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Aliases for CLK1 Gene

Aliases for CLK1 Gene

  • CDC-Like Kinase 1 2 3 4
  • CLK 3 4 6
  • EC 2.7.12.1 4 63
  • STY 3 6
  • Dual Specificity Protein Kinase CLK1 3
  • Protein Tyrosine Kinase STY 3
  • CDC28/CDC2-Like Kinase 3
  • CLK/STY 3

External Ids for CLK1 Gene

Previous GeneCards Identifiers for CLK1 Gene

  • GC02M199934
  • GC02M200442
  • GC02M201681
  • GC02M201920
  • GC02M201533
  • GC02M201425
  • GC02M201417
  • GC02M201717
  • GC02M193569

Summaries for CLK1 Gene

Entrez Gene Summary for CLK1 Gene

  • This gene encodes a member of the CDC2-like (or LAMMER) family of dual specificity protein kinases. In the nucleus, the encoded protein phosphorylates serine/arginine-rich proteins involved in pre-mRNA processing, releasing them into the nucleoplasm. The choice of splice sites during pre-mRNA processing may be regulated by the concentration of transacting factors, including serine/arginine rich proteins. Therefore, the encoded protein may play an indirect role in governing splice site selection. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]

GeneCards Summary for CLK1 Gene

CLK1 (CDC-Like Kinase 1) is a Protein Coding gene. Diseases associated with CLK1 include 3mc syndrome 2. Among its related pathways are Legionellosis and mRNA Splicing - Major Pathway. GO annotations related to this gene include protein serine/threonine kinase activity and protein serine/threonine/tyrosine kinase activity. An important paralog of this gene is CLK4.

UniProtKB/Swiss-Prot for CLK1 Gene

  • Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates: SRSF1, SRSF3 and PTPN1. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells and adenovirus E1A pre-mRNA.

Tocris Summary for CLK1 Gene

  • CLKs (Cdc2-like kinase)�are dual specificity protein kinases which are involved in gene splicing regulation. The CLK family has four family members: CLK1/STY, CLK2, CLK3 and CLK4. CLKs are useful targets for studying diseases attributed to gene mis-splicing events.

Gene Wiki entry for CLK1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLK1 Gene

Genomics for CLK1 Gene

Regulatory Elements for CLK1 Gene

Genomic Location for CLK1 Gene

Start:
200,853,009 bp from pter
End:
200,864,744 bp from pter
Size:
11,736 bases
Orientation:
Minus strand

Genomic View for CLK1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CLK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLK1 Gene

Proteins for CLK1 Gene

  • Protein details for CLK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49759-CLK1_HUMAN
    Recommended name:
    Dual specificity protein kinase CLK1
    Protein Accession:
    P49759
    Secondary Accessions:
    • B4DFW7
    • Q0P694
    • Q8N5V8

    Protein attributes for CLK1 Gene

    Size:
    484 amino acids
    Molecular mass:
    57291 Da
    Quaternary structure:
    • Interacts with PPIG and UBL5.

    Three dimensional structures from OCA and Proteopedia for CLK1 Gene

    Alternative splice isoforms for CLK1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CLK1 Gene

Proteomics data for CLK1 Gene at MOPED

Selected DME Specific Peptides for CLK1 Gene

Post-translational modifications for CLK1 Gene

Other Protein References for CLK1 Gene

Domains for CLK1 Gene

Gene Families for CLK1 Gene

HGNC:
  • CLK :CDC-like kinases
IUPHAR :

Suggested Antigen Peptide Sequences for CLK1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P49759

UniProtKB/Swiss-Prot:

CLK1_HUMAN :
  • P49759
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily.
genes like me logo Genes that share domains with CLK1: view

Function for CLK1 Gene

Molecular function for CLK1 Gene

GENATLAS Biochemistry: CDC-like kinase 1,with two alternatively spliced forms,one catalytically active and one inactive isoforms,interacting with and inducing the nuclear redistribution of SR proteins SFRS* (see symbols),widely expressed
UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot EnzymeRegulation: Regulates splicing of its own pre-mRNA according to its kinase activity; increased expression of the catalytically active form influences splicing to generate the catalytically inactive splicing variant lacking the kinase domain. Leucettine L41 inhibits its kinase activity and affects the regulation of alternative splicing mediated by phosphorylation of SR proteins (By similarity).
UniProtKB/Swiss-Prot Function: Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates: SRSF1, SRSF3 and PTPN1. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells and adenovirus E1A pre-mRNA.

Enzyme Numbers (IUBMB) for CLK1 Gene

Gene Ontology (GO) - Molecular Function for CLK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity IDA 10480872
GO:0004712 protein serine/threonine/tyrosine kinase activity IEA --
GO:0004713 protein tyrosine kinase activity --
GO:0004715 non-membrane spanning protein tyrosine kinase activity TAS 1825055
genes like me logo Genes that share ontologies with CLK1: view
genes like me logo Genes that share phenotypes with CLK1: view

miRNA for CLK1 Gene

miRTarBase miRNAs that target CLK1

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for CLK1 Gene

Localization for CLK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLK1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CLK1 Gene COMPARTMENTS Subcellular localization image for CLK1 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for CLK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with CLK1: view

Pathways for CLK1 Gene

SuperPathways for CLK1 Gene

genes like me logo Genes that share pathways with CLK1: view

Pathways by source for CLK1 Gene

1 BioSystems pathway for CLK1 Gene
1 KEGG pathway for CLK1 Gene

Gene Ontology (GO) - Biological Process for CLK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation --
GO:0008283 cell proliferation TAS 1704889
GO:0018105 peptidyl-serine phosphorylation IEA --
GO:0018107 peptidyl-threonine phosphorylation IEA --
GO:0018108 peptidyl-tyrosine phosphorylation IEA --
genes like me logo Genes that share ontologies with CLK1: view

Compounds for CLK1 Gene

(1) Tocris Compounds for CLK1 Gene

Compound Action Cas Number
TG 003 Potent, ATP-competitive inhibitor of Clk-family kinases [719277-26-6]

(2) HMDB Compounds for CLK1 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0

(2) Drugbank Compounds for CLK1 Gene

(1) Novoseek inferred chemical compound relationships for CLK1 Gene

Compound -log(P) Hits PubMed IDs
serine 59.1 1
genes like me logo Genes that share compounds with CLK1: view

Transcripts for CLK1 Gene

Unigene Clusters for CLK1 Gene

CDC-like kinase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CLK1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c · 4d · 4e · 4f ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b ^
SP1: - - - - - - - - - - - -
SP2: - - - - - - - - - - - - -
SP3: - - - - - - - -
SP4: - - - - - - - - - - - - -
SP5: - - -
SP6: - - - - - - -
SP7: - - - - - - - - - -
SP8: - - - - - -
SP9: - - - - - - - - -
SP10:
SP11:
SP12: - - -
SP13:
SP14: - - - -
SP15: -
SP16: - - - - -

ExUns: 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b
SP1: -
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for CLK1 Gene

GeneLoc Exon Structure for
CLK1
ECgene alternative splicing isoforms for
CLK1

Expression for CLK1 Gene

mRNA expression in normal human tissues for CLK1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CLK1 Gene

SOURCE GeneReport for Unigene cluster for CLK1 Gene Hs.433732

mRNA Expression by UniProt/SwissProt for CLK1 Gene

P49759-CLK1_HUMAN
Tissue specificity: Endothelial cells.
genes like me logo Genes that share expressions with CLK1: view

No data available for mRNA differential expression in normal tissues for CLK1 Gene

Orthologs for CLK1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CLK1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CLK1 35
  • 99.68 (n)
  • 99.43 (a)
CLK1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CLK1 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CLK1 35
  • 90.65 (n)
  • 92.35 (a)
CLK1 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Clk1 35
  • 88.15 (n)
  • 90.02 (a)
Clk1 16
Clk1 36
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CLK1 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CLK1 36
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Clk1 35
  • 87.94 (n)
  • 90.64 (a)
chicken
(Gallus gallus)
Aves CLK1 35
  • 73.68 (n)
  • 76 (a)
CLK1 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CLK1 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia clk1 35
  • 70.32 (n)
  • 71.18 (a)
zebrafish
(Danio rerio)
Actinopterygii clk4a 36
  • 56 (a)
ManyToMany
clk4b 36
  • 58 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Doa 36
  • 13 (a)
OneToMany
Doa 37
  • 60 (a)
worm
(Caenorhabditis elegans)
Secernentea tag-172 36
  • 23 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KNS1 36
  • 23 (a)
OneToMany
KNS1 38
corn
(Zea mays)
Liliopsida Zm.16829 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.719 36
  • 48 (a)
OneToMany
Species with no ortholog for CLK1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CLK1 Gene

ENSEMBL:
Gene Tree for CLK1 (if available)
TreeFam:
Gene Tree for CLK1 (if available)

Paralogs for CLK1 Gene

Paralogs for CLK1 Gene

Selected SIMAP similar genes for CLK1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CLK1: view

Variants for CLK1 Gene

Sequence variations from dbSNP and Humsavar for CLK1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs7224 -- 200,853,187(-) TGTTT(A/C)TTTTG utr-variant-3-prime, nc-transcript-variant
rs12709 - 200,853,385(-) GTTGG(A/G)GTATG reference, missense, nc-transcript-variant
rs14379 -- 200,854,666(-) GCAAT(G/T)ATGGA reference, missense, nc-transcript-variant
rs15175 -- 200,853,290(-) GGACA(G/T)CTCTC utr-variant-3-prime, nc-transcript-variant
rs1042600 -- 200,855,038(-) CATTC(A/T)TATTG missense, reference, nc-transcript-variant

Relevant External Links for CLK1 Gene

HapMap Linkage Disequilibrium report
CLK1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CLK1 Gene

Disorders for CLK1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for CLK1 Gene including...

Search for CLK1 Gene in MalaCards »
genes like me logo Genes that share disorders with CLK1: view

No data available for UniProtKB/Swiss-Prot for CLK1 Gene

Publications for CLK1 Gene

  1. Molecular cloning of a novel human cdc2/CDC28-like protein kinase. (PMID: 1704889) Johnson K.W. … Smith K.A. (J. Biol. Chem. 1991) 3 4 23
  2. Characterization by cDNA cloning of two new human protein kinases. Evidence by sequence comparison of a new family of mammalian protein kinases. (PMID: 7990150) Hanes J.J. … Scheit K.H. (J. Mol. Biol. 1994) 3 4
  3. Manipulation of alternative splicing by a newly developed inhibitor of Clks. (PMID: 15010457) Muraki M. … Hagiwara M. (J. Biol. Chem. 2004) 3 23
  4. Chromosomal mapping of three human LAMMER protein-kinase-encoding genes. (PMID: 9856501) Talmadge C.B. … Rabinow L. (Hum. Genet. 1998) 2 3
  5. The CLK family kinases, CLK1 and CLK2, phosphorylate and activate the tyrosine phosphatase, PTP-1B. (PMID: 10480872) Moeslein F.M. … Landreth G.E. (J. Biol. Chem. 1999) 3 4

Products for CLK1 Gene

  • Addgene plasmids for CLK1

Sources for CLK1 Gene

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