species with no ortholog for DBX1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DBX1 Gene

ENSEMBL:
Gene Tree for DBX1 (if available)
TreeFam:
Gene Tree for DBX1 (if available)

Paralogs for DBX1 Gene

Paralogs for DBX1 Gene

genes like me logo Genes that share paralogs with DBX1: view

Variants for DBX1 Gene

Sequence variations from dbSNP and Humsavar for DBX1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs831462 -- 20,156,664(+) TCGGG(A/T)GCAGG intron-variant
rs831463 -- 20,156,684(+) TCGGG(A/C)TGTGT intron-variant
rs831464 -- 20,157,171(+) GCCCC(G/T)CCGAG synonymous-codon, reference
rs831465 -- 20,157,339(-) GAGCG(C/T)TTTAA intron-variant
rs2139751 -- 20,157,685(-) TCTTT(A/C)TCAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DBX1 Gene

Variant ID Type Subtype PubMed ID
nsv469939 CNV Gain 18288195
nsv467720 CNV Gain 19166990

Relevant External Links for DBX1 Gene

HapMap Linkage Disequilibrium report
DBX1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DBX1 Gene

Disorders for DBX1 Gene

Relevant External Links for DBX1

Genetic Association Database (GAD)
DBX1
genes like me logo Genes that share disorders with DBX1: view

No data available for UniProtKB/Swiss-Prot for DBX1 Gene

Publications for DBX1 Gene

  1. Control of interneuron fate in the developing spinal cord by the progenitor homeodomain protein Dbx1. (PMID: 11239429) Pierani A. … Jessell T.M. (Neuron 2001) 2 3
  2. Developmental origin of preBAPtzinger complex respiratory neurons. (PMID: 21048147) Gray P.A. … Del Negro C.A. (J. Neurosci. 2010) 3
  3. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 4

Products for DBX1 Gene

Sources for DBX1 Gene

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