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Aliases for SERPINA3 Gene

Aliases for SERPINA3 Gene

  • Serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 3 2 3
  • AACT 3 4 6
  • ACT 3 4 6
  • Cell Growth-Inhibiting Gene 24/25 Protein 3 4
  • Alpha-1-Antichymotrypsin 2 3
  • Serpin A3 3 4
  • Serine (Or Cysteine) Proteinase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 3 2
  • Serine (Or Cysteine) Proteinase Inhibitor, Clade A, Member 3 3
  • Growth-Inhibiting Protein 24 3
  • Growth-Inhibiting Protein 25 3
  • GIG24 3
  • GIG25 3

External Ids for SERPINA3 Gene

Previous HGNC Symbols for SERPINA3 Gene

  • AACT

Previous GeneCards Identifiers for SERPINA3 Gene

  • GC14P092585
  • GC14P088870
  • GC14P093019
  • GC14P093020
  • GC14P093070
  • GC14P094148
  • GC14P095078
  • GC14P075259

Summaries for SERPINA3 Gene

Entrez Gene Summary for SERPINA3 Gene

  • The protein encoded by this gene is a plasma protease inhibitor and member of the serine protease inhibitor class. Polymorphisms in this protein appear to be tissue specific and influence protease targeting. Variations in this protein's sequence have been implicated in Alzheimer's disease, and deficiency of this protein has been associated with liver disease. Mutations have been identified in patients with Parkinson disease and chronic obstructive pulmonary disease. [provided by RefSeq, Jul 2008]

GeneCards Summary for SERPINA3 Gene

SERPINA3 (Serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 3) is a Protein Coding gene. Diseases associated with SERPINA3 include alpha-1-antichymotrypsin deficiency and cerebrovascular disease. Among its related pathways are Selenium Pathway and Jak/Stat Pathway. GO annotations related to this gene include serine-type endopeptidase inhibitor activity. An important paralog of this gene is SERPINA10.

UniProtKB/Swiss-Prot for SERPINA3 Gene

  • Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2.

Gene Wiki entry for SERPINA3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SERPINA3 Gene

Genomics for SERPINA3 Gene

Regulatory Elements for SERPINA3 Gene

Genomic Location for SERPINA3 Gene

Start:
94,612,377 bp from pter
End:
94,624,055 bp from pter
Size:
11,679 bases
Orientation:
Plus strand

Genomic View for SERPINA3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SERPINA3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERPINA3 Gene

Proteins for SERPINA3 Gene

  • Protein details for SERPINA3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01011-AACT_HUMAN
    Recommended name:
    Alpha-1-antichymotrypsin
    Protein Accession:
    P01011
    Secondary Accessions:
    • B3KVQ7
    • Q13703
    • Q2TU87
    • Q2TU88
    • Q59GP9
    • Q6LBY8
    • Q6LDT7
    • Q6NSC9
    • Q8N177
    • Q96DW8
    • Q9UC47
    • Q9UNU9

    Protein attributes for SERPINA3 Gene

    Size:
    423 amino acids
    Molecular mass:
    47651 Da
    Quaternary structure:
    • Interacts with DNAJC1.
    Miscellaneous:
    • Alpha-1-antichymotrypsin can bind DNA
    SequenceCaution:
    • Sequence=AAA51543.1; Type=Frameshift; Positions=101, 106, 111, 117, 123, 129, 421; Evidence={ECO:0000305}; Sequence=AAT08029.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAT08029.1; Type=Frameshift; Positions=4; Evidence={ECO:0000305}; Sequence=BAD92297.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAA48671.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SERPINA3 Gene

    Alternative splice isoforms for SERPINA3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SERPINA3 Gene

Proteomics data for SERPINA3 Gene at MOPED

Post-translational modifications for SERPINA3 Gene

  • N- and O-glycosylated.
  • Glycosylation at Asn33, Asn93, Asn106, Asn127, Asn186, Asn271, and Thr347
  • Modification sites at PhosphoSitePlus

Other Protein References for SERPINA3 Gene

Antibody Products

  • R&D Systems Antibodies for SERPINA3 (Serpin A3/alpha 1-Antichymotrypsin)

Protein Products

No data available for DME Specific Peptides for SERPINA3 Gene

Domains for SERPINA3 Gene

Gene Families for SERPINA3 Gene

HGNC:
  • SERPIN :Serine (or cysteine) peptidase inhibitors

Protein Domains for SERPINA3 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SERPINA3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P01011

UniProtKB/Swiss-Prot:

AACT_HUMAN :
  • P01011
Domain:
  • The reactive center loop (RCL) extends out from the body of the protein and directs binding to the target protease. The protease cleaves the serpin at the reactive site within the RCL, establishing a covalent linkage between the carboxyl group of the serpin reactive site and the serine hydroxyl of the protease. The resulting inactive serpin-protease complex is highly stable
Family:
  • Belongs to the serpin family.
genes like me logo Genes that share domains with SERPINA3: view

Function for SERPINA3 Gene

Molecular function for SERPINA3 Gene

UniProtKB/Swiss-Prot Function:
Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2.

Gene Ontology (GO) - Molecular Function for SERPINA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding TAS 14668352
GO:0004867 serine-type endopeptidase inhibitor activity TAS 2404007
GO:0005515 protein binding IPI 12709365
genes like me logo Genes that share ontologies with SERPINA3: view

Animal Model Products

CRISPR Products

miRNA for SERPINA3 Gene

miRTarBase miRNAs that target SERPINA3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SERPINA3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SERPINA3 Gene

Localization for SERPINA3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SERPINA3 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SERPINA3 Gene COMPARTMENTS Subcellular localization image for SERPINA3 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 2
endoplasmic reticulum 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SERPINA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region NAS 14718574
GO:0005615 extracellular space IDA 16502470
GO:0005622 intracellular NAS 9880565
GO:0005634 nucleus TAS 14668352
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with SERPINA3: view

Pathways for SERPINA3 Gene

genes like me logo Genes that share pathways with SERPINA3: view

Pathways by source for SERPINA3 Gene

1 BioSystems pathway for SERPINA3 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for SERPINA3 Gene

Gene Ontology (GO) - Biological Process for SERPINA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006953 acute-phase response IEA --
GO:0006954 inflammatory response NAS 12475184
GO:0010951 negative regulation of endopeptidase activity IBA --
GO:0019216 regulation of lipid metabolic process NAS 11835318
GO:0030162 regulation of proteolysis --
genes like me logo Genes that share ontologies with SERPINA3: view

Compounds for SERPINA3 Gene

(56) Novoseek inferred chemical compound relationships for SERPINA3 Gene

Compound -log(P) Hits PubMed IDs
contrapsin 74.6 2
serine 70.8 63
naphthol as-d chloroacetate 46.9 2
cpsa 41.8 1
fibrinogen 40.7 26

(1) PharmGKB related drug/compound annotations for SERPINA3 Gene

Drug/compound Annotation
antineoplastic agents CA
genes like me logo Genes that share compounds with SERPINA3: view

Transcripts for SERPINA3 Gene

Unigene Clusters for SERPINA3 Gene

Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SERPINA3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SERPINA3 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d ^ 10
SP1: - - -
SP2: - -
SP3: - - - - - - -
SP4: - - - - - - - - - -
SP5: - - - -
SP6: - - - - - -
SP7: - - - -
SP8: - -
SP9: - - -
SP10: - -
SP11: -
SP12: - - - - - - - - - - - - - - - -
SP13:

Relevant External Links for SERPINA3 Gene

GeneLoc Exon Structure for
SERPINA3
ECgene alternative splicing isoforms for
SERPINA3

Expression for SERPINA3 Gene

mRNA expression in normal human tissues for SERPINA3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SERPINA3 Gene

This gene is overexpressed in Liver (24.0) and Pancreas (11.8).

Protein differential expression in normal tissues for SERPINA3 Gene

This gene is overexpressed in Serum (11.3), Plasma (10.9), and Synovial fluid (7.6).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for SERPINA3 Gene

SOURCE GeneReport for Unigene cluster for SERPINA3 Gene Hs.534293

mRNA Expression by UniProt/SwissProt for SERPINA3 Gene

P01011-AACT_HUMAN
Tissue specificity: Plasma. Synthesized in the liver. Like the related alpha-1-antitrypsin, its concentration increases in the acute phase of inflammation or infection. Found in the amyloid plaques from the hippocampus of Alzheimer disease brains.
genes like me logo Genes that share expressions with SERPINA3: view

Expression partners for SERPINA3 Gene

In Situ Assay Products

Orthologs for SERPINA3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SERPINA3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SERPINA3-1 35
  • 74.81 (n)
  • 66.07 (a)
-- 36
  • 63 (a)
OneToMany
-- 36
  • 63 (a)
OneToMany
-- 36
  • 65 (a)
OneToMany
-- 36
  • 62 (a)
OneToMany
-- 36
  • 63 (a)
OneToMany
SERPINA3-1 36
  • 64 (a)
OneToMany
SERPINA3-6 36
  • 63 (a)
OneToMany
dog
(Canis familiaris)
Mammalia SERPINA3 35
  • 73.65 (n)
  • 64.29 (a)
SERPINA3 36
  • 61 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Serpina3n 35
  • 70.39 (n)
  • 62.28 (a)
Serpina3n 16
Serpina3a 36
  • 51 (a)
OneToMany
Serpina3b 36
  • 52 (a)
OneToMany
Serpina3c 36
  • 59 (a)
OneToMany
Serpina3f 36
  • 55 (a)
OneToMany
Serpina3g 36
  • 55 (a)
OneToMany
Serpina3i 36
  • 60 (a)
OneToMany
Serpina3j 36
  • 53 (a)
OneToMany
Serpina3k 36
  • 59 (a)
OneToMany
Serpina3m 36
  • 61 (a)
OneToMany
Serpina3n 36
  • 62 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia SERPINA3 35
  • 98.5 (n)
  • 97.4 (a)
SERPINA3 36
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Serpina3n 35
  • 70.32 (n)
  • 62.34 (a)
oppossum
(Monodelphis domestica)
Mammalia SERPINA3 36
  • 48 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 54 (a)
OneToMany
Species with no ortholog for SERPINA3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SERPINA3 Gene

ENSEMBL:
Gene Tree for SERPINA3 (if available)
TreeFam:
Gene Tree for SERPINA3 (if available)

Paralogs for SERPINA3 Gene

Pseudogenes.org Pseudogenes for SERPINA3 Gene

genes like me logo Genes that share paralogs with SERPINA3: view

Variants for SERPINA3 Gene

Sequence variations from dbSNP and Humsavar for SERPINA3 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs4934 Benign, - 94,614,466(+) TCCTG(A/G)CTCTG missense, reference
rs10956 - 94,623,762(+) TACAG(A/G)CACCC reference, missense
rs17473 Pathogenic, - 94,619,305(+) CTATA(C/G)CTTAC reference, missense
rs733815 -- 94,621,529(-) GATGC(C/T)TGTCA intron-variant
rs737007 -- 94,623,457(+) AGTTG(A/G)CAGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SERPINA3 Gene

Variant ID Type Subtype PubMed ID
nsv470662 CNV Gain 18288195
nsv832865 CNV Gain 17160897

Relevant External Links for SERPINA3 Gene

HapMap Linkage Disequilibrium report
SERPINA3
Human Gene Mutation Database (HGMD)
SERPINA3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SERPINA3 Gene

Disorders for SERPINA3 Gene

(93) Novoseek inferred disease relationships for SERPINA3 Gene

Disease -log(P) Hits PubMed IDs
alzheimers disease 74.1 139
senile plaques 72.4 34
response acute phase 71.6 7
malignant fibrous histiocytoma 65.8 8
benign prostatic hyperplasia 63.5 11

Relevant External Links for SERPINA3

Genetic Association Database (GAD)
SERPINA3
Human Genome Epidemiology (HuGE) Navigator
SERPINA3
genes like me logo Genes that share disorders with SERPINA3: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for SERPINA3 Gene

Publications for SERPINA3 Gene

  1. A leucine-to-proline substitution causes a defective alpha 1- antichymotrypsin allele associated with familial obstructive lung disease. (PMID: 8244391) Poller W. … Heidtmann H.-H. (Genomics 1993) 3 4 23 48
  2. Alpha-1-antichymotrypsin gene A1252G variant (ACT Isehara-1) is associated with a lacunar type of ischemic cerebrovascular disease. (PMID: 11289720) Tachikawa H. … Shinohara Y. (J. Hum. Genet. 2001) 3 4 23 48
  3. Genetic risk factors of sporadic Alzheimer's disease among Chinese in Taiwan. (PMID: 11099722) Hu C.J. … Chang J.G. (J. Neurol. Sci. 2000) 3 23 48
  4. Increased frequency of the alpha-1-antichymotrypsin T allele in cerebral amyloid angiopathy. (PMID: 11132933) Durany N. … Cruz-SA!nchez F.F. (Neuropathology 2000) 3 23 48
  5. A linkage disequilibrium between genes at the serine protease inhibitor gene cluster on chromosome 14q32.1 is associated with Wegener's granulomatosis. (PMID: 11161981) Borgmann S. … Fricke H. (Clin. Immunol. 2001) 3 23 48

Products for SERPINA3 Gene

Sources for SERPINA3 Gene

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