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Aliases for CLIC2 Gene

Aliases for CLIC2 Gene

  • Chloride Intracellular Channel 2 2 3
  • XAP121 3 4 6
  • MRXS32 3 6
  • Chloride Intracellular Channel Protein 2 3
  • CLIC2b 3

External Ids for CLIC2 Gene

Previous GeneCards Identifiers for CLIC2 Gene

  • GC0XP148554
  • GC0XP150871
  • GC0XM152023
  • GC0XM152928
  • GC0XM154070
  • GC0XM154158
  • GC0XM154505
  • GC0XM143049

Summaries for CLIC2 Gene

Entrez Gene Summary for CLIC2 Gene

  • This gene encodes a chloride intracellular channel protein. Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. This protein may play a role in inhibiting the function of ryanodine receptor 2. A mutation in this gene is the cause of X-linked mental retardation-32. [provided by RefSeq, Aug 2013]

GeneCards Summary for CLIC2 Gene

CLIC2 (Chloride Intracellular Channel 2) is a Protein Coding gene. Diseases associated with CLIC2 include mental retardation, x-linked, syndromic 32 and x-linked intellectual disability - cardiomegaly - congestive heart failure. Among its related pathways are Activation of cAMP-Dependent PKA and Activation of cAMP-Dependent PKA. GO annotations related to this gene include chloride channel activity and glutathione peroxidase activity. An important paralog of this gene is CLIC1.

UniProtKB/Swiss-Prot for CLIC2 Gene

  • Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Modulates the activity of RYR2 and inhibits calcium influx.

Gene Wiki entry for CLIC2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLIC2 Gene

Genomics for CLIC2 Gene

Genomic Location for CLIC2 Gene

155,276,207 bp from pter
155,334,681 bp from pter
58,475 bases
Minus strand

Genomic View for CLIC2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CLIC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLIC2 Gene

No data available for Regulatory Elements for CLIC2 Gene

Proteins for CLIC2 Gene

  • Protein details for CLIC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Chloride intracellular channel protein 2
    Protein Accession:
    Secondary Accessions:
    • A8K9S0
    • O15174
    • Q5JT80
    • Q8TCE3

    Protein attributes for CLIC2 Gene

    247 amino acids
    Molecular mass:
    28356 Da
    Quaternary structure:
    • Monomer. Interacts with TRAPPC2 and RYR2.
    • Sequence=CAA73228.1; Type=Frameshift; Positions=244; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CLIC2 Gene

neXtProt entry for CLIC2 Gene

Proteomics data for CLIC2 Gene at MOPED

Post-translational modifications for CLIC2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CLIC2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CLIC2 Gene

Domains for CLIC2 Gene

Gene Families for CLIC2 Gene

  • CLIC :Ion channels / Chloride channels : Intracellular

Suggested Antigen Peptide Sequences for CLIC2 Gene

Graphical View of Domain Structure for InterPro Entry



  • O15247
  • Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion
  • Contains 1 GST C-terminal domain.
  • Belongs to the chloride channel CLIC family.
genes like me logo Genes that share domains with CLIC2: view

Function for CLIC2 Gene

Molecular function for CLIC2 Gene

UniProtKB/Swiss-Prot Function: Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Modulates the activity of RYR2 and inhibits calcium influx.

Gene Ontology (GO) - Molecular Function for CLIC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004364 NOT glutathione transferase activity IDA 15147738
GO:0004602 glutathione peroxidase activity IDA 15147738
GO:0005244 voltage-gated ion channel activity IEA --
GO:0005247 voltage-gated chloride channel activity --
GO:0005254 chloride channel activity IEA --
genes like me logo Genes that share ontologies with CLIC2: view

Animal Model Products

CRISPR Products

miRNA for CLIC2 Gene

miRTarBase miRNAs that target CLIC2

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CLIC2 Gene

Localization for CLIC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLIC2 Gene

Cytoplasm. Membrane; Single-pass membrane protein. Note=Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain.

Subcellular locations from

Jensen Localization Image for CLIC2 Gene COMPARTMENTS Subcellular localization image for CLIC2 gene
Compartment Confidence
nucleus 5
cytosol 3
endoplasmic reticulum 1
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CLIC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA --
GO:0005634 nucleus TAS 16130169
GO:0005737 cytoplasm TAS 16130169
GO:0034707 chloride channel complex IEA --
genes like me logo Genes that share ontologies with CLIC2: view

Pathways for CLIC2 Gene

genes like me logo Genes that share pathways with CLIC2: view

Interacting Proteins for CLIC2 Gene

Gene Ontology (GO) - Biological Process for CLIC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport TAS 9339381
GO:0007165 signal transduction TAS 16130169
GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum IDA 15147738
GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion IC 15147738
GO:0044070 regulation of anion transport --
genes like me logo Genes that share ontologies with CLIC2: view

Compounds for CLIC2 Gene

(1) HMDB Compounds for CLIC2 Gene

Compound Synonyms Cas Number PubMed IDs
  • Cl2

(4) Novoseek inferred chemical compound relationships for CLIC2 Gene

Compound -log(P) Hits PubMed IDs
ryanodine 68.5 5
chloride 65.2 7
calcium 16.3 7
lipid 6.42 1
genes like me logo Genes that share compounds with CLIC2: view

Transcripts for CLIC2 Gene

mRNA/cDNA for CLIC2 Gene

Unigene Clusters for CLIC2 Gene

Chloride intracellular channel 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CLIC2

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CLIC2 Gene

No ASD Table

Relevant External Links for CLIC2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CLIC2 Gene

mRNA expression in normal human tissues for CLIC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CLIC2 Gene

SOURCE GeneReport for Unigene cluster for CLIC2 Gene Hs.655445

mRNA Expression by UniProt/SwissProt for CLIC2 Gene

Tissue specificity: Expressed in adult and fetal brain, heart, skeletal muscle, liver, lung, and spleen. Detected in adult stomach and testis. Expressed in fetal thymus and kidney.
genes like me logo Genes that share expressions with CLIC2: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for CLIC2 Gene

Orthologs for CLIC2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CLIC2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CLIC2 35
  • 99.87 (n)
  • 100 (a)
CLIC2 36
  • 100 (a)
(Bos Taurus)
Mammalia CLIC2 35
  • 90.82 (n)
  • 93.12 (a)
CLIC2 36
  • 93 (a)
(Canis familiaris)
Mammalia CLIC2 35
  • 93.42 (n)
  • 97.48 (a)
CLIC2 36
  • 97 (a)
(Monodelphis domestica)
Mammalia CLIC2 36
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia CLIC2 36
  • 87 (a)
(Rattus norvegicus)
Mammalia Clic2 35
  • 88.84 (n)
  • 92.65 (a)
(Gallus gallus)
Aves CLIC2 35
  • 73.7 (n)
  • 78.06 (a)
CLIC2 36
  • 76 (a)
(Danio rerio)
Actinopterygii clic2 35
  • 68.64 (n)
  • 72.57 (a)
clic2 36
  • 71 (a)
fruit fly
(Drosophila melanogaster)
Insecta Clic 36
  • 28 (a)
(Caenorhabditis elegans)
Secernentea exc-4 36
  • 21 (a)
exl-1 36
  • 28 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons DHAR3 35
  • 47.38 (n)
  • 32.49 (a)
(Oryza sativa)
Liliopsida Os06g0232600 35
  • 45.86 (n)
  • 30.39 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6991 36
  • 43 (a)
Species with no ortholog for CLIC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CLIC2 Gene

Gene Tree for CLIC2 (if available)
Gene Tree for CLIC2 (if available)

Paralogs for CLIC2 Gene

Paralogs for CLIC2 Gene

Selected SIMAP similar genes for CLIC2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CLIC2: view

Variants for CLIC2 Gene

Sequence variations from dbSNP and Humsavar for CLIC2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs481097 -- 155,320,691(-) gttta(G/T)ttccc intron-variant
rs494699 -- 155,281,489(+) AAAGG(A/C)TAAAA intron-variant
rs495736 -- 155,327,741(+) ACCTA(A/T)ATAAC intron-variant
rs496740 -- 155,327,848(+) GAATG(A/G)TTCAA intron-variant
rs497502 -- 155,284,522(+) ccaaa(C/G)tgctg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CLIC2 Gene

Variant ID Type Subtype PubMed ID
esv33784 CNV Gain+Loss 17666407
esv29972 CNV Gain 17803354
esv273048 CNV Insertion 20981092
esv26400 CNV Loss 19812545
nsv508817 CNV Insertion 20534489

Relevant External Links for CLIC2 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)
Locus Specific Mutation Databases (LSDB)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLIC2 Gene

Disorders for CLIC2 Gene

(1) OMIM Diseases for CLIC2 Gene (300138)


  • Mental retardation, X-linked, syndromic, 32 (MRXS32) [MIM:300886]: A mental retardation syndrome characterized by profound intellectual deficit, delayed psychomotor development beginning in infancy and little or no speech development. Additional features include seizures, large joint contractures, and abnormal positioning of the thumbs. Mental retardation is defined by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. {ECO:0000269 PubMed:22814392}. Note=The disease is caused by mutations affecting the gene represented in this entry.
genes like me logo Genes that share disorders with CLIC2: view

Publications for CLIC2 Gene

  1. Genomic structure of a novel chloride channel gene, CLIC2, in Xq28. (PMID: 9339381) Heiss N.S. … Poustka A. (Genomics 1997) 2 3 4 23
  2. CLIC-2 modulates cardiac ryanodine receptor Ca2+ release channels. (PMID: 15147738) Board P.G. … Dulhunty A.F. (Int. J. Biochem. Cell Biol. 2004) 3 4 23
  3. A recently identified member of the glutathione transferase structural family modifies cardiac RyR2 substate activity, coupled gating and activation by Ca2+ and ATP. (PMID: 15916532) Dulhunty A.F. … Board P.G. (Biochem. J. 2005) 3 4 23
  4. Expression, purification, crystallization and preliminary X-ray diffraction analysis of chloride intracellular channel 2 (CLIC2). (PMID: 18007051) Cromer B.A. … Parker M.W. (Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2007) 3 23
  5. Interaction of sedlin with chloride intracellular channel proteins. (PMID: 12681486) Fan L. … Zhu X. (FEBS Lett. 2003) 3 4

Products for CLIC2 Gene

Sources for CLIC2 Gene

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