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Aliases for DBX1 Gene

Aliases for DBX1 Gene

  • Developing Brain Homeobox 1 2 3 5
  • Developing Brain Homeobox Protein 1 4

External Ids for DBX1 Gene

Previous GeneCards Identifiers for DBX1 Gene

  • GC11M020135
  • GC11M019861

Summaries for DBX1 Gene

GeneCards Summary for DBX1 Gene

DBX1 (Developing Brain Homeobox 1) is a Protein Coding gene. Diseases associated with DBX1 include Central Hypoventilation Syndrome, Congenital. GO annotations related to this gene include sequence-specific DNA binding. An important paralog of this gene is DBX2.

UniProtKB/Swiss-Prot for DBX1 Gene

  • Could have a role in patterning the central nervous system during embryogenesis. Has a key role in regulating the distinct phenotypic features that distinguish two major classes of ventral interneurons, V0 and V1 neurons. Regulates the transcription factor profile, neurotransmitter phenotype, intraspinal migratory path and axonal trajectory of V0 neurons, features that differentiate them from an adjacent set of V1 neurons (By similarity).

Gene Wiki entry for DBX1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DBX1 Gene

Genomics for DBX1 Gene

Regulatory Elements for DBX1 Gene

Enhancers for DBX1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G020109 1.6 Ensembl ENCODE dbSUPER 10.5 +49.0 49021 3.9 HDGF PKNOX1 CREB3L1 ARID4B SIN3A ZNF2 ZNF766 ZNF143 FOS ZNF263 DBX1 PIR54389 GC11M020007
GH11G019917 1.2 Ensembl ENCODE dbSUPER 9.9 +241.4 241440 2.4 PKNOX1 ESRRA SIN3A MAX YY1 CTBP1 SCRT2 FOSL2 FOS MAFK DBX1 GC11P019860 NAV2-AS3
GH11G020128 1 ENCODE dbSUPER 10.5 +32.2 32174 0.2 ZNF263 CTCF ZNF654 ZFP64 TRIM22 ZNF426 ZNF394 REST NR3C1 ZNF518A DBX1 HTATIP2 ENSG00000279266 NAV2-AS1
GH11G019928 1 ENCODE dbSUPER 9.9 +231.2 231249 1.7 ELF3 CTCF FOXA2 SAP130 ZNF644 RAD21 FOXK2 SMC3 ZNF600 RELB DBX1 NAV2-AS3 GC11P019860
GH11G020101 0.7 dbSUPER 10.2 +57.3 57331 3.8 PKNOX1 ZMYM3 ATF2 ZNF664 MAFF JUND ZNF316 POLR2A SCRT2 NR2F6 DBX1 PIR54389 GC11M020007
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DBX1 on UCSC Golden Path with GeneCards custom track

Genomic Location for DBX1 Gene

Chromosome:
11
Start:
20,156,155 bp from pter
End:
20,160,613 bp from pter
Size:
4,459 bases
Orientation:
Minus strand

Genomic View for DBX1 Gene

Genes around DBX1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DBX1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DBX1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DBX1 Gene

Proteins for DBX1 Gene

  • Protein details for DBX1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NMT0-DBX1_HUMAN
    Recommended name:
    Homeobox protein DBX1
    Protein Accession:
    A6NMT0

    Protein attributes for DBX1 Gene

    Size:
    343 amino acids
    Molecular mass:
    37283 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DBX1 Gene

Post-translational modifications for DBX1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DBX1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DBX1 Gene

Domains & Families for DBX1 Gene

Gene Families for DBX1 Gene

Protein Domains for DBX1 Gene

Suggested Antigen Peptide Sequences for DBX1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NMT0

UniProtKB/Swiss-Prot:

DBX1_HUMAN :
  • Belongs to the H2.0 homeobox family.
Family:
  • Belongs to the H2.0 homeobox family.
genes like me logo Genes that share domains with DBX1: view

Function for DBX1 Gene

Molecular function for DBX1 Gene

UniProtKB/Swiss-Prot Function:
Could have a role in patterning the central nervous system during embryogenesis. Has a key role in regulating the distinct phenotypic features that distinguish two major classes of ventral interneurons, V0 and V1 neurons. Regulates the transcription factor profile, neurotransmitter phenotype, intraspinal migratory path and axonal trajectory of V0 neurons, features that differentiate them from an adjacent set of V1 neurons (By similarity).

Gene Ontology (GO) - Molecular Function for DBX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with DBX1: view
genes like me logo Genes that share phenotypes with DBX1: view

Animal Models for DBX1 Gene

MGI Knock Outs for DBX1:

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for DBX1 Gene

Localization for DBX1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DBX1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DBX1 gene
Compartment Confidence
nucleus 5
mitochondrion 2
cytosol 2

Gene Ontology (GO) - Cellular Components for DBX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with DBX1: view

Pathways & Interactions for DBX1 Gene

No Data Available

Interacting Proteins for DBX1 Gene

Gene Ontology (GO) - Biological Process for DBX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA --
GO:0007275 multicellular organism development IEA --
GO:0021521 ventral spinal cord interneuron specification IEA --
genes like me logo Genes that share ontologies with DBX1: view

No data available for Pathways by source and SIGNOR curated interactions for DBX1 Gene

Transcripts for DBX1 Gene

mRNA/cDNA for DBX1 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
-
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DBX1 Gene

Developing brain homeobox 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DBX1 Gene

No ASD Table

Relevant External Links for DBX1 Gene

GeneLoc Exon Structure for
DBX1
ECgene alternative splicing isoforms for
DBX1

Expression for DBX1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DBX1 Gene

mRNA differential expression in normal tissues according to GTEx for DBX1 Gene

This gene is overexpressed in Testis (x26.0) and Pituitary (x7.9).

Protein differential expression in normal tissues from HIPED for DBX1 Gene

This gene is overexpressed in Cerebrospinal fluid (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DBX1 Gene



Protein tissue co-expression partners for DBX1 Gene

NURSA nuclear receptor signaling pathways regulating expression of DBX1 Gene:

DBX1

SOURCE GeneReport for Unigene cluster for DBX1 Gene:

Hs.558604

Evidence on tissue expression from TISSUES for DBX1 Gene

  • Nervous system(2.1)
genes like me logo Genes that share expression patterns with DBX1: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DBX1 Gene

Orthologs for DBX1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DBX1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DBX1 34 35
  • 97.84 (n)
cow
(Bos Taurus)
Mammalia DBX1 34 35
  • 90.36 (n)
mouse
(Mus musculus)
Mammalia Dbx1 34 16 35
  • 83.78 (n)
rat
(Rattus norvegicus)
Mammalia Dbx1 34
  • 83.48 (n)
dog
(Canis familiaris)
Mammalia DBX1 34 35
  • 82.49 (n)
oppossum
(Monodelphis domestica)
Mammalia DBX1 35
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves DBX1 34 35
  • 76.21 (n)
lizard
(Anolis carolinensis)
Reptilia DBX1 35
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495433 34
  • 72.63 (n)
African clawed frog
(Xenopus laevis)
Amphibia dbx-A 34
zebrafish
(Danio rerio)
Actinopterygii dbx1b 34 35
  • 64.31 (n)
dbx1a 35
  • 63 (a)
OneToMany
-- 34
Species where no ortholog for DBX1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DBX1 Gene

ENSEMBL:
Gene Tree for DBX1 (if available)
TreeFam:
Gene Tree for DBX1 (if available)

Paralogs for DBX1 Gene

Paralogs for DBX1 Gene

genes like me logo Genes that share paralogs with DBX1: view

Variants for DBX1 Gene

Sequence variations from dbSNP and Humsavar for DBX1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000190330 -- 20,160,850(+) AAGAA(C/G)CCACT upstream-variant-2KB
rs1000434461 -- 20,156,420(+) CTCTT(C/G/T)GTTCC reference, missense
rs1000743757 -- 20,156,162(+) CCCCA(A/C)CTCTT downstream-variant-500B
rs1001186326 -- 20,157,434(+) CAACC(A/G)TGCAA intron-variant
rs1002408184 -- 20,158,860(+) ATCGT(A/G)GCCAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DBX1 Gene

Variant ID Type Subtype PubMed ID
nsv467720 CNV gain 19166990
nsv469939 CNV gain 18288195
nsv553678 CNV gain 21841781

Variation tolerance for DBX1 Gene

Gene Damage Index Score: 5.71; 73.17% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DBX1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DBX1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DBX1 Gene

Disorders for DBX1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DBX1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
central hypoventilation syndrome, congenital
  • central hypoventilation syndrome, congenital, with or without hirschsprung disease
- elite association - COSMIC cancer census association via MalaCards
Search DBX1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for DBX1

Genetic Association Database (GAD)
DBX1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DBX1
genes like me logo Genes that share disorders with DBX1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DBX1 Gene

Publications for DBX1 Gene

  1. Control of interneuron fate in the developing spinal cord by the progenitor homeodomain protein Dbx1. (PMID: 11239429) Pierani A. … Jessell T.M. (Neuron 2001) 2 3 64
  2. Developmental origin of preBAPtzinger complex respiratory neurons. (PMID: 21048147) Gray P.A. … Del Negro C.A. (J. Neurosci. 2010) 3 64
  3. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 4 64

Products for DBX1 Gene

Sources for DBX1 Gene

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