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Aliases for OR51F2 Gene

Aliases for OR51F2 Gene

  • Olfactory Receptor Family 51 Subfamily F Member 2 2 3 5
  • Olfactory Receptor OR11-23 3 4
  • Olfactory Receptor, Family 51, Subfamily F, Member 2 2
  • Olfactory Receptor 51F2 3
  • OR11-23 3

External Ids for OR51F2 Gene

Previous GeneCards Identifiers for OR51F2 Gene

  • GC11U990517
  • GC11P004808
  • GC11P004799
  • GC11P004842

Summaries for OR51F2 Gene

Entrez Gene Summary for OR51F2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR51F2 Gene

OR51F2 (Olfactory Receptor Family 51 Subfamily F Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR51F1.

UniProtKB/Swiss-Prot for OR51F2 Gene

  • Odorant receptor.

Gene Wiki entry for OR51F2 Gene

Additional gene information for OR51F2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR51F2 Gene

Genomics for OR51F2 Gene

Regulatory Elements for OR51F2 Gene

Enhancers for OR51F2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H004881 0.7 ENCODE 9.8 +60.9 60903 0 TBL1XR1 TAL1 TCF12 FOXK2 GATA2 NCOR1 CREM RNF2 MTA2 ZBTB11 OR51F2 OR51T1 OR51A6P
GH11H004626 0.6 ENCODE 10.2 -195.0 -194956 0 CTCF ZNF654 RB1 REST ZNF2 RAD21 CC2D1A ZNF316 ZNF143 SMC3 OR51F2 OR52I2 C11orf40 TRIM68 GC11P004628 OR51D1
GH11H004484 0.3 FANTOM5 3.8 -336.8 -336847 0 OR52K1 TRIM21 OR51F2 OR52K2 OR51D1 OR51T1 OR51G1 OR52M2P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OR51F2 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR51F2 Gene

Chromosome:
11
Start:
4,821,321 bp from pter
End:
4,822,456 bp from pter
Size:
1,136 bases
Orientation:
Plus strand

Genomic View for OR51F2 Gene

Genes around OR51F2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR51F2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR51F2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR51F2 Gene

Proteins for OR51F2 Gene

  • Protein details for OR51F2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NH61-O51F2_HUMAN
    Recommended name:
    Olfactory receptor 51F2
    Protein Accession:
    Q8NH61
    Secondary Accessions:
    • Q6IFI1

    Protein attributes for OR51F2 Gene

    Size:
    342 amino acids
    Molecular mass:
    38518 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC05776.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for OR51F2 Gene

Post-translational modifications for OR51F2 Gene

  • Glycosylation at Asn17
  • Modification sites at PhosphoSitePlus

Other Protein References for OR51F2 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR51F2 Gene

Domains & Families for OR51F2 Gene

Gene Families for OR51F2 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Plasma proteins
  • Predicted membrane proteins

Protein Domains for OR51F2 Gene

Suggested Antigen Peptide Sequences for OR51F2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NH61

UniProtKB/Swiss-Prot:

O51F2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR51F2: view

Function for OR51F2 Gene

Molecular function for OR51F2 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR51F2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR51F2: view
genes like me logo Genes that share phenotypes with OR51F2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for OR51F2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR51F2 Gene

Localization for OR51F2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR51F2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR51F2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR51F2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IBA,TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR51F2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR51F2 Gene

Pathways & Interactions for OR51F2 Gene

genes like me logo Genes that share pathways with OR51F2: view

Pathways by source for OR51F2 Gene

Interacting Proteins for OR51F2 Gene

Gene Ontology (GO) - Biological Process for OR51F2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IBA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR51F2: view

No data available for SIGNOR curated interactions for OR51F2 Gene

Drugs & Compounds for OR51F2 Gene

No Compound Related Data Available

Transcripts for OR51F2 Gene

mRNA/cDNA for OR51F2 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for OR51F2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for OR51F2 Gene

No ASD Table

Relevant External Links for OR51F2 Gene

GeneLoc Exon Structure for
OR51F2
ECgene alternative splicing isoforms for
OR51F2

Expression for OR51F2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR51F2 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OR51F2 Gene



NURSA nuclear receptor signaling pathways regulating expression of OR51F2 Gene:

OR51F2

SOURCE GeneReport for Unigene cluster for OR51F2 Gene:

Hs.553562
genes like me logo Genes that share expression patterns with OR51F2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR51F2 Gene

Orthologs for OR51F2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR51F2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC466352 33
  • 98.93 (n)
OR51F2 34
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OR51F2 33 34
  • 88.82 (n)
rat
(Rattus norvegicus)
Mammalia LOC100912515 33
  • 85.82 (n)
dog
(Canis familiaris)
Mammalia OR51F2 34
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Or51f2 52 Olfr568 33 16 34
  • 84.19 (n)
oppossum
(Monodelphis domestica)
Mammalia OR51F2 34
  • 75 (a)
OneToOne
Species where no ortholog for OR51F2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR51F2 Gene

ENSEMBL:
Gene Tree for OR51F2 (if available)
TreeFam:
Gene Tree for OR51F2 (if available)

Paralogs for OR51F2 Gene

Paralogs for OR51F2 Gene

(403) SIMAP similar genes for OR51F2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR51F2: view

Variants for OR51F2 Gene

Sequence variations from dbSNP and Humsavar for OR51F2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000381622 -- 4,820,289(+) GGGAT(A/G)AGAAA upstream-variant-2KB
rs1000579753 -- 4,820,654(+) TCTGT(A/C)ATCGT upstream-variant-2KB
rs1001900909 -- 4,819,953(+) CTTGG(C/T)CCTTT upstream-variant-2KB
rs1002506790 -- 4,820,190(+) TTAGA(C/T)ATGCA upstream-variant-2KB
rs1003517169 -- 4,819,878(+) CTGGC(A/C)TCAAC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR51F2 Gene

Variant ID Type Subtype PubMed ID
dgv1026n100 CNV loss 25217958
dgv1587n54 CNV loss 21841781
dgv1588n54 CNV loss 21841781
esv2673268 CNV deletion 23128226
esv2760633 CNV loss 21179565
esv3579253 CNV loss 25503493
esv3625193 CNV loss 21293372
esv3625194 CNV loss 21293372
esv3891914 CNV gain 25118596
nsv1054847 CNV gain 25217958
nsv467666 CNV loss 19166990

Variation tolerance for OR51F2 Gene

Residual Variation Intolerance Score: 88.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.72; 66.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR51F2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR51F2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR51F2 Gene

Disorders for OR51F2 Gene

Relevant External Links for OR51F2

Genetic Association Database (GAD)
OR51F2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR51F2

No disorders were found for OR51F2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR51F2 Gene

Publications for OR51F2 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 60
  2. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 60
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 60

Products for OR51F2 Gene

Sources for OR51F2 Gene

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